Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
7801
[ "In", "addition", ",", "a", "somewhat", "divergent", "region", "of", "STP-C488", "is", "critical", "for", "TRAF", "association", "." ]
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7802
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7803
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7804
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7805
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7806
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7807
[ "Cleavage", "of", "transcription", "factor", "SP1", "by", "caspases", "during", "anti-IgM-induced", "B-cell", "apoptosis", "." ]
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7808
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7809
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7810
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7811
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7812
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7813
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7814
[ "Recombinant", "caspase", "6", "(", "Mch", "2", ")", "primarily", "generates", "a", "68-kDa", "cleavage", "product", ",", "as", "observed", "after", "calcium", "ionophore", "(", "CaI", ")", "induced", "B-cell", "apoptosis", "." ]
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7815
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7816
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7817
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7818
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7819
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7820
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7821
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7822
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7823
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7824
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7825
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7826
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7827
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7828
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7829
[ "Human", "immunodeficiency", "virus-associated", "Hodgkin", "'s", "disease", "derives", "from", "post-germinal", "center", "B", "cells", "." ]
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7830
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7831
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7832
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7833
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7834
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7835
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7836
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7837
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7838
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7839
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7840
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7841
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7842
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7843
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7844
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7845
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7846
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7847
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7848
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7849
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7850
[ "We", "propose", "that", "mutations", "of", "MDS1/EVI1", "either", "by", "gene", "truncation", "resulting", "in", "the", "transcription", "repressor", "EVI1", "or", "by", "gene", "fusion", "to", "AML1", "lead", "to", "an", "altered", "cellular", "response", "to", "growth", "and", "differentiation", "factors", "that", "could", "result", "in", "leukemic", "transformation", "." ]
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7851
[ "The", "different", "response", "of", "myeloid", "cells", "ectopically", "expressing", "the", "normal", "or", "the", "fusion", "protein", "to", "G-CSF", "and", "TGF-beta1", "could", "depend", "on", "the", "different", "transactivation", "properties", "of", "these", "proteins", "resulting", "in", "divergent", "expression", "of", "downstream", "genes", "regulated", "by", "the", "two", "proteins", "." ]
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7852
[ "Abnormalities", "of", "cyclic", "adenosine", "monophosphate", "signaling", "in", "platelets", "from", "untreated", "patients", "with", "bipolar", "disorder", "." ]
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7853
[ "BACKGROUND", ":", "Abnormalities", "in", "the", "cyclic", "adenosine", "monophosphate", "(", "cAMP", ")", "-dependent", "phosphorylation", "system", "have", "been", "recently", "reported", "in", "patients", "with", "bipolar", "disorder", "." ]
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7854
