Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
9201
[ "beta", "2-m", "increased", "the", "binding", "to", "the", "HLA-A3", "molecule", "but", "did", "not", "influence", "the", "binding", "to", "the", "HLA-Cw*0702", "." ]
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9202
[ "The", "stability", "of", "already", "formed", "complexed", "was", "somewhat", "different", "in", "the", "HLA-A3", "and", "HLA-Cw*0702", "system", ":", "both", "were", "more", "stable", "at", "26", "degrees", "C", "than", "at", "37", "degrees", "C", "but", "while", "the", "beta", "2-m", "and", "FCS", "did", "not", "influence", "the", "stability", "of", "the", "HLA-A3/peptide", "complex", ",", "they", "seemed", "to", "cause", "opposite", "effects", "in", "the", "HLA-Cw*0702", "system", "(", "beta", "2-m", "stabilized", "and", "FCS", "destabilized", "the", "complex", ")", "." ]
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9203
[ "Finally", ",", "we", "were", "able", "to", "generate", "a", "specific", "CD8+", "CTL", "line", "against", "a", "K-RAS", "mutated", "peptide", "." ]
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9204
[ "CONCLUSIONS", ":", "Although", "binding", "motifs", "and", "actual", "HLA", "binding", "can", "be", "detected", "in", "several", "cases", ",", "the", "generation", "of", "a", "cellular", "response", "is", "infrequent", ",", "confirming", "that", "HLA", "binding", "is", "necessary", "but", "not", "sufficient", "to", "obtain", "an", "in", "vitro", "response", "." ]
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9205
[ "Further", "optimization", "of", "culture", "conditions", ",", "type", "of", "Antigen", "Presenting", "Cells", "(", "APC", ")", ",", "peptides", ",", "use", "of", "stabilizers", "like", "beta", "2-m", "are", "still", "needed", "." ]
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9206
[ "OCA-B", "is", "a", "functional", "analog", "of", "VP16", "but", "targets", "a", "separate", "surface", "of", "the", "Oct-1", "POU", "domain", "[", "published", "erratum", "appears", "in", "Mol", "Cell", "Biol", "1998", "Apr", ";", "18", "(", "4", ")", ":", "2430", "]" ]
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9207
[ "OCA-B", "is", "a", "B-cell-specific", "coregulator", "of", "the", "broadly", "expressed", "POU", "domain", "transcription", "factor", "Oct-1", "." ]
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9208
[ "OCA-B", "associates", "with", "the", "Oct-1", "POU", "domain", ",", "a", "bipartite", "DNA-binding", "structure", "containing", "a", "POU-specific", "(", "POU", "[", "S", "]", ")", "domain", "joined", "by", "a", "flexible", "linker", "to", "a", "POU", "homeodomain", "(", "POU", "[", "H", "]", ")", "." ]
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9209
[ "Here", ",", "we", "show", "that", "OCA-B", "alters", "the", "activity", "of", "Oct-1", "in", "two", "ways", "." ]
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9210
[ "It", "provides", "a", "transcriptional", "activation", "domain", "which", ",", "unlike", "Oct-1", ",", "activates", "an", "mRNA-type", "promoter", "effectively", ",", "and", "it", "stabilizes", "Oct-1", "on", "the", "Oct-1-responsive", "octamer", "sequence", "ATGCAAAT", "." ]
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9211
[ "These", "properties", "of", "OCA-B", "parallel", "those", "displayed", "by", "the", "herpes", "simplex", "virus", "Oct-1", "coregulator", "VP16", "." ]
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9212
[ "OCA-B", ",", "however", ",", "interacts", "with", "a", "different", "surface", "of", "the", "DNA-bound", "Oct-1", "POU", "domain", ",", "interacting", "with", "both", "the", "POU", "(", "S", ")", "and", "POU", "(", "H", ")", "domains", "and", "the", "center", "of", "the", "ATGCAAAT", "octamer", "sequence", "." ]
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9213
[ "The", "OCA-B", "and", "VP16", "interactions", "with", "the", "Oct-1", "POU", "domain", "are", "sufficiently", "different", "to", "permit", "OCA-B", "and", "VP16", "to", "bind", "the", "Oct-1", "POU", "domain", "simultaneously", "." ]
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9214
[ "These", "results", "emphasize", "the", "structural", "versatility", "of", "the", "Oct-1", "POU", "domain", "in", "its", "interaction", "with", "coregulators", "." ]
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9215
[ "Phosphatidylinositol", "3-kinase", "couples", "the", "interleukin-2", "receptor", "to", "the", "cell", "cycle", "regulator", "E2F", "." ]
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9216
[ "Cell", "cycle", "progression", "initiated", "by", "interleukin-2", "(", "IL-2", ")", "in", "T", "cells", "is", "critical", "for", "lymphoproliferation", "and", "an", "immune", "response", "." ]
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9217
[ "Phosphatidyl", "inositol", "3-kinase", "(", "PI3K", ")", "is", "activated", "by", "IL-2", "." ]
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9218
[ "However", ",", "nuclear", "targets", "for", "PI3K", "are", "not", "known", "." ]
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9219
[ "Here", "we", "identify", "the", "cell", "cycle", "regulator", "E2F", "as", "an", "IL-2", "target", "in", "T", "lymphocytes", "and", "PI3K", "as", "the", "critical", "signaling", "pathway", "." ]
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9220
[ "We", "eliminate", "both", "Stat5", "and", "Raf", "/MEK", "pathways", "from", "E2F", "regulation", "." ]
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9221
[ "Protein", "kinase", "B", "(", "PKB", ")", "is", "activated", "by", "IL-2", "via", "PI3K", "." ]
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9222
[ "The", "expression", "of", "an", "active", "PKB", "is", "sufficient", "to", "induce", "E2F", "activity", "." ]
