Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
8001
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8002
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8003
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8004
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8005
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8006
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8007
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8008
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8009
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8010
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8011
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8012
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8013
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8014
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8015
[ "Differential", "regulation", "of", "4E-BP1", "and", "4E-BP2", ",", "two", "repressors", "of", "translation", "initiation", ",", "during", "human", "myeloid", "cell", "differentiation", "." ]
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8016
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8017
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8018
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8019
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8020
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8021
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8022
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8023
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8024
[ "Nonimmunoglobulin", "gene", "hypermutation", "in", "germinal", "center", "B", "cells", "." ]
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8025
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8026
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8027
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8028
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8029
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8030
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8031
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8032
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8033
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8034
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8035
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8036
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8037
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8038
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8039
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8040
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8041
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8042
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8043
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8044
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8045
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8046
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8047
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8048
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8049
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8050
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8051
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8054
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8055
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8056
[ "Thus", ",", "this", "therapeutic", "potency", "may", "reside", "in", "retention", "of", "inactive", "nuclear", "factor-kappaB", "in", "the", "cytosol", "thereby", "abrogating", "interleukin-1beta", "gene", "transcription", "." ]
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8057
[ "Cellular", "disposition", "of", "sulphamethoxazole", "and", "its", "metabolites", ":", "implications", "for", "hypersensitivity", "." ]
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8058
[ "1.", "Bioactivation", "of", "sulphamethoxazole", "(", "SMX", ")", "to", "chemically-reactive", "metabolites", "and", "subsequent", "protein", "conjugation", "is", "thought", "to", "be", "involved", "in", "SMX", "hypersensitivity", "." ]
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8059
[ "We", "have", "therefore", "examined", "the", "cellular", "metabolism", ",", "disposition", "and", "conjugation", "of", "SMX", "and", "its", "metabolites", "in", "vitro", "." ]
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8060
[ "2.", "Flow", "cytometry", "revealed", "binding", "of", "N-hydroxy", "(", "SMX-NHOH", ")", "and", "nitroso", "(", "SMX-NO", ")", "metabolites", "of", "SMX", ",", "but", "not", "of", "SMX", "itself", ",", "to", "the", "surface", "of", "viable", "white", "blood", "cells", "." ]
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8061
[ "Cellular", "haptenation", "by", "SMX-NO", "was", "reduced", "by", "exogenous", "glutathione", "(", "GSH", ")", "." ]
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8062
[ "3.", "SMX-NHOH", "and", "SMX-NO", "were", "rapidly", "reduced", "back", "to", "the", "parent", "compound", "by", "cysteine", "(", "CYS", ")", ",", "GSH", ",", "human", "peripheral", "blood", "cells", "and", "plasma", ",", "suggesting", "that", "this", "is", "an", "important", "and", "ubiquitous", "bioinactivation", "mechanism", "." ]
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8063
