Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
9401
[ "Cdk2-dependent", "phosphorylation", "therefore", "provides", "a", "switch", "during", "late", "G1-to-S", "phase", "that", "both", "nullifies", "an", "early", "G1", "cell", "cycle", "regulatory", "function", "of", "Id3", "and", "modulates", "its", "target", "bHLH", "specificity", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
9402
[ "These", "data", "also", "demonstrate", "that", "the", "ability", "of", "Id3", "to", "promote", "cell", "cycle", "S", "phase", "entry", "is", "not", "simply", "a", "function", "of", "its", "ability", "to", "modulate", "bHLH", "heterodimer-dependent", "gene", "expression", "and", "establish", "a", "biologically", "important", "mechanism", "through", "which", "Cdk2", "and", "Id-bHLH", "functions", "are", "integrated", "in", "the", "coordination", "of", "cell", "proliferation", "and", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9403
[ "Molecular", "cloning", "and", "functional", "characterization", "of", "murine", "cDNA", "encoding", "transcription", "factor", "NFATc", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
9404
[ "Transcription", "factors", "of", "the", "NFAT", "(", "nuclear", "factor", "of", "activated", "T", "cells", ")", "family", "play", "important", "roles", "in", "immune", "and", "inflammatory", "responses", "by", "regulating", "the", "expression", "of", "genes", "encoding", "cytokines", "and", "immunoregulatory", "proteins", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9405
[ "Here", "we", "describe", "cloning", "and", "characterization", "of", "full-length", "cDNA", "encoding", "murine", "(", "m", ")", "NFATc", "which", "predicts", "that", "the", "protein", "has", "all", "the", "conserved", "structural", "motifs", "of", "NFAT", "family", "members", ",", "including", "the", "rel", "homology", "domain", ",", "the", "NFAT", "homology", "domain", "and", "the", "nuclear", "translocation", "signals", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
9406
[ "mNFATc", "complexed", "with", "AP-1", "bound", "specifically", "to", "the", "murine", "IL-2", "NFAT", "recognition", "sequence", "and", "activated", "transcription", "from", "the", "co-transfected", "IL-2", "promoter", "in", "COS-7", "cells", "." ]
[ 9, 0, 0, 9, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 1, 2, 0, 5, 6, 0 ]
9407
[ "Northern", "blot", "analysis", "showed", "that", "the", "cDNA", "probe", "hybridized", "with", "a", "4.5", "kb", "transcript", "which", "is", "highly", "inducible", "in", "murine", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
9408
[ "By", "Northern", "and", "in", "situ", "hybridization", ",", "mNFATc", "transcript", "was", "detected", "from", "the", "early", "stage", "of", "development", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9409
[ "In", "the", "mouse", "embryo", ",", "mNFATc", "transcript", "was", "strongly", "expressed", "in", "thymus", ",", "lung", "and", "submandibular", "gland", "and", "weakly", "in", "skeletal", "muscle", "and", "heart", "suggesting", "that", "mNFATc", "may", "have", "a", "role", "both", "in", "embryogenesis", "and", "in", "mature", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
9410
[ "TNFalpha", "cooperates", "with", "the", "protein", "kinase", "A", "pathway", "to", "synergistically", "increase", "HIV-1", "LTR", "transcription", "via", "downstream", "TRE-like", "cAMP", "response", "elements", "." ]
[ 9, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 1, 2, 0, 0, 0, 1, 2, 2, 2, 0 ]
9411
[ "Activating", "protein-1", "(", "AP-1", ")", "binding", "TPA", "responsive", "elements", "(", "TRE", ")", "are", "located", "downstream", "of", "the", "transcription", "initiation", "site", "in", "the", "U5", "region", "of", "the", "HIV-1", "long", "terminal", "repeat", "(", "LTR", ")", "." ]
[ 9, 10, 0, 9, 0, 0, 1, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0 ]
9412
[ "These", "downstream", "sequence", "elements", ",", "termed", "DSE", ",", "can", "bind", "both", "AP-1", "and", "CREB/ATF", "transcription", "factors", "." ]
