Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
9801
[ "CD30", "is", "a", "cell-surface", "receptor", "that", "can", "augment", "lymphocyte", "activation", "and", "survival", "through", "its", "ability", "to", "induce", "the", "transcription", "factor", "NF-kappaB", "." ]
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9802
[ "CD30", ",", "however", ",", "has", "also", "been", "implicated", "in", "the", "induction", "of", "apoptotic", "cell", "death", "of", "lymphocytes", "." ]
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9803
[ "Here", "we", "show", "that", "one", "of", "the", "effects", "of", "CD30", "signal", "transduction", "is", "to", "render", "cells", "sensitive", "to", "apoptosis", "induced", "by", "the", "type", "1", "tumor", "necrosis", "factor", "receptor", "(", "TNFR1", ")", "." ]
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9804
[ "This", "sensitization", "is", "dependent", "on", "the", "TRAF-binding", "sites", "within", "the", "CD30", "cytoplasmic", "domain", "." ]
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9805
[ "One", "of", "the", "proteins", "that", "binds", "to", "these", "sites", "is", "TRAF2", ",", "a", "signal", "transduction", "molecule", "that", "is", "also", "utilized", "by", "TNFR1", "to", "mediate", "the", "activation", "of", "several", "downstream", "kinases", "and", "transcription", "factors", "." ]
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9806
[ "During", "CD30", "signal", "transduction", ",", "we", "found", "that", "binding", "of", "TRAF2", "to", "the", "cytoplasmic", "domain", "of", "CD30", "results", "in", "the", "rapid", "depletion", "of", "TRAF2", "and", "the", "associated", "protein", "TRAF1", "by", "proteolysis", "." ]
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9807
[ "These", "data", "suggest", "a", "model", "in", "which", "CD30", "limits", "its", "own", "ability", "to", "transduce", "cell", "survival", "signals", "through", "signal-coupled", "depletion", "of", "TRAF2", "." ]
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9808
[ "Depletion", "of", "intracellular", "TRAF2", "and", "its", "coassociated", "proteins", "also", "increased", "the", "sensitivity", "of", "the", "cell", "to", "undergoing", "apoptosis", "during", "activation", "of", "death-inducing", "receptors", "such", "as", "TNFR1", "." ]
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9809
[ "Consistent", "with", "this", "hypothesis", ",", "expression", "of", "a", "dominant-negative", "form", "of", "TRAF2", "was", "found", "to", "potentiate", "TNFR1", "-mediated", "death", "." ]
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9810
[ "These", "studies", "provide", "a", "potential", "mechanism", "through", "which", "CD30", ",", "as", "well", "as", "other", "TRAF-binding", "members", "of", "the", "TNFR", "superfamily", ",", "can", "negatively", "regulate", "cell", "survival", "." ]
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9811
[ "Analysis", "of", "myeloid-associated", "genes", "in", "human", "hematopoietic", "progenitor", "cells", "." ]
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9812
[ "The", "distribution", "of", "myeloid", "lineage-associated", "cytokine", "receptors", "and", "lysosomal", "proteins", "was", "analyzed", "in", "human", "CD34+", "cord", "blood", "cell", "(", "CB", ")", "subsets", "at", "different", "stages", "of", "myeloid", "commitment", "by", "reverse-transcriptase", "polymerase", "chain", "reaction", "(", "RT-PCR", ")", "." ]
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9813
[ "The", "highly", "specific", "granulomonocyte-associated", "lysosomal", "proteins", "myeloperoxidase", "(", "MPO", ")", "and", "lysozyme", "(", "LZ", ")", ",", "as", "well", "as", "the", "transcription", "factor", "PU.1", ",", "were", "already", "detectable", "in", "the", "most", "immature", "CD34+Thy-1+", "subset", "." ]
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9814
[ "Messenger", "RNA", "(", "mRNA", ")", "levels", "for", "the", "granulocyte-colony", "stimulating", "factor", "(", "G-CSF", ")", "receptor", ",", "granulocyte-macrophage", "(", "GM", ")", "-CSF", "receptor", "alpha", "subunit", "and", "tumor", "necrosis", "factor", "(", "TNF", ")", "receptors", "I", "(", "p55", ")", "and", "II", "(", "p75", ")", "were", "also", "detected", "in", "this", "subset", "in", "addition", "to", "c-kit", "and", "flt-3", ",", "receptors", "known", "to", "be", "expressed", "on", "progenitor", "cells", "." ]
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9815
[ "By", "contrast", ",", "the", "monocyte-macrophage", "colony", "stimulating", "factor", "(", "M-CSF", ")", "receptor", "was", "largely", "absent", "at", "this", "stage", "and", "in", "the", "CD34+Thy-1-CD45RA-", "subsets", "." ]
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9816
[ "The", "M-CSF", "receptor", "was", "first", "detectable", "in", "the", "myeloid-committed", "CD34+Thy-l-CD45RA+", "subset", "." ]
