Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
7501
[ "Activation", "of", "p38", "MAPK", "correlates", "closely", "with", "the", "stimulation", "of", "T", "cell", "proliferation", "." ]
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7502
[ "In", "contrast", ",", "PMA-induced", "JNK", "activation", "is", "inhibited", "by", "Ca2+", "ionophore", "." ]
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7503
[ "T", "cell", "proliferation", "and", "production", "of", "IL-2", ",", "IL-4", ",", "and", "IFN-gamma", "induced", "by", "both", "CD3", "and", "CD3", "/CD28", "ligation", "and", "the", "nuclear", "expression", "of", "the", "c-Jun", "and", "ATF-2", "proteins", "are", "each", "blocked", "by", "the", "p38", "MAPK", "inhibitor", "SB203580", "." ]
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7504
[ "Our", "findings", "demonstrate", "that", "p38", "MAPK", "1", ")", "plays", "an", "important", "role", "in", "signal", "integration", "during", "costimulation", "of", "primary", "mouse", "T", "cells", ",", "2", ")", "may", "be", "involved", "in", "the", "induction", "of", "c-Jun", "activation", "and", "augmentation", "of", "AP-1", "transcriptional", "activity", ",", "and", "3", ")", "regulates", "whether", "T", "cells", "enter", "a", "state", "of", "functional", "unresponsiveness", "." ]
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7505
[ "Erythroid", "gene", "expression", "is", "differentially", "regulated", "by", "erythropoietin", ",", "haemin", "and", "delta-aminolaevulinic", "acid", "in", "UT-7", "cells", "." ]
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7506
[ "Erythropoietin", "(", "Epo", ")", "is", "essential", "for", "the", "later", "stages", "of", "erythropoiesis", ",", "acting", "to", "promote", "cell", "survival", "and", "proliferation", ",", "but", "its", "role", "in", "differentiation", "remains", "to", "be", "defined", "." ]
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7507
[ "The", "UT-7", "cell", "line", "exhibits", "both", "erythroid", "and", "megakaryocytic", "characteristics", "and", "can", "be", "induced", "to", "differentiate", "along", "the", "erythroid", "pathway", "by", "Epo", "or", "the", "megakaryocytic", "pathway", "by", "phorbol", "myristic", "acetate", "." ]
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7508
[ "We", "have", "compared", "the", "effects", "of", "Epo", "and", "the", "chemical", "inducers", ",", "delta-aminolaevulinic", "acid", "(", "delta-ALA", ")", "and", "haemin", "on", "the", "differentiation", "capacity", "of", "UT-7", "cells", "." ]
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7509
[ "Epo", "alone", "promoted", "relatively", "early", "events", "in", "erythroid", "maturation", ",", "without", "significant", "changes", "in", "haemoglobin", "production", "or", "morphology", "." ]
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7510
[ "GATA-2", "and", "c-myb", "were", "down-regulated", "by", "Epo", ",", "and", "GATA-2", "was", "further", "down-modulated", "by", "the", "inducers", "." ]
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7511
[ "Conversely", ",", "SCL", "expression", "was", "up-regulated", "by", "Epo", "and", "further", "increased", "by", "haemin", "and", "delta-ALA", "." ]
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7512
[ "Epo", "caused", "an", "increase", "in", "the", "proportion", "of", "cells", "expressing", "cell", "surface", "glycophorin", "A", "(", "GPA", ")", "and", "up-regulated", "beta-", "and", "gamma-globin", "by", "several", "fold", "." ]
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7513
[ "Both", "haemin", "and", "delta-ALA", "caused", "a", "de", "novo", "increase", "in", "alpha-globin", "expression", "as", "well", "as", "enhancing", "Epo", "-induced", "beta-globin", "expression", ",", "leading", "to", "a", "marked", "increase", "in", "haemoglobin", "production", "." ]
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7514
[ "These", "results", "suggest", "that", "haemoglobin", "production", "in", "UT-7", "cells", "is", "limited", "by", "a", "deficiency", "of", "erythroid-specific", "aminolaevulinic", "acid", "synthase", "(", "ALAS-E", ")", "activity", "or", "globin", "synthesis", "as", "a", "consequence", "of", "their", "immaturity", "as", "a", "multipotential", "cell", "line", "." ]
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7515
[ "Essential", "role", "of", "alveolar", "macrophages", "in", "intrapulmonary", "activation", "of", "NF-kappaB", "." ]
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7516
[ "Acute", "inflammatory", "injury", "in", "rat", "lung", "induced", "by", "deposition", "of", "immunoglobulin", "G", "immune", "complexes", "requires", "expression", "of", "cytokines", "and", "chemokines", "as", "well", "as", "activation", "of", "the", "transcription", "factor", "nuclear", "factor", "(", "NF", ")", "-kappaB", "." ]
