Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
7601
[ "These", "observations", "correlated", "with", "the", "modulation", "of", "NF-kappaB", "activity", "in", "EC", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 0 ]
7602
[ "All", "agents", "tested", "induced", "expression", "of", "Hsp60", "6", "hr", "after", "application", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
7603
[ "In", "addition", ",", "aspirin", "and", "indomethacin", ",", "but", "not", "CyA", ",", "induced", "Hsp70", "expression", "in", "HUVECs", "that", "correlated", "with", "induction", "of", "HSF-1", "activity", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 0, 0, 0, 0, 0, 9, 0, 0 ]
7604
[ "CONCLUSION", ":", "Our", "results", "show", "that", "the", "tested", "agents", "(", "except", "indomethacin", ")", "are", "inhibitors", "of", "the", "T", "cell-mediated", "immune", "response", ",", "as", "expected", ",", "that", "aspirin", "is", "an", "effective", "suppressor", "of", "adhesion", "molecule", "expression", ",", "and", "that", "all", "three", "agents", "can", "induce", "Hsp60", "in", "HUVECs", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 0 ]
7605
[ "These", "data", "provide", "the", "molecular", "basis", "for", "the", "notion", "that", "(", "1", ")", "part", "of", "the", "anti-atherogenic", "effect", "of", "aspirin", "may", "be", "due", "to", "the", "prevention", "of", "the", "adhesion", "of", "sensitized", "T", "cells", "to", "stressed", "EC", ";", "(", "2", ")", "that", "part", "of", "the", "atherosclerosis-promoting", "effect", "of", "CyA", "may", "be", "due", "to", "its", "potential", "as", "an", "inducer", "of", "Hsp60", "expression", "and", "its", "inability", "to", "down-regulate", "adhesion", "molecule", "expression", "on", "EC", ";", "and", "(", "3", ")", "that", "down-regulation", "of", "MCP-1", "expression", "by", "aspirin", "may", "result", "in", "decreased", "recruitment", "of", "monocytes", "into", "the", "arterial", "intima", "beneath", "stressed", "EC", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 7, 0 ]
7606
[ "In", "vivo", "modulation", "of", "glucocorticoid", "receptor", "mRNA", "by", "inhaled", "fluticasone", "propionate", "in", "bronchial", "mucosa", "and", "blood", "lymphocytes", "in", "subjects", "with", "mild", "asthma", "." ]
[ 0, 0, 0, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0 ]
7607
[ "BACKGROUND", ":", "In", "vivo", "regulation", "of", "the", "glucocorticoid", "receptor", "(", "GR", ")", "by", "glucocorticoids", "provides", "a", "means", "of", "modulating", "sensitivity", "of", "targeted", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7608
[ "OBJECTIVE", ":", "We", "sought", "to", "determine", "the", "in", "vivo", "modulation", "of", "GR", "mRNA", "expression", "by", "fluticasone", "propionate", "(", "FP", ")", "in", "subjects", "with", "mild", "asthma", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7609
[ "METHODS", ":", "Ten", "atopic", "asthmatic", "subjects", "were", "treated", "with", "FP", "250", "microg", "twice", "daily", "for", "4", "weeks", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7610
[ "Before", "and", "after", "treatment", ",", "the", "patients", "underwent", "fiberoptic", "bronchoscopy", "with", "endobronchial", "biopsy", "and", "sampling", "of", "venous", "blood", "for", "measurements", "of", "GR", "mRNA", "levels", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0 ]
7611
[ "A", "solution", "hybridization", "assay", "was", "used", "for", "quantitative", "analysis", "of", "GR", "mRNA", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0 ]
7612
[ "In", "addition", ",", "a", "24-hour", "urinary", "cortisol", "excretion", "and", "an", "adrenocorticotropic", "hormone", "test", "before", "and", "after", "treatment", "with", "FP", "were", "performed", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7613
