Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
8701
[ "Surprisingly", ",", "overexpression", "of", "GRbeta", "in", "Jurkat", "cells", "did", "not", "cause", "significant", "inhibition", "of", "GRalpha", "-induced", "transactivation", "of", "a", "GRE-dependent", "luciferase", "reporter", "gene", "either", "." ]
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8702
[ "We", "conclude", "that", "the", "transrepressive", "effect", "of", "glucocorticoids", "on", "IL-2", "gene", "transcription", "is", "exclusively", "mediated", "by", "GRalpha", "." ]
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8703
[ "GRbeta", "can", "neither", "antagonize", "GRalpha", "-mediated", "transactivation", "nor", "transrepression", "in", "Jurkat", "cells", ",", "indicating", "a", "cell", "type-specific", "pattern", "of", "GRbeta", "-mediated", "antiglucocorticoid", "activity", "." ]
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8704
[ "Extinction", "of", "immunoglobulin", "gene", "expression", "in", "B", "cells", "upon", "fusion", "with", "HeLa", "cells", "is", "preceded", "by", "rapid", "nuclear", "depletion", "of", "essential", "transcription", "factors", "and", "is", "accompanied", "by", "widespread", "inactivation", "of", "genes", "expressed", "in", "a", "B", "cell-specific", "manner", "." ]
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8705
[ "When", "immunoglobulin", "(", "Ig", ")", "expressing", "B", "cells", "are", "fused", "with", "non-B", "cells", ",", "Ig", "expression", "is", "rapidly", "suppressed", "at", "the", "level", "of", "transcription", ",", "a", "phenomenon", "termed", "extinction", "." ]
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8706
[ "Here", "we", "demonstrate", "that", "fusion", "of", "HeLa", "cells", "with", "either", "diploid", "or", "tetraploid", "B", "cells", "(", "Daudi", ")", "results", "in", "widespread", "extinction", "of", "several", "other", "B", "cell-encoded", "genes", "that", "are", "expressed", "in", "a", "B", "cell-specific", "manner", "." ]
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8707
[ "In", "contrast", ",", "expression", "of", "B", "cell-expressed", "genes", "that", "are", "not", "dependent", "on", "cell-specific", "controls", "is", "unaffected", "." ]
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8708
[ "We", "show", "that", "the", "molecular", "mechanism", "(", "s", ")", "underlying", "Ig", "gene", "extinction", "can", "be", "explained", ",", "at", "least", "in", "part", ",", "by", "a", "lack", "of", "transcription", "factors", "that", "are", "essential", "for", "Ig", "gene", "transcription", "." ]
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8709
[ "These", "transcription", "factors", "are", "either", "not", "produced", "due", "to", "block", "of", "transcription", "of", "their", "respective", "genes", "(", "Oct-2", ",", "OBF-1", ",", "PU.1", ")", ",", "or", "are", "rendered", "inactive", "posttranslationally", "(", "NF-kappa", "B", ",", "E47", ")", "." ]
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8710
[ "By", "isolating", "Daudi", "x", "HeLa", "heterokaryons", "a", "few", "hours", "after", "fusion", ",", "we", "have", "studied", "the", "initial", "fate", "of", "two", "B", "cell-specific", "transcription", "factors", "involved", "in", "Ig", "gene", "transcription", ",", "Oct-2", "and", "NF-kappa", "B", "." ]
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8711
[ "This", "report", "provides", "the", "first", "demonstration", "that", "upon", "fusion", "with", "HeLa", "cells", ",", "the", "nuclear", "contents", "of", "B", "cell-expressed", "transcription", "factors", "are", "depleted", "within", "a", "few", "hours", "with", "kinetics", "that", "are", "as", "fast", "or", "faster", "than", "that", "of", "Ig", "gene", "extinction", "." ]
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8712
[ "Thus", ",", "the", "extinguishing", "mechanism", "is", "effective", "very", "early", "after", "fusion", "." ]
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8713
[ "We", "suggest", "that", "extinction", "of", "Ig", "genes", "is", "part", "of", "a", "global", "mechanism", "that", "suppresses", "the", "differentiation", "program", "foreign", "to", "the", "HeLa", "phenotype", "." ]
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8714
[ "Evidence", "for", "suppressed", "activity", "of", "the", "transcription", "factor", "NFAT1", "at", "its", "proximal", "binding", "element", "P0", "in", "the", "IL-4", "promoter", "associated", "with", "enhanced", "IL-4", "gene", "transcription", "in", "T", "cells", "of", "atopic", "patients", "." ]
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8715
[ "Allergen-specific", "T", "cells", "in", "atopic", "patients", "are", "polarized", "IL-4-producing", "Th2", "cells", ",", "promoting", "IgE", "synthesis", "by", "B", "cells", "." ]
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8716
[ "The", "molecular", "basis", "for", "increased", "IL-4", "gene", "expression", "in", "atopy", "is", "not", "fully", "understood", "." ]
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8717