[ 0, 1, 2, 2, 0, 0, 1, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0 ]
9413
[ "Recently", ",", "we", "demonstrated", "that", "the", "DSE", "are", "also", "cAMP-responsive", "elements", "(", "CRE", ")", ",", "since", "they", "mediated", "activation", "signals", "elicited", "by", "cholera", "toxin", "(", "Ctx", ")", ",", "a", "potent", "activator", "of", "the", "cAMP-dependent", "protein", "kinase", "A", "(", "PKA", ")", "signal", "transduction", "pathway", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0 ]
9414
[ "In", "the", "present", "study", ",", "we", "demonstrate", "that", "the", "HIV-1", "DSE", "can", "mediate", "the", "transcriptional", "synergy", "elicited", "by", "the", "combination", "of", "Ctx", "and", "TNFalpha", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0 ]
9415
[ "Ctx", "combined", "with", "TNFalpha", "or", "IL-1beta", "to", "produce", "a", "synergistic", "increase", "in", "p24", "antigen", "production", "in", "U1", "promonocytic", "cells", "." ]
[ 9, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 5, 6, 6, 0 ]
9416
[ "Transfection", "studies", "of", "LTR", "reporter", "constructs", "indicated", "that", "mutation", "of", "the", "DSE", "sites", "abrogated", "the", "LTR", "-mediated", "synergy", "induced", "by", "Ctx", "and", "TNFalpha", ",", "whereas", "the", "synergy", "induced", "by", "Ctx", "and", "IL-1beta", "was", "unaffected", ",", "suggesting", "TNFalpha", "and", "IL-1beta", "cooperate", "differently", "with", "the", "cAMP", "/PKA", "activation", "pathway", "to", "induce", "HIV-1", "expression", "in", "U1", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]
9417
[ "Because", "the", "DSE", "are", "also", "TRE", "sites", ",", "we", "assessed", "the", "effect", "of", "the", "agonist", "combinations", "on", "AP-1", "-dependent", "transcription", "." ]
[ 0, 0, 1, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
9418
[ "TNFalpha", "as", "well", "as", "IL-1beta", "cooperated", "with", "Ctx", "to", "produce", "a", "synergistic", "activation", "of", "AP-1", "-mediated", "transcription", "." ]
[ 9, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
9419
[ "These", "data", "indicate", "that", "the", "TRE-like", "cAMP-responsive", "DSE", "sites", "within", "the", "5'-untranslated", "leader", "can", "mediate", "the", "transcriptional", "cooperativity", "between", "TNFalpha", "and", "the", "cAMP", "/PKA", "pathway", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
9420
[ "Since", "the", "DSE", "and", "TRE", "sites", "can", "not", "bind", "CREB/ATF", "homodimers", ",", "we", "propose", "a", "mechanism", "in", "which", "the", "HIV-1", "DSE", "bind", "heterodimers", "composed", "of", "both", "AP-1", "and", "CREB/ATF", "proteins", "." ]
[ 0, 0, 1, 0, 1, 2, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0 ]
9421
[ "Copyright", "1997", "Academic", "Press", "." ]
[ 0, 0, 0, 0, 0 ]
9422
[ "Association", "of", "glucocorticoid", "insensitivity", "with", "increased", "expression", "of", "glucocorticoid", "receptor", "beta", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
9423
[ "In", "many", "chronic", "inflammatory", "disorders", ",", "glucocorticoid", "(", "GC", ")", "insensitivity", "is", "a", "challenging", "clinical", "problem", "associated", "with", "life-threatening", "disease", "progression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9424
[ "The", "molecular", "basis", "of", "GC", "insensitivity", ",", "however", ",", "is", "unknown", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9425
[ "Alternative", "splicing", "of", "the", "GC", "receptor", "(", "R", ")", "pre-messenger", "RNA", "generates", "a", "second", "GCR", ",", "termed", "GCR-beta", ",", "which", "does", "not", "bind", "GCs", "but", "antagonizes", "the", "transactivating", "activity", "of", "the", "classic", "GCR", ",", "termed", "GCR-alpha", "." ]
[ 0, 0, 0, 0, 3, 4, 4, 4, 4, 4, 4, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0 ]
9426
