Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
9001
[ "This", "was", "in", "contrast", "to", "normal", "peripheral", "blood", "B", "lymphocytes", "or", "CD5+", ")", "B", "cells", "isolated", "from", "tonsils", ",", "in", "which", "this", "phosphorylation", "was", "absent", "." ]
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9002
[ "Serine", "phosphorylation", "of", "STAT1", "and", "STAT3", "was", "seen", "occasionally", "in", "other", "leukemias", ",", "but", "it", "was", "a", "universal", "finding", "only", "in", "CLL", "." ]
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9003
[ "The", "serine", "phosphorylation", "of", "these", "STATs", "was", "a", "continuous", "process", ",", "as", "incubation", "of", "CLL", "cells", "with", "the", "kinase", "inhibitor", "H7", "led", "to", "the", "dephosphorylation", "of", "these", "serine", "residues", "." ]
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9004
[ "The", "STAT", "serine", "kinase", "in", "CLL", "cells", "has", "not", "been", "identified", ",", "and", "appears", "to", "be", "neither", "mitogen-activated", "protein", "kinase", "nor", "pp70", "(", "s6k", ")", "." ]
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9005
[ "In", "summary", ",", "the", "constitutive", "serine", "phosphorylation", "of", "STAT1", "and", "STAT3", "is", "present", "in", "all", "CLL", "samples", "tested", "to", "date", ",", "although", "the", "physiologic", "significance", "of", "this", "modification", "remains", "to", "be", "determined", "." ]
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9006
[ "Activation", "of", "human", "immunodeficiency", "virus", "type", "1", "expression", "by", "Gardnerella", "vaginalis", "." ]
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9007
[ "Bacterial", "vaginosis", "(", "BV", ")", "is", "associated", "with", "an", "increased", "rate", "of", "sexual", "transmission", "of", "human", "immunodeficiency", "virus", "(", "HIV", ")", "type", "1", ",", "and", "Gardnerella", "vaginalis", "is", "frequently", "isolated", "from", "the", "genital", "tracts", "of", "women", "with", "BV", "." ]
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9008
[ "G.", "vaginalis", "lysates", "were", "found", "to", "significantly", "stimulate", "HIV", "expression", "in", "monocytoid", "cells", "." ]
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9009
[ "Stimulation", "was", "significantly", "higher", "when", "lysates", "were", "heated", "at", "100", "degrees", "C", "for", "5", "min", "but", "was", "reduced", "by", "treatment", "with", "lysozyme", "or", "protease", "." ]
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9010
[ "G.", "vaginalis", "lysates", "also", "activated", "HIV", "expression", "in", "certain", "T", "cell", "lines", "." ]
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9011
[ "G.", "vaginalis", "lysates", "activated", "HIV", "long-terminal", "repeat", "transcription", "in", "HIV-infected", "cells", "and", "increased", "NF-kappaB", "binding", "activity", ",", "indicating", "an", "effect", "by", "G.", "vaginalis", "on", "HIV", "transcription", "." ]
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9012
[ "The", "activation", "of", "HIV", "production", "by", "G.", "vaginalis", "suggests", "that", "genital", "tract", "infection", "with", "G.", "vaginalis", "increases", "the", "risk", "of", "HIV", "transmission", "by", "increasing", "HIV", "expression", "in", "the", "genital", "tract", "." ]
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9013
[ "This", "may", "explain", ",", "at", "least", "in", "part", ",", "the", "increased", "rate", "of", "HIV", "transmission", "in", "women", "with", "BV", "." ]
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9014
[ "Interleukin-10", "inhibits", "expression", "of", "both", "interferon", "alpha-", "and", "interferon", "gamma-", "induced", "genes", "by", "suppressing", "tyrosine", "phosphorylation", "of", "STAT1", "." ]
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9015