[ "We", "evaluated", "the", "immunoreactivity", "of", "the", "regulatory", "and", "catalytic", "subunits", "of", "cAMP-dependent", "protein", "kinase", "(", "protein", "kinase", "A", ")", "and", "1", "of", "its", "substrates", ",", "Rap1", ",", "in", "platelets", "from", "untreated", "euthymic", ",", "manic", ",", "and", "depressed", "patients", "with", "bipolar", "disorder", "and", "healthy", "subjects", "." ]
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7855
[ "METHODS", ":", "Platelets", "were", "collected", "from", "112", "drug-free", "patients", "with", "bipolar", "disorder", "(", "52", "euthymic", ",", "29", "depressed", ",", "and", "31", "manic", ")", "and", "62", "healthy", "subjects", "." ]
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7856
[ "The", "levels", "of", "cAMP-dependent", "protein", "kinase", "and", "Rap1", "were", "assessed", "by", "Western", "blot", "analysis", ",", "immunostaining", ",", "and", "computer-assisted", "imaging", "." ]
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7857
[ "RESULTS", ":", "The", "immunolabeling", "of", "the", "catalytic", "subunit", "of", "cAMP-dependent", "protein", "kinase", "was", "significantly", "different", "among", "groups", "(", "P", "<", ".001", ")", ",", "with", "higher", "values", "in", "untreated", "depressed", "and", "manic", "patients", "with", "bipolar", "disorder", "compared", "with", "untreated", "euthymic", "patients", "with", "bipolar", "disorder", "and", "healthy", "subjects", "." ]
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7858
[ "No", "significant", "differences", "were", "found", "in", "the", "immunolabeling", "of", "the", "regulatory", "subunits", "(", "type", "I", "and", "type", "II", ")", "of", "cAMP-dependent", "protein", "kinase", "." ]
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7859
[ "The", "immunolabeling", "of", "Rap1", "was", "significantly", "higher", "(", "P", "<", ".001", ")", "in", "untreated", "euthymic", ",", "depressed", ",", "and", "manic", "patients", "than", "in", "healthy", "persons", "." ]
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7860
[ "CONCLUSIONS", ":", "Levels", "of", "Rap1", "and", "the", "catalytic", "subunit", "of", "cAMP-dependent", "protein", "kinase", "are", "altered", "in", "the", "platelets", "of", "bipolar", "patients", "." ]
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7861
[ "These", "findings", "may", "provide", "clues", "toward", "understanding", "the", "involvement", "of", "cAMP", "signaling", "in", "the", "pathogenesis", "of", "bipolar", "disorder", "." ]
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7862
[ "Molecular", "regulation", "of", "cytokine", "gene", "expression", "during", "the", "immune", "response", "." ]
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7863
[ "Cytokine", "expression", "by", "immune", "system", "cells", "plays", "an", "important", "role", "in", "the", "regulation", "of", "the", "immune", "response", "." ]
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7864
[ "On", "first", "encounter", "with", "antigen", ",", "naive", "CD4+", "T", "helper", "(", "Th", ")", "cells", "differentiate", "into", "cytokine-producing", "effector", "cells", "." ]
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7865
[ "Two", "types", "of", "effector", "cells", "characterized", "by", "their", "distinct", "expression", "of", "cytokine", "profiles", "have", "been", "described", "." ]
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7866
[ "Th1", "cells", "produce", "IL-2", "and", "IFN-gamma", ",", "whereas", "Th2", "cells", "produce", "IL-4", ",", "IL-5", ",", "IL-6", ",", "IL-10", ",", "and", "IL-13", "." ]
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7867
[ "In", "many", "pathological", "situations", ",", "the", "balance", "between", "Th1", "and", "Th2", "immune", "responses", "determines", "the", "outcome", "of", "diverse", "immunologically", "mediated", "clinical", "syndromes", "including", "infectious", ",", "autoimmune", ",", "and", "allergic", "diseases", "." ]
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7868
[ "However", ",", "the", "molecular", "basis", "for", "the", "tissue-specific", "expression", "of", "Th1/Th2-like", "cytokines", "has", "remained", "elusive", "." ]
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7869
[ "In", "this", "review", "we", "evaluate", "the", "possible", "in", "vivo", "role", "of", "different", "transcription", "factors", "and", "transcriptional", "mechanisms", "in", "T", "cell", "differentiation", "and", "the", "immune", "response", "." ]
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7870
[ "Tcf-1", "-mediated", "transcription", "in", "T", "lymphocytes", ":", "differential", "role", "for", "glycogen", "synthase", "kinase-3", "in", "fibroblasts", "and", "T", "cells", "." ]
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7871
