Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
9901
[ "HeLa", "cells", "stably", "or", "transiently", "transfected", "with", "mutant", "CIITA", "constructs", "showed", "up", "to", "99", "%", "suppression", "of", "MHC", "class", "II", "antigen", "induction", "by", "IFN-gamma", "and", "marked", "suppression", "of", "HLA-DRA", "mRNA", "expression", "." ]
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9902
[ "Transient", "transfection", "of", "a", "B", "lymphoma", "line", "resulted", "in", "up", "to", "89", "%", "reduction", "of", "constitutive", "MHC", "class", "II", "expression", "within", "5", "days", "and", "suppression", "of", "HLA-DRA", "mRNA", "synthesis", "." ]
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9903
[ "Helenalin", ",", "an", "anti-inflammatory", "sesquiterpene", "lactone", "from", "Arnica", ",", "selectively", "inhibits", "transcription", "factor", "NF-kappaB", "[", "see", "comments", "]" ]
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9904
[ "Alcoholic", "extracts", "prepared", "form", "Arnicae", "flos", ",", "the", "collective", "name", "for", "flowerheads", "from", "Arnica", "montana", "and", "A.", "chamissonis", "ssp.", "foliosa", ",", "are", "used", "therapeutically", "as", "anti-inflammatory", "remedies", "." ]
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9905
[ "The", "active", "ingredients", "mediating", "the", "pharmacological", "effect", "are", "mainly", "sesquiterpene", "lactones", ",", "such", "as", "helenalin", ",", "11alpha", ",", "13-dihydrohelenalin", ",", "chamissonolid", "and", "their", "ester", "derivatives", "." ]
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9906
[ "While", "these", "compounds", "affect", "various", "cellular", "processes", ",", "current", "data", "do", "not", "fully", "explain", "how", "sesquiterpene", "lactones", "exert", "their", "anti-inflammatory", "effect", "." ]
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9907
[ "We", "show", "here", "that", "helenalin", ",", "and", ",", "to", "a", "much", "lesser", "degree", ",", "11alpha", ",", "13-dihydrohelenalin", "and", "chamissonolid", ",", "inhibit", "activation", "of", "transcription", "factor", "NF-kappaB", "." ]
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9908
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9909
[ "NF-kappaB", ",", "which", "resides", "in", "an", "inactive", ",", "cytoplasmic", "complex", "in", "unstimulated", "cells", ",", "is", "activated", "by", "phosphorylation", "and", "degradation", "of", "its", "inhibitory", "subunit", ",", "IkappaB", "." ]
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9910
[ "Helenalin", "inhibits", "NF-kappaB", "activation", "in", "response", "to", "four", "different", "stimuli", "in", "T-cells", ",", "B-cells", "and", "epithelial", "cells", "and", "abrogates", "kappaB", "-driven", "gene", "expression", "." ]
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9911
[ "This", "inhibition", "is", "selective", ",", "as", "the", "activity", "of", "four", "other", "transcription", "factors", ",", "Oct-1", ",", "TBP", ",", "Sp1", "and", "STAT", "5", "was", "not", "affected", "." ]
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9912
[ "We", "show", "that", "inhibition", "is", "not", "due", "to", "a", "direct", "modification", "of", "the", "active", "NF-kappaB", "heterodimer", "." ]
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9913
[ "Rather", ",", "helenalin", "modifies", "the", "NF-kappaB/IkappaB", "complex", ",", "preventing", "the", "release", "of", "IkappaB", "." ]
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9914
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9915
[ "The", "tax", "protein", "of", "human", "T-cell", "leukemia", "virus", "type", "1", "mediates", "the", "transactivation", "of", "the", "c-sis/platelet-derived", "growth", "factor-B", "promoter", "through", "interactions", "with", "the", "zinc", "finger", "transcription", "factors", "Sp1", "and", "NGFI-A/Egr-1", "." ]
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9916
[ "Transcriptional", "up-regulation", "of", "the", "c-sis/platelet-derived", "growth", "factor-B", "(", "PDGF-B", ")", "proto-oncogene", "by", "the", "Tax", "protein", "of", "human", "T-cell", "leukemia", "virus", "type", "1", "has", "been", "implicated", "as", "one", "possible", "mechanism", "of", "cellular", "transformation", "by", "human", "T-cell", "leukemia", "virus", "type", "1", "." ]
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9917
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9918
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9919
[ "In", "the", "present", "work", ",", "we", "have", "investigated", "the", "mechanism", "(", "s", ")", "whereby", "Tax", "transactivates", "the", "c-sis/PDGF-B", "proto-oncogene", "." ]