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7517
[ "There", "is", "little", "direct", "evidence", "regarding", "the", "role", "of", "alveolar", "macrophages", "in", "these", "activation", "events", "." ]
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7518
[ "In", "the", "present", "studies", ",", "rat", "lungs", "were", "depleted", "of", "alveolar", "macrophages", "by", "airway", "instillation", "of", "liposome-encapsulated", "dichloromethylene", "diphosphonate", "." ]
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7519
[ "These", "procedures", ",", "which", "greatly", "reduced", "the", "number", "of", "retrievable", "alveolar", "macrophages", ",", "suppressed", "activation", "of", "lung", "NF-kappaB", "in", "the", "inflammatory", "model", "." ]
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7520
[ "In", "addition", ",", "bronchoalveolar", "lavage", "levels", "of", "tumor", "necrosis", "factor-alpha", "(", "TNF-alpha", ")", "and", "the", "CXC", "chemokine", ",", "macrophage", "inflammatory", "protein-2", ",", "were", "substantially", "reduced", "." ]
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7521
[ "In", "parallel", ",", "upregulation", "of", "the", "lung", "vascular", "adhesion", "molecule", ",", "intercellular", "adhesion", "molecule-1", ",", "was", "greatly", "reduced", "by", "intrapulmonary", "instillation", "of", "phosphonate-containing", "liposomes", "." ]
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7522
[ "Neutrophil", "accumulation", "and", "development", "of", "lung", "injury", "were", "also", "substantially", "diminished", "." ]
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7523
[ "Lung", "instillation", "of", "TNF-alpha", "in", "alveolar", "macrophage-depleted", "rats", "restored", "the", "NF-kappaB", "activation", "response", "in", "whole", "lung", "." ]
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7524
[ "These", "data", "suggest", "that", ",", "in", "this", "inflammatory", "model", ",", "initial", "activation", "of", "NF-kappaB", "occurs", "in", "alveolar", "macrophages", "and", "the", "ensuing", "production", "of", "TNF-alpha", "may", "propagate", "NF-kappaB", "activation", "to", "other", "cell", "types", "in", "the", "lung", "." ]
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7525
[ "Interferon-beta", "mediates", "stromal", "cell", "rescue", "of", "T", "cells", "from", "apoptosis", "." ]
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7526
[ "The", "resolution", "of", "immune", "responses", "is", "characterized", "by", "extensive", "apoptosis", "of", "activated", "T", "cells", "." ]
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7527
[ "However", ",", "to", "generate", "and", "maintain", "immunological", "memory", ",", "some", "antigen-specific", "T", "cells", "must", "survive", "and", "revert", "to", "a", "resting", "G0/G1", "state", "." ]
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7528
[ "Cytokines", "that", "bind", "to", "the", "common", "gamma", "chain", "of", "the", "IL-2", "receptor", "promote", "the", "survival", "of", "T", "cell", "blasts", ",", "but", "also", "induce", "proliferation", "." ]
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7529
[ "In", "contrast", ",", "soluble", "factors", "secreted", "by", "stromal", "cells", "induce", "Tcell", "survival", "in", "a", "resting", "G0/G1", "state", "." ]
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7530
[ "We", "now", "report", "that", "interferon-beta", "is", "the", "principal", "mediator", "of", "stromal", "cell-mediated", "Tcell", "rescue", "from", "apoptosis", "." ]
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7531
[ "Interferon-alpha", "and", "-beta", "promote", "the", "reversion", "of", "blast", "Tcells", "to", "a", "resting", "G0/G1", "configuration", "with", "all", "the", "characteristic", "features", "of", "stromal", "cell", "rescue", ";", "such", "as", "high", "Bcl-XL", "expression", "and", "low", "Bcl-2", "." ]
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7532
[ "Type", "I", "interferons", "and", "stromal", "cells", "stimulate", "apparently", "identical", "signaling", "pathways", ",", "leading", "to", "STAT-1", "activation", "." ]
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7533
[ "We", "also", "show", "that", "this", "mechanism", "may", "play", "a", "fundamental", "role", "in", "the", "persistence", "of", "T", "cells", "at", "sites", "of", "chronic", "inflammation", ";", "suggesting", "that", "chronic", "inflammation", "is", "an", "aberrant", "consequence", "of", "immunological", "memory", "." ]
