Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
10001
[ "This", "reversal", "of", "apoptosis", "almost", "to", "the", "control", "level", "by", "inhibitor", "of", "NF-kappa", "B", "activation", "may", "indicate", "involvement", "of", "this", "signaling", "molecule", "in", "MTBE", "and", "benzene", "induction", "of", "programmed", "cell", "death", "." ]
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10002
[ "Purification", "and", "characterization", "of", "the", "human", "SR", "31747A-binding", "protein", "." ]
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10003
[ "A", "nuclear", "membrane", "protein", "related", "to", "yeast", "sterol", "isomerase", "." ]
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10004
[ "SR", "31747A", ",", "defined", "as", "a", "sigma", "ligand", ",", "is", "a", "novel", "immunosuppressive", "agent", "that", "blocks", "proliferation", "of", "human", "and", "mouse", "lymphocytes", "." ]
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10005
[ "Using", "a", "radiolabeled", "chemical", "probe", ",", "we", "here", "purified", "a", "target", "of", "SR", "31747A", "and", "called", "it", "SR", "31747A-binding", "protein", "(", "SR-BP", ")", "." ]
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10006
[ "Purified", "SR-BP", "retained", "its", "binding", "properties", "and", "migrated", "on", "SDS-polyacrylamide", "gel", "as", "a", "Mr", "28", ",", "000", "protein", "." ]
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10007
[ "Cloning", "of", "the", "cDNA", "encoding", "human", "SR-BP", "shows", "an", "open", "reading", "frame", "for", "a", "223-amino", "acid", "protein", ",", "which", "is", "homologous", "to", "the", "recently", "cloned", "sigma", "1", "receptor", "." ]
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10008
[ "Interestingly", ",", "the", "deduced", "amino", "acid", "sequence", "was", "found", "to", "be", "related", "to", "fungal", "C8-C7", "sterol", "isomerase", ",", "encoded", "by", "the", "ERG2", "gene", "." ]
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10009
[ "The", "ERG2", "gene", "product", "has", "been", "identified", "recently", "as", "the", "molecular", "target", "of", "SR", "31747A", "that", "mediates", "antiproliferative", "effects", "of", "the", "drug", "in", "yeast", "." ]
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10010
[ "Northern", "blot", "analysis", "of", "SR-BP", "gene", "expression", "revealed", "a", "single", "transcript", "of", "2", "kilobases", "which", "was", "widely", "expressed", "among", "organs", ",", "with", "the", "highest", "abundance", "in", "liver", "and", "the", "lowest", "abundance", "in", "brain", "." ]
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10011
[ "Subcellular", "localization", "analysis", "in", "various", "cells", ",", "using", "a", "specific", "monoclonal", "antibody", "raised", "against", "SR-BP", ",", "demonstrated", "that", "this", "protein", "was", "associated", "with", "the", "nuclear", "envelope", "." ]
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10012
[ "When", "studying", "the", "binding", "of", "SR", "31747A", "on", "membranes", "from", "yeast", "expressing", "SR-BP", ",", "we", "found", "a", "pharmacological", "profile", "of", "sigma", "1", "receptors", ";", "binding", "was", "displaced", "by", "(", "+", ")", "-pentazocine", ",", "haloperidol", ",", "and", "(", "+", ")", "-SKF", "10", ",", "047", ",", "with", "(", "+", ")", "-SKF", "10", ",", "047", "being", "a", "more", "potent", "competitor", "than", "(", "-", ")", "-SKF", "10", ",", "047", "." ]
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10013
[ "Scatchard", "plot", "analysis", "revealed", "Kd", "values", "of", "7.1", "nM", "and", "0.15", "nM", "for", "(", "+", ")", "-pentazocine", "and", "SR", "31747A", ",", "respectively", ",", "indicating", "an", "affinity", "of", "SR-BP", "50-fold", "higher", "for", "SR", "31747A", "than", "for", "pentazocine", "." ]
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10014
[ "Additionally", ",", "we", "showed", "that", "pentazocine", ",", "a", "competitive", "inhibitor", "of", "SR", "31747A", "binding", ",", "also", "prevents", "the", "immunosuppressive", "effect", "of", "SR", "31747A", "." ]
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10015
[ "Taken", "together", ",", "these", "findings", "strongly", "suggest", "that", "SR-BP", "represents", "the", "molecular", "target", "for", "SR", "31747A", "in", "mammalian", "tissues", ",", "which", "could", "be", "critical", "for", "T", "cell", "proliferation", "." ]
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10016
[ "Phospholipase", "C", "gamma", "1", "overexpression", "and", "activation", "induced", "by", "interferon", "beta", "in", "human", "T", "lymphocytes", ":", "an", "ISGF3", "-independent", "response", "." ]
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10017
