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9301
[ "Thus", ",", "qualitative", "differences", "in", "the", "capacity", "to", "regulate", "these", "factors", "could", "not", "be", "shown", "in", "fetal", "blood", "cells", "." ]
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9302
[ "Quantitative", "experiments", "comparing", "binding", "of", "these", "transcription", "factors", "to", "the", "IL-2", "promoter", "are", "currently", "under", "investigation", "." ]
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9303
[ "Nuclear", "accumulation", "of", "NFAT4", "opposed", "by", "the", "JNK", "signal", "transduction", "pathway", "." ]
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9304
[ "The", "nuclear", "factor", "of", "activated", "T", "cells", "(", "NFAT", ")", "group", "of", "transcription", "factors", "is", "retained", "in", "the", "cytoplasm", "of", "quiescent", "cells", "." ]
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9305
[ "NFAT", "activation", "is", "mediated", "in", "part", "by", "induced", "nuclear", "import", "." ]
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9306
[ "This", "process", "requires", "calcium-dependent", "dephosphorylation", "of", "NFAT", "caused", "by", "the", "phosphatase", "calcineurin", "." ]
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9307
[ "The", "c-Jun", "amino-terminal", "kinase", "(", "JNK", ")", "phosphorylates", "NFAT4", "on", "two", "sites", "." ]
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9308
[ "Mutational", "removal", "of", "the", "JNK", "phosphorylation", "sites", "caused", "constitutive", "nuclear", "localization", "of", "NFAT4", "." ]
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9309
[ "In", "contrast", ",", "JNK", "activation", "in", "calcineurin-stimulated", "cells", "caused", "nuclear", "exclusion", "of", "NFAT4", "." ]
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9310
[ "These", "findings", "show", "that", "the", "nuclear", "accumulation", "of", "NFAT4", "promoted", "by", "calcineurin", "is", "opposed", "by", "the", "JNK", "signal", "transduction", "pathway", "." ]
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9311
[ "Thiol", "modulation", "inhibits", "the", "interleukin", "(", "IL", ")", "-1", "-mediated", "activation", "of", "an", "IL-1", "receptor-associated", "protein", "kinase", "and", "NF-kappa", "B", "." ]
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9312
[ "The", "interleukin-1", "receptor", "type", "I", "(", "IL-1RI", ")", "is", "associated", "with", "other", "proteins", "thus", "forming", "a", "complex", "system", "by", "which", "IL-1", "exerts", "its", "various", "signals", "." ]
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9313
[ "The", "initiating", "event", "is", "still", "uncertain", ",", "but", "activation", "of", "a", "recently", "described", "receptor-associated", "protein", "kinase", "is", "one", "of", "the", "earliest", "events", "detectable", "(", "Martin", "et", "al.", ",", "Eur.J.Immunol.1994.24", ":", "1566", ")", "." ]
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9314
[ "IL-1", "signaling", "is", "commonly", "accompanied", "by", "oxidative", "processes", "and", "is", "thought", "to", "be", "subject", "to", "redox", "regulation", "." ]
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9315
[ "We", "therefore", "investigated", "whether", "the", "activation", "of", "the", "IL-1RI-associated", "protein", "kinase", "could", "be", "a", "target", "for", "redox", "regulation", "and", "whether", "an", "altered", "activity", "of", "the", "kinase", "could", "influence", "IL-1", "-mediated", "NF-kappa", "B", "activation", "." ]
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9316
[ "A", "murine", "T", "cell", "line", ",", "EL4", ",", "was", "stimulated", "with", "IL-1", "with", "and", "without", "pretreatment", "with", "different", "compounds", "known", "to", "influence", "the", "cellular", "redox", "status", "." ]
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9317
[ "Thiol", "modifying", "agents", "like", "diamide", ",", "menadione", ",", "pyrrolidine", "dithiocarbamate", "(", "PDTC", ")", ",", "diethyl", "dithiocarbamate", "or", "phenylarsine", "oxide", "inhibited", "the", "IL-1", "-induced", "activation", "of", "the", "IL-1RI-associated", "protein", "kinase", "." ]
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9318
[ "N-Acetylcysteine", ",", "alpha", ",", "alpha'-dipyridyl", ",", "aminotriazole", "or", "nitrofurantoin", "did", "not", "show", "any", "effect", "." ]
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9319
[ "The", "inhibition", "by", "PDTC", "was", "reversible", "unless", "glutathione", "synthesis", "was", "blocked", "by", "buthionine", "sulfoximine", "." ]
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9320
[ "The", "described", "conditions", "which", "inhibited", "or", "prevented", "the", "activation", "of", "the", "IL-1RI-associated", "kinase", "similarly", "impaired", "the", "activation", "of", "NF-kappa", "B", "in", "EL4", "cells", "." ]
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9321
[ "From", "these", "observations", "we", "conclude", "that", "free", "thiols", "in", "the", "IL-1RI", "complex", "are", "essential", "for", "the", "activation", "of", "the", "IL-1RI-associated", "protein", "kinase", "and", "that", "this", "process", "is", "mandatory", "for", "IL-1", "signaling", "leading", "to", "NF-kappa", "B", "activation", "." ]