[ "Beta-catenin", "is", "the", "vertebrate", "homolog", "of", "the", "Drosophila", "segment", "polarity", "gene", "Armadillo", "and", "plays", "roles", "in", "both", "cell-cell", "adhesion", "and", "transduction", "of", "the", "Wnt", "signaling", "cascade", "." ]
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7872
[ "Recently", ",", "members", "of", "the", "Lef/Tcf", "transcription", "factor", "family", "have", "been", "identified", "as", "protein", "partners", "of", "beta-catenin", ",", "explaining", "how", "beta-catenin", "alters", "gene", "expression", "." ]
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7873
[ "Here", "we", "report", "that", "in", "T", "cells", ",", "Tcf-1", "also", "becomes", "transcriptionally", "active", "through", "interaction", "with", "beta-catenin", ",", "suggesting", "that", "the", "Wnt", "signal", "transduction", "pathway", "is", "operational", "in", "T", "lymphocytes", "as", "well", "." ]
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7874
[ "However", ",", "although", "Wnt", "signals", "are", "known", "to", "inhibit", "the", "activity", "of", "the", "negative", "regulatory", "protein", "kinase", "glycogen", "synthase", "kinase-3beta", "(", "GSK-3beta", ")", ",", "resulting", "in", "increased", "levels", "of", "beta-catenin", ",", "we", "find", "no", "evidence", "for", "involvement", "of", "GSK-3beta", "in", "Tcf-mediated", "transcription", "in", "T", "cells", "." ]
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7875
[ "That", "is", ",", "a", "dominant", "negative", "GSK-3beta", "does", "not", "specifically", "activate", "Tcf", "transcription", "and", "stimuli", "(", "lithium", "or", "phytohemagglutinin", ")", "that", "inhibit", "GSK-3beta", "activity", "also", "do", "not", "activate", "Tcf", "reporter", "genes", "." ]
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7876
[ "Thus", ",", "inhibition", "of", "GSK-3beta", "is", "insufficient", "to", "activate", "Tcf-dependent", "transcription", "in", "T", "lymphocytes", "." ]
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7877
[ "In", "contrast", ",", "in", "C57MG", "fibroblast", "cells", ",", "lithium", "inactivates", "GSK-3beta", "and", "induces", "Tcf-controlled", "transcription", "." ]
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7878
[ "This", "is", "the", "first", "demonstration", "that", "lithium", "can", "alter", "gene", "expression", "of", "Tcf-responsive", "genes", ",", "and", "points", "to", "a", "difference", "in", "regulation", "of", "Wnt", "signaling", "between", "fibroblasts", "and", "lymphocytes", "." ]
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7879
[ "SHP2-interacting", "transmembrane", "adaptor", "protein", "(", "SIT", ")", ",", "a", "novel", "disulfide-linked", "dimer", "regulating", "human", "T", "cell", "activation", "." ]
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7880
[ "T", "lymphocytes", "express", "several", "low", "molecular", "weight", "transmembrane", "adaptor", "proteins", "that", "recruit", "src", "homology", "(", "SH", ")", "2", "domain-containing", "intracellular", "molecules", "to", "the", "cell", "membrane", "via", "tyrosine-based", "signaling", "motifs", "." ]
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7881
[ "We", "describe", "here", "a", "novel", "molecule", "of", "this", "group", "termed", "SIT", "(", "SHP2", "interacting", "transmembrane", "adaptor", "protein", ")", "." ]
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7882
[ "SIT", "is", "a", "disulfide-linked", "homodimeric", "glycoprotein", "that", "is", "expressed", "in", "lymphocytes", "." ]
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7883
[ "After", "tyrosine", "phosphorylation", "by", "src", "and", "possibly", "syk", "protein", "tyrosine", "kinases", "SIT", "recruits", "the", "SH2", "domain-containing", "tyrosine", "phosphatase", "SHP2", "via", "an", "immunoreceptor", "tyrosine-based", "inhibition", "motif", "." ]
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7884
[ "Overexpression", "of", "SIT", "in", "Jurkat", "cells", "downmodulates", "T", "cell", "receptor-", "and", "phytohemagglutinin-mediated", "activation", "of", "the", "nuclear", "factor", "of", "activated", "T", "cells", "(", "NF-AT", ")", "by", "interfering", "with", "signaling", "processes", "that", "are", "probably", "located", "upstream", "of", "activation", "of", "phospholipase", "C", "." ]
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7885
[ "However", ",", "binding", "of", "SHP2", "to", "SIT", "is", "not", "required", "for", "inhibition", "of", "NF-AT", "induction", ",", "suggesting", "that", "SIT", "not", "only", "regulates", "NF-AT", "activity", "but", "also", "controls", "NF-AT", "unrelated", "pathways", "of", "T", "cell", "activation", "involving", "SHP2", "." ]
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7886
[ "Extracellular-regulated", "kinase", "1/2", ",", "Jun", "N-terminal", "kinase", ",", "and", "c-Jun", "are", "involved", "in", "NF-kappa", "B", "-dependent", "IL-6", "expression", "in", "human", "monocytes", "." ]