[ "RESULTS", ":", "A", "high", "interindividual", "variation", "in", "GR", "mRNA", "expression", "was", "seen", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0 ]
7614
[ "However", ",", "we", "detected", "a", "significant", "reduction", "of", "the", "GR", "mRNA", "levels", "in", "the", "endobronchial", "biopsy", "specimens", "after", "FP", "treatment", "(", "36.6", "+/-", "23.1", "and", "25.0", "+/-", "10.9", "amol", "GR", "mRNA", "/microg", "RNA", ",", "respectively", ";", "P", "<", ".01", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7615
[ "In", "the", "peripheral", "blood", "lymphocytes", "an", "even", "more", "striking", "downregulation", "of", "the", "GR", "by", "its", "cognate", "ligand", "was", "documented", "(", "30.3", "+/-", "26.5", "and", "8.8", "+/-", "5", "amol", "GR", "mRNA", "/microg", "RNA", ",", "respectively", ";", "P", "<", ".001", ")", ",", "possibly", "reflecting", "differences", "in", "glucocorticoid", "sensitivity", "between", "tissues", "." ]
[ 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7616
[ "A", "small", "but", "significant", "reduction", "of", "the", "24-hour", "urinary", "cortisol", "excretion", "was", "observed", "(", "233", "+/-", "109", "and", "157", "+/-", "66", "nmol/L", ",", "respectively", ";", "P", "<", ".01", ")", ",", "whereas", "the", "feedback", "regulation", "of", "glucocorticoid", "synthesis", "by", "means", "of", "the", "hypothalamic-pituitary-adrenal", "axis", "as", "assessed", "by", "the", "adrenocorticotropic", "hormone", "test", "remained", "normal", "after", "treatment", "with", "FP", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7617
[ "CONCLUSION", ":", "The", "results", "in", "this", "study", "confirm", "the", "potency", "of", "the", "inhaled", "corticosteroid", "FP", "and", "provide", "evidence", "for", "a", "considerable", "tissue-specific", "interindividual", "variation", "in", "the", "expression", "of", "the", "GR", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
7618
[ "[", "Corticoids", "and", "allergy", "]" ]
[ 0, 0, 0, 0, 0 ]
7619
[ "Inflammation", "is", "constantly", "observed", "in", "allergic", "reactions", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0 ]
7620
[ "Corticosteroids", "are", "most", "effective", "in", "preventing", "the", "late", "phase", "of", "allergic", "reaction", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7621
[ "The", "action", "of", "glucocorticosteroids", "is", "mediated", "through", "glucocorticoid", "receptors", "present", "in", "the", "cellular", "cytoplasm", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0 ]
7622
[ "When", "activated", ",", "glucocorticoid", "receptors", "form", "a", "dimer", "and", "bind", "to", "DNA", "after", "migration", "into", "the", "nucleus", "." ]
[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7623
[ "Interaction", "to", "DNA", "induces", "changes", "in", "the", "transcription", "rate", ",", "leading", "to", "either", "gene", "induction", "or", "gene", "repression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7624
[ "Glucocorticoid", "receptors", "are", "also", "able", "to", "interact", "with", "transcriptional", "factors", "such", "as", "AP-1", "(", "activator", "protein-1", ")", "of", "NF-kappa", "B", "(", "nuclear", "factor-kappa", "B", ")", "." ]
[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 9, 10, 0, 9, 10, 10, 0, 0 ]
7625
[ "Through", "these", "actions", "glucocorticosteroids", "are", "susceptible", "to", "modify", "functions", "of", "cells", "involved", "in", "the", "allergic", "inflammatory", "response", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7626
[ "They", "are", "in", "particular", "able", "to", "inhibit", "most", "of", "the", "pro-inflammatory", "functions", "of", "the", "eosinophils", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0 ]
7627
[ "Jeg-3", "human", "choriocarcinoma-induced", "immunosuppression", ":", "downregulation", "of", "interleukin-2", ",", "interleukin-2", "receptor", "alpha-chain", ",", "and", "its", "Jak/Stat", "signaling", "pathway", "." ]
