Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
7901
[ "EBNA2", "-dependent", "transcriptional", "induction", "of", "the", "IFN-beta", "promoter", "occurred", "in", "EBV-negative", "Burkitt", "'s", "lymphoma", "cells", ",", "indicating", "that", "other", "EBV", "genes", "were", "not", "required", "for", "the", "induction", "of", "IFN-beta", "synthesis", "." ]
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7902
[ "PGG-glucan", ",", "a", "soluble", "beta-", "(", "1", ",", "3", ")", "-glucan", ",", "enhances", "the", "oxidative", "burst", "response", ",", "microbicidal", "activity", ",", "and", "activates", "an", "NF-kappa", "B-like", "factor", "in", "human", "PMN", ":", "evidence", "for", "a", "glycosphingolipid", "beta-", "(", "1", ",", "3", ")", "-glucan", "receptor", "." ]
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7903
[ "PGG-Glucan", ",", "a", "soluble", "beta-", "(", "1", ",", "6", ")", "-branched", "beta-", "(", "1", ",", "3", ")", "-linked", "glucose", "homopolymer", "derived", "from", "the", "cell", "wall", "of", "the", "yeast", "Saccharomyces", "cerevisiae", ",", "is", "an", "immunomodulator", "which", "enhances", "leukocyte", "anti-infective", "activity", "and", "enhances", "myeloid", "and", "megakaryocyte", "progenitor", "proliferation", "." ]
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7904
[ "Incubation", "of", "human", "whole", "blood", "with", "PGG-Glucan", "significantly", "enhanced", "the", "oxidative", "burst", "response", "of", "subsequently", "isolated", "blood", "leukocytes", "to", "both", "soluble", "and", "particulate", "activators", "in", "a", "dose-dependent", "manner", ",", "and", "increased", "leukocyte", "microbicidal", "activity", "." ]
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7905
[ "No", "evidence", "for", "inflammatory", "cytokine", "production", "was", "obtained", "under", "these", "conditions", "." ]
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7906
[ "Electrophoretic", "mobility", "shift", "assays", "demonstrated", "that", "PGG-Glucan", "induced", "the", "activation", "of", "an", "NF-kappaB-like", "nuclear", "transcription", "factor", "in", "purified", "human", "neutrophils", "." ]
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7907
[ "The", "binding", "of", "3H-PGG-Glucan", "to", "human", "leukocyte", "membranes", "was", "specific", ",", "concentration-dependent", ",", "saturable", ",", "and", "high", "affinity", "(", "Kd", "approximately", "6", "nM", ")", "." ]
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7908
[ "A", "monoclonal", "antibody", "specific", "to", "the", "glycosphingolipid", "lactosylceramide", "was", "able", "to", "inhibit", "activation", "of", "the", "NF-kappaB-like", "factor", "by", "PGG-Glucan", ",", "and", "ligand", "binding", "data", ",", "including", "polysaccharide", "specificity", ",", "suggested", "that", "the", "PGG-Glucan", "binding", "moiety", "was", "lactosylceramide", "." ]
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7909
[ "These", "results", "indicate", "that", "PGG-Glucan", "enhances", "neutrophil", "anti-microbial", "functions", "and", "that", "interaction", "between", "this", "beta-glucan", "and", "human", "neutrophils", "is", "mediated", "by", "the", "glycosphingolipid", "lactosylceramide", "present", "at", "the", "cell", "surface", "." ]
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7910
[ "Glucocorticoids", "promote", "nonphlogistic", "phagocytosis", "of", "apoptotic", "leukocytes", "." ]
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7911
[ "Phagocyte", "recognition", ",", "uptake", ",", "and", "nonphlogistic", "degradation", "of", "neutrophils", "and", "other", "leukocytes", "undergoing", "apoptosis", "promote", "the", "resolution", "of", "inflammation", "." ]
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7912
[ "This", "study", "assessed", "the", "effects", "of", "anti-inflammatory", "glucocorticoids", "on", "this", "leukocyte", "clearance", "mechanism", "." ]
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7913
[ "Pretreatment", "of", "``", "semimature", "''", "5-day", "human", "monocyte-derived", "macrophages", "(", "M", "phi", ")", "for", "24", "h", "with", "methylprednisolone", ",", "dexamethasone", ",", "and", "hydrocortisone", ",", "but", "not", "the", "nonglucocorticoid", "steroids", "aldosterone", ",", "estradiol", ",", "and", "progesterone", ",", "potentiated", "phagocytosis", "of", "apoptotic", "neutrophils", "." ]
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7914
[ "These", "effects", "were", "specific", "in", "that", "the", "potentiated", "phagocytosis", "of", "apoptotic", "neutrophils", "was", "completely", "blocked", "by", "the", "glucocorticoid", "receptor", "antagonist", "RU38486", ",", "and", "glucocorticoids", "did", "not", "promote", "5-day", "M", "phi", "ingestion", "of", "opsonized", "erythrocytes", "." ]
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7915
[ "Similar", "glucocorticoid-mediated", "potentiation", "was", "observed", "with", "5-day", "M", "phi", "uptake", "of", "alternative", "apoptotic", "``", "targets", "''", "(", "eosinophils", "and", "Jurkat", "T", "cells", ")", "and", "in", "uptake", "of", "apoptotic", "neutrophils", "by", "alternative", "phagocytes", "(", "human", "glomerular", "mesangial", "cells", "and", "murine", "M", "phi", "elicited", "into", "the", "peritoneum", "or", "derived", "from", "bone", "marrow", ")", "." ]
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7916
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7917