[ "IL-4", "gene", "regulation", "in", "general", "involves", "the", "nuclear", "factor", "of", "activated", "T", "cells", "(", "NFAT", ")", "family", "of", "transcription", "factors", ",", "of", "which", "NFAT1", "and", "NFAT2", "are", "most", "prominent", "in", "peripheral", "T", "cells", "." ]
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8718
[ "Recently", ",", "a", "unique", "inhibitory", "role", "of", "NFAT1", "in", "IL-4", "gene", "control", "was", "shown", "in", "the", "mouse", "." ]
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8719
[ "In", "a", "series", "of", "electrophoretic", "mobility", "shift", "assays", "with", "protein", "extracts", "of", "highly", "polarized", "Th2", "clones", "from", "atopics", "and", "Th1", "clones", "from", "controls", "we", "compared", "DNA-binding", "activities", "at", "the", "two", "NFAT-binding", "elements", "P0", "and", "P1", "of", "the", "crucial", "proximal", "human", "IL-4", "promoter", "." ]
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8720
[ "At", "the", "most", "proximal", "P0", "site", ",", "NFAT-containing", "complexes", "devoid", "of", "NFAT2", "were", "readily", "inducible", "in", "the", "Th1", "clones", ",", "but", "hardly", "or", "not", "in", "the", "Th2", "clones", "." ]
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8721
[ "In", "contrast", ",", "both", "in", "Th1", "and", "Th2", "clones", "NFAT-containing", "complexes", "were", "strongly", "inducible", "at", "the", "P1", "site", ",", "consisting", "of", "NFAT2", "and", "a", "P0", "-compatible", "NFAT", "activity", ",", "without", "apparent", "differences", "between", "Th1", "and", "Th2", "clones", "." ]
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8722
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8723
[ "These", "findings", "suggest", "that", "high-level", "IL-4", "production", "in", "atopic", "Th2", "cells", "is", "associated", "with", "selective", "reduction", "of", "suppressive", "NFAT1", "activity", "at", "the", "IL-4", "P0", "element", "and", "that", "some", "patients", "with", "this", "multifactorial", "disease", "may", "have", "a", "putative", "systemic", "disorder", "at", "this", "level", "." ]
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8724
[ "Differential", "expression", "and", "phosphorylation", "of", "CTCF", ",", "a", "c-myc", "transcriptional", "regulator", ",", "during", "differentiation", "of", "human", "myeloid", "cells", "." ]
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8725
[ "CTCF", "is", "a", "transcriptional", "repressor", "of", "the", "c-myc", "gene", "." ]
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8726
[ "Although", "CTCF", "has", "been", "characterized", "in", "some", "detail", ",", "there", "is", "very", "little", "information", "about", "the", "regulation", "of", "CTCF", "activity", "." ]
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8727
[ "Therefore", "we", "investigated", "CTCF", "expression", "and", "phosphorylation", "during", "induced", "differentiation", "of", "human", "myeloid", "leukemia", "cells", "." ]
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8728
[ "We", "found", "that", ":", "(", "i", ")", "both", "CTCF", "mRNA", "and", "protein", "are", "down-regulated", "during", "terminal", "differentiation", "in", "most", "cell", "lines", "tested", ";", "(", "ii", ")", "CTCF", "down-regulation", "is", "retarded", "and", "less", "pronounced", "than", "that", "of", "c-myc", ";", "(", "iii", ")", "CTCF", "protein", "is", "differentially", "phosphorylated", "and", "the", "phosphorylation", "profiles", "depend", "on", "the", "differentiation", "pathway", "." ]
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8729
[ "We", "concluded", "that", "CTCF", "expression", "and", "activity", "is", "controlled", "at", "transcriptional", "and", "post-transcriptional", "levels", "." ]
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8730
[ "Glucocorticoid", "resistance", "in", "the", "squirrel", "monkey", "is", "associated", "with", "overexpression", "of", "the", "immunophilin", "FKBP51", "." ]
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8731
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8732
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8733
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8734
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8735
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8736
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8737
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8738
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8739
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8740
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8741
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8742
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8743
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8744
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8745
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8746
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8747
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8748
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[ "Copyright", "1999", "Academic", "Press", "." ]
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