[ "Interferons", "exert", "their", "antiviral", ",", "antiproliferative", "and", "immunoregulatory", "activities", "by", "stimulating", "the", "expression", "of", "several", "genes", "." ]
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10018
[ "Such", "genes", "disclose", "a", "common", "element", "within", "their", "promoters", ",", "defined", "Interferon", "Stimulated", "Response", "Element", "(", "ISRE", ")", ",", "which", "binds", "a", "nuclear", "factor", "(", "s", ")", "translocated", "from", "the", "cytoplasm", "to", "the", "nucleus", "(", "ISGF3", ")", "after", "the", "binding", "of", "interferon", "(", "IFN", ")", "to", "the", "specific", "receptor", "." ]
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10019
[ "Here", "we", "report", "the", "induction", "of", "the", "synthesis", "and", "of", "the", "hydrolytic", "activity", "of", "phospholipase", "C", "gamma", "1", "(", "PLC", "gamma", "1", ")", "in", "human", "T", "lymphocytes", "by", "IFN-beta", "." ]
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10020
[ "The", "increased", "level", "of", "PLC", "gamma", "1", "becomes", "evident", "after", "90", "min", "of", "IFN-beta", "treatment", "and", "is", "still", "detectable", "after", "24", "h", "." ]
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10021
[ "Neither", "the", "PLC", "gamma", "1", "overexpression", "induced", "by", "IFN", "nor", "the", "increased", "hydrolytic", "activity", "of", "the", "enzyme", "appear", "to", "be", "affected", "by", "pretreatment", "of", "the", "cells", "with", "the", "protein", "tyrosine", "kinase", "inhibitor", "genistein", ",", "which", "is", "known", "to", "prevent", "the", "association", "of", "ISGF3", "components", "." ]
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10022
[ "These", "results", "suggest", "that", "in", "human", "T", "lymphocytes", "IFN-beta", "can", "activate", "other", "transcription", "factor", "(", "s", ")", "distinct", "from", "ISGF3", "to", "regulate", "PLC", "gamma", "1", "expression", "." ]
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10023
[ "In", "addition", ",", "the", "ability", "of", "this", "enzyme", "to", "hydrolyse", "PIP2", ",", "also", "in", "the", "presence", "of", "genistein", ",", "implies", "the", "possibility", "that", "this", "enzyme", "can", "exert", "its", "hydrolytic", "activity", "independently", "of", "protein", "tyrosine", "kinase", "activation", "." ]
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10024
[ "Negative", "regulation", "by", "HLA-DO", "of", "MHC", "class", "II", "-restricted", "antigen", "processing", "." ]
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10025
[ "HLA-DM", "is", "a", "major", "histocompatibility", "complex", "(", "MHC", ")", "class", "II-like", "molecule", "that", "facilitates", "antigen", "processing", "by", "catalyzing", "the", "exchange", "of", "invariant", "chain-derived", "peptides", "(", "CLIP", ")", "from", "class", "II", "molecules", "for", "antigenic", "peptides", "." ]
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10026
[ "HLA-DO", "is", "a", "second", "class", "II-like", "molecule", "that", "physically", "associates", "with", "HLA-DM", "in", "B", "cells", "." ]
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10027
[ "HLA-DO", "was", "shown", "to", "block", "HLA-DM", "function", "." ]
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10028
[ "Purified", "HLA-DM-DO", "complexes", "could", "not", "promote", "peptide", "exchange", "in", "vitro", "." ]
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10029
[ "Expression", "of", "HLA-DO", "in", "a", "class", "II+", "and", "DM+", ",", "DO-", "human", "T", "cell", "line", "caused", "the", "accumulation", "of", "class", "II-CLIP", "complexes", ",", "indicating", "that", "HLA-DO", "blocked", "DM", "function", "in", "vivo", "and", "suggesting", "that", "HLA-DO", "is", "an", "important", "modulator", "of", "class", "II-restricted", "antigen", "processing", "." ]
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10030
[ "Vitamin", "D", "receptor", ":", "no", "evidence", "for", "allele-specific", "mRNA", "stability", "in", "cells", "which", "are", "heterozygous", "for", "the", "Taq", "I", "restriction", "enzyme", "polymorphism", "." ]
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10031
[ "Allelic", "variations", "of", "the", "vitamin", "D", "receptor", "(", "VDR", ")", "gene", "have", "been", "associated", "with", "the", "risk", "of", "developing", "prostate", "cancer", "in", "men", "and", "osteoporosis", "in", "postmenopausal", "women", "." ]
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10032
[ "Three", "RFLPs", "(", "TaqI", ",", "ApaI", ",", "BsmI", ")", "define", "two", "common", "haplotypes", ":", "BAt", "and", "baT", "." ]
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10033
