Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
9701
[ "Our", "findings", "demonstrate", "that", "truncated", "TSG101", "and", "FHIT", "transcripts", "are", "commonly", "detected", "in", "both", "normal", "and", "malignant", "tissues", "and", "that", "a", "significant", "fraction", "of", "these", "are", "likely", "to", "be", "the", "result", "of", "aberrant", "splicing", "." ]
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9702
[ "While", "we", "can", "not", "exclude", "that", "alterations", "in", "TSG101", "and", "FHIT", "occur", "during", "cancer", "development", ",", "our", "data", "indicate", "that", "in", "this", "context", "the", "commonly", "observed", "transcript", "abnormalities", "are", "misleading", "." ]
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9703
[ "Inhibition", "of", "proliferation", "and", "apoptosis", "of", "human", "and", "rat", "T", "lymphocytes", "by", "curcumin", ",", "a", "curry", "pigment", "." ]
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9704
[ "Curcumin", "(", "diferuoylmethane", ")", ",", "the", "yellow", "pigment", "in", "the", "rhizome", "of", "tumeric", "(", "Curcuma", "longa", ")", ",", "an", "ingredient", "of", "curry", "spice", ",", "is", "known", "to", "exhibit", "a", "variety", "of", "pharmacological", "effects", "including", "antitumor", ",", "antiinflammatory", ",", "and", "antiinfectious", "activities", "." ]
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9705
[ "Although", "its", "precise", "mode", "of", "action", "remains", "elusive", ",", "curcumin", "has", "been", "shown", "to", "suppress", "the", "activity", "of", "the", "AP-1", "transcription", "factor", "in", "cells", "stimulated", "to", "proliferate", "." ]
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9706
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9707
[ "The", "pigment", "also", "inhibited", "apoptosis", "in", "dexamethasone-treated", "rat", "thymocytes", "and", "in", "UV-irradiated", "Jurkat", "cells", "as", "judged", "by", "DNA", "ladder", "formation", ",", "cellular", "morphological", "changes", ",", "and", "flow", "cytometry", "analysis", "." ]
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9708
[ "The", "inhibition", "of", "apoptosis", "by", "curcumin", "in", "rat", "thymocytes", "was", "accompanied", "by", "partial", "suppression", "of", "AP-1", "activity", "." ]
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9709
[ "Complete", "suppression", "of", "AP-1", "activity", "was", "observed", "in", "Con", "A-treated", ",", "proliferating", "thymocytes", "." ]
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9710
[ "The", "capacity", "of", "curcumin", "to", "inhibit", "both", "cell", "growth", "and", "death", "strongly", "implies", "that", "these", "two", "biological", "processes", "share", "a", "common", "pathway", "at", "some", "point", "and", "that", "curcumin", "affects", "a", "common", "step", ",", "presumably", "involving", "a", "modulation", "of", "the", "AP-1", "transcription", "factor", "." ]
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9711
[ "Interleukin-7", "upregulates", "the", "interleukin-2-gene", "expression", "in", "activated", "human", "T", "lymphocytes", "at", "the", "transcriptional", "level", "by", "enhancing", "the", "DNA", "binding", "activities", "of", "both", "nuclear", "factor", "of", "activated", "T", "cells", "and", "activator", "protein-1", "." ]
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9712
[ "In", "the", "present", "report", ",", "we", "studied", "the", "role", "of", "the", "stromal-derived", "cytokine", "interleukin-7", "(", "IL-7", ")", "in", "the", "IL-2-gene", "regulation", "in", "activated", "T", "lymphocytes", "." ]
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9713
[ "Production", "of", "IL-2", "requires", "the", "formation", "of", "transcription", "factors", "involved", "in", "the", "IL-2-gene", "regulation", "." ]
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9714
[ "T-cell", "receptor", "(", "TCR", ")", "/CD3", "engagement", "results", "in", "the", "activation", "of", "nuclear", "factor", "of", "activated", "T", "cells", "(", "NFAT", ")", ",", "activator", "protein-1", "(", "AP-1", ")", ",", "and", "nuclear", "factor", "kappaB", "(", "NFkappaB", ")", ",", "whereas", "the", "CD28", "responsive", "complex", "(", "CD28RC", ")", "is", "activated", "in", "response", "to", "the", "CD28", "signal", "." ]
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9715
[ "Costimulation", "of", "phytohemagglutinin/anti-CD28", "activated", "T", "lymphocytes", "with", "IL-7", "induces", "a", "fivefold", "enhanced", "IL-2", "-mRNA", "accumulation", "and", "a", "2.5-fold", "enhanced", "protein", "secretion", "." ]
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9716
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9717
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9718
[ "We", "also", "show", "that", "the", "IL-7", "-induced", "enhancement", "of", "the", "AP-1", "-DNA", "binding", "activity", "is", "not", "cyclosporin", "A-sensitive", "." ]
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9719
[ "Since", "AP-1", "is", "part", "of", "the", "NFAT", "complex", ",", "we", "conclude", "that", "the", "IL-7", "-signaling", "pathway", "is", "involved", "in", "the", "activation", "of", "the", "fos", "and", "jun", "proteins", "of", "which", "AP-1", "consists", "." ]
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9720
[ "The", "spatial", "distribution", "of", "human", "immunoglobulin", "genes", "within", "the", "nucleus", ":", "evidence", "for", "gene", "topography", "independent", "of", "cell", "type", "and", "transcriptional", "activity", "." ]
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9721
[ "The", "three-dimensional", "positioning", "of", "immunoglobulin", "(", "Ig", ")", "genes", "within", "the", "nucleus", "of", "human", "cells", "was", "investigated", "using", "in", "situ", "hybridization", "and", "confocal", "microscopy", "." ]