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9223
[ "Inhibition", "of", "PI3K", "inhibits", "phosphorylation", "of", "Rb", ",", "induction", "of", "cyclin", "D3", ",", "and", "degradation", "of", "p27kip1", "." ]
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9224
[ "These", "results", "establish", "a", "crucial", "PI3K", "/", "PKB", "-mediated", "link", "between", "the", "IL-2", "teceptor", "and", "the", "cell", "cycle", "machinery", "." ]
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9225
[ "The", "Epstein-Barr", "virus", "oncogene", "product", "latent", "membrane", "protein", "1", "engages", "the", "tumor", "necrosis", "factor", "receptor-associated", "death", "domain", "protein", "to", "mediate", "B", "lymphocyte", "growth", "transformation", "and", "activate", "NF-kappaB", "." ]
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9226
[ "The", "Epstein-Barr", "virus", "latent", "membrane", "protein", "1", "(", "LMP1", ")", "is", "essential", "for", "the", "transformation", "of", "B", "lymphocytes", "into", "lymphoblastoid", "cell", "lines", "." ]
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9227
[ "Previous", "data", "are", "consistent", "with", "a", "model", "that", "LMP1", "is", "a", "constitutively", "activated", "receptor", "that", "transduces", "signals", "for", "transformation", "through", "its", "carboxyl-terminal", "cytoplasmic", "tail", "." ]
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9228
[ "One", "transformation", "effector", "site", "(", "TES1", ")", ",", "located", "within", "the", "membrane", "proximal", "45", "residues", "of", "the", "cytoplasmic", "tail", ",", "constitutively", "engages", "tumor", "necrosis", "factor", "receptor-associated", "factors", "." ]
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9229
[ "Signals", "from", "TES1", "are", "sufficient", "to", "drive", "initial", "proliferation", "of", "infected", "resting", "B", "lymphocytes", ",", "but", "most", "lymphoblastoid", "cells", "infected", "with", "a", "virus", "that", "does", "not", "express", "the", "155", "residues", "beyond", "TES1", "fail", "to", "grow", "as", "long-term", "cell", "lines", "." ]
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9230
[ "We", "now", "find", "that", "mutating", "two", "tyrosines", "to", "an", "isoleucine", "at", "the", "carboxyl", "end", "of", "the", "cytoplasmic", "tail", "cripples", "the", "ability", "of", "EBV", "to", "cause", "lymphoblastoid", "cell", "outgrowth", ",", "thereby", "marking", "a", "second", "transformation", "effector", "site", ",", "TES2", "." ]
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9231
[ "A", "yeast", "two-hybrid", "screen", "identified", "TES2", "interacting", "proteins", ",", "including", "the", "tumor", "necrosis", "factor", "receptor-associated", "death", "domain", "protein", "(", "TRADD", ")", "." ]
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9232
[ "TRADD", "was", "the", "only", "protein", "that", "interacted", "with", "wild-type", "TES2", "and", "not", "with", "isoleucine-mutated", "TES2", "." ]
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9233
[ "TRADD", "associated", "with", "wild-type", "LMP1", "but", "not", "with", "isoleucine-mutated", "LMP1", "in", "mammalian", "cells", ",", "and", "TRADD", "constitutively", "associated", "with", "LMP1", "in", "EBV-transformed", "cells", "." ]
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9234
[ "In", "transfection", "assays", ",", "TRADD", "and", "TES2", "synergistically", "mediated", "high-level", "NF-kappaB", "activation", "." ]
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9235
[ "These", "results", "indicate", "that", "LMP1", "appropriates", "TRADD", "to", "enable", "efficient", "long-term", "lymphoblastoid", "cell", "outgrowth", "." ]
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9236
[ "High-level", "NF-kappaB", "activation", "also", "appears", "to", "be", "a", "critical", "component", "of", "long-term", "outgrowth", "." ]
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9237
[ "Inhibition", "of", "T", "cell", "and", "promotion", "of", "natural", "killer", "cell", "development", "by", "the", "dominant", "negative", "helix", "loop", "helix", "factor", "Id3", "." ]
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9238
[ "Bipotential", "T/natural", "killer", "(", "NK", ")", "progenitor", "cells", "are", "present", "in", "the", "human", "thymus", "." ]
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9239
[ "Despite", "their", "bipotential", "capacity", ",", "these", "progenitors", "develop", "predominantly", "to", "T", "cells", "in", "the", "thymus", "." ]
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9240
[ "The", "mechanisms", "controlling", "this", "developmental", "choice", "are", "unknown", "." ]
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9241
[ "Here", "we", "present", "evidence", "that", "a", "member", "(", "s", ")", "of", "the", "family", "of", "basic", "helix", "loop", "helix", "(", "bHLH", ")", "transcription", "factors", "determines", "lineage", "specification", "of", "NK/T", "cell", "progenitors", "." ]
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9242
[ "The", "natural", "dominant", "negative", "HLH", "factor", "Id3", ",", "which", "blocks", "transcriptional", "activity", "of", "a", "number", "of", "known", "bHLH", "factors", ",", "was", "expressed", "in", "CD34+", "progenitor", "cells", "by", "retrovirus-mediated", "gene", "transfer", "." ]
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9243
[ "Constitutive", "expression", "of", "Id3", "completely", "blocks", "development", "of", "CD34+", "cells", "into", "T", "cells", "in", "a", "fetal", "thymic", "organ", "culture", "(", "FTOC", ")", "." ]
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9244