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9817
[ "All", "other", "molecules", "studied", "were", "found", "to", "be", "expressed", "at", "this", "stage", "of", "differentiation", "." ]
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9818
[ "Different", "cocktails", "of", "the", "identified", "ligands", "were", "added", "to", "sorted", "CD34+Thy-1+", "single", "cells", "." ]
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9819
[ "Low", "proliferative", "capacity", "was", "observed", "after", "1", "week", "in", "culture", "in", "the", "presence", "of", "stem", "cell", "factor", "(", "SCF", ")", "+", "Flt-3", "ligand", "(", "FL", ")", "+", "G-CSF", "." ]
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9820
[ "Addition", "of", "GM-CSF", "to", "this", "basic", "cocktail", "consistently", "increased", "the", "clonogenic", "capacity", "of", "single", "CD34+Thy-1+", "cells", ",", "and", "this", "effect", "was", "further", "enhanced", "(", "up", "to", "72.3", "+/-", "4.3", "%", "on", "day", "7", ")", "by", "the", "inclusion", "of", "TNF-alpha", "." ]
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9821
[ "In", "conclusion", ",", "the", "presence", "of", "myeloid-associated", "growth", "factor", "receptor", "transcripts", "in", "CD34+", "CB", "subsets", "does", "not", "discriminate", "the", "various", "stages", "of", "differentiation", ",", "with", "the", "exception", "of", "the", "M-CSF", "receptor", "." ]
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9822
[ "In", "addition", ",", "we", "show", "that", "TNF-alpha", "is", "a", "potent", "costimulatory", "factor", "of", "the", "very", "immature", "CD34+Thy-1+", "CB", "subset", "." ]
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9823
[ "Induction", "of", "endothelial", "cell", "surface", "adhesion", "molecules", "by", "tumor", "necrosis", "factor", "is", "blocked", "by", "protein", "tyrosine", "phosphatase", "inhibitors", ":", "role", "of", "the", "nuclear", "transcription", "factor", "NF-kappa", "B", "." ]
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9824
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9825
[ "Since", "TNF", "is", "one", "of", "the", "major", "inducers", "of", "various", "adhesion", "molecules", "in", "human", "endothelial", "cells", "and", "their", "expression", "is", "known", "to", "require", "the", "activation", "of", "NF-kappa", "B", ",", "we", "examined", "the", "effect", "of", "PTPase", "inhibitors", "on", "the", "TNF", "-mediated", "induction", "of", "intracellular", "adhesion", "molecule", "(", "ICAM", ")", "-1", ",", "vascular", "cell", "adhesion", "molecule", "(", "VCAM", ")", "-1", "and", "endothelial", "leukocyte", "adhesion", "molecule", "(", "ELAM", ")", "-1", "." ]
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9826
[ "Like", "ML-1a", ",", "human", "dermal", "microvessel", "endothelial", "cells", "(", "MVEC", ")", "treated", "with", "TNF", "rapidly", "activated", "(", "within", "30", "min", ")", "NF-kappa", "B", ";", "this", "effect", "was", "completely", "abolished", "by", "co-treatment", "with", "phenylarsine", "oxide", "(", "PAO", ")", ",", "a", "specific", "inhibitor", "of", "PTPase", "." ]
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9827
[ "The", "induction", "of", "ICAM-1", ",", "VCAM-1", ",", "and", "ELAM-1", "by", "TNF", "in", "MVEC", "occurred", "within", "6", "h", "and", "was", "also", "completely", "down-regulated", "by", "PAO", "in", "a", "dose-dependent", "manner", "." ]
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9828
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9829
[ "Besides", "PAO", ",", "other", "inhibitors", "of", "PTPase", ",", "including", "pervanadate", "and", "diamide", ",", "also", "blocked", "TNF", "-dependent", "NF-kappa", "B", "activation", "and", "induction", "of", "all", "the", "three", "adhesion", "proteins", "." ]
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9830
[ "Consistent", "with", "these", "results", ",", "the", "attachment", "of", "monocytes", "to", "MVEC", "was", "also", "blocked", "by", "the", "PTPase", "inhibitors", "." ]
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9831
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9832
[ "Because", "of", "their", "role", "in", "cell", "adhesion", ",", "PTPase", "may", "provide", "a", "novel", "target", "of", "drug", "development", "for", "treatment", "of", "inflammation", ",", "atherogenesis", ",", "and", "tumor", "metastasis", "." ]
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9833
[ "Regulation", "of", "nuclear", "factor-kappa", "B", "and", "its", "inhibitor", "I", "kappa", "B-alpha/MAD-3", "in", "monocytes", "by", "Mycobacterium", "tuberculosis", "and", "during", "human", "tuberculosis", "." ]
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9834