[ "Furthermore", ",", "longer-term", "potentiation", "by", "methylprednisolone", "was", "observed", "in", "maturing", "human", "monocyte-derived", "M", "phi", ",", "with", "greater", "increases", "in", "5-day", "M", "phi", "uptake", "of", "apoptotic", "cells", "being", "observed", "the", "earlier", "glucocorticoids", "were", "added", "during", "monocyte", "maturation", "into", "M", "phi", "." ]
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7918
[ "We", "conclude", "that", "potentiation", "of", "nonphlogistic", "clearance", "of", "apoptotic", "leukocytes", "by", "phagocytes", "is", "a", "hitherto", "unrecognized", "property", "of", "glucocorticoids", "that", "has", "potential", "implications", "for", "therapies", "aimed", "at", "promoting", "the", "resolution", "of", "inflammatory", "diseases", "." ]
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7919
[ "1", ",", "25-Dihydroxyvitamin", "D3", "induces", "differentiation", "of", "a", "retinoic", "acid-resistant", "acute", "promyelocytic", "leukemia", "cell", "line", "(", "UF-1", ")", "associated", "with", "expression", "of", "p21", "(", "WAF1/CIP1", ")", "and", "p27", "(", "KIP1", ")", "." ]
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7920
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7921
[ "However", ",", "the", "mechanisms", "and", "strategies", "to", "overcome", "RA", "resistance", "by", "APL", "cells", "are", "still", "unclear", "." ]
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7922
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7923
[ "RXRs", "heterodimerize", "with", "1", ",", "25-dihydroxyvitamin", "D3", "[", "1", ",", "25", "(", "OH", ")", "2D3", "]", "receptor", "(", "VDR", ")", ",", "enabling", "their", "efficient", "transcriptional", "activation", "." ]
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7924
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7925
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7926
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7927
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7928
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7929
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7930
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7931
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7932
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7933
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7934
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7935
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7936
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7937
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7938
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7939
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7940
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7941
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7942
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7943
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7945
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7946
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7947
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7948
[ "This", "study", "demonstrates", "that", "changes", "in", "endothelial", "cell", "GSSG/GSH", "cause", "transcription-independent", "and", "transcription-dependent", "surface", "expression", "of", "different", "endothelial", "cell", "adhesion", "molecules", ",", "which", "leads", "to", "a", "2-phase", "neutrophil", "-endothelial", "adhesion", "response", "." ]
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7949
[ "Glucocorticoid", "hormone", "suppression", "of", "human", "neutrophil", "-mediated", "tumor", "cell", "cytostasis", "." ]
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7950
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7951
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7952
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7953
[ "Dex", "was", "found", "to", "inhibit", "these", "neutrophil", "properties", ",", "and", "RU38486", "completely", "suppressed", "both", "forms", "of", "Dex", "inhibition", "." ]
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7954
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7955
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7956
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7957
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7958
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7959
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7960
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7962
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7963
[ "Leukocyte", "populations", ",", "hormone", "receptors", "and", "apoptosis", "in", "eutopic", "and", "ectopic", "first", "trimester", "human", "pregnancies", "." ]
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7964
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7965
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7966
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7967
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7968
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7969
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7970
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7971
[ "The", "ratio", "of", "BCL2+", "to", "CD3+", "cells", "in", "ectopic", "pregnancy", "was", "0.41", "." ]
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7972
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7973
[ "Tissues", "from", "both", "ectopic", "and", "uterine", "pregnancies", "were", "positive", "for", "PR", "." ]