[ "In", "the", "current", "study", ",", "we", "demonstrate", "that", "GC-insensitive", "asthma", "is", "associated", "with", "a", "significantly", "higher", "number", "of", "GCR-beta-immunoreactive", "cells", "in", "peripheral", "blood", "than", "GC-sensitive", "asthmatics", "or", "normal", "controls", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9427
[ "Furthermore", ",", "we", "show", "that", "patients", "with", "GC-insensitive", "asthma", "have", "cytokine-induced", "abnormalities", "in", "the", "DNA", "binding", "capability", "of", "the", "GCR", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
9428
[ "These", "abnormalities", "can", "be", "reproduced", "by", "transfection", "of", "cell", "lines", "with", "the", "GCR-beta", "gene", "resulting", "in", "significant", "reduction", "of", "their", "GCR-alpha", "DNA", "binding", "capacity", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0 ]
9429
[ "We", "conclude", "that", "increased", "expression", "of", "GCR-beta", "is", "cytokine", "inducible", "and", "may", "account", "for", "GC", "insensitivity", "in", "this", "common", "inflammatory", "condition", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9430
[ "Epstein-Barr", "virus", "EBNA3C", "represses", "Cp", ",", "the", "major", "promoter", "for", "EBNA", "expression", ",", "but", "has", "no", "effect", "on", "the", "promoter", "of", "the", "cell", "gene", "CD21", "." ]
[ 9, 10, 10, 0, 1, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
9431
[ "EBNA3C", "is", "a", "potent", "repressor", "of", "transcription", "when", "bound", "to", "DNA", "as", "a", "fusion", "with", "the", "DNA", "binding", "domain", "(", "DBD", ")", "of", "GALA", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9432
[ "A", "survey", "of", "promoters", "has", "revealed", "that", "the", "wild-type", ",", "unfused", "EBNA3C", "can", "specifically", "repress", "expression", "from", "reporter", "plasmids", "containing", "the", "Epstein-Barr", "virus", "Cp", "latency-associated", "promoter", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
9433
[ "Repression", "of", "Cp", "activity", "required", "amino", "acids", "207", "to", "368", ",", "which", "encompasses", "a", "region", "resembling", "a", "basic", "DBD", "adjacent", "to", "a", "leucine", "zipper", "DNA", "binding", "motif", "and", "a", "site", "which", "binds", "to", "the", "cellular", "factor", "CBF1/RBP-Jkappa", "." ]
[ 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
9434
[ "However", ",", "amino", "acids", "207", "to", "368", "are", "dispensable", "when", "the", "protein", "is", "bound", "to", "DNA", "as", "a", "fusion", "with", "the", "GAL4", "DBD", ",", "thus", "implicating", "this", "region", "in", "DNA", "binding", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9435
[ "Mutation", "of", "the", "CBF1/RBP-Jkappa", "binding", "site", "in", "EBNA3C", "abrogated", "repression", ",", "strongly", "suggesting", "that", "CBF1/RBP-Jkappa", "is", "necessary", "for", "targeting", "the", "viral", "protein", "to", "Cp", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0 ]
9436
[ "Consistent", "with", "this", "result", ",", "mutation", "of", "the", "EBNA2", "response", "element", "(", "a", "CBF1/RBP-Jkappa", "binding", "site", ")", "in", "Cp", "also", "prevented", "significant", "repression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 0, 0, 1, 0, 0, 0, 0, 0 ]
9437
[ "In", "addition", ",", "amino", "acids", "346", "to", "543", ",", "which", "were", "previously", "defined", "as", "important", "for", "the", "repressor", "activity", "of", "the", "GAL4-EBNA3C", "fusion", "proteins", ",", "also", "appear", "to", "be", "necessary", "for", "the", "repression", "of", "Cp", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0 ]
9438
[ "Since", "repression", "by", "these", "fusions", "was", "not", "observed", "in", "all", "cell", "types", ",", "it", "seems", "likely", "that", "EBNA3C", "either", "depends", "on", "a", "corepressor", "which", "may", "interact", "with", "amino", "acids", "346", "to", "543", "or", "is", "modified", "in", "a", "cell-specific", "manner", "in", "order", "to", "repress", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9439