[ "Interleukin-10", "(", "IL-10", ")", "helps", "maintain", "polarized", "T-helper", "cells", "in", "a", "T-helper", "lymphocyte", "2", "(", "Th2", ")", "phenotype", "." ]
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9016
[ "Part", "of", "this", "process", "involves", "the", "prevention", "of", "the", "development", "of", "Th1", "cells", ",", "which", "are", "a", "primary", "source", "of", "interferon", "gamma", "(", "IFNgamma", ")", ",", "a", "potent", "activator", "of", "monocytes", "and", "an", "inhibitor", "of", "Th2", "proliferation", "." ]
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9017
[ "Because", "monocytes", "and", "macrophages", "are", "important", "mediators", "of", "Th1-type", "responses", ",", "such", "as", "delayed-type", "hypersensitivity", ",", "we", "sought", "to", "determine", "if", "IL-10", "could", "directly", "mediate", "inhibition", "of", "IFNgamma-", "and", "IFNalpha-induced", "gene", "expression", "in", "these", "cells", "." ]
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9018
[ "Highly", "purified", "monocytes", "were", "incubated", "with", "IL-10", "for", "60", "to", "90", "minutes", "before", "the", "addition", "of", "IFNgamma", "or", "IFNalpha", "." ]
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9019
[ "IL-10", "preincubation", "resulted", "in", "the", "inhibition", "of", "gene", "expression", "for", "several", "IFN-induced", "genes", ",", "such", "as", "IP-10", ",", "ISG54", ",", "and", "intercellular", "adhesion", "molecule-1", "." ]
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9020
[ "The", "reduction", "in", "gene", "expression", "resulted", "from", "the", "ability", "of", "IL-10", "to", "suppress", "IFN", "-induced", "assembly", "of", "signal", "transducer", "and", "activator", "of", "transcription", "(", "STAT", ")", "factors", "to", "specific", "promoter", "motifs", "on", "IFNalpha-", "and", "IFNgamma-inducible", "genes", "." ]
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9021
[ "This", "was", "accomplished", "by", "preventing", "the", "IFN-induced", "tyrosine", "phosphorylation", "of", "STAT1", ",", "a", "component", "of", "both", "IFNalpha-", "and", "IFNgamma-induced", "DNA", "binding", "complexes", "." ]
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9022
[ "Therefore", ",", "IL-10", "can", "directly", "inhibit", "STAT-dependent", "early", "response", "gene", "expression", "induced", "by", "both", "IFNalpha", "and", "IFNgamma", "in", "monocytes", "by", "suppressing", "the", "tyrosine", "phosphorylation", "of", "STAT1", "." ]
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9023
[ "This", "may", "occur", "through", "the", "ability", "of", "IL-10", "to", "induce", "expression", "of", "the", "gene", ",", "suppressor", "of", "cytokine", "signaling", "3", "(", "SOCS3", ")", "." ]
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9024
[ "Clonality", "analysis", "of", "refractory", "anemia", "with", "ring", "sideroblasts", ":", "simultaneous", "study", "of", "clonality", "and", "cytochemistry", "of", "bone", "marrow", "progenitors", "." ]
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9025
[ "X", "chromosome", "inactivation", "and", "polymorphism", "of", "the", "human", "androgen", "receptor", "(", "HUMARA", ")", "gene", "has", "been", "applied", "for", "analyzing", "the", "clonality", "of", "blood", "cells", "." ]
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9026
[ "In", "the", "present", "study", ",", "the", "clonal", "relationship", "was", "investigated", "between", "peripheral", "blood", "polymorphonuclear", "cells", "(", "PMNCs", ")", "and", "marrow", "progenitor", "cells", "and", "the", "origin", "of", "ringed", "sideroblasts", "in", "patients", "with", "refractory", "anemia", "with", "ring", "sideroblasts", "(", "RARS", ")", "by", "polymerase", "chain", "reaction", "(", "PCR", ")", "of", "HUMARA", "gene", "." ]
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9027
[ "The", "X-inactivation", "patterns", "of", "circulating", "PMNCs", "and", "T", "lymphocytes", "as", "well", "as", "individual", "granulocyte", "colonies", "grown", "in", "vitro", "from", "bone", "marrow", "cells", "were", "analyzed", "." ]
