Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
7401
[ "A", "novel", "lipopolysaccharide-induced", "transcription", "factor", "regulating", "tumor", "necrosis", "factor", "alpha", "gene", "expression", ":", "molecular", "cloning", ",", "sequencing", ",", "characterization", ",", "and", "chromosomal", "assignment", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7402
[ "Lipopolysaccharide", "(", "LPS", ")", "is", "a", "potent", "stimulator", "of", "monocytes", "and", "macrophages", ",", "causing", "secretion", "of", "tumor", "necrosis", "factor", "alpha", "(", "TNF-alpha", ")", "and", "other", "inflammatory", "mediators", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0 ]
7403
[ "Given", "the", "deleterious", "effects", "to", "the", "host", "of", "TNF-alpha", ",", "it", "has", "been", "postulated", "that", "TNF-alpha", "gene", "expression", "must", "be", "tightly", "regulated", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0 ]
7404
[ "The", "nature", "of", "the", "nuclear", "factor", "(", "s", ")", "that", "control", "TNF-alpha", "gene", "transcription", "in", "humans", "remains", "obscure", ",", "although", "NF-kappaB", "has", "been", "suggested", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0 ]
7405
[ "Our", "previous", "studies", "pertaining", "to", "macrophage", "response", "to", "LPS", "identified", "a", "novel", "DNA-binding", "domain", "located", "from", "-550", "to", "-487", "in", "the", "human", "TNF-alpha", "promoter", "that", "contains", "transcriptional", "activity", ",", "but", "lacks", "any", "known", "NF-kappaB", "-binding", "sites", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
7406
[ "We", "have", "used", "this", "DNA", "fragment", "to", "isolate", "and", "purify", "a", "60-kDa", "protein", "binding", "to", "this", "fragment", "and", "obtained", "its", "amino-terminal", "sequence", ",", "which", "was", "used", "to", "design", "degenerate", "probes", "to", "screen", "a", "cDNA", "library", "from", "THP-1", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]
7407
[ "A", "novel", "cDNA", "clone", "(", "1.8", "kb", ")", "was", "isolated", "and", "fully", "sequenced", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7408
[ "Characterization", "of", "this", "cDNA", "clone", "revealed", "that", "its", "induction", "was", "dependent", "on", "LPS", "activation", "of", "THP-1", "cells", ";", "hence", ",", "the", "name", "LPS-induced", "TNF-alpha", "factor", "(", "LITAF", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0 ]
7409
[ "Inhibition", "of", "LITAF", "mRNA", "expression", "in", "THP-1", "cells", "resulted", "in", "a", "reduction", "of", "TNF-alpha", "transcripts", "." ]
[ 0, 0, 3, 4, 0, 0, 5, 6, 0, 0, 0, 0, 0, 9, 0, 0 ]
7410
[ "In", "addition", ",", "high", "level", "of", "expression", "of", "LITAF", "mRNA", "was", "observed", "predominantly", "in", "the", "placenta", ",", "peripheral", "blood", "leukocytes", ",", "lymph", "nodes", ",", "and", "the", "spleen", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0 ]
7411
[ "Finally", ",", "chromosomal", "localization", "using", "fluorescence", "in", "situ", "hybridization", "revealed", "that", "LITAF", "mapped", "to", "chromosome", "16p12-16p13.3", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 1, 2, 0 ]
7412
[ "Together", ",", "these", "findings", "suggest", "that", "LITAF", "plays", "an", "important", "role", "in", "the", "activation", "of", "the", "human", "TNF-alpha", "gene", "and", "proposes", "a", "new", "mechanism", "to", "control", "TNF-alpha", "gene", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0 ]
7413
[ "A", "human", "IFNGR1", "small", "deletion", "hotspot", "associated", "with", "dominant", "susceptibility", "to", "mycobacterial", "infection", "[", "see", "comments", "]" ]
[ 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7414
[ "The", "immunogenetic", "basis", "of", "severe", "infections", "caused", "by", "bacille", "Calmette-Guerin", "vaccine", "and", "environmental", "mycobacteria", "in", "humans", "remains", "largely", "unknown", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7415
[ "We", "describe", "18", "patients", "from", "several", "generations", "of", "12", "unrelated", "families", "who", "were", "heterozygous", "for", "1", "to", "5", "overlapping", "IFNGR1", "frameshift", "small", "deletions", "and", "a", "wild-type", "IFNGR1", "allele", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
7416
[ "There", "were", "12", "independent", "mutation", "events", "at", "a", "single", "mutation", "site", ",", "defining", "a", "small", "deletion", "hotspot", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7417
[ "Neighbouring", "sequence", "analysis", "favours", "a", "small", "deletion", "model", "of", "slipped", "mispairing", "events", "during", "replication", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7418
[ "The", "mutant", "alleles", "encode", "cell-surface", "IFNgamma", "receptors", "that", "lack", "the", "intra-cytoplasmic", "domain", ",", "which", ",", "through", "a", "combination", "of", "impaired", "recycling", ",", "abrogated", "signalling", "and", "normal", "binding", "to", "IFNgamma", "exert", "a", "dominant-negative", "effect", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
7419
[ "We", "thus", "report", "a", "hotspot", "for", "human", "IFNGR1", "small", "deletions", "that", "confer", "dominant", "susceptibility", "to", "infections", "caused", "by", "poorly", "virulent", "mycobacteria", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7420
[ "Characterization", "of", "expression", "of", "the", "gene", "for", "human", "pterin", "carbinolamine", "dehydratase/dimerization", "cofactor", "of", "HNF1", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0 ]
7421
[ "Pterin", "carbinolamine", "dehydratase/dimerization", "cofactor", "of", "HNF1", "(", