Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
8801
[ "T", "cell", "responses", "to", "some", "nuclear", "antigens", ",", "particularly", "U1RNP", ",", "have", "been", "detected", "in", "patients", "with", "systemic", "lupus", "erythematosus", "(", "SLE", ")", "and", "in", "healthy", "subjects", "." ]
[ 7, 8, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8802
[ "We", "investigated", "T", "cell", "reactivity", "to", "the", "autoantigen", "SSB", "in", "patients", "with", "SS", "and", "healthy", "controls", "." ]
[ 0, 0, 7, 8, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]
8803
[ "METHODS", "." ]
[ 0, 0 ]
8804
[ "Using", "the", "[", "3H", "]", "thymidine", "proliferation", "assay", ",", "we", "determined", "reactivity", "to", "purified", "recombinant", "SSB", "(", "rSSB", ")", "in", "20", "patients", "with", "SS", "and", "19", "controls", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8805
[ "Specificity", "was", "determined", "using", "tetanus", "toxoid", ",", "endotoxin", ",", "and", "3", "other", "autoantigens", "(", "PBC.M2", ",", "Sc170", ",", "and", "GAD", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0 ]
8806
[ "Precursor", "frequency", "was", "calculated", "by", "limiting", "dilution", "analysis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8807
[ "HLA", "Class", "II", "dependency", "was", "investigated", "using", "anti-Class", "II", "monoclonal", "antibodies", "." ]
[ 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8808
[ "HLA-DR", "typing", "was", "by", "polymerase", "chain", "reaction", "and", "sequence", "specific", "oligonucleotide", "typing", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8809
[ "RESULTS", "." ]
[ 0, 0 ]
8810
[ "Six", "of", "20", "patients", "with", "SS", "and", "10/19", "controls", "proliferated", "to", "La", "(", "rSSB", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0 ]
8811
[ "Precursor", "frequency", "of", "anti-SSB", "T", "cells", "was", "1", ":", "77", ",", "040", "and", "1", ":", "115", ",", "000", "in", "2", "healthy", "subjects", "and", "1", ":", "230", ",", "250", "and", "1", ":", "103", ",", "034", "in", "two", "patients", "with", "SS", "." ]
[ 0, 0, 0, 9, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8812
[ "Anti-", "HLA-DR", "abrogated", "proliferation", "to", "SSB", "and", "tetanus", "toxoid", "." ]
[ 9, 10, 0, 0, 0, 9, 0, 0, 0, 0 ]
8813
[ "Thirteen", "of", "15", "patients", "with", "SS", "and", "4/17", "controls", "were", "HLA-DR3", "positive", ",", "with", "no", "apparent", "association", "of", "HLA-DR3", "with", "SSB", "reactivity", "in", "controls", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0 ]
8814
[ "CONCLUSION", "." ]
[ 0, 0 ]
8815
[ "Anti-La", "(", "SSB", ")", "specific", "T", "cells", "occur", "in", "a", "significant", "proportion", "of", "controls", "and", "in", "some", "patients", "with", "SS", "." ]
[ 9, 10, 10, 10, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8816
[ "The", "function", "of", "SSB", "T", "cells", "in", "controls", "remains", "to", "be", "defined", "." ]
[ 0, 0, 0, 9, 7, 8, 0, 0, 0, 0, 0, 0, 0 ]
8817
[ "They", "may", "represent", "immunoregulatory", "cells", ",", "and", "further", "analysis", "of", "these", "cells", ",", "and", "a", "comparison", "to", "those", "found", "in", "patients", "with", "SS", ",", "may", "elucidate", "normal", "immunoregulation", "and", "the", "derangements", "that", "lead", "to", "Sjogren", "'s", "syndrome", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8818
[ "Anti-rheumatic", "compound", "aurothioglucose", "inhibits", "tumor", "necrosis", "factor-alpha", "-induced", "HIV-1", "replication", "in", "latently", "infected", "OM10.1", "and", "Ach2", "cells", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 5, 0, 5, 6, 0 ]
8819
[ "NF-kappaB", "is", "a", "potent", "cellular", "activator", "of", "HIV-1", "gene", "expression", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8820
[ "Down-regulation", "of", "NF-kappaB", "activation", "is", "known", "to", "inhibit", "HIV", "replication", "from", "the", "latently", "infected", "cells", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8821
[ "Gold", "compounds", "have", "been", "effectively", "used", "for", "many", "decades", "in", "the", "treatment", "of", "rheumatoid", "arthritis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8822
[ "We", "previously", "reported", "that", "gold", "compounds", ",", "especially", "aurothioglucose", "(", "AuTG", ")", "containing", "monovalent", "gold", "ion", ",", "inhibited", "the", "DNA-binding", "of", "NF-kappaB", "in", "vitro", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
8823
[ "In", "this", "report", "we", "have", "examined", "the", "efficacy", "of", "the", "gold", "compound", "AuTG", "as", "an", "inhibitor", "of", "HIV", "replication", "in", "latently", "infected", "OM10.1", "and", "Ach2", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 5, 6, 0 ]
8824
[ "Tumor", "necrosis", "factor", "(", "TNF", ")", "-alpha", "-induced", "HIV-1", "replication", "in", "OM10.1", "or", "Ach2", "cells", "was", "significantly", "inhibited", "by", "non-cytotoxic", "doses", "of", "AuTG", "(", ">", "10", "microM", "in", "OM10.1", "cells", "and", ">", "25", "F.M", "in", "Ach2", "cells", ")", ",", "while", "25", "microM", "of", "the", "counter-anion", "thioglucose", "(", "TG", ")", "or", "gold", "compound", "containing", "divalent", "gold", "ion", ",", "HAuCl3", ",", "had", "no", "effect", "." ]
[ 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 5, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8825
[ "The", "effect", "of", "AuTG", "on", "NF-kappaB", "-dependent", "gene", "expression", "was", "confirmed", "by", "a", "transient", "CAT", "assay", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
8826
[ "Specific", "staining", "as", "well", "as", "electron", "microscopic", "examinations", "revealed", "the", "accumulation", "of", "metal", "gold", "in", "the", "cells", ",", "supporting", "our", "previous", "hypothesis", "that", "gold", "ions", "could", "block", "NF-kappaB", "-DNA", "binding", "by", "a", "redox", "mechanism", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
8827
[ "These", "observations", "indicate", "that", "the", "monovalent", "gold", "compound", "AuTG", "is", "a", "potentially", "useful", "drug", "for", "the", "treatment", "of", "patients", "infected", "with", "HIV", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8828
[ "Clonality", "of", "isolated", "eosinophils", "in", "the", "hypereosinophilic", "syndrome", "." ]
[ 0, 0, 0, 7, 0, 0, 0, 0, 0 ]
8829
[ "The", "idiopathic", "hypereosinophilic", "syndrome", "(", "IHES", ")", "is", "a", "rare", "disorder", "characterized", "by", "unexplained", ",", "persistent", "eosinophilia", "associated", "with", "multiple", "organ", "dysfunction", "due", "to", "eosinophilic", "tissue", "infiltration", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8830
[ "In", "the", "absence", "of", "karyotypic", "abnormalities", ",", "there", "is", "no", "specific", "test", "to", "detect", "clonal", "eosinophilia", "in", "IHES", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8831
[ "Analysis", "of", "X-chromosome", "inactivation", "patterns", "can", "be", "used", "to", "determine", "whether", "proliferative", "disorders", "are", "clonal", "in", "origin", "." ]
[ 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8832
[ "Methylation", "of", "HpaII", "and", "Hha", "I", "sites", "near", "the", "polymorphic", "trinucleotide", "repeat", "of", "the", "human", "androgen", "receptor", "gene", "(", "HUMARA", ")", "has", "been", "shown", "to", "correlate", "with", "X-inactivation", "." ]
[ 0, 0, 1, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8833
[ "In", "this", "study", ",", "we", "have", "used", "the", "polymerase", "chain", "reaction", "(", "PCR", ")", "with", "nested", "primers", "to", "analyze", "X-inactivation", "patterns", "of", "the", "HUMARA", "loci", "in", "purified", "eosinophils", "from", "female", "patients", "with", "eosinophilia", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 7, 0, 0, 0, 0, 0, 0 ]
8834
[ "Peripheral", "blood", "eosinophils", "were", "isolated", "by", "their", "autofluoresence", "using", "flow", "cytometric", "sorting", "." ]
[ 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8835
[ "Eosinophils", "purified", "from", "a", "female", "patient", "presenting", "with", "IHES", "were", "found", "to", "show", "a", "clonal", "pattern", "of", "X-inactivation", "." ]
[ 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8836
[ "Eosinophil-depleted", "leukocytes", "from", "this", "patient", "were", "polyclonal", "by", "HUMARA", "analysis", ",", "thus", "excluding", "skewedness", "of", "random", "X-inactivation", "." ]
[ 0, 7, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8837
[ "After", "corticosteroid", "suppression", "of", "her", "blood", "eosinophilia", ",", "a", "clonal", "population", "of", "eosinophils", "could", "no", "longer", "be", "detected", "in", "purified", "eosinophils", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 7, 0 ]
8838
[ "In", "contrast", ",", "eosinophils", "purified", "from", "a", "patient", "with", "Churg-Strauss", "syndrome", "and", "from", "six", "patients", "with", "reactive", "eosinophilias", "attributed", "to", "allergy", ",", "parasitic", "infection", ",", "or", "drug", "reaction", "showed", "a", "polyclonal", "pattern", "of", "X-inactivation", "by", "HUMARA", "analysis", "." ]
[ 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0 ]
8839
[ "The", "finding", "of", "clonal", "eosinophilia", "in", "a", "patient", "presenting", "with", "IHES", "indicates", "that", "such", "patients", "may", "have", ",", "in", "reality", ",", "a", "low-grade", "clonal", "disorder", "that", "can", "be", "distinguished", "from", "reactive", "eosinophilias", "by", "HUMARA", "analysis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0 ]
8840
[ "Further", ",", "the", "method", "described", "can", "be", "used", "to", "monitor", "disease", "progression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8841
[ "GA-binding", "protein", "factors", ",", "in", "concert", "with", "the", "coactivator", "CREB", "binding", "protein/p300", ",", "control", "the", "induction", "of", "the", "interleukin", "16", "promoter", "in", "T", "lymphocytes", "." ]
[ 9, 10, 10, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 7, 8, 0 ]
8842
[ "Interleukin", "16", "(", "IL-16", ")", "is", "a", "chemotactic", "cytokine", "that", "binds", "to", "the", "CD4", "receptor", "and", "affects", "the", "activation", "of", "T", "cells", "and", "replication", "of", "HIV", "." ]
[ 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0 ]
8843
[ "It", "is", "expressed", "as", "a", "large", "67-kDa", "precursor", "protein", "(", "pro-IL-16", ")", "in", "lymphocytes", ",", "macrophages", ",", "and", "mast", "cells", ",", "as", "well", "as", "in", "airway", "epithelial", "cells", "from", "asthmatics", "after", "challenge", "with", "allergen", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 0, 7, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0 ]
8844
[ "This", "pro-IL-16", "is", "subsequently", "processed", "to", "the", "mature", "cytokine", "of", "13", "kDa", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8845
[ "To", "study", "the", "expression", "of", "IL-16", "at", "the", "transcriptional", "level", ",", "we", "cloned", "the", "human", "chromosomal", "IL-16", "gene", "and", "analyzed", "its", "promoter", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0 ]
8846
[ "The", "human", "IL-16", "gene", "consists", "of", "seven", "exons", "and", "six", "introns", "." ]
[ 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0 ]
8847
[ "The", "5", "'", "sequences", "up", "to", "nucleotide", "-120", "of", "the", "human", "and", "murine", "IL-16", "genes", "share", ">", "84", "%", "sequence", "homology", "and", "harbor", "promoter", "elements", "for", "constitutive", "and", "inducible", "transcription", "in", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
8848
[ "Although", "both", "promoters", "lack", "any", "TATA", "box", ",", "they", "contain", "two", "CAAT", "box-like", "motifs", "and", "three", "binding", "sites", "of", "GA-binding", "protein", "(", "GABP", ")", "transcription", "factors", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0 ]
8849
[ "Two", "of", "these", "motifs", "are", "part", "of", "a", "highly", "conserved", "and", "inducible", "dyad", "symmetry", "element", "shown", "previously", "to", "control", "a", "remote", "IL-2", "enhancer", "and", "the", "CD18", "promoter", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 0 ]
8850
[ "In", "concert", "with", "the", "coactivator", "CREB", "binding", "protein/p300", ",", "which", "interacts", "with", "GABPalpha", ",", "the", "binding", "of", "GABPalpha", "and", "-beta", "to", "the", "dyad", "symmetry", "element", "controls", "the", "induction", "of", "IL-16", "promoter", "in", "T", "cells", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 7, 8, 0 ]
8851