[ "Blood", "monocytes", "from", "patients", "with", "active", "tuberculosis", "are", "activated", "in", "vivo", ",", "as", "evidenced", "by", "an", "increase", "in", "the", "stimulated", "release", "of", "proinflammatory", "cytokines", ",", "such", "as", "TNF-alpha", ",", "and", "the", "spontaneous", "expression", "of", "IL-2R", "." ]
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9835
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9836
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9837
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9838
[ "We", "found", "a", "constitutive", "degradation", "of", "I", "kappa", "B-alpha", ",", "the", "major", "cytoplasmic", "inhibitor", "of", "nuclear", "factor", "kappa", "B", "(", "NF-kappa", "B", ")", ",", "in", "freshly", "isolated", "PBMC", "and", "monocytes", "from", "patients", "with", "tuberculosis", "." ]
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9839
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9840
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9841
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9842
[ "By", "contrast", ",", "the", "expression", "of", "other", "adherence-associated", "early", "genes", ",", "such", "as", "IL-8", "and", "IL-1", "beta", ",", "was", "not", "up-regulated", "in", "PBMC", "of", "tuberculous", "patients", "." ]
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9843
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9844
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9845
[ "Spi-1/PU.1", "is", "a", "myeloid-", "and", "B-cell", "specific", "transcription", "factor", "which", "is", "also", "involved", "in", "Friend", "virus-induced", "murine", "erythroleukemia", "." ]
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9846
[ "The", "pre-leukemic", "phase", "of", "Friend", "erythroleukemia", "results", "from", "activation", "of", "the", "erythropoietin", "receptor", "(", "EpoR", ")", "by", "the", "spleen", "focus", "forming", "virus", "(", "SFFV", ")", "envelope", "glycoprotein", ",", "followed", "by", "the", "emergence", "of", "leukemic", "clones", "characterized", "by", "overexpression", "of", "Spi-1", "and", "mutation", "of", "the", "p53", "tumor", "suppressor", "gene", "." ]
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9847
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9848
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9849
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9850
[ "Although", "devoid", "of", "any", "effect", "by", "itself", ",", "a", "mutant", "p53", "cooperated", "with", "Spi-1", "and", "EpoR", "(", "R129C", ")", "to", "reinforce", "both", "phenotypes", "." ]
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9851
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9857
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9859
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9860
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9861
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9863
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9865
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9866
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9867
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9870
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9871
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9872
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9873
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9874
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9875
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9877
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9878
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9879
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9880
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9881
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9882
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9883
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9884
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9885
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9886
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9887
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9888
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9889
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9890
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9891
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9892
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9893
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9894
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9895
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9896
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9897
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9898
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9899
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