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7887
[ "In", "the", "present", "study", "we", "investigated", "the", "possible", "involvement", "of", "the", "mitogen-activated", "protein", "kinase", "family", "members", "extracellular-regulated", "kinase", "1/2", "(", "ERK1/2", ")", "and", "c-", "Jun", "N-terminal", "kinase", "(", "JNK", ")", "in", "mediating", "IL-6", "gene", "expression", "in", "human", "monocytes", ",", "in", "particular", "their", "role", "in", "enhancing", "NF-kappa", "B", "activity", "." ]
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7888
[ "Freshly", "isolated", "monocytes", "treated", "with", "the", "protein", "phosphatase", "inhibitor", "okadaic", "acid", "secreted", "high", "levels", "of", "IL-6", "protein", ",", "which", "coincided", "with", "enhanced", "binding", "activity", "of", "NF-kappa", "B", "as", "well", "as", "with", "phosphorylation", "and", "activation", "of", "the", "ERK1/2", "and", "JNK", "proteins", "." ]
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7889
[ "The", "ERK", "pathway-specific", "inhibitor", "PD98059", "inhibited", "IL-6", "secretion", "from", "monocytes", "." ]
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7890
[ "Transient", "overexpression", "of", "inactive", "mutants", "of", "either", "Raf-1", "or", "JNK1", "showed", "that", "both", "pathways", "were", "involved", "in", "kappa", "B-dependent", "IL-6", "promoter", "activity", "." ]
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7891
[ "By", "using", "PD98059", ",", "we", "demonstrated", "that", "the", "Raf1/MEK1/", "ERK1/2", "pathway", "did", "not", "affect", "the", "DNA", "binding", "of", "NF-kappa", "B", "but", ",", "rather", ",", "acted", "at", "the", "level", "of", "transcriptional", "activity", "of", "NF-kappa", "B", "." ]
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7892
[ "Interestingly", ",", "it", "was", "shown", "that", "NF-kappa", "B", "-mediated", "gene", "transcription", ",", "both", "in", "the", "context", "of", "the", "IL-6", "promoter", "as", "well", "as", "on", "its", "own", ",", "was", "dependent", "on", "both", "serine", "kinase", "activity", "and", "interaction", "with", "c-Jun", "protein", "." ]
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7893
[ "We", "conclude", "that", "okadaic", "acid-induced", "IL-6", "gene", "expression", "is", "at", "least", "partly", "mediated", "through", "the", "ERK1/2", "and", "JNK", "pathway-dependent", "activation", "of", "NF-kappa", "B", "transcriptional", "capacity", "." ]
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7894
[ "Our", "results", "suggest", "that", "the", "JNK", "pathway", "may", "regulate", "NF-kappa", "B", "-mediated", "gene", "transcription", "through", "its", "phosphorylation", "and", "activation", "of", "c-Jun", "." ]
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7895
[ "The", "Epstein-Barr", "virus", "nuclear", "antigen", "2", "(", "EBNA2", ")", ",", "a", "protein", "required", "for", "B", "lymphocyte", "immortalization", ",", "induces", "the", "synthesis", "of", "type", "I", "interferon", "in", "Burkitt", "'s", "lymphoma", "cell", "lines", "." ]
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7896
[ "Epstein-Barr", "virus", "nuclear", "antigen", "2", "(", "EBNA2", ")", ",", "a", "protein", "involved", "in", "cell", "transformation", ",", "interferes", "with", "the", "cellular", "response", "to", "type", "I", "interferons", "(", "IFN-alpha/beta", ")", "." ]
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7897
[ "We", "investigated", "the", "function", "of", "conditionally", "expressed", "EBNA2", "in", "the", "context", "of", "the", "IFN", "response", "in", "Burkitt", "'s", "lymphoma", "cell", "lines", "." ]
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7898
[ "Expression", "of", "EBNA2", "led", "to", "the", "transcriptional", "activation", "of", "both", "endogenous", "or", "transfected", "IFN-stimulated", "genes", "(", "ISGs", ")", ",", "genes", "which", "contain", "within", "their", "promoters", "either", "the", "interferon-stimulated", "response", "element", "(", "ISRE", ")", "or", "the", "gamma", "interferon", "activation", "site", "(", "GAS", ")", "." ]
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7899
[ "In", "search", "of", "a", "molecular", "mechanism", "for", "the", "transcriptional", "induction", "of", "ISGs", ",", "we", "observed", "an", "EBNA2", "-dependent", "synthesis", "of", "IFN-beta", "mRNA", "at", "low", "levels", "and", "the", "secretion", "of", "low", "amounts", "of", "IFN", "." ]
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7900
[ "A", "transfected", "IFN-beta", "promoter", "responded", "to", "EBNA2", "activation", ",", "and", "a", "sequence", "closely", "resembling", "a", "RBP-Jkappa", "binding", "site", "was", "pinpointed", "as", "a", "potential", "target", "of", "EBNA2", "activity", "." ]
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