[ "These", "data", "are", "consistent", "with", "EBNA3C", "contributing", "to", "the", "regulation", "of", "EBNA", "expression", "in", "latently", "infected", "B", "cells", "through", "CBF1/RBP-Jkappa", "and", "another", "factor", ",", "but", "this", "need", "not", "directly", "involve", "EBNA2", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 7, 8, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
9440
[ "Finally", ",", "although", "it", "has", "been", "reported", "that", "EBNA3C", "can", "upregulate", "CD21", "in", "some", "B", "cells", ",", "we", "were", "unable", "to", "demonstrate", "any", "effect", "of", "EBNA3C", "on", "reporter", "plasmids", "which", "contain", "the", "CD21", "promoter", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
9441
[ "Relationship", "between", "glucocorticoid", "receptor", "and", "response", "to", "glucocorticoid", "therapy", "in", "ulcerative", "colitis", "." ]
[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9442
[ "PURPOSE", ":", "To", "clarify", "the", "relationship", "between", "the", "glucocorticoid", "receptor", "and", "the", "effectiveness", "of", "glucocorticoid", "therapy", "in", "patients", "with", "ulcerative", "colitis", ",", "we", "investigated", "the", "number", "and", "apparent", "dissociation", "constant", "of", "glucocorticoid", "receptor", "in", "peripheral", "blood", "mononuclear", "leukocytes", "of", "patients", "with", "ulcerative", "colitis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0 ]
9443
[ "MATERIALS", "AND", "METHODS", ":", "Eleven", "patients", "with", "ulcerative", "colitis", "(", "5", "who", "responded", "to", "intravenous", "glucocorticoids", "and", "6", "who", "did", "not", ")", "and", "ten", "control", "subjects", "were", "studied", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9444
[ "The", "number", "and", "apparent", "dissociation", "constant", "of", "glucocorticoid", "receptor", "were", "measured", "using", "a", "whole-cell", "binding", "assay", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]
9445
[ "Results", "were", "expressed", "as", "a", "median", "(", "interquartile", "range", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9446
[ "RESULTS", ":", "The", "number", "of", "glucocorticoid", "receptors", "from", "the", "six", "nonresponders", ",", "five", "responders", ",", "and", "ten", "healthy", "controls", "were", "4922", "(", "range", ",", "4484-5643", ")", ",", "3413", "(", "range", ",", "3183-4450", ")", ",", "and", "3610", "(", "range", ",", "2594-3979", ")", "binding", "sites/cell", ",", "respectively", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9447
[ "The", "apparent", "dissociation", "constant", "of", "the", "glucocorticoid", "receptors", "from", "the", "nonresponders", ",", "responders", ",", "and", "healthy", "controls", "were", "7.03", "(", "range", ",", "5.66-10", ")", ",", "4.27", "(", "range", ",", "4-5.13", ")", ",", "and", "6.18", "(", "range", ",", "5.86-6.74", ")", "nM", ",", "respectively", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9448
[ "Nonresponders", "had", "a", "significant", "increase", "both", "in", "the", "number", "of", "binding", "sites", "and", "in", "the", "apparent", "dissociation", "constant", "compared", "with", "responders", "(", "P", "=", "0.045", ";", "P", "=", "0.029", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9449
[ "CONCLUSIONS", ":", "The", "increased", "number", "and", "apparent", "dissociation", "constant", "of", "glucocorticoid", "receptor", "are", "closely", "associated", "with", "the", "effectiveness", "of", "glucocorticoid", "therapy", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9450
[ "The", "measurement", "of", "the", "number", "and", "apparent", "dissociation", "constant", "of", "glucocorticoid", "receptor", "may", "be", "useful", "in", "predicting", "response", "to", "glucocorticoids", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9451