[ "4.", "Fluorescence", "HPLC", "showed", "that", "SMX-NHOH", "and", "SMX-NO", "depleted", "CYS", "and", "GSH", "in", "buffer", ",", "and", "to", "a", "lesser", "extent", ",", "in", "cells", "and", "plasma", "." ]
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8064
[ "5.", "Neutrophil", "apoptosis", "and", "inhibition", "of", "neutrophil", "function", "were", "induced", "at", "lower", "concentrations", "of", "SMX-NHOH", "and", "SMX-NO", "than", "those", "inducing", "loss", "of", "membrane", "viability", ",", "with", "SMX", "having", "no", "effect", "." ]
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8065
[ "Lymphocytes", "were", "significantly", "(", "P", "<", "0.05", ")", "more", "sensitive", "to", "the", "direct", "cytotoxic", "effects", "of", "SMX-NO", "than", "neutrophils", "." ]
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8066
[ "6.", "Partitioning", "of", "SMX-NHOH", "into", "red", "blood", "cells", "was", "significantly", "(", "P", "<", "0.05", ")", "lower", "than", "with", "the", "hydroxylamine", "of", "dapsone", "." ]
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8067
[ "7.", "Our", "results", "suggest", "that", "the", "balance", "between", "oxidation", "of", "SMX", "to", "its", "toxic", "metabolites", "and", "their", "reduction", "is", "an", "important", "protective", "cellular", "mechanism", "." ]
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8068
[ "If", "an", "imbalance", "exists", ",", "haptenation", "of", "the", "toxic", "metabolites", "to", "bodily", "proteins", "including", "the", "surface", "of", "viable", "cells", "can", "occur", ",", "and", "may", "result", "in", "drug", "hypersensitivity", "." ]
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8069
[ "Bcl-6", "expression", "in", "reactive", "follicular", "hyperplasia", ",", "follicular", "lymphoma", ",", "and", "angioimmunoblastic", "T-cell", "lymphoma", "with", "hyperplastic", "germinal", "centers", ":", "heterogeneity", "of", "intrafollicular", "T-cells", "and", "their", "altered", "distribution", "in", "the", "pathogenesis", "of", "angioimmunoblastic", "T-cell", "lymphoma", "." ]
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8070
[ "BACKGROUND", ":", "The", "Bcl-6", "gene", "product", ",", "a", "nuclear", "phosphoprotein", ",", "is", "expressed", "independently", "of", "Bcl-6", "gene", "rearrangement", "." ]
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8071
[ "In", "lymph", "nodes", ",", "expression", "of", "Bcl-6", "protein", "is", "restricted", "to", "germinal", "center", "(", "GC", ")", "B-cells", "and", "10", "%", "to", "15", "%", "of", "CD3/CD4+", "intrafollicular", "T", "cells", "." ]
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8072
[ "Interfollicular", "cells", "are", "negative", "for", "Bcl-6", "protein", ",", "except", "for", "rare", "CD3+/CD4+", "T", "cells", "." ]
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8073
[ "Recently", ",", "we", "reported", "cases", "of", "angioimmunoblastic", "T-cell", "lymphoma", "(", "AITL", ")", "with", "hyperplastic", "GCs", "(", "AITL/GC", ")", ",", "and", "observed", "that", "borders", "of", "enlarged", "GCs", "were", "ill", "defined", ",", "with", "features", "suggestive", "of", "an", "outward", "migration", "of", "GC", "cells", "to", "surrounding", "interfollicular", "zones", "." ]
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8074
[ "This", "prompted", "a", "study", "of", "follicular", "borders", "with", "Bcl-6", "staining", "in", "reactive", "follicular", "hyperplasias", "and", "follicular", "lymphomas", "to", "compare", "with", "AITL/GC", "." ]
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8075
[ "MATERIALS", "AND", "METHODS", ":", "Formalin-fixed", "paraffin", "sections", "were", "used", "for", "immunostaining", "of", "Bcl-6", "." ]
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8076
[ "Six", "cases", "of", "AITL/GC", ",", "12", "nonspecific", "reactive", "follicular", "hyperplasia", "(", "FH", ")", ",", "7", "HIV", "adenopathy", ",", "10", "follicular", "lymphoma", "(", "FL", ")", ",", "and", "8", "typical", "AITL", "(", "ie", ",", "AITL", "without", "GC", ")", "were", "studied", "." ]
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8077
[ "Double", "staining", "for", "Bcl-6/CD20", ",", "Bcl-6/CD3", ",", "and", "Bcl-6/CD57", "was", "performed", "in", "selected", "cases", "." ]
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8078
[ "RESULTS", ":", "In", "FH", "and", "HIV", "adenopathy", ",", "staining", "for", "Bcl-6", "revealed", "densely", "populated", "GCs", "with", "well-defined", "and", "regular", "GC", "borders", ",", "whereas", "Bcl-6+", "cells", "were", "rare", "in", "the", "interfollicular", "areas", "." ]
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8079
[ "An", "occasional", "GC", "with", "an", "ill-defined", "border", "was", "invariably", "surrounded", "by", "a", "broad", "mantle", "zone", ";", "those", "with", "indistinct", "mantle", "zones", "had", "well-defined", ",", "regular", "borders", "." ]
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8080
[ "In", "FL", ",", "follicles", "were", "densely", "populated", ",", "and", "their", "borders", "were", "irregular", ",", "with", "some", "Bcl-6+", "cells", "in", "the", "interfollicular", "zones", "." ]
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8081