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9028
[ "The", "development", "of", "ringed", "sideroblasts", "in", "erythroid", "colonies", "by", "iron", "staining", "and", "their", "X-inactivation", "pattern", "were", "also", "examined", "." ]
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9029
[ "All", "three", "RARS", "patients", "showed", "monoclonal", "PMNCs", "." ]
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9030
[ "In", "granulocyte", "colonies", ",", "however", ",", "two", "different", "X-inactivation", "patterns", "were", "observed", "in", "all", "patients", ",", "indicating", "that", "non-clonal", "progenitor", "cells", "remained", "in", "the", "bone", "marrow", "." ]
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9031
[ "All", "erythroid", "colonies", "consisted", "of", "ringed", "sideroblasts", "exclusively", "showed", "one", "pattern", "dominant", "in", "those", "of", "PMNCs", "." ]
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9032
[ "Our", "findings", "suggest", "that", "non-clonal", "progenitor", "cells", "persist", "in", "some", "RARS", "cases", ",", "that", "erythroid", "progenitors", "show", "mosaicism", ",", "and", "that", "ringed", "sideroblasts", "may", "be", "derived", "from", "an", "abnormal", "clone", "involved", "in", "the", "pathogenesis", "of", "this", "disease", "." ]
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9033
[ "Granulosa", "cell", "tumor", "of", "the", "ovary", "." ]
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9034
[ "Immunohistochemical", "evidence", "of", "low", "proliferative", "activity", "and", "virtual", "absence", "of", "mutation", "of", "the", "p53", "tumor-suppressor", "gene", "." ]
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9035
[ "BACKGROUND", "AND", "METHODS", ":", "Because", "the", "use", "of", "immunohistochemistry", "in", "the", "diagnosis", "of", "granulosa", "cell", "tumor", "(", "GCT", ")", "has", "not", "been", "fully", "explored", ",", "routinely", "processed", "(", "formalin-fixed", ",", "paraffin-embedded", ")", "tissue", "from", "11", "GCT", ",", "adult", "type", ",", "was", "investigated", "immunohistochemically", "(", "ABC", "method", ")", "with", "a", "broad", "spectrum", "of", "antibodies", "against", "various", "markers", ",", "including", "p53", "and", "Ki-67", "." ]
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9036
[ "All", "of", "the", "tumors", "exhibited", "typical", "morphology", ",", "were", "limited", "to", "the", "ovary", "(", "stage", "I", ")", ",", "and", "7", "cases", "followed", "a", "benign", "clinical", "course", "." ]
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9037
[ "RESULTS", ":", "All", "the", "tumors", "exhibited", "strong", "expression", "of", "vimentin", ",", "but", "most", "other", "antigens", "(", "including", "smooth", "muscle", "actin", ")", "were", "expressed", "infrequently", "by", "a", "minority", "of", "tumor", "cells", "or", "not", "at", "all", "." ]
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9038
[ "Tumor", "cells", "in", "9", "GCT", "expressed", "inhibin", "A", "." ]
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9039
[ "All", "the", "tumors", "exhibited", "very", "low", "proliferative", "activity", ",", "fewer", "than", "10", "%", "of", "the", "tumor", "cell", "nuclei", "being", "stained", "by", "the", "antibody", "MIB-1", "(", "Ki-67", "antigen", ")", "." ]
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9040
[ "The", "antibody", "D07", "revealed", "marked", "overexpression", "of", "p53", "protein", "in", "only", "one", "tumor", "." ]
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9041
[ "Clinical", "outcome", "was", "not", "found", "to", "be", "related", "to", "immunophenotypic", "differences", "." ]
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9042