[ "Supplementing", "the", "data", "on", "the", "processing", "of", "pro-IL-16", ",", "our", "results", "indicate", "the", "complexity", "of", "IL-16", "expression", ",", "which", "is", "tightly", "controlled", "at", "the", "transcriptional", "and", "posttranslational", "levels", "in", "T", "lymphocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
8852
[ "Tuberculosis", "and", "chronic", "hepatitis", "B", "virus", "infection", "in", "Africans", "and", "variation", "in", "the", "vitamin", "D", "receptor", "gene", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]
8853
[ "The", "active", "metabolite", "of", "vitamin", "D", ",", "1", ",", "25", "dihydroxyvitamin", "D3", ",", "is", "an", "important", "immunoregulatory", "hormone", "[", "1", "]", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8854
[ "Its", "effects", "are", "exerted", "by", "interaction", "with", "the", "vitamin", "D", "receptor", ",", "which", "is", "present", "on", "human", "monocytes", "and", "activated", "T", "and", "B", "lymphocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 7, 8, 0, 0, 7, 8, 8, 8, 0 ]
8855
[ "Variation", "in", "the", "vitamin", "D", "receptor", "gene", "was", "typed", "in", "2015", "subjects", "from", "large", "case-control", "studies", "of", "three", "major", "infectious", "diseases", ":", "tuberculosis", ",", "malaria", ",", "and", "hepatitis", "B", "virus", "." ]
[ 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8856
[ "Homozygotes", "for", "a", "polymorphism", "at", "codon", "352", "(", "genotype", "tt", ")", "were", "significantly", "underrepresented", "among", "those", "with", "tuberculosis", "(", "chi2=6.22", ",", "1", "df", ",", "P=.01", ")", "and", "persistent", "hepatitis", "B", "infection", "(", "chi2=6.25", ",", "1", "df", ",", "P=.01", ")", "but", "not", "in", "subjects", "with", "clinical", "malaria", "compared", "with", "the", "other", "genotypes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8857
[ "Therefore", ",", "this", "genetic", "variant", ",", "which", "predisposes", "to", "low", "bone", "mineral", "density", "in", "many", "populations", ",", "may", "confer", "resistance", "to", "certain", "infectious", "diseases", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8858
[ "Inhibition", "of", "NF-kappa", "B", "activation", "in", "vitro", "and", "in", "vivo", ":", "role", "of", "26S", "proteasome", "." ]
[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
8859
[ "It", "is", "becoming", "increasingly", "apparent", "that", "NF-kappa", "B", "plays", "a", "critical", "role", "in", "regulating", "the", "inflammatory", "response", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8860
[ "Data", "obtained", "from", "studies", "in", "our", "laboratories", "demonstrate", "that", "the", "proteasome", "plays", "an", "important", "role", "in", "the", "inflammatory", "cascade", "by", "regulating", "the", "activation", "of", "NF-kappa", "B", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
8861
[ "Indeed", ",", "the", "availability", "of", "selective", "and", "orally", "active", "proteasome", "inhibitors", "should", "prove", "useful", "in", "delineating", "the", "roles", "of", "the", "proteasome", "and", "NF-kappa", "B", "in", "other", "pathophysiological", "conditions", "such", "as", "cancer", "and", "heart", "disease", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8862
[ "Tissue", "factor", "expression", "of", "human", "monocytes", "is", "suppressed", "by", "lysophosphatidylcholine", "." ]
[ 9, 10, 0, 0, 7, 8, 0, 0, 0, 0, 0 ]
8863
[ "The", "expression", "of", "tissue", "factor", "(", "TF", ")", ",", "the", "principal", "initiator", "of", "coagulation", ",", "is", "increased", "during", "inflammation", "and", "atherosclerosis", "." ]
[ 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8864
[ "Both", "conditions", "are", "promoted", "by", "lysophosphatidylcholine", "(", "lysoPC", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8865
[ "We", "observed", "in", "the", "present", "study", "that", "lysoPC", "(", "1", "to", "10", "micromol/L", ")", "dose-dependently", "reduced", "TF", "activity", "in", "human", "monocytes", ",", "as", "elicited", "by", "lipopolysaccharide", "(", "LPS", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8866
[ "Lysophosphatidylethanolamine", "(", "lysoPE", ")", "and", "other", "lysophospholipids", "did", "not", "affect", "LPS-induced", "TF", "activity", "of", "human", "monocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0 ]
8867