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9322
[ "Switching", "gears", "during", "T-cell", "maturation", ":", "RANTES", "and", "late", "transcription", "." ]
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9323
[ "Although", "much", "is", "understood", "about", "the", "induction", "of", "genes", "expressed", "early", "(", "within", "24", "h", ")", "after", "T-cell", "activation", ",", "little", "is", "known", "about", "the", "regulation", "of", "expression", "of", "genes", "expressed", "'late", "'", "(", "three", "or", "more", "days", ")", "post-stimulation", "." ]
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9324
[ "A", "better", "understanding", "of", "transcriptional", "regulation", "at", "this", "important", "stage", "of", "T-cell", "maturation", "may", "yield", "new", "insights", "into", "T-cell", "development", "and", "new", "immunotherapeutic", "targets", "." ]
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9325
[ "Involvement", "of", "different", "transduction", "pathways", "in", "NF-kappa", "B", "activation", "by", "several", "inducers", "." ]
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9326
[ "Double-stimulation", "was", "used", "to", "demonstrate", "that", ",", "in", "a", "T", "lymphocytic", "cell", "line", "(", "CEM", ")", ",", "phorbol", "myristate", "acetate", "(", "PMA", ")", "rapidly", "induced", "NF-kappa", "B", "through", "a", "signaling", "pathway", "which", "did", "not", "involve", "reactive", "oxygen", "species", "(", "ROS", ")", "and", "was", "different", "from", "the", "activation", "triggered", "by", "either", "H2O2", "or", "tumor", "necrosis", "factor-alpha", "(", "TNF-alpha", ")", "." ]
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9327
[ "Since", "these", "latter", "compounds", "were", "known", "to", "activate", "NF-kappa", "B", "translocation", "in", "a", "redox-sensitive", "way", ",", "we", "have", "demonstrated", "that", "NF-kappa", "B", "activation", "by", "PMA", "was", "resistant", "to", "antioxidant", "N-acetyl-L-cysteine", "(", "NAC", ")", "and", "sensitive", "to", "kinase", "inhibitors", "staurosporine", "and", "H7", "while", "activation", "by", "H2O2", "or", "TNF-alpha", "were", "not", "." ]
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9328
[ "Blockade", "of", "T-cell", "activation", "by", "dithiocarbamates", "involves", "novel", "mechanisms", "of", "inhibition", "of", "nuclear", "factor", "of", "activated", "T", "cells", "." ]
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9329
[ "Dithiocarbamates", "(", "DTCs", ")", "have", "recently", "been", "reported", "as", "powerful", "inhibitors", "of", "NF-kappaB", "activation", "in", "a", "number", "of", "cell", "types", "." ]
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9330
[ "Given", "the", "role", "of", "this", "transcription", "factor", "in", "the", "regulation", "of", "gene", "expression", "in", "the", "inflammatory", "response", ",", "NF-kappaB", "inhibitors", "have", "been", "suggested", "as", "potential", "therapeutic", "drugs", "for", "inflammatory", "diseases", "." ]
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9331
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9332
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9333
[ "Accordingly", ",", "electrophoretic", "mobility", "shift", "assays", "(", "EMSAs", ")", "indicated", "that", "pyrrolidine", "DTC", "(", "PDTC", ")", "prevented", "NF-kappaB", ",", "and", "NFAT", "DNA-binding", "activity", "in", "T", "cells", "stimulated", "with", "either", "phorbol", "myristate", "acetate", "plus", "ionophore", "or", "antibodies", "against", "the", "CD3-T-cell", "receptor", "complex", "and", "simultaneously", "activated", "the", "binding", "of", "AP-1", "." ]
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9334
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9335
[ "Strikingly", ",", "Western", "blotting", "and", "immunocytochemical", "experiments", "indicated", "that", "PDTC", "promoted", "a", "transient", "and", "rapid", "shuttling", "of", "NFATp", "and", "NFATc", ",", "leading", "to", "their", "accelerated", "export", "from", "the", "nucleus", "of", "activated", "T", "cells", "." ]
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9336
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9337
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9338
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9339
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9340
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9341
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9342
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9343
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9344
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9345
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9346
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9347
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9348
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9349
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9350
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9351
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