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7534
[ "Reduction", "of", "tumour", "necrosis", "factor", "alpha", "expression", "and", "signalling", "in", "peripheral", "blood", "mononuclear", "cells", "from", "patients", "with", "thalassaemia", "or", "sickle", "cell", "anaemia", "upon", "treatment", "with", "desferrioxamine", "." ]
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7535
[ "Recent", "evidence", "indicates", "that", "the", "rate", "of", "progression", "of", "the", "HIV-1", "disease", "is", "significantly", "reduced", "in", "thalassaemia", "major", "patients", "upon", "treatment", "with", "high", "doses", "of", "desferrioxamine", "(", "DFX", ")", "." ]
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7536
[ "The", "authors", "have", "previously", "demonstrated", "that", "in", "vitro", "exposure", "of", "mononuclear", "cells", "to", "DFX", "decreases", "the", "bioavailability", "of", "tumour", "necrosis", "factor", "alpha", "(", "TNF-alpha", ")", "which", "has", "a", "stimulatory", "effect", "on", "HIV-1", "replication", "." ]
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7537
[ "In", "this", "study", ",", "therefore", ",", "TNF-alpha", "bioavailability", "from", "mononuclear", "cells", "isolated", "from", "10", "patients", "with", "thalassaemia", "or", "sickle", "cell", "anaemia", "given", "DFX", "as", "compared", "to", "10", "untreated", "subjects", "has", "been", "evaluated", "." ]
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7538
[ "Evidence", "is", "presented", "showing", "that", "DFX", "treatment", "reduces", "TNF-alpha", "bioavailability", "(", "P", "<", "0.05", ")", "by", "inhibiting", "its", "steady", "state", "(", "P", "<", "0.05", ")", "and", "by", "enhancing", "its", "inactivation", "through", "binding", "to", "soluble", "TNF-alpha", "receptor", "type", "II", "(", "P", "<", "0.05", ")", "." ]
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7539
[ "We", "also", "show", "that", "DFX", "treatment", "limits", "the", "in", "vivo", "activation", "of", "NF-kappaB", ",", "a", "transcription", "factor", "involved", "in", "both", "TNF-alpha", "gene", "transcription", "and", "TNF-alpha", "signalling", "(", "P", "<", "0.005", ")", "." ]
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7540
[ "We", "conclude", "that", "TNF-alpha", "bioavailability", "and", "signalling", "are", "impaired", "in", "patients", "upon", "DFX", "treatment", "." ]
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7541
[ "This", "mechanism", "may", "contribute", "to", "delayed", "progression", "of", "the", "HIV-1", "infection", "in", "vivo", "." ]
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7542
[ "Copyright", "1999", "Academic", "Press", "." ]
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7543
[ "Involvement", "of", "NF-kappaB", "p50/p65", "heterodimer", "in", "activation", "of", "the", "human", "pro-interleukin-1beta", "gene", "at", "two", "subregions", "of", "the", "upstream", "enhancer", "element", "." ]
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7544
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7545
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7546
[ "The", "results", "obtained", "by", "transient", "transfection", "of", "fos", "-CAT", "constructs", "that", "contained", "serial", "5'-deletion", "mutations", "showed", "that", "the", "region", "between", "-3134", "and", "-3059", "appears", "to", "be", "required", "for", "the", "induction", "of", "transcription", "by", "LPS", "." ]
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7547
[ "Gel", "shift", "assay", "studies", "with", "synthetic", "oligonucleotides", "corresponding", "to", "partial", "sequences", "of", "the", "latter", "region", "and", "nuclear", "extracts", "from", "stimulated", "cells", "revealed", "specific", "protein", "binding", "sites", "between", "-3110", "and", "-3090", "and", "between", "-3079", "and", "-3059", "." ]
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7548
[ "These", "specific", "bindings", "were", "time", "and", "LPS", "dose", "dependent", "." ]
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7549
[ "The", "results", "of", "supershift", "analysis", "using", "specific", "antibodies", "against", "transcription", "factors", "suggested", "that", "both", "binding", "complexes", "contained", "the", "NF-kappaB", "components", "p50", "and", "p65", ",", "and", "did", "not", "contain", "other", "NF-kappaB", "proteins", "(", "p52", ",", "c-Rel", ",", "Rel", "B", ")", ",", "AP-1", "proteins", "(", "c-Fos", ",", "C-Jun", ")", ",", "CREB", "or", "C/EBPbeta", "(", "NF-IL6", ")", "." ]
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7550