[ "None", "of", "these", "polymorphisms", "change", "the", "translated", "protein", "." ]
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10034
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10035
[ "Indirect", "evidence", "suggested", "that", "allele", "T", "is", "less", "stable", "than", "allele", "t", "." ]
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10036
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10037
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10038
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10039
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10040
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10041
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10042
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10043
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10044
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10045
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10046
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10047
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10048
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10049
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10050
[ "Hypoxia", "enhances", "induction", "of", "endothelial", "ICAM-1", ":", "role", "for", "metabolic", "acidosis", "and", "proteasomes", "." ]
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10051
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10052
[ "Coincident", "with", "many", "inflammatory", "diseases", "is", "tissue", "hypoxia", "." ]
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10053
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10054
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10055
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10056
[ "Combinations", "of", "hypoxia", "and", "LPS", "significantly", "increased", "lymphocyte", "binding", ",", "and", "such", "increases", "were", "inhibited", "by", "addition", "of", "anti-ICAM-1", "antibodies", "or", "antisense", "oligonucleotides", "." ]
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10057
[ "Hypoxic", "endothelia", "showed", "a", ">", "10-fold", "increase", "in", "sensitivity", "to", "inhibitors", "of", "proteasome", "activation", ",", "and", "combinations", "of", "hypoxia", "and", "LPS", "enhanced", "proteasome", "-dependent", "cytoplasmic-to-nuclear", "localization", "of", "the", "nuclear", "transcription", "factor-kappa", "B", "p65", "(", "Rel", "A", ")", "subunit", "." ]
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10058
[ "Such", "proteasome", "activation", "correlated", "with", "hypoxia-evoked", "decreases", "in", "both", "extracellular", "and", "intracellular", "pH", "." ]
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10059
[ "We", "conclude", "from", "these", "studies", "that", "endothelial", "hypoxia", "provides", "a", "novel", ",", "proteasome", "-dependent", "stimulus", "for", "ICAM-1", "induction", "." ]
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10060
[ "Differanisole", "A", ",", "a", "novel", "antitumor", "antibiotic", ",", "enhances", "growth", "inhibition", "and", "differentiation", "of", "human", "myeloid", "leukemia", "cells", "induced", "by", "9-cis", "retinoic", "acid", "." ]
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10061
[ "Differanisole", "A", ",", "3", ",", "5-dichloro-2-hydroxy-4-methoxy-6-n-propylbenzoic", "acid", ",", "inhibited", "growth", "of", "human", "myeloid", "leukemia", "cells", "." ]
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10062
[ "The", "compound", "induced", "G1", "arrest", "and", "granulocytic", "differentiation", "of", "HL-60", "cells", ",", "although", "the", "differentiation-inducing", "effect", "was", "modest", "." ]
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10063
[ "Differanisole", "A", "and", "9-cis", "retinoic", "acid", "(", "9cisRA", ")", "synergistically", "inhibited", "the", "growth", "and", "induced", "functional", "and", "morphologic", "differentiation", "of", "HL-60", "and", "NB4", "cells", ",", "whereas", "the", "combined", "treatment", "with", "differanisole", "A", "and", "all-trans", "retinoic", "acid", "or", "1alpha", ",", "25-dihydroxyvitamin", "D3", "was", "less", "effective", "." ]
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10064
[ "Similar", "results", "were", "obtained", "in", "primary", "culture", "of", "leukemia", "cells", "from", "a", "patient", "with", "acute", "promyelocytic", "leukemia", "." ]
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10065
[ "The", "synergistic", "effect", "on", "growth", "inhibition", "and", "induction", "of", "differentiation", "required", "simultaneous", "treatment", "with", "differanisole", "A", "and", "9cisRA", "." ]
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10066