[ "Cooperation", "of", "binding", "sites", "for", "STAT6", "and", "NF", "kappa", "B/rel", "in", "the", "IL-4", "-induced", "up-regulation", "of", "the", "human", "IgE", "germline", "promoter", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0, 0, 9, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]
9452
[ "Ig", "heavy", "chain", "class", "switching", "is", "directed", "by", "cytokines", "inducing", "transcription", "from", "unrearranged", "CH", "genes", "." ]
[ 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
9453
[ "Subsequently", ",", "such", "primed", "cells", "can", "undergo", "switch", "recombination", "to", "express", "the", "selected", "new", "isotype", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9454
[ "In", "the", "case", "of", "IgE", "class", "switching", ",", "IL-4", "activates", "the", "IgE", "germline", "promoter", "by", "inducing", "the", "interaction", "of", "the", "transcription", "factor", "STAT6", "(", "IL-4STAT", ")", "with", "a", "responsive", "DNA", "element", "in", "the", "proximal", "region", "of", "the", "promoter", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9455
[ "This", "study", "describes", "the", "characterization", "of", "two", "additional", "cis-acting", "elements", "that", "interact", "with", "members", "of", "the", "NF", "kappa", "B/rel", "transcription", "factor", "family", "in", "an", "IL-4", "-independent", "fashion", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 9, 0, 0, 0 ]
9456
[ "Electrophoretic", "mobility", "shift", "assays", "show", "that", "the", "nucleoprotein", "complex", "formed", "on", "the", "upstream", "site", "(", "NF", "kappa", "B1", ")", "contains", "the", "classical", "p50/p65", "heterodimer", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 9, 10, 0 ]
9457
[ "The", "complex", "on", "the", "proximal", "site", "(", "NF", "kappa", "B2", ")", "appears", "to", "be", "composed", "of", "p50", "and", "relB", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0 ]
9458
[ "IgE", "germline", "promoter", "reporter", "gene", "constructs", "carrying", "point", "mutations", "in", "the", "NF", "kappa", "B2", "site", "were", "largely", "unresponsive", "to", "IL-4", "stimulation", "in", "transient", "transfection", "experiments", ",", "while", "plasmids", "with", "similar", "mutations", "in", "the", "NF", "kappa", "B1", "site", "responded", "to", "cytokine", "stimulation", "better", "than", "the", "wild-type", "promoter", "." ]
[ 1, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9459
[ "The", "NF", "kappa", "B2", "effect", "was", "dependent", "on", "the", "presence", "of", "the", "STAT6", "binding", "site", ",", "demonstrating", "that", "the", "NF", "kappa", "B2", "motif", "is", "necessary", "but", "not", "sufficient", "for", "mediating", "cytokine", "up-regulation", "." ]
[ 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9460
[ "In", "addition", ",", "the", "combination", "of", "a", "NF", "kappa", "B/rel", "binding", "site", "and", "the", "STAT6", "response", "element", "conferred", "IL-4", "inducibility", "to", "a", "heterologous", "minimal", "promoter", ",", "while", "the", "individual", "sites", "had", "no", "effect", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 1, 2, 2, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9461
[ "The", "available", "data", "suggest", "that", "the", "NF", "kappa", "B2", "nucleoprotein", "complex", "may", "cooperate", "with", "DNA-bound", "STAT6", "to", "achieve", "IL-4", "-dependent", "activation", "of", "the", "human", "IgE", "germline", "gene", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]
9462
[ "Alcohol-induced", "regulation", "of", "nuclear", "regulatory", "factor-kappa", "beta", "in", "human", "monocytes", "." ]
[ 0, 0, 0, 9, 10, 10, 10, 0, 7, 8, 0 ]
9463
[ "Acute", "ethanol", "exposure", "has", "the", "capacity", "to", "modulate", "immune", "functions", ",", "particularly", ",", "to", "down", "regulate", "monocyte", "production", "of", "inflammatory", "cytokines", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0 ]
9464