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9722
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9723
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9724
[ "Although", "subtle", "gene", "movements", "within", "those", "defined", "topographical", "regions", "can", "not", "be", "excluded", "by", "this", "study", ",", "the", "results", "indicate", "that", "tissue", "specificity", "of", "gene", "expression", "is", "not", "accompanied", "by", "drastic", "changes", "in", "gene", "nuclear", "topography", ",", "rather", "suggesting", "that", "gene", "organization", "within", "the", "nucleus", "may", "be", "primarily", "dependent", "on", "structural", "constraints", "imposed", "on", "the", "respective", "chromosomes", "." ]
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9725
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9726
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9727
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9728
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9729
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9730
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9731
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9732
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9733
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9734
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9735
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9738
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9740
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9741
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9742
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9743
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9744
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9747
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9749
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9750
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[ "Regulation", "of", "NF-kappa", "B", "activity", "by", "I", "kappa", "B", "alpha", "and", "I", "kappa", "B", "beta", "stability", "." ]
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9759
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9760
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9761
[ "TNF-alpha", "signaling", "leads", "to", "a", "rapid", "depletion", "of", "cellular", "I", "kappa", "B", "beta", "pools", "." ]
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9762
[ "I", "kappa", "B", "alpha", "is", "efficiently", "resynthesized", "whereas", "I", "kappa", "B", "beta", "levels", "stay", "low", "for", "a", "prolonged", "time", "." ]
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9763
[ "NF-kappa", "B", "binding", "activity", "can", "be", "detected", "for", "several", "hours", "after", "stimulation", "." ]
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9764
[ "We", "found", "that", "removal", "of", "the", "TNF-alpha", "containing", "medium", "causes", "a", "rapid", "decrease", "in", "nuclear", "NF-kappa", "B", "." ]
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9765
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9766
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9767
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9768
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9769
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9770
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9771
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9772
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9773
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9774
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9775
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9776
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9777
[ "Molecular", "mechanisms", "of", "anoxia/reoxygenation-induced", "neutrophil", "adherence", "to", "cultured", "endothelial", "cells", "." ]
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9778
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9779
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9780
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9781
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9782
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9783
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9784
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9785
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9786
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9787
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9788
[ "CD40", "signaling", "to", "B", "cells", "is", "important", "for", "generating", "an", "effective", "humoral", "immune", "response", "." ]
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9789
[ "CD40", "ligation", "leads", "to", "B", "cell", "activation", "events", "such", "as", "proliferation", ",", "Ig", "secretion", ",", "isotype", "switching", ",", "and", "up-regulation", "of", "cell", "surface", "molecules", ",", "as", "well", "as", "the", "generation", "of", "memory", "B", "cells", "." ]
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9790
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9791
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9792
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9793
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9794
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9795
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9796
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9797
[ "CD40-", "or", "pervanadate-mediated", "I", "kappa", "B", "tyrosine", "phosphorylation", "was", "not", "detected", "." ]
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9798
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9799
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9800
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