[ "Differanisole", "A", "and", "an", "RXR-specific", "ligand", "(", "Ro47-5944", ")", "cooperatively", "inhibited", "the", "cell", "growth", ",", "while", "the", "combined", "effect", "of", "differanisole", "A", "and", "an", "RAR-specific", "ligand", "Am80", "was", "just", "additive", "." ]
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10067
[ "Differanisole", "A", "in", "combination", "with", "9cisRA", "may", "have", "implications", "for", "therapy", "of", "acute", "promyelocytic", "leukemia", "patients", "." ]
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10068
[ "The", "activation", "of", "the", "JAK2", "/STAT5", "pathway", "is", "commonly", "involved", "in", "signaling", "through", "the", "human", "IL-5", "receptor", "." ]
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10069
[ "The", "JAK", "(", "Janus", "kinase", ")", "family", "of", "protein", "tyrosine", "kinases", "and", "the", "STATs", "(", "signal", "transducers", "and", "activators", "of", "transcription", ")", "have", "been", "shown", "to", "be", "activated", "in", "response", "to", "a", "number", "of", "cytokines", "and", "growth", "factors", "." ]
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10070
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10071
[ "Immunoprecipitation", "and", "electrophoretic", "mobility", "shift", "analysis", "revealed", "that", "tyrosine", "phosphorylation", "of", "JAK2", "and", "activation", "of", "STAT5", "were", "induced", "upon", "stimulation", "with", "hIL-5", "in", "all", "three", "cell", "types", ",", "while", "STAT1", "activation", "was", "only", "observed", "in", "eosinophils", "." ]
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10072
[ "These", "results", "indicate", "that", "JAK2", "/STAT5", "activation", "is", "a", "common", "JAK", "/STAT", "pathway", "for", "hIL-5", "-mediated", "signal", "in", "these", "cells", "." ]
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10073
[ "Dysregulation", "of", "monocytic", "nuclear", "factor-kappa", "B", "by", "oxidized", "low-density", "lipoprotein", "." ]
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10074
[ "Nuclear", "factor-kappa", "B", "(", "NF-kappa", "B", ")", "/Rel", "transcription", "factors", "may", "be", "involved", "in", "atherosclerosis", ",", "as", "is", "suggested", "by", "the", "presence", "of", "activated", "NF-kappa", "B", "in", "human", "atherosclerotic", "lesions", "." ]
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10075
[ "The", "aim", "of", "the", "present", "study", "was", "to", "investigate", "the", "effects", "of", "oxidized", "LDL", "(", "oxLDL", ")", "on", "the", "NF-kappa", "B", "system", "in", "human", "THP-1", "monocytic", "cells", "as", "well", "as", "adherent", "monocytes", "." ]
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10076
[ "Our", "results", "demonstrate", "that", "short-term", "incubation", "of", "these", "cells", "with", "oxLDL", "activated", "p50/p65", "containing", "NF-kappa", "B", "dimers", "and", "induced", "the", "expression", "of", "the", "target", "gene", "IL-8", "." ]
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10077
[ "This", "activation", "of", "NF-kappa", "B", "was", "inhibited", "by", "the", "antioxidant", "and", "H2O2", "scavenger", "pyrrolidine", "dithiocarbamate", "and", "the", "proteasome", "inhibitor", "PSI", "." ]
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10078
[ "The", "oxLDL", "-induced", "NF-kappa", "B", "activation", "was", "accompanied", "by", "an", "initial", "depletion", "of", "I", "kappa", "B-alpha", "followed", "by", "a", "slight", "transient", "increase", "in", "the", "level", "of", "this", "inhibitor", "protein", "." ]
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10079
[ "In", "contrast", ",", "long-term", "treatment", "with", "oxLDL", "prevented", "the", "lipopolysaccharide-induced", "depletion", "of", "I", "kappa", "B-alpha", ",", "accompanied", "by", "an", "inhibition", "of", "both", "NF-kappa", "B", "activation", "and", "the", "expression", "of", "tumor", "necrosis", "factor-alpha", "and", "interleukin-1", "beta", "genes", "." ]
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10080
[ "These", "observations", "provide", "additional", "evidence", "that", "oxLDL", "is", "a", "potent", "modulator", "of", "gene", "expression", "and", "suggest", "that", "(", "dys", ")", "regulation", "of", "NF-kappa", "B/Rel", "is", "likely", "to", "play", "an", "important", "role", "in", "atherogenesis", "." ]
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10081
[ "Suppression", "of", "nuclear", "factor", "kappa", "B", "and", "CD18", "-mediated", "leukocyte", "adhesion", "to", "the", "corneal", "endothelium", "by", "dexamethasone", "." ]
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10082