[ "However", ",", "the", "intracellular", "mechanisms", "for", "these", "effects", "of", "ethanol", "are", "yet", "to", "be", "understood", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9465
[ "Considering", "that", "nuclear", "regulatory", "factor-kappa", "beta", "(", "NF-kappa", "B", ")", "/Rel", "is", "a", "common", "regulatory", "element", "of", "the", "promoter", "region", "of", "the", "inflammatory", "cytokine", "genes", ",", "herein", ",", "we", "tested", "the", "hypothesis", "that", "acute", "ethanol", "affects", "NF-kappa", "B", "activation", "in", "human", "monocytes", "." ]
[ 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 7, 8, 0 ]
9466
[ "Adherence-isolated", "monocytes", "showed", "constitutive", "DNA", "binding", "activity", "of", "NF-kappa", "B", "." ]
[ 0, 7, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
9467
[ "A", "clinically", "relevant", "dose", "(", "25", "mM", ")", "of", "acute", "ethanol", "treatment", "in", "vitro", "increased", "NF-kappa", "B", "binding", "activity", "in", "monocytes", "with", "a", "preferential", "induction", "of", "the", "inhibitory", ",", "p50/p50", ",", "NF-kappa", "B/Rel", "homodimer", ",", "and", "resulted", "in", "no", "induction", "of", "the", "p65/p50", "heterodimer", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
9468
[ "In", "contrast", ",", "lipopolysaccharide", "stimulation", "primarily", "induced", "the", "p65/p50", "heterodimer", "that", "has", "been", "shown", "to", "result", "in", "gene", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9469
[ "Thus", ",", "such", "unique", "activation", "of", "the", "inhibitory", "p50/p50", "homodimer", "by", "acute", "ethanol", "treatment", "may", "result", "in", "inhibition", "rather", "than", "activation", "of", "NF-kappa", "B-regulated", "inflammatory", "cytokine", "genes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0 ]
9470
[ "Consequently", ",", "these", "results", "suggest", "that", "physiologically", "relevant", "concentrations", "of", "ethanol", "may", "affect", "production", "of", "inflammatory", "cytokines", ",", "such", "as", "tumor", "necrosis", "factor-alpha", ",", "interleukin-1", "beta", ",", "and", "interleukin-6", "by", "disrupting", "NF-kappa", "B", "signaling", "in", "monocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 10, 0, 0, 9, 0, 0, 9, 10, 0, 0, 7, 0 ]
9471
[ "LPS", "tolerance", "in", "monocytes/macrophages", ":", "three", "3", "'", "cytosins", "are", "required", "in", "the", "DNA", "binding", "motif", "for", "detection", "of", "upregulated", "NF-kappa", "B", "p50", "homodimers", "." ]
[ 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]
9472
[ "When", "monocytes", "are", "stimulated", "with", "LPS", "(", "lipopolysaccharide", ")", "repeatedly", "then", "the", "initially", "high", "expression", "of", "the", "TNF", "(", "tumor", "necrosis", "factor", ")", "gene", "is", "only", "very", "low", ",", "i.e.", "the", "cells", "are", "tolerant", "to", "LPS", "." ]
[ 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9473
[ "Tolerant", "cells", "still", "express", "the", "CD14", "receptor", "and", "they", "can", "still", "be", "activated", "to", "mobilize", "NF-kappa", "B", "into", "nucleus", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0 ]
9474
[ "Analysis", "of", "the", "binding", "proteins", "employing", "the", "-605", "motif", "of", "the", "human", "TNF", "promoter", "(", "GGGGCTGTCCC", ")", "revealed", "that", "in", "tolerant", "cells", "of", "the", "human", "monocytic", "cell", "line", "Mono", "Mac", "6", "there", "is", "a", "predominance", "of", "p50p50", "of", "NF-kappa", "B", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 6, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0 ]
9475
[ "We", "now", "show", "that", "a", "mutant", "motif", "that", "exchanges", "the", "terminal", "3", "'", "C", "for", "a", "G", "fails", "to", "bind", "the", "p50", "homodimer", "that", "is", "upregulated", "in", "LPS", "toler", "ant", "human", "Mono", "Mac", "6", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0 ]
9476