[ 5, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0, 0, 0, 9, 0, 0, 0 ]
7628
[ "PROBLEM", ":", "The", "mechanisms", "of", "the", "immunosuppressive", "and", "immunosuppression-inducing", "capacities", "of", "Jeg-3", "human", "choriocarcinoma", "cell", "line", "supernatants", "(", "HCSs", ")", "are", "not", "yet", "completely", "understood", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7629
[ "The", "influence", "on", "interleukin", "(", "IL", ")", "-2", ",", "IL-4", "and", "interferon", "(", "IFN", ")", "-gamma", "production", ";", "IL-2", "receptor", "(", "IL-2R", ")", "alpha", "-", ",", "beta", "-", ",", "and", "gamma-chain", ";", "and", "the", "signaling", "pathway", "molecules", "Janus", "kinase", "(", "Jak", ")", "1", ",", "Jak3", ",", "signal", "transducers", "and", "activators", "of", "transcription", "(", "Stat", ")", "1", ",", "Stat3", ",", "and", "Stat5", "should", "be", "investigated", "." ]
[ 0, 0, 0, 9, 10, 10, 10, 10, 0, 9, 0, 9, 10, 10, 10, 10, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 9, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 9, 0, 0, 9, 0, 0, 0, 0 ]
7630
[ "METHOD", "OF", "STUDY", ":", "For", "assessment", "of", "IL", "production", ",", "whole", "peripheral", "venous", "blood", "from", "healthy", "donors", "was", "stimulated", "with", "phorbol-myristate-acetate", "and", "ionomycine", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7631
[ "Secretion", "of", "ILs", "was", "blocked", "with", "monensine", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0 ]
7632
[ "Intracellular", "ILs", "were", "analyzed", "by", "flow", "cytometry", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 0 ]
7633
[ "For", "IL-2R", "and", "signaling", "pathway", "molecule", "analysis", ",", "peripheral", "blood", "lymphocytes", "were", "stimulated", "with", "phytohemagglutinin", "(", "PHA", ")", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 9, 0, 9, 0, 0 ]
7634
[ "IL-2R", "chains", "were", "measured", "by", "flow", "cytometry", ",", "and", "Jaks/Stats", "by", "sodium", "dodecyl", "sulfate", "polyacrylamide", "gel", "electrophoresis", "(", "SDS-PAGE", ")", "and", "Western", "blot", "." ]
[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7635
[ "RESULTS", ":", "Phorbol-myristate-acetate", "and", "ionomycine", "strongly", "increase", "the", "percent-age", "of", "IL-2+", "cells", ";", "an", "additional", "50", "%", "HCSs", "significantly", "suppresses", "the", "percentage", "to", ",", "or", "below", "the", "level", "of", "unstimulated", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7636
[ "IFN-gamma", "production", "is", "strongly", "decreased", "by", "HCSs", "in", "some", "cases", ",", "but", "not", "in", "others", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7637
[ "PHA", "stimulates", "IL-2R", "alpha-", ",", "beta-", ",", "and", "gamma-chain", "expression", "and", "their", "signaling", "pathway", "molecules", "Jak1", ",", "Jak3", ",", "Stat1", ",", "Stat3", ",", "and", "Stat5", "." ]
[ 9, 0, 9, 10, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 9, 0, 0, 9, 0 ]
7638
[ "50", "%", "HCS", "downregulates", "the", "alpha-chain", "and", "slightly", "upregulates", "the", "beta-chain", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7639
[ "Jak1", ",", "Jak3", ",", "Stat1", ",", "Stat3", ",", "and", "Stat5", "expression", "is", "suppressed", "approximately", "to", ",", "or", "below", "the", "level", "of", "unstimulated", "cells", "." ]
[ 9, 0, 9, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7640
[ "CONCLUSIONS", ":", "HCS", "forcefully", "blocks", "the", "production", "of", "IL-2", ";", "the", "IL-2R", "alpha-chain", ";", "and", "Jak1", ",", "Jak3", ",", "Stat1", ",", "Stat3", ",", "and", "Stat5", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 0, 0, 9, 0, 9, 0, 9, 0, 9, 0, 0, 9, 0, 0 ]
7641