[ "PURPOSE", ":", "To", "demonstrate", "that", "leukocyte", "adhesion", "to", "cultured", "corneal", "endothelial", "cells", "is", "mediated", "by", "the", "CD18", "antigen", ",", "and", "to", "determine", "whether", "dexamethasone", "directly", "suppresses", "adhesion", "by", "inhibiting", "activation", "of", "nuclear", "factor", "kappa", "B", "(", "NFkappaB", ")", "." ]
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10083
[ "METHODS", ":", "Cultured", "bovine", "corneal", "endothelium", "was", "stimulated", "for", "6", "hours", "by", "40", "micron/ml", "tumor", "necrosis", "factor", "alpha", "(", "TNFalpha", ")", "." ]
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10084
[ "Dexamethasone", "was", "added", "1", "hour", "before", "TNFalpha", "stimulation", "in", "the", "dexamethasone", "group", "." ]
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10085
[ "After", "stimulation", ",", "neutrophils", "separated", "from", "a", "healthy", "human", "volunteer", "were", "added", "with", "or", "without", "anti-CD18", "antibody", "." ]
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10086
[ "The", "culture", "plate", "was", "settled", "for", "15", "minutes", "at", "37", "degrees", "C", ",", "and", "then", "neutrophils", "were", "activated", "by", "N-formyl-methionyl-leucyl-phenylalanine", "for", "5", "minutes", "." ]
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10087
[ "Nonadherent", "neutrophils", "were", "removed", "by", "sealing", "and", "inverting", "the", "culture", "well", "." ]
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10088
[ "The", "intracellular", "localization", "of", "NFkappaB", "after", "TNFalpha", "simulation", "was", "determined", "by", "confocal", "immunocytochemistry", "using", "an", "anti-p65", "antibody", "." ]
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10089
[ "RESULTS", ":", "Neutrophil", "adhesion", "to", "cultured", "corneal", "endothelial", "cells", "increased", "significantly", "on", "exposure", "to", "TNFalpha", "(", "451.4+/-45.4", "cells/mm2", ",", "n", "=", "16", ")", "compared", "to", "control", "(", "156.7+/-27.3", "cells/mm2", ",", "n", "=", "16", ",", "P", "<", "0.01", ")", "." ]
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10090
[ "This", "increased", "adhesion", "was", "suppressed", "by", "the", "addition", "of", "anti-CD18", "antibody", "(", "157.6+/-25.1", "cells/mm2", ",", "n", "=", "8", ",", "P", "<", "0.01", ")", "and", "by", "pretreatment", "with", "10", "(", "-7", ")", "M", "dexamethasone", "(", "207.9+/-31.5", "cells/mm2", ",", "n", "=", "10", ",", "P", "<", "0.01", ")", "." ]
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10091
[ "Immunocytochemistry", "60", "minutes", "after", "stimulation", "revealed", "that", "NFkappaB", "was", "located", "in", "the", "cytoplasm", "in", "unstimulated", "cells", ";", "however", ",", "the", "addition", "of", "TNFalpha", "caused", "NFkappaB", "to", "translocate", "into", "the", "nucleus", "." ]
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10092
[ "Pretreatment", "with", "dexamethasone", "tapered", "NFkappaB", "translocation", "into", "the", "nucleus", "." ]
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10093
[ "CONCLUSIONS", ":", "Leukocyte", "adhesion", "to", "the", "corneal", "endothelium", "was", "shown", "to", "be", "mediated", "by", "CD18", "expressed", "on", "activated", "leukocytes", "." ]
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10094
[ "Pretreatment", "of", "the", "endothelium", "with", "dexamethasone", "inhibited", "leukocyte", "adhesion", ";", "this", "may", "be", "due", "in", "part", "to", "the", "suppression", "of", "NFkappaB", "entry", "into", "the", "nucleus", "." ]
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10095
[ "Molecular", "characterization", "and", "pattern", "of", "tissue", "expression", "of", "the", "gene", "for", "neutrophil", "gelatinase-associated", "lipocalin", "from", "humans", "." ]
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10096
[ "Neutrophil", "gelatinase-associated", "lipocalin", "(", "NGAL", ")", "is", "a", "25-kDa", "lipocalin", "first", "identified", "as", "a", "protein", "stored", "in", "specific", "granules", "of", "the", "human", "neutrophil", "." ]
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10097
[ "The", "protein", "is", "believed", "to", "bind", "small", "lipophilic", "substances", "such", "as", "bacterial", "derived", "formylpeptides", "and", "lipopolysaccharides", "(", "LPS", ")", "and", "might", "function", "as", "a", "modulator", "of", "inflammation", "." ]
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10098
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10099
[ "The", "transcriptional", "start", "sites", "were", "identified", "by", "an", "RNase", "protection", "assay", "." ]
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10100
[ "The", "NGAL", "gene", "is", "highly", "homologous", "to", "the", "mouse", "gene", "24p3", "." ]
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