[ "Mutation", "of", "either", "of", "the", "putative", "NF-kappaB-binding", "sites", "in", "the", "enhancer", "element", "decreased", "the", "LPS-stimulated", "transcriptional", "activity", "." ]
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7551
[ "These", "data", "indicated", "that", "two", "NF-kappaB-binding", "sites", ",", "which", "are", "located", "between", "-3134", "and", "-3059", ",", "are", "critical", "for", "the", "activation", "of", "proIL-1beta", "gene", "transcription", "." ]
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7552
[ "Copyright", "1999", "Academic", "Press", "." ]
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7553
[ "N-acetyl-L-cysteine", "inhibits", "primary", "human", "T", "cell", "responses", "at", "the", "dendritic", "cell", "level", ":", "association", "with", "NF-kappaB", "inhibition", "." ]
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7554
[ "N-acetyl-L-cysteine", "(", "NAC", ")", "is", "an", "antioxidant", "molecule", "endowed", "with", "immunomodulatory", "properties", "." ]
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7555
[ "To", "investigate", "the", "effect", "of", "NAC", "on", "the", "induction", "phase", "of", "T", "cell", "responses", ",", "we", "analyzed", "its", "action", "on", "human", "dendritic", "cells", "(", "DC", ")", "derived", "from", "adherent", "PBMC", "cultured", "with", "IL-4", "and", "granulocyte-macrophage", "CSF", "." ]
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7556
[ "We", "first", "found", "that", "NAC", "inhibited", "the", "constitutive", "as", "well", "as", "the", "LPS-induced", "activity", "of", "the", "transcription", "factor", "NF-kappaB", "." ]
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[ "Gel", "supershift", "assays", "demonstrated", "that", "thrombin", "induced", "binding", "of", "NF-kappa", "Bp65", "(", "Rel", "A", ")", "to", "downstream", "NF-kappa", "B", "site", "of", "the", "ICAM-1", "promoter", "." ]
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7570
[ "Differential", "inhibition", "of", "Smad6", "and", "Smad7", "on", "bone", "morphogenetic", "protein-", "and", "activin-mediated", "growth", "arrest", "and", "apoptosis", "in", "B", "cells", "." ]
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[ "Smad6", "and", "Smad7", "prevent", "ligand-induced", "activation", "of", "signal-transducing", "Smad", "proteins", "in", "the", "transforming", "growth", "factor-beta", "family", "." ]
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7573
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[ "We", "previously", "reported", "that", "Smad7", "is", "an", "activin", "A-inducible", "antagonist", "of", "activin", "A-induced", "growth", "arrest", "and", "apoptosis", "in", "HS-72", "cells", "." ]
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7575
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[ "Moreover", ",", "we", "found", "that", "the", "ectopic", "expression", "of", "Smad7", ",", "but", "not", "Smad6", ",", "inhibited", "the", "activin", "A-induced", "Smad2", "phosphorylation", "in", "HS-72", "cells", "." ]
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[ "Thus", ",", "Smad6", "and", "Smad7", "exhibit", "differential", "inhibitory", "effects", "in", "bone", "morphogenetic", "protein-2-", "and", "activin", "A-mediated", "signaling", "in", "B", "lineage", "cells", "." ]
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7578
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[ "Retinoids", "are", "bifunctional", "regulators", "of", "growth", "and", "differentiation", "of", "hematopoietic", "cells", "." ]
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7580
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7581
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[ "The", "effect", "was", "dose", "dependent", "and", "appeared", "relatively", "late", "." ]
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[ "Significant", "differences", "were", "observed", "from", "day", "4", "onward", "." ]
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7584
[ "Apoptosis", ",", "or", "programmed", "cell", "death", ",", "was", "demonstrated", "as", "the", "mode", "of", "cell", "death", "by", "using", "the", "TUNEL", "assay", ",", "which", "detects", "single", "strand", "nicks", "in", "DNA", ",", "or", "by", "the", "Nicoletti", "technique", "demonstrating", "a", "subdiploid", "population", "by", "DNA", "staining", "." ]
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[ "RA", "previously", "was", "found", "to", "inhibit", "granulocyte", "colony-stimulating", "factor", "--", "and", "not", "granulocyte-macrophage", "colony-stimulating", "factor", "--", "stimulated", "proliferation", "of", "CD34+", "cells", "." ]