[ "The", "same", "is", "true", "for", "nuclear", "extracts", "taken", "from", "the", "murine", "P388D1", "macrophage", "cell", "line", "when", "tested", "with", "the", "-516", "motif", "of", "the", "murine", "TNF", "promoter", "(", "GGGGGCTTTCCC", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0 ]
9477
[ "Here", "the", "wild", "type", "motif", "gives", "efficient", "binding", "of", "p50p50", "that", "again", "is", "upregulated", "in", "tolerant", "cells", "whereas", "a", "mutant", "with", "a", "3", "'", "G", "shows", "hardly", "any", "binding", "of", "p50p50", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
9478
[ "Conversely", ",", "the", "murine", "kappa", "light", "chain", "enhancer", "motif", "(", "GGGGACTTTCCG", ")", "does", "not", "efficiently", "bind", "the", "nuclear", "p50p50", "from", "tolerant", "murine", "P388", "macrophages", "." ]
[ 0, 0, 0, 1, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 5, 6, 6, 0 ]
9479
[ "Binding", "is", ",", "however", ",", "readily", "detected", "when", "the", "3", "'", "G", "is", "replaced", "by", "a", "C", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9480
[ "These", "data", "show", "that", "the", "detection", "of", "upregulated", "p50", "homodimers", "in", "LPS", "tolerant", "cells", "is", "dependent", "on", "subtle", "differences", "in", "the", "sequence", "of", "the", "DNA", "binding", "motif", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9481
[ "Cyclosporin", "A", "inhibits", "early", "mRNA", "expression", "of", "G0/G1", "switch", "gene", "2", "(", "G0S2", ")", "in", "cultured", "human", "blood", "mononuclear", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 1, 0, 0, 0, 7, 8, 8, 8, 0 ]
9482
[ "Cyclosporin", "A", "(", "CsA", ")", "may", "achieve", "its", "immunosuppressive", "effects", "by", "inhibiting", "the", "calcium-", "and", "calmodulin-dependent", "phosphatase", "calcineurin", "which", "is", "required", "for", "activation", "of", "target", "genes", "by", "members", "of", "the", "NFAT", "(", "nuclear", "factor", "of", "activated", "T", "cells", ")", "transcription", "factor", "family", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0 ]
9483
[ "Among", "these", "target", "genes", "is", "the", "gene", "encoding", "interleukin-2", "(", "IL2", ")", ",", "a", "cytokine", "facilitating", "progression", "through", "the", "G1", "phase", "of", "the", "cell", "cycle", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9484
[ "However", ",", "IL2", "does", "not", "reverse", "CsA", "inhibition", ",", "suggesting", "that", "at", "least", "one", "other", "NFAT-sensitive", "gene", "may", "be", "involved", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0 ]
9485
[ "The", "human", "G0/G1", "switch", "gene", ",", "G0S2", ",", "has", "potential", "NFAT-binding", "sites", "in", "the", "5", "'", "flank", "and", "encodes", "a", "small", "basic", "potential", "phosphoprotein", "of", "unknown", "function", "." ]
[ 0, 1, 2, 2, 2, 0, 1, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9486
[ "Using", "a", "sensitive", ",", "reverse", "transcription-polymerase", "chain", "reaction", "(", "RT-PCR", ")", "assay", ",", "G0S2", "mRNA", "levels", "were", "assayed", "in", "cultured", "blood", "mononuclear", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
9487
[ "Freshly", "isolated", "cells", "contain", "high", "levels", "of", "G0S2", "mRNA", "which", "rapidly", "decline", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0 ]
9488
[ "This", "``", "spontaneous", "stimulation", "''", "is", "also", "noted", "with", "some", "other", "G0S", "genes", "and", "has", "been", "attributed", "to", "some", "aspect", "of", "the", "isolation", "procedure", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9489
[ "In", "cells", "that", "have", "been", "preincubated", "to", "lower", "mRNA", "levels", ",", "there", "is", "a", "transient", "increase", "in", "G0S2", "mRNA", ",", "peaking", "between", "1-2", "h", ",", "in", "response", "to", "Concanavalin-A", "(", "ConA", ")", ",", "or", "to", "the", "combination", "of", "phorbol", "ester", "(", "TPA", ")", ",", "and", "the", "calcium", "ionophore", ",", "ionomycin", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9490