[ "In", "contrast", ",", "development", "into", "NK", "cells", "in", "an", "FTOC", "is", "enhanced", "." ]
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9245
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9246
[ "Our", "results", "identify", "a", "molecular", "switch", "for", "lineage", "specification", "in", "early", "lymphoid", "precursors", "of", "humans", "." ]
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9247
[ "Late", "gene", "expression", "from", "the", "Epstein-Barr", "virus", "BcLF1", "and", "BFRF3", "promoters", "does", "not", "require", "DNA", "replication", "in", "cis", "." ]
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9248
[ "Late", "gene", "expression", "follows", "and", "is", "dependent", "upon", "lytic", "replication", "of", "the", "viral", "genome", "." ]
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9249
[ "Although", "experimental", "evidence", "is", "lacking", ",", "lytic", "viral", "DNA", "replication", "is", "believed", "to", "remove", "modifications", "or", "binding", "factors", "from", "the", "genome", "which", "serve", "to", "repress", "late", "gene", "expression", "during", "latency", "or", "the", "early", "lytic", "cycle", "." ]
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9250
[ "We", "have", "developed", "a", "reporter", "assay", "to", "begin", "characterizing", "the", "mechanisms", "that", "regulate", "late", "gene", "expression", "in", "Epstein-Barr", "virus", "(", "EBV", ")", "." ]
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9251
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9252
[ "This", "system", "faithfully", "recapitulates", "late", "expression", "patterns", "from", "the", "endogenous", "virus", ",", "implicating", "specific", "cis-active", "sequences", "in", "the", "control", "of", "late", "gene", "expression", "." ]
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9253
[ "In", "addition", ",", "these", "promoters", "respond", "only", "indirectly", "to", "the", "viral", "immediate-early", "transactivator", ",", "ZEBRA", "." ]
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9254
[ "This", "indirect", "response", "is", "mediated", "by", "other", "viral", "or", "virally", "induced", "activities", "downstream", "of", "ZEBRA", "in", "the", "lytic", "cascade", "." ]
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9255
[ "In", "this", "system", ",", "late", "gene", "expression", "is", "sensitive", "to", "inhibitors", "of", "the", "viral", "DNA", "polymerase", "such", "as", "phosphonoacetic", "acid", ",", "although", "the", "reporters", "lack", "a", "eukaryotic", "origin", "of", "replication", "and", "are", "not", "replicated", "under", "the", "assay", "conditions", "." ]
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9256
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9257
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9258
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9259
[ "Human", "C/EBP", "epsilon", "is", "a", "newly", "cloned", "gene", "coding", "for", "a", "CCAAT/enhancer", "binding", "protein", "that", "may", "be", "involved", "in", "the", "regulation", "of", "myeloid", "differentiation", "." ]
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9260
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9265
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9266
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9267
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9268
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9269
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9270
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9271
[ "We", "suspect", "that", "the", "C/EBP", "epsilon", "promoter/enhancer", "contains", "a", "retinoic", "acid-response", "element", "that", "is", "directly", "stimulated", "by", "retinoids", "." ]
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9272
[ "Dual", "effects", "of", "LPS", "antibodies", "on", "cellular", "uptake", "of", "LPS", "and", "LPS-induced", "proinflammatory", "functions", "." ]
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9273
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9274
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9275
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9276
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9277
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9278
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9279
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9280
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9281
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9282
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9283
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9284
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9286
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9287
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9288
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9289
[ "NFAT/AP-1", "complex", "formed", "only", "with", "P", "and", "P2", "." ]
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9290
[ "Cross-competition", "assays", "among", "the", "P-like", "elements", "revealed", "element-specific", "and", "common", "complexes", "." ]
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9291
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9292
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9293
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9294
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9295
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9296
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9297
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9298
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9299
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9300
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