Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
8601
[ "These", "data", "suggest", "that", "the", "B29", "gene", "is", "a", "genetic", "target", "for", "EBF", "in", "early", "B-cell", "development", "." ]
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8602
[ "Delta-opioid", "receptors", "expressed", "by", "Jurkat", "T", "cells", "enhance", "IL-2", "secretion", "by", "increasing", "AP-1", "complexes", "and", "activity", "of", "the", "NF-AT/AP-1-binding", "promoter", "element", "." ]
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8603
[ "Recent", "molecular", "evidence", "points", "to", "transient", "and/or", "stage-specific", "expression", "of", "delta-", "and", "kappa-opioid", "receptors", "by", "thymic", "and", "peripheral", "T", "lymphocytes", "." ]
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8604
[ "Since", "medical", "treatments", "or", "stress", "commonly", "increase", "opioid", "levels", ",", "it", "is", "important", "to", "understand", "the", "mechanisms", "by", "which", "opioids", "affect", "T", "lymphocyte", "functions", "." ]
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8605
[ "We", "therefore", "created", "and", "studied", "a", "T", "cell", "line", "expressing", "the", "cloned", "delta-opioid", "receptor", "(", "DOR1", ")", "." ]
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8606
[ "DOR1", "ligation", "by", "a", "specific", "DOR1", "agonist", ",", "deltorphin", ",", "augmented", "IL-2", "secretion", "by", "synergizing", "with", "signals", "from", "TCR-CD3", "and", "CD28", "." ]
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8607
[ "Reporter", "gene", "constructs", "were", "used", "to", "map", "this", "effect", "of", "deltorphin", "to", "the", "AP-1-", "and", "NF-AT/AP-1-binding", "sites", "of", "the", "IL-2", "promoter", "." ]
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8608
[ "Although", "DOR1", "signaling", "increased", "[", "Ca2+", "]", "i", ",", "deltorphin", "enhanced", "transcriptional", "activity", "of", "the", "NF-AT/AP-1-binding", "site", "via", "a", "mechanism", "independent", "of", "calcineurin", "and", "distinct", "from", "the", "effects", "of", "elevated", "[", "Ca2+", "]", "i", "." ]
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8609
[ "Deltorphin", "also", "increased", "accumulation", "of", "AP-1", "transcription", "factor", "complexes", ",", "suggesting", "that", "DOR1", "augments", "IL-2", "secretion", "by", "increasing", "the", "AP-1", "component", "of", "the", "NF-AT/AP-1", "transcription", "factor", "." ]
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8610
[ "These", "results", "advance", "the", "molecular", "understanding", "of", "opioid", "effects", "on", "lymphocytes", ",", "and", "in", "addition", ",", "demonstrate", "regulation", "of", "IL-2", "synthesis", "and", "secretion", "by", "the", "novel", "mechanism", "of", "receptor-mediated", "AP-1", "induction", "." ]
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8611
[ "Induction", "of", "interleukin-12", "p40", "transcript", "by", "CD40", "ligation", "via", "activation", "of", "nuclear", "factor-kappaB", "." ]
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8612
[ "Interleukin-12", "is", "produced", "in", "response", "to", "infection", "with", "bacteria", "or", "parasites", "or", "to", "bacterial", "constituents", "such", "as", "LPS", "in", "monocytes/macrophages", "and", "dendritic", "cells", ",", "and", "also", "generated", "by", "the", "interaction", "between", "activated", "T", "cells", "and", "antigen-presenting", "cells", "via", "CD40-CD40", "ligand", "(", "CD40L", ")", "." ]
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8613
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8614
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8615
[ "These", "cells", ",", "stimulated", "by", "an", "agonistic", "monoclonal", "antibody", "against", "CD40", "or", "by", "transfection", "with", "a", "CD40L", "expression", "vector", ",", "secreted", "p40", "and", "showed", "enhanced", "p40", "mRNA", "expression", "." ]
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8616
[ "Sequence", "analysis", "of", "the", "p40", "promoter", "region", "identified", "two", "potential", "nuclear", "factor", "(", "NF", ")", "-kappaB", "binding", "sites", "conserved", "between", "mouse", "and", "human", "." ]
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8617
[ "Electrophoretic", "mobility", "shift", "assay", "revealed", "that", "the", "potential", "NF-kappaB", "binding", "sequence", "which", "is", "located", "around", "120", "bp", "upstream", "of", "the", "transcription", "initiation", "site", "in", "murine", "and", "human", "p40", "genes", "formed", "an", "NF-kappaB", "complex", "with", "nuclear", "extract", "from", "Daudi", "cells", "stimulated", "by", "CD40", "ligation", "." ]
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8618
[ "Moreover", ",", "transfection", "of", "Daudi", "cells", "with", "the", "polymerized", "NF-kappaB", "binding", "sequence", "ligated", "to", "a", "thymidine", "kinase/chloramphenicol", "acetyltransferase", "(", "CAT", ")", "reporter", "plasmid", "greatly", "induced", "CAT", "activity", ",", "but", "transfection", "with", "the", "polymerized", "mutated", "NF-kappaB", "binding", "sequence", "did", "not", "." ]
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8619