[ "The", "observed", "phenomena", "might", "be", "caused", "by", "downregulation", "of", "an", "IL-2R", "regulation", "gene", ",", "and", "might", "play", "a", "key", "role", "in", "the", "expansion", "of", "choriocarcinoma", ",", "and", "possibly", "in", "the", "survival", "of", "the", "fetal", "allograft", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7642
[ "Apoptosis-resistant", "T", "cells", "have", "a", "deficiency", "in", "NF-kappaB", "-mediated", "induction", "of", "Fas", "ligand", "transcription", "." ]
[ 0, 7, 8, 0, 0, 0, 0, 9, 0, 0, 0, 9, 10, 0, 0 ]
7643
[ "Apoptosis", "induced", "through", "the", "TCR", "in", "CD4+", "T", "cells", "is", "mostly", "mediated", "by", "the", "inducible", "expression", "of", "Fas", "ligand", "(", "FasL", ")", "as", "a", "primary", "event", "leading", "to", "the", "commitment", "to", "death", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7644
[ "To", "gain", "a", "better", "understanding", "of", "the", "transcriptional", "events", "that", "regulate", "this", "expression", ",", "we", "took", "advantage", "of", "our", "previously", "described", "mutant", "Jurkat", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]
7645
[ "These", "cells", "are", "deficient", "in", "FasL", "expression", "and", "apoptosis", "induced", "upon", "TCR", "triggering", ",", "although", "their", "cytokine", "(", "IL-2", "and", "IFN-gamma", ")", "production", "is", "normal", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0 ]
7646
[ "Here", "we", "show", "that", "both", "a", "FasL-", "and", "a", "consensus", "NF-kappaB-", "reporter", "construct", "are", "inefficiently", "induced", "in", "these", "cells", "compared", "to", "wild-type", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7647
[ "In", "addition", ",", "we", "demonstrate", "that", "the", "inducible", "transcriptional", "activity", "of", "the", "FasL", "reporter", "is", "abolished", "by", "specific", "inhibitors", "of", "NF-kappaB", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
7648
[ "Thus", ",", "we", "could", "trace", "the", "deficit", "of", "the", "mutant", "cells", "to", "an", "inefficient", "NF-kappaB", "activation", ",", "evidencing", "a", "relevant", "role", "for", "NF-kappaB", "in", "the", "regulation", "of", "FasL", "expression", "in", "activated", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 7, 8, 0 ]
7649
[ "Furthermore", ",", "our", "results", "suggest", "that", "the", "induction", "of", "FasL", "versus", "cytokine", "gene", "expression", "is", "differentially", "sensitive", "to", "NF-kappaB", "deprivation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
7650
[ "Decreased", "proteasome", "-mediated", "degradation", "in", "T", "cells", "from", "the", "elderly", ":", "A", "role", "in", "immune", "senescence", "." ]
[ 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7651
[ "Induction", "of", "NFkappaB", "is", "a", "highly", "regulated", "process", "requiring", "phosphorylation", ",", "ubiquitination", ",", "and", "proteasome", "-mediated", "degradation", "of", "the", "cytosolic", "inhibitor", "IkappaBalpha", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
7652
[ "Analyses", "of", "the", "regulation", "of", "IkappaBalpha", "in", "TNF-alpha-treated", "T", "lymphocytes", "from", "young", "and", "elderly", "donors", "revealed", "severely", "compromised", "degradation", "of", "IkappaBalpha", "in", "T", "cells", "from", "the", "elderly", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 8, 0, 0, 0, 0 ]
7653
[ "Examination", "of", "activation-induced", "phosphorylation", "and", "ubiquitination", "of", "IkappaBalpha", "did", "not", "demonstrate", "any", "significant", "age-related", "alterations", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
7654
[ "However", ",", "examination", "of", "proteasome", "activity", "in", "these", "T", "cells", "using", "fluorogenic", "peptide", "assays", "revealed", "a", "significant", "age-related", "decline", "in", "chymotryptic", "activity", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7655