[ "TF", "antigen", "expression", "as", "elicited", "by", "LPS", "was", "also", "lowered", "by", "lysoPC", "." ]
[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8868
[ "Phospholipid", "analyses", "indicated", "a", "selective", "increase", "in", "the", "lysoPC", "content", "of", "the", "monocytes", "after", "preincubation", "with", "the", "lysophospholipid", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0 ]
8869
[ "LysoPC", "inhibited", "the", "TF", "activity", "of", "Mono", "Mac-6", "cells", "to", "a", "similar", "extent", "as", "in", "the", "monocytes", "." ]
[ 0, 0, 0, 9, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 7, 0 ]
8870
[ "LPS", "binding", "to", "plasma", "membrane", "receptors", "and", "internalization", "of", "LPS", "into", "monocytes", "were", "not", "affected", "by", "lysoPC", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0 ]
8871
[ "In", "contrast", ",", "LPS-mediated", "nuclear", "binding", "of", "nuclear", "factor-kappaB/Rel", "to", "a", "TF-specific", "kappaB", "site", "was", "inhibited", "by", "lysoPC", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0 ]
8872
[ "Induction", "of", "TF", "mRNA", "expression", "by", "LPS", "tended", "to", "be", "partially", "reduced", "by", "the", "lysophospholipid", "." ]
[ 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8873
[ "Preincubation", "with", "lysoPC", "increased", "monocytic", "cAMP", "levels", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0 ]
8874
[ "Inhibition", "of", "adenylyl", "cyclase", "by", "pretreatment", "with", "2'-deoxy-3'-adenosine", "monophosphate", "partially", "reversed", "the", "inhibition", "of", "TF", "activity", "promoted", "by", "lysoPC", "." ]
[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
8875
[ "In", "conclusion", ",", "lysoPC", "markedly", "decreases", "LPS-mediated", "TF", "expression", "of", "human", "monocytes", ",", "the", "effect", "probably", "being", "mediated", "by", "both", "transcriptional", "and", "posttranscriptional", "mechanisms", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8876
[ "LysoPC", "may", "thus", "attenuate", "activation", "of", "coagulation", "during", "inflammation", "and", "atherosclerosis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8877
[ "Regulation", "of", "fas-ligand", "expression", "during", "activation-induced", "cell", "death", "in", "T", "lymphocytes", "via", "nuclear", "factor", "kappaB", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 7, 8, 0, 9, 10, 10, 0 ]
8878
[ "T", "cell", "receptor", "engagement", "activates", "transcription", "factors", "important", "for", "cytokine", "gene", "regulation", "." ]
[ 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8879
[ "Additionally", ",", "this", "signaling", "pathway", "also", "leads", "to", "activation-induced", "apoptosis", "in", "T", "lymphocytes", "that", "is", "dependent", "on", "FasL", "transcription", "and", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 9, 0, 0, 0, 0 ]
8880
[ "Here", "we", "demonstrate", "that", "nuclear", "factor", "kappaB", "(", "NF-kappaB", ")", ",", "which", "is", "involved", "in", "the", "transcriptional", "regulation", "of", "many", "cytokine", "genes", "expressed", "in", "activated", "lymphocytes", ",", "also", "plays", "a", "role", "in", "T", "cell", "activation-induced", "FasL", "expression", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 7, 8, 0, 9, 0, 0 ]
8881
[ "Inhibition", "of", "NF-kappaB", "activity", "in", "a", "T", "cell", "hybridoma", "leads", "to", "decreased", "FasL", "expression", "and", "apoptosis", "upon", "T", "cell", "receptor", "stimulation", "." ]
[ 0, 0, 9, 0, 0, 0, 7, 8, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 10, 0, 0 ]
8882
[ "We", "identified", "the", "NF-kappaB", "site", "in", "the", "FasL", "promoter", "that", "contributes", "to", "such", "regulation", "." ]
[ 0, 0, 0, 1, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0 ]
8883
[ "Co-expression", "of", "p65", "(", "Rel", "A", ")", "with", "the", "FasL", "promoter", "enhanced", "its", "activity", ",", "and", "co-expression", "of", "IkappaB", "dramatically", "inhibited", "the", "inducible", "promoter", "activity", "." ]
[ 0, 0, 9, 0, 9, 10, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
8884
[ "In", "contrast", ",", "the", "transcription", "factor", "AP-1", "is", "not", "required", "for", "activation-induced", "FasL", "promoter", "activity", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 1, 2, 0, 0 ]