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9920
[ "In", "vitro", "transcription", "assays", "showed", "that", "Tax", "was", "able", "to", "significantly", "increase", "the", "transcriptional", "activity", "of", "a", "template", "containing", "the", "-257", "to", "+74", "region", "of", "the", "c-sis/PDGF-B", "promoter", "." ]
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9921
[ "Electrophoretic", "mobility", "shift", "assay", "analysis", "showed", "that", "Tax", "increased", "the", "DNA", "binding", "activity", "of", "both", "Sp1", "and", "NGFI-A/Egr-1", "using", "a", "TRE1", "probe", "." ]
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9922
[ "Analysis", "of", "Tax", "mutants", "showed", "that", "two", "mutants", ",", "IEXC29S", "and", "IEXL320G", ",", "were", "unable", "to", "significantly", "transactivate", "the", "c-sis/PDGF-B", "promoter", "." ]
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9923
[ "Finally", ",", "co-immunoprecipitation", "analysis", "revealed", "that", "Tax", "is", "able", "to", "stably", "bind", "to", "both", "Sp1", "and", "NGFI-A/Egr-1", "." ]
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9924
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9925
[ "Nuclear", "localization", "of", "RelB", "is", "associated", "with", "effective", "antigen-presenting", "cell", "function", "." ]
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9926
[ "Dendritic", "cells", "(", "DC", ")", "are", "potent", "APCs", "that", "enter", "resting", "tissues", "as", "precursors", "and", ",", "after", "Ag", "exposure", ",", "differentiate", "and", "migrate", "to", "draining", "lymph", "nodes", "." ]
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9927
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9928
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9929
[ "RelB", "protein", "and", "mRNA", "were", "detected", "constitutively", "in", "lymphocytes", "and", "in", "activated", "monocytes", ",", "differentiated", "DC", ",", "and", "monocyte-derived", "DC", "." ]
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9930
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9931
[ "Active", "nuclear", "RelB", "was", "detected", "by", "supershift", "assay", "only", "in", "differentiated", "DC", "derived", "from", "either", "PB", "precursors", "or", "monocytes", "and", "in", "activated", "B", "cells", "." ]
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9932
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9933
[ "The", "data", "indicate", "that", "RelB", "expression", "is", "regulated", "both", "transcriptionally", "and", "post-translationally", "in", "myeloid", "cells", "." ]
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9934
[ "Within", "the", "nucleus", ",", "RelB", "may", "specifically", "transactivate", "genes", "that", "are", "critical", "for", "APC", "function", "." ]
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9935
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9936
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9937
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9938
[ "A", "member", "of", "the", "tumor", "necrosis", "factor", "receptor", "superfamily", "was", "isolated", "by", "virtue", "of", "its", "affinity", "for", "CAML", "." ]
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9939
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9940
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9941
[ "Rel/NF-kappa", "B", "transcription", "factors", "and", "the", "control", "of", "apoptosis", "." ]
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9942
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9943
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9944
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9945
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9946
[ "A", "thiol", "antioxidant", "regulates", "IgE", "isotype", "switching", "by", "inhibiting", "activation", "of", "nuclear", "factor-kappaB", "." ]
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9947
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9948
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9949
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9950
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9951
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9952
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9953
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9954
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9955
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9956
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9957
[ "Pathogenesis", "." ]
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9958
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10000
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