[ "These", "results", "suggest", "that", "a", "decline", "in", "proteasome", "activity", "results", "in", "a", "failure", "to", "fully", "degrade", "IkappaBalpha", "in", "the", "elderly", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0 ]
7656
[ "This", "failure", "to", "degrade", "IkappaBalpha", "may", "underlie", "both", "the", "observed", "decrease", "in", "NFkappaB", "induction", "and", "the", "IL-2", "receptor", "expression", "in", "TNF-treated", "T", "cells", "during", "aging", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 10, 0, 0, 0, 7, 8, 0, 0, 0 ]
7657
[ "Thus", ",", "decreased", "proteasome", "-mediated", "degradation", "may", "be", "central", "to", "immune", "dysfunction", "that", "accompanies", "aging", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7658
[ "Copyright", "1999", "Academic", "Press", "." ]
[ 0, 0, 0, 0, 0 ]
7659
[ "Inhibition", "of", "IL-4", "-inducible", "gene", "expression", "in", "human", "monocytes", "by", "type", "I", "and", "type", "II", "interferons", "." ]
[ 0, 0, 1, 2, 2, 0, 0, 7, 8, 0, 9, 10, 0, 9, 10, 10, 0 ]
7660
[ "The", "Th2-type", "cytokines", ",", "interleukin-4", "(", "IL-4", ")", "and", "interleukin-13", "(", "IL-13", ")", ",", "induce", "expression", "of", "a", "distinct", "subset", "of", "genes", "in", "human", "monocytes", ",", "including", "FcepsilonRIIb", "(", "CD23", ")", ",", "15-lipoxygenase", ",", "IL-1", "receptor", "antagonist", "(", "IL-1ra", ")", ",", "and", "type", "I", "and", "type", "II", "IL-1", "receptors", "(", "IL-1R", ")", "." ]
[ 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 1, 0, 1, 0, 0, 1, 0, 0, 0, 0, 0, 1, 0, 0, 0, 1, 2, 0, 1, 2, 2, 2, 0, 1, 0, 0 ]
7661
[ "Type", "I", "interferons", "(", "IFN-alpha", "and", "IFN-beta", ")", "and", "type", "II", "interferon", "(", "IFN-gamma", ")", "inhibit", "induction", "of", "these", "genes", "by", "IL-4", "and", "IL-13", "." ]
[ 9, 10, 10, 0, 9, 0, 9, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0 ]
7662
[ "However", ",", "the", "mechanism", "by", "which", "IFNs", "mediate", "this", "inhibition", "has", "not", "been", "defined", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
7663
[ "In", "this", "overview", ",", "we", "discuss", "the", "role", "of", "the", "transcription", "factor", ",", "STAT6", "(", "signal", "transducer", "and", "activator", "of", "transcription-6", ")", "in", "mediating", "IL-4-", "and", "IL-13-induced", "gene", "expression", "in", "monocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 1, 0, 1, 2, 0, 0, 7, 0 ]
7664
[ "We", "also", "discuss", "our", "recent", "findings", "that", "type", "I", "and", "type", "II", "IFNs", "suppress", "IL-4", "/", "IL-13", "-inducible", "gene", "expression", "by", "inhibiting", "tyrosine", "phosphorylation", "and", "nuclear", "translocation", "of", "STAT6", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 10, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
7665
[ "The", "ability", "of", "type", "I", "and", "type", "II", "IFNs", "to", "inhibit", "IL-4", "/", "IL-13", "-induced", "STAT6", "activity", "is", "dose-", "and", "time-dependent", ",", "and", "is", "not", "unique", "to", "monocytes", "because", "IFNs", "induce", "the", "same", "effects", "in", "fibroblasts", "." ]
[ 0, 0, 0, 9, 10, 0, 9, 10, 10, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 9, 0, 0, 0, 0, 0, 7, 0 ]
7666
[ "Inhibition", "of", "STAT6", "activity", "is", "not", "evident", "unless", "cells", "are", "preincubated", "with", "IFN", "for", "at", "least", "1", "h", "before", "IL-4", "stimulation", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
7667
[ "Furthermore", ",", "inhibition", "can", "be", "blocked", "by", "actinomycin", "D", ",", "indicating", "a", "requirement", "for", "de", "novo", "transcription", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7668