[ "Both", "these", "responses", "are", "inhibited", "by", "CsA", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0 ]
9491
[ "Our", "results", "suggest", "that", "G0S2", "expression", "is", "required", "to", "commit", "cells", "to", "enter", "the", "G1", "phase", "of", "the", "cell", "cycle", ",", "and", "that", ",", "while", "not", "excluding", "other", "possible", "targets", ",", "early", "inhibition", "of", "G0S2", "expression", "by", "CsA", "may", "be", "important", "in", "achieving", "immunosuppression", "." ]
[ 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9492
[ "G0S2", "may", "be", "of", "value", "as", "a", "reporter", "gene", "for", "analyzing", "the", "mechanism", "of", "action", "of", "CsA", "and", "its", "influence", "on", "the", "positive", "and", "negative", "selection", "of", "lymphocytes", "in", "response", "to", "self", "and", "not-self", "antigens", "." ]
[ 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0 ]
9493
[ "c-Rel", "and", "p65", "subunits", "bind", "to", "an", "upstream", "NF-kappaB", "site", "in", "human", "granulocyte", "macrophage-colony", "stimulating", "factor", "promoter", "involved", "in", "phorbol", "ester", "response", "in", "5637", "cells", "." ]
[ 9, 0, 9, 10, 0, 0, 0, 0, 1, 2, 0, 1, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]
9494
[ "To", "further", "clarify", "the", "complex", "transcriptional", "regulation", "of", "the", "human", "GM-CSF", "gene", ",", "which", "was", "extensively", "investigated", "in", "activated", "T", "cells", ",", "we", "have", "studied", "the", "role", "of", "an", "upstream", "NF-kappaB", "like", "site", "in", "the", "5637", "non-lymphoid", "cell", "line", ",", "which", "derives", "from", "a", "bladder", "carcinoma", "and", "constitutively", "produces", "GM-CSF", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
9495
[ "This", "sequence", ",", "named", "the", "A", "element", ",", "has", "an", "active", "role", "on", "GM-CSF", "transcription", "and", "is", "responsive", "to", "the", "tumor", "promoter", "PMA", "in", "transient", "transfection", "experiments", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9496
[ "We", "describe", "here", "a", "heterodimeric", "binding", "complex", "of", "NF-kappaB", "subunits", "(", "c-Rel", "and", "p65", ")", "which", "is", "identical", "to", "the", "one", "obtained", "using", "the", "HIV-LTR-kappaB", "site", "as", "recognition", "sequence", "and", "different", "from", "the", "one", "(", "c-Rel", "and", "p50", ")", "observed", "with", "nuclear", "extracts", "from", "Mo", "T-lymphoid", "HTLV-II", "infected", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9497
[ "Repression", "of", "human", "immunodeficiency", "virus", "type", "1", "through", "the", "novel", "cooperation", "of", "human", "factors", "YY1", "and", "LSF", "[", "published", "erratum", "appears", "in", "J", "Virol", "1998", "Feb", ";", "72", "(", "2", ")", ":", "1709", "]" ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9498
[ "A", "subpopulation", "of", "stably", "infected", "CD4+", "cells", "capable", "of", "producing", "virus", "upon", "stimulation", "has", "been", "identified", "in", "human", "immunodeficiency", "virus", "(", "HIV", ")", "-positive", "individuals", "(", "T.-W.Chun", ",", "D.Finzi", ",", "J.Margolick", ",", "K.Chadwick", ",", "D.Schwartz", ",", "and", "R.F.Siliciano", ",", "Nat.Med.1", ":", "1284-1290", ",", "1995", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9499
[ "Few", "host", "factors", "that", "directly", "limit", "HIV-1", "transcription", "and", "could", "support", "this", "state", "of", "nonproductive", "HIV-1", "infection", "have", "been", "described", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9500
[ "YY1", ",", "a", "widely", "distributed", "human", "transcription", "factor", ",", "is", "known", "to", "inhibit", "HIV-1", "long", "terminal", "repeat", "(", "LTR", ")", "transcription", "and", "virus", "production", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0 ]