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7974
[ "Fewer", "apoptotic", "cell", "bodies", "were", "present", "in", "ectopic", "pregnancy", "." ]
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7975
[ "The", "use", "of", "tissue", "obtained", "from", "ectopic", "pregnancy", "may", "become", "an", "excellent", "model", "to", "identify", "the", "mechanism", "of", "trophoblast", "invasion", "in", "eutopic", "pregnancies", "." ]
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7976
[ "Angiotensin", "II", "activates", "the", "proinflammatory", "transcription", "factor", "nuclear", "factor-kappaB", "in", "human", "monocytes", "." ]
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7977
[ "The", "renin", "-angiotensin", "system", "may", "contribute", "to", "the", "pathogenesis", "of", "atherosclerosis", "." ]
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7978
[ "A", "common", "feature", "of", "all", "stages", "of", "atherosclerosis", "is", "inflammation", "of", "the", "vessel", "wall", "." ]
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7979
[ "The", "transcription", "factor", "nuclear", "factor-kappaB", "(", "NF-kappaB", ")", "participates", "in", "most", "signaling", "pathways", "involved", "in", "inflammation", "." ]
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7980
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7981
[ "ANG", "II", ",", "like", "TNFalpha", ",", "caused", "rapid", "activation", "of", "NF-kappaB", "in", "human", "mononuclear", "cells", "isolated", "from", "peripheral", "blood", "by", "Ficoll", "density", "gradient", "." ]
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7982
[ "This", "ANG", "II", "effect", "was", "blocked", "by", "the", "angiotensin", "AT1", "receptor", "antagonist", "losartan", "." ]
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7983
[ "Specificity", "of", "ANG", "II", "-induced", "NF-kappaB", "activation", "was", "ascertained", "by", "supershift", "and", "competition", "experiments", "." ]
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7984
[ "Moreover", ",", "ANG", "II", "stimulated", "NF-kappaB", "activation", "in", "human", "monocytes", ",", "but", "not", "in", "lymphocytes", "from", "the", "same", "preparation", "." ]
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7985
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7986
[ "Copyright", "1999", "Academic", "Press", "." ]
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7987
[ "Signal", "transduction", "pathways", "activated", "in", "endothelial", "cells", "following", "infection", "with", "Chlamydia", "pneumoniae", "." ]
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7988
[ "Chlamydia", "pneumoniae", "is", "an", "important", "respiratory", "pathogen", "." ]
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7989
[ "Recently", ",", "its", "presence", "has", "been", "demonstrated", "in", "atherosclerotic", "lesions", "." ]
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7990
[ "In", "this", "study", ",", "we", "characterized", "C.", "pneumoniae-mediated", "activation", "of", "endothelial", "cells", "and", "demonstrated", "an", "enhanced", "expression", "of", "endothelial", "adhesion", "molecules", "followed", "by", "subsequent", "rolling", ",", "adhesion", ",", "and", "transmigration", "of", "leukocytes", "(", "monocytes", ",", "granulocytes", ")", "." ]
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7991
[ "These", "effects", "were", "blocked", "by", "mAbs", "against", "endothelial", "and/or", "leukocyte", "adhesion", "molecules", "(", "beta1", "and", "beta2", "integrins", ")", "." ]
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7992
[ "Additionally", ",", "activation", "of", "different", "signal", "transduction", "pathways", "in", "C.", "pneumoniae-infected", "endothelial", "cells", "was", "shown", ":", "protein", "tyrosine", "phosphorylation", ",", "up-regulation", "of", "phosphorylated", "p42/p44", "mitogen-activated", "protein", "kinase", ",", "and", "NF-kappaB", "activation/translocation", "occurred", "within", "10-15", "min", "." ]
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7993
[ "Increased", "mRNA", "and", "surface", "expression", "of", "E-selectin", ",", "ICAM-1", ",", "and", "VCAM-1", "were", "noted", "within", "hours", "." ]
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7994
[ "Thus", ",", "C.", "pneumoniae", "triggers", "a", "cascade", "of", "events", "that", "could", "lead", "to", "endothelial", "activation", ",", "inflammation", ",", "and", "thrombosis", ",", "which", "in", "turn", "may", "result", "in", "or", "may", "promote", "atherosclerosis", "." ]
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7995
[ "Transient", "pseudo-hypoaldosteronism", "following", "resection", "of", "the", "ileum", ":", "normal", "level", "of", "lymphocytic", "aldosterone", "receptors", "outside", "the", "acute", "phase", "." ]
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7996
[ "Pseudo-hypoaldosteronism", "(", "PHA", ")", "is", "due", "to", "mineralocorticoid", "resistance", "and", "manifests", "as", "hyponatremia", "and", "hyperkalemia", "with", "increased", "plasma", "aldosterone", "levels", "." ]
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7997
[ "It", "may", "be", "familial", "or", "secondary", "to", "abnormal", "renal", "sodium", "handling", "." ]
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7998
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7999
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8000
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