[ "We", "propose", "a", "model", "in", "which", "stimulation", "of", "monocytes", "by", "IFN", "activates", "de", "novo", "synthesis", "of", "an", "inhibitory", "factor", ",", "possibly", "one", "or", "more", "members", "of", "the", "SOCS/", "SSI/CIS", "gene", "family", ",", "capable", "of", "suppressing", "activation", "of", "STAT6", "by", "IL-4", "and", "IL-13", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0 ]
7669
[ "Because", "STAT6", "activation", "plays", "an", "essential", "role", "in", "IL-4", "/", "IL-13", "-induced", "gene", "expression", ",", "the", "ability", "of", "IFN-beta", "and", "IFN-gamma", "to", "inhibit", "STAT6", "activity", "provides", "an", "explanation", "for", "how", "IFNs", "can", "suppress", "IL-4", "/", "IL-13", "-inducible", "gene", "expression", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 1, 2, 2, 2, 2, 0, 0 ]
7670
[ "HLA", "class", "I", "-mediated", "induction", "of", "cell", "proliferation", "involves", "cyclin", "E", "-mediated", "inactivation", "of", "Rb", "function", "and", "induction", "of", "E2F", "activity", "." ]
[ 9, 10, 10, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0 ]
7671
[ "Chronic", "rejection", "of", "transplanted", "organs", "is", "manifested", "as", "atherosclerosis", "of", "the", "blood", "vessels", "of", "the", "allograft", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7672
[ "HLA", "class", "I", "Ags", "have", "been", "implicated", "to", "play", "a", "major", "role", "in", "this", "process", ",", "since", "signaling", "via", "HLA", "class", "I", "molecules", "can", "induce", "the", "proliferation", "of", "aortic", "endothelial", "as", "well", "as", "smooth", "muscle", "cells", "." ]
[ 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
7673
[ "In", "this", "study", ",", "we", "show", "that", "HLA", "class", "I", "-mediated", "induction", "of", "cell", "proliferation", "correlates", "with", "inactivation", "of", "the", "Rb", "protein", "in", "the", "T", "cell", "line", "Jurkat", "as", "well", "as", "human", "aortic", "endothelial", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 5, 6, 6, 6, 0, 0, 0, 7, 8, 8, 8, 0 ]
7674
[ "HLA", "class", "I", "-mediated", "inactivation", "of", "Rb", "can", "be", "inhibited", "specifically", "by", "neutralizing", "Abs", "to", "basic", "fibroblast", "growth", "factor", "(", "bFGF", ")", ",", "suggesting", "a", "role", "for", "FGF", "receptors", "in", "the", "signaling", "process", "." ]
[ 9, 10, 10, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]
7675
[ "Signaling", "through", "HLA", "class", "I", "molecules", "induced", "cyclin", "E", "-associated", "kinase", "activity", "within", "4", "h", "in", "quiescent", "endothelial", "cells", ",", "and", "appeared", "to", "mediate", "the", "inactivation", "of", "Rb", "." ]
[ 0, 0, 9, 10, 10, 10, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
7676
[ "A", "cdk2", "inhibitor", ",", "Olomoucine", ",", "as", "well", "as", "a", "dominant-negative", "cdk2", "construct", "prevented", "HLA", "class", "I", "-mediated", "inactivation", "of", "Rb", ";", "in", "contrast", ",", "dominant-negative", "cdk4", "and", "cdk6", "constructs", "had", "no", "effect", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 9, 10, 10, 0, 0, 0, 9, 0, 0, 0, 0, 0, 1, 0, 1, 2, 0, 0, 0, 0 ]
7677
[ "Furthermore", ",", "there", "was", "no", "increase", "in", "cyclin", "D-associated", "kinase", "activity", "upon", "HLA", "class", "I", "ligation", ",", "suggesting", "that", "cyclin", "E-dependent", "kinase", "activity", "mediates", "Rb", "inactivation", ",", "leading", "to", "E2F", "activation", "and", "cell", "proliferation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 10, 10, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
7678
[ "Immunosuppressant", "PG490", "(", "triptolide", ")", "inhibits", "T-cell", "interleukin-2", "expression", "at", "the", "level", "of", "purine-box/nuclear", "factor", "of", "activated", "T-cells", "and", "NF-kappaB", "transcriptional", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 7, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 9, 0, 0, 0 ]