8885
[ "These", "results", "define", "a", "role", "for", "NF-kappaB", "in", "mediating", "FasL", "expression", "during", "T", "cell", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 7, 8, 0, 0 ]
8886
[ "Promoter", "sequence", ",", "exon", ":", "intron", "structure", ",", "and", "synteny", "of", "genetic", "location", "show", "that", "a", "chicken", "cytokine", "with", "T-cell", "proliferative", "activity", "is", "IL2", "and", "not", "IL15", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 9, 0, 0, 9, 0 ]
8887
[ "The", "gene", "encoding", "a", "chicken", "cytokine", "with", "T-cell", "proliferative", "activity", "was", "cloned", ",", "sequenced", ",", "and", "mapped", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8888
[ "The", "results", "show", "that", "this", "cytokine", "is", "chicken", "IL2", "and", "not", "IL15", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 0 ]
8889
[ "The", "exon", ":", "intron", "structure", "of", "chicken", "IL2", "corresponds", "almost", "exactly", "to", "those", "of", "mammalian", "IL2s", "with", "the", "exceptions", "of", "exon", "2", "and", "introns", "2", "and", "3", "which", "are", "shorter", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8890
[ "Chicken", "IL2", "contains", "five", "repeats", "of", "the", "``", "instability", "''", "motif", "ATTTA", "in", "the", "3'untranslated", "region", "in", "exon", "4", "." ]
[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8891
[ "It", "is", "a", "single-copy", "gene", ",", "with", "neither", "structural", "(", "amino", "acid", ")", "nor", "promoter", "sequence", "polymorphisms", "identified", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8892
[ "Analysis", "of", "the", "predicted", "amino", "acid", "sequence", "suggests", "that", "overall", "protein", "structure", "is", "conserved", ",", "but", "the", "receptor", "binding", "sites", "are", "not", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8893
[ "A", "number", "of", "potential", "regulatory", "sequences", "similar", "to", "those", "found", "in", "mammals", "have", "been", "identified", "in", "the", "promoter", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8894
[ "These", "include", "(", "5'-3", "'", ")", "a", "composite", "NF-AT/", "``", "AP-1", "''", "element", ",", "a", "CD28", "response", "element", ",", "an", "AP-1", "element", ",", "an", "NF-AT", "element", ",", "and", "the", "AP-1", "part", "of", "an", "AP-1/octamer", "composite", "element", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 0, 0, 1, 2, 0, 0, 0, 1, 0, 0, 0, 1, 2, 2, 0 ]
8895
[ "The", "mammalian", "NF-kappaB", "and", "octamer", "binding", "sites", "seem", "to", "be", "absent", ",", "although", "there", "are", "alternative", "potential", "NF-kappaB", "and", "octamer-binding", "elements", "in", "the", "chicken", "IL2", "promoter", ",", "in", "close", "proximity", "to", "their", "mammalian", "homologues", "." ]
[ 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8896
[ "Sequence", "comparisons", "also", "predict", "other", "potential", "transcription", "factor", "binding", "sites", "as", "yet", "undescribed", "in", "mammalian", "IL2", "promoters", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
8897
[ "A", "Taq", "I", "polymorphism", "was", "identified", "which", "enabled", "chicken", "IL2", "to", "be", "mapped", "to", "chromosome", "4", ",", "linked", "to", "ANX5", ",", "with", "synteny", "with", "mouse", "chromosome", "3", "and", "human", "chromosome", "4", "." ]
[ 0, 9, 10, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 1, 2, 0, 0, 0, 1, 0, 0, 0, 0, 1, 2, 2, 0, 1, 2, 2, 0 ]
8898
[ "This", "is", "the", "first", "non-mammalian", "cytokine", "gene", "to", "be", "mapped", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8899
[ "Endothelial", "production", "of", "MCP-1", ":", "modulation", "by", "heparin", "and", "consequences", "for", "mononuclear", "cell", "activation", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0 ]
8900
[ "Heparin", "is", "a", "polyanionic", "glycosaminoglycan", "(", "GAG", ")", "that", "can", "bind", "with", "high", "affinity", "to", "a", "range", "of", "cytokines", "including", "interferon-gamma", "(", "IFN-gamma", ")", "and", "members", "of", "the", "chemokine", "superfamily", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]