[ "In", "AITL/GC", ",", "GCs", "were", "less", "dense", ",", "GC", "borders", "were", "ill", "defined", "and", "irregular", ",", "and", "the", "number", "of", "interfollicular", "Bcl-6+", "cells", "was", "markedly", "increased", "." ]
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8082
[ "Double", "staining", "revealed", "that", "these", "interfollicular", "Bcl-6+", "cells", "in", "AITL/GC", "were", "Bcl6+/CD3+/CD20-/CD57-", "T", "cells", "." ]
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8083
[ "Moreover", ",", "CD3+", "intrafollicular", "T", "cells", "were", "depleted", "in", "AITL/GC", ",", "whereas", "they", "were", "abundant", "in", "FH", "." ]
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8084
[ "Intrafollicular", "CD57+", "cells", "did", "not", "stain", "for", "Bcl-6", ",", "and", "were", "also", "depleted", "in", "AITL/GC", "." ]
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8085
[ "In", "typical", "AITL", ",", "some", "neoplastic", "cells", "were", "positive", "for", "Bcl-6", ",", "showing", "variable", "degrees", "of", "staining", "." ]
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8086
[ "CONCLUSIONS", ":", "(", "1", ")", "GCs", "of", "AITL/GC", "differed", "from", "those", "of", "other", "reactive", "follicular", "hyperplasias", "and", "follicular", "lymphomas", ",", "and", "staining", "for", "Bcl-6", "was", "useful", "to", "discern", "them", "." ]
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8087
[ "(", "2", ")", "Intrafollicular", "CD3+", "T", "cells", ",", "many", "of", "which", "were", "also", "positive", "for", "Bcl-6", ",", "were", "markedly", "depleted", "in", "AITL/GC", ",", "with", "increased", "interfollicular", "Bcl-6+/CD3+", "cells", ",", "suggesting", "an", "outward", "migration", "of", "intrafollicular", "T", "cells", "in", "this", "condition", "." ]
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8088
[ "(", "3", ")", "Interfollicular", "Bcl-6+/CD3+", "cells", "in", "AITL/GC", "were", "too", "numerous", "to", "be", "accounted", "for", "by", "migration", "alone", ",", "suggesting", "local", "proliferation", "." ]
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8089
[ "(", "4", ")", "Intrafollicular", "CD57+", "cells", "were", "negative", "for", "Bcl-6", ",", "indicating", "heterogeneity", "of", "the", "intrafollicular", "T-cell", "population", "." ]
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8090
[ "(", "5", ")", "Some", "neoplastic", "cells", "in", "AITL", "stained", "for", "Bcl-6", ",", "suggesting", "up-regulation", "of", "Bcl-6", "expression", "in", "this", "tumor", "." ]
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8091
[ "Human", "cytomegalovirus", "binding", "to", "human", "monocytes", "induces", "immunoregulatory", "gene", "expression", "." ]
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8092
[ "To", "continue", "our", "investigation", "of", "the", "cellular", "events", "that", "occur", "following", "human", "CMV", "(", "HCMV", ")", "infection", ",", "we", "focused", "on", "the", "regulation", "of", "cellular", "activation", "following", "viral", "binding", "to", "human", "monocytes", "." ]
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8093
[ "First", ",", "we", "showed", "that", "viral", "binding", "induced", "a", "number", "of", "immunoregulatory", "genes", "(", "IL-1beta", ",", "A20", ",", "NF-kappaB-p105/p50", ",", "and", "IkappaBalpha", ")", "in", "unactivated", "monocytes", "and", "that", "neutralizing", "Abs", "to", "the", "major", "HCMV", "glycoproteins", ",", "gB", "(", "UL55", ")", "and", "gH", "(", "UL75", ")", ",", "inhibited", "the", "induction", "of", "these", "genes", "." ]
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8094
[ "Next", ",", "we", "demonstrated", "that", "these", "viral", "ligands", "directly", "up-regulated", "monocyte", "gene", "expression", "upon", "their", "binding", "to", "their", "appropriate", "cellular", "receptors", "." ]
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8095
[ "We", "then", "investigated", "if", "HCMV", "binding", "also", "resulted", "in", "the", "translation", "and", "secretion", "of", "cytokines", "." ]
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8096
[ "Our", "results", "showed", "that", "HCMV", "binding", "to", "monocytes", "resulted", "in", "the", "production", "and", "release", "of", "IL-1beta", "protein", "." ]
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8097
[ "Because", "these", "induced", "gene", "products", "have", "NF-kappaB", "sites", "in", "their", "promoter", "regions", ",", "we", "next", "examined", "whether", "there", "was", "an", "up-regulation", "of", "nuclear", "NF-kappaB", "levels", "." ]
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8098
[ "These", "experiments", "showed", "that", ",", "in", "fact", ",", "NF-kappaB", "was", "translocated", "to", "the", "nucleus", "following", "viral", "binding", "or", "purified", "viral", "ligand", "binding", "." ]
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8099
[ "Changes", "in", "IkappaBalpha", "levels", "correlated", "with", "the", "changes", "in", "NF-kappaB", "translocation", "." ]
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8100
[ "Lastly", ",", "we", "demonstrated", "that", "p38", "kinase", "activity", "played", "a", "central", "role", "in", "IL-1beta", "production", "and", "that", "it", "was", "rapidly", "up-regulated", "following", "infection", "." ]
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