7679
[ "PG490", "(", "triptolide", ")", "is", "a", "diterpene", "triepoxide", "with", "potent", "immunosuppressive", "and", "antiinflammatory", "properties", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7680
[ "PG490", "inhibits", "interleukin", "(", "IL", ")", "-2", "expression", "by", "normal", "human", "peripheral", "blood", "lymphocytes", "stimulated", "with", "phorbol", "12-myristate", "13-acetate", "(", "PMA", ")", "and", "antibody", "to", "CD3", "(", "IC50", "of", "10", "ng/ml", ")", ",", "and", "with", "PMA", "and", "ionomycin", "(", "Iono", ",", "IC50", "of", "40", "ng/ml", ")", "." ]
[ 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7681
[ "In", "Jurkat", "T-cells", ",", "PG490", "inhibits", "PMA/Iono-stimulated", "IL-2", "transcription", "." ]
[ 0, 5, 6, 0, 0, 0, 0, 9, 0, 0 ]
7682
[ "PG490", "inhibits", "the", "induction", "of", "DNA", "binding", "activity", "at", "the", "purine-box/antigen", "receptor", "response", "element", "(", "ARRE", ")", "/nuclear", "factor", "of", "activated", "T-cells", "(", "NF-AT", ")", "target", "sequence", "but", "not", "at", "the", "NF-kappaB", "site", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 1, 2, 0 ]
7683
[ "PG490", "can", "completely", "inhibit", "transcriptional", "activation", "at", "the", "purine-box/ARRE/NF-AT", "and", "NF-kappaB", "target", "DNA", "sequences", "triggered", "by", "all", "stimuli", "examined", "(", "PMA", ",", "PMA/Iono", ",", "tumor", "necrosis", "factor-alpha", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0 ]
7684
[ "PG490", "also", "inhibits", "PMA-stimulated", "activation", "of", "a", "chimeric", "transcription", "factor", "in", "which", "the", "C-terminal", "TA1", "transactivation", "domain", "of", "NF-kappaB", "p65", "is", "fused", "to", "the", "DNA", "binding", "domain", "of", "GAL4", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
7685
[ "In", "16HBE", "human", "bronchial", "epithelial", "cells", ",", "IL-8", "expression", "is", "regulated", "predominantly", "by", "NF-kappaB", ",", "and", "PG490", "but", "not", "cyclosporin", "A", "can", "completely", "inhibit", "expression", "of", "IL-8", "." ]
[ 0, 5, 6, 6, 6, 6, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
7686
[ "The", "mechanism", "of", "PG490", "inhibition", "of", "cytokine", "gene", "expression", "differs", "from", "cyclosporin", "A", "and", "involves", "nuclear", "inhibition", "of", "transcriptional", "activation", "of", "NF-kappaB", "and", "the", "purine-box", "regulator", "operating", "at", "the", "ARRE/NF-AT", "site", "at", "a", "step", "after", "specific", "DNA", "binding", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0 ]
7687
[ "Unexpected", "and", "coordinated", "expression", "of", "Spi-1", ",", "Fli-1", ",", "and", "megakaryocytic", "genes", "in", "four", "Epo-dependent", "cell", "lines", "established", "from", "transgenic", "mice", "displaying", "erythroid-specific", "expression", "of", "a", "thermosensitive", "SV40", "T", "antigen", "." ]
[ 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
7688
[ "Most", "erythroleukemic", "cell", "lines", "established", "in", "vitro", "coexpress", "erythrocytic", "and", "megakaryocytic", "markers", "that", "often", "are", "associated", "with", "expression", "of", "Spi-1", "and/or", "Fli-1", "transcription", "factors", "known", "as", "transactivators", "of", "megakaryocyte-specific", "promoters", "." ]
[ 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0 ]
7689
[ "In", "the", "present", "study", ",", "we", "examined", "the", "possibility", "of", "establishing", "new", "cell", "lines", "keeping", "strictly", "erythroid-specific", "properties", "in", "vitro", "through", "the", "targeted", "and", "conditional", "immortalization", "of", "erythrocytic", "progenitors", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
7690