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[ "However", ",", "we", "found", "that", "RA", "opposed", "anti-apoptotic", "effects", "of", "G-CSF", "and", "GM-CSF", "on", "CD34+", "cells", "(", "G-CSF", ":", "8", "%", "dead", "cells", "at", "day", "6", ";", "G-CSF", "+", "RA", ":", "20", "%", ";", "GM-CSF", ":", "12", "%", ";", "GM-CSF", "+", "RA", ":", "27", "%", ")", "." ]
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[ "Moreover", ",", "RA", "induced", "apoptosis", "of", "CD34+", "cells", "and", "CD34+CD71+", "cells", "stimulated", "with", "erythropoietin", "." ]
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7588
[ "To", "explore", "the", "receptor", "signaling", "pathways", "involved", "in", "RA-induced", "apoptosis", ",", "we", "used", "selective", "ligands", "for", "retinoic", "acid", "receptors", "(", "RARs", ";", "RO13-7410", ")", "and", "retinoid", "X", "receptors", "(", "RXRs", ";", "RO", "25-6603", ")", "." ]
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7589
[ "We", "found", "that", "RARs", "were", "involved", "in", "RA-mediated", "apoptosis", "of", "myeloid", "progenitor", "cells", ",", "whereas", "RARs", "as", "well", "as", "RXRs", "were", "involved", "in", "RA-mediated", "apoptosis", "of", "erythroid", "progenitor", "cells", "." ]
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7590
[ "Suppressive", "effects", "of", "anti-inflammatory", "agents", "on", "human", "endothelial", "cell", "activation", "and", "induction", "of", "heat", "shock", "proteins", "." ]
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7591
[ "BACKGROUND", ":", "Studies", "from", "our", "laboratory", "have", "shown", "that", "the", "earliest", "stages", "of", "atherosclerosis", "may", "be", "mediated", "by", "an", "autoimmune", "reaction", "against", "heat", "shock", "protein", "60", "(", "Hsp60", ")", "." ]
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7592
[ "The", "interactions", "of", "Hsp60-specific", "T", "cells", "with", "arterial", "endothelial", "cells", "(", "EC", ")", "require", "expression", "of", "both", "Hsp60", "and", "certain", "adhesion", "molecules", "shown", "to", "be", "induced", "simultaneously", "in", "EC", "by", "mechanical", "and", "other", "types", "of", "stress", "." ]
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7593
[ "Recently", ",", "it", "was", "shown", "that", "suppression", "of", "T", "cell-mediated", "immune", "responses", "by", "cyclosporin", "A", "(", "CyA", ")", "enhanced", "atherosclerotic", "lesion", "formation", "in", "mice", "." ]
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7594
[ "In", "contrast", ",", "aspirin", "was", "found", "to", "lower", "the", "risk", "of", "myocardial", "infarction", "in", "men", "." ]
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7595
[ "These", "conflicting", "observations", "may", "be", "due", "to", "different", "effects", "of", "anti-inflammatory", "agents", "on", "adhesion", "molecule", "and", "Hsp", "expression", "in", "EC", ",", "respectively", "." ]
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7596
[ "MATERIAL", "AND", "METHODS", ":", "In", "the", "present", "study", ",", "we", "analyzed", "the", "effects", "of", "CyA", ",", "aspirin", ",", "and", "indomethacin", "on", "T", "cell", "proliferation", "using", "a", "proliferation", "assay", "." ]
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7597
[ "To", "explore", "the", "expression", "of", "adhesion", "molecules", ",", "monocyte", "chemoattractant", "protein-1", "(", "MCP-1", ")", ",", "and", "Hsp60", "in", "human", "umbilical", "vein", "endothelial", "cells", "(", "HUVECs", ")", ",", "Northern", "blot", "analyses", "were", "used", "." ]
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7598
[ "To", "examine", "the", "activation", "status", "of", "the", "transcription", "factors", "nuclear", "factor", "kappaB", "(", "NF-kappaB", ")", "and", "heat", "shock", "factor-1", "(", "HSF-1", ")", ",", "electrophoretic", "mobility", "shift", "assays", "were", "performed", "." ]
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7599
[ "RESULTS", ":", "With", "the", "exception", "of", "indomethacin", ",", "the", "used", "immunosuppressive", "and", "anti-inflammatory", "agents", "significantly", "inhibited", "T", "cell", "proliferation", "in", "response", "to", "influenza", "virus", "antigen", "in", "a", "dose-dependent", "manner", "." ]
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7600
[ "Interestingly", ",", "CyA", "and", "indomethacin", "did", "not", "suppress", "tumor", "necrosis", "factor-alpha", "(", "TNF-alpha", ")", "-induced", "adhesion", "molecule", "expression", "on", "HUVECs", ",", "whereas", "aspirin", "had", "an", "inhibitory", "effect", "." ]
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