[ "These", "results", "suggest", "that", "the", "NF-kappaB", "binding", "site", "located", "around", "120", "bp", "upstream", "of", "the", "transcription", "initiation", "site", "in", "murine", "and", "human", "p40", "promoter", "regions", "could", "be", "important", "for", "the", "p40", "induction", "by", "CD40", "ligation", "via", "activation", "of", "NF-kappaB", "." ]
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8620
[ "High", "frequency", "of", "germ-line", "BRCA2", "mutations", "among", "Hungarian", "male", "breast", "cancer", "patients", "without", "family", "history", "." ]
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8621
[ "To", "determine", "the", "contribution", "of", "BRCA1", "and", "BRCA2", "mutations", "to", "the", "pathogenesis", "of", "male", "breast", "cancer", "in", "Hungary", ",", "the", "country", "with", "the", "highest", "male", "breast", "cancer", "mortality", "rates", "in", "continental", "Europe", ",", "a", "series", "of", "18", "male", "breast", "cancer", "patients", "and", "three", "patients", "with", "gynecomastia", "was", "analyzed", "for", "germ-line", "mutations", "in", "both", "BRCA1", "and", "BRCA2", "." ]
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8622
[ "Although", "no", "germ-line", "BRCA1", "mutation", "was", "observed", ",", "6", "of", "the", "18", "male", "breast", "cancer", "cases", "(", "33", "%", ")", "carried", "truncating", "mutations", "in", "the", "BRCA2", "gene", "." ]
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8623
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8624
[ "Four", "of", "six", "truncating", "mutations", "were", "novel", ",", "and", "two", "mutations", "were", "recurrent", "." ]
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8625
[ "Four", "patients", "(", "22", "%", ")", "had", "a", "family", "history", "of", "breast/ovarian", "cancer", "in", "at", "least", "one", "first-", "or", "second-degree", "relative", ";", "however", ",", "no", "BRCA2", "mutation", "was", "identified", "among", "them", "." ]
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8626
[ "No", "mutation", "was", "identified", "in", "either", "of", "the", "genes", "in", "the", "gynecomastias", "." ]
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8627
[ "These", "results", "provide", "evidence", "for", "a", "strong", "genetic", "component", "of", "male", "breast", "cancer", "in", "Hungary", "." ]
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8628
[ "T-cell", "expression", "of", "the", "human", "GATA-3", "gene", "is", "regulated", "by", "a", "non-lineage-specific", "silencer", "." ]
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8629
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8630
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8631
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8632
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8633
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8634
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8635
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8636
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8637
[ "Reactive", "oxygen", "intermediate-dependent", "NF-kappaB", "activation", "by", "interleukin-1beta", "requires", "5-lipoxygenase", "or", "NADPH", "oxidase", "activity", "." ]
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8638
[ "We", "previously", "reported", "that", "the", "role", "of", "reactive", "oxygen", "intermediates", "(", "ROIs", ")", "in", "NF-kappaB", "activation", "by", "proinflammatory", "cytokines", "was", "cell", "specific", "." ]
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8639
[ "However", ",", "the", "sources", "for", "ROIs", "in", "various", "cell", "types", "are", "yet", "to", "be", "determined", "and", "might", "include", "5-lipoxygenase", "(", "5-LOX", ")", "and", "NADPH", "oxidase", "." ]
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8640
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8641
[ "Stimulation", "of", "lymphoid", "cells", "with", "interleukin-1beta", "(", "IL-1beta", ")", "led", "to", "ROI", "production", "and", "NF-kappaB", "activation", ",", "which", "could", "both", "be", "blocked", "by", "antioxidants", "or", "FLAP", "inhibitors", ",", "confirming", "that", "5-LOX", "was", "the", "source", "of", "ROIs", "and", "was", "required", "for", "NF-kappaB", "activation", "in", "these", "cells", "." ]
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8642
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8643
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8644
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8645
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8646
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8647
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8648
[ "Two", "variants", "of", "the", "IL-4R", "alpha-chain", "(", "IL-4Ralpha", ")", "gene", "have", "been", "recently", "identified", "in", "association", "with", "different", "atopic", "disorders", "." ]
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8649
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8650
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8651
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8652
[ "CD23", "expression", "and", "IgE", "synthesis", "by", "IL-4", "were", "augmented", "in", "Ile50-bearing", "PBMC", ",", "compared", "with", "those", "bearing", "Val50", "." ]
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