[ "For", "that", "purpose", ",", "we", "established", "several", "lines", "of", "transgenic", "mice", "displaying", "erythroid-specific", "expression", "of", "a", "thermosensitive", "SV40", "T", "antigen", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
7691
[ "As", "expected", ",", "these", "transgenic", "mice", "developed", "splenomegaly", "due", "to", "the", "massive", "amplification", "of", "Ter", "119", "positive", "erythroid", "nucleated", "cells", "expressing", "T", "antigen", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 9, 10, 0 ]
7692
[ "Despite", "this", "drastic", "effect", "in", "vivo", ",", "the", "in", "vitro", "immortalization", "of", "erythropoietin-dependent", "erythroid", "progenitors", "unexpectedly", "occurred", "at", "low", "frequency", ",", "and", "all", "four", "cell", "lines", "established", "expressed", "both", "erythrocytic", "(", "globins", ")", "and", "megakaryocytic", "markers", "(", "glycoprotein", "IIb", ",", "platelet", "factor", "4", ")", "as", "well", "as", "Spi-1", "and", "Fli-1", "transcripts", "at", "permissive", "temperature", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 10, 0, 0, 0, 0, 3, 0, 3, 4, 0, 0, 0, 0 ]
7693
[ "Switching", "the", "cells", "to", "the", "nonpermissive", "temperature", "led", "to", "a", "marked", "increase", "in", "globin", "gene", "expression", "and", "concomitant", "decrease", "in", "expression", "of", "Spi-1", ",", "Fli-1", ",", "and", "megakaryocytic", "genes", "in", "an", "erythropoietin", "-dependent", "manner", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
7694
[ "Interestingly", ",", "enhanced", "expression", "of", "Spi-1", "and", "Fli-1", "genes", "already", "was", "detected", "in", "the", "Ter", "119", "positive", "cell", "population", "of", "transgenic", "mice", "spleen", "in", "vivo", "." ]
[ 0, 0, 0, 0, 0, 1, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7695
[ "However", ",", "like", "normal", "Ter", "119", "erythroid", "cells", ",", "these", "Ter", "119", "positive", "cells", "from", "transgenic", "mice", "still", "expressed", "high", "levels", "of", "beta-globin", "and", "very", "low", "or", "undetectable", "glycoprotein", "IIb", "and", "platelet", "factor", "4", "megakaryocytic", "transcripts", "." ]
[ 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 3, 4, 0, 3, 4, 4, 4, 4, 0 ]
7696
[ "Taken", "together", ",", "these", "data", "indicate", "that", "the", "unexpected", "expression", "of", "megakaryocytic", "genes", "is", "a", "specific", "property", "of", "immortalized", "cells", "that", "can", "not", "be", "explained", "only", "by", "enhanced", "expression", "of", "Spi-1", "and/or", "Fli-1", "genes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 9, 10, 0 ]
7697
[ "Fludarabine-induced", "immunosuppression", "is", "associated", "with", "inhibition", "of", "STAT1", "signaling", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
7698
[ "Fludarabine", "is", "a", "nucleoside", "analog", "used", "in", "the", "treatment", "of", "hematologic", "malignancies", "that", "can", "induce", "severe", "and", "prolonged", "immunosuppression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7699
[ "Although", "it", "can", "be", "incorporated", "into", "the", "DNA", "of", "dividing", "cells", ",", "fludarabine", "is", "also", "a", "potent", "inhibitor", "of", "cells", "with", "a", "low", "growth", "fraction", ",", "thus", "it", "must", "have", "other", "mechanisms", "of", "action", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7700
[ "STAT1", ",", "which", "is", "activated", "in", "response", "to", "many", "lymphocyte-activating", "cytokines", "including", "the", "interferons", ",", "is", "essential", "for", "cell-mediated", "immunity", ",", "as", "the", "absence", "of", "this", "protein", "is", "associated", "with", "prominent", "defects", "in", "the", "ability", "to", "control", "viral", "infections", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]