[ "CONCLUSIONS", ":", "The", "diagnosis", "of", "GCT", "should", "be", "based", "primarily", "on", "the", "typical", "morphology", "revealed", "by", "conventional", "stains", ",", "but", "additional", "immunohistochemical", "staining", "with", "a", "small", "panel", "of", "selected", "antibodies", "(", "for", "example", ",", "against", "keratin", ",", "vimentin", ",", "and", "inhibin", "A", ")", "may", "be", "helpful", "in", "a", "few", "cases", "." ]
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9043
[ "The", "very", "low", "proliferative", "activity", "and", "the", "lack", "of", "overexpression", "of", "p53", "protein", "are", "consistent", "with", "the", "benign", "clinical", "behavior", "of", "the", "majority", "of", "GCT", "." ]
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9044
[ "Protective", "effects", "of", "notch-1", "on", "TCR", "-induced", "apoptosis", "." ]
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9045
[ "The", "Notch", "receptor", "protein", "was", "originally", "identified", "in", "Drosophila", "and", "is", "known", "to", "mediate", "cell", "to", "cell", "communication", "and", "influence", "cell", "fate", "decisions", "." ]
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9046
[ "Members", "of", "this", "family", "have", "been", "isolated", "from", "invertebrates", "as", "well", "as", "vertebrates", "." ]
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9047
[ "We", "isolated", "mouse", "Notch-1", "in", "a", "yeast", "two-hybrid", "screen", "with", "Nur77", ",", "which", "is", "a", "protein", "that", "has", "been", "shown", "previously", "to", "be", "required", "for", "apoptosis", "in", "T", "cell", "lines", "." ]
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9048
[ "The", "data", "presented", "below", "indicate", "that", "Notch-1", "expression", "provides", "significant", "protection", "to", "T", "cell", "lines", "from", "TCR", "-mediated", "apoptosis", "." ]
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9049
[ "These", "data", "demonstrate", "a", "new", "antiapoptotic", "role", "for", "Notch-1", ",", "providing", "evidence", "that", ",", "in", "addition", "to", "regulating", "cell", "fate", "decisions", ",", "Notch-1", "can", "play", "a", "critical", "role", "in", "controlling", "levels", "of", "cell", "death", "in", "T", "cells", "." ]
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9050
[ "Comparison", "of", "primary", "sensitization", "of", "naive", "human", "T", "cells", "to", "varicella-zoster", "virus", "peptides", "by", "dendritic", "cells", "in", "vitro", "with", "responses", "elicited", "in", "vivo", "by", "varicella", "vaccination", "." ]
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9051
[ "Dendritic", "cells", "(", "DC", ")", "are", "potent", "APC", "during", "primary", "and", "secondary", "immune", "responses", "." ]
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9052
[ "The", "first", "objective", "of", "this", "study", "was", "to", "determine", "whether", "human", "DC", "mediate", "in", "vitro", "sensitization", "of", "naive", "CD4+", "T", "cells", "to", "epitopes", "of", "the", "immediate", "early", "62", "(", "IE62", ")", "protein", "of", "varicella", "zoster", "virus", "(", "VZV", ")", "." ]
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9053
[ "The", "induction", "of", "CD4+", "T", "cell", "proliferative", "responses", "to", "eight", "synthetic", "peptides", "representing", "amino", "acid", "sequences", "of", "the", "VZV", "IE62", "protein", "was", "assessed", "using", "T", "cells", "and", "DC", "from", "VZV-susceptible", "donors", "." ]
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9054
[ "The", "second", "objective", "was", "to", "compare", "in", "vitro", "responses", "of", "naive", "T", "cells", "with", "responses", "to", "VZV", "peptides", "induced", "in", "vivo", "after", "immunization", "with", "varicella", "vaccine", "." ]
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9055
[ "T", "cell", "proliferation", "was", "induced", "by", "three", "peptides", ",", "P1", ",", "P4", ",", "and", "P7", ",", "in", "71-100", "%", "of", "the", "donors", "tested", "before", "and", "after", "vaccination", "using", "DC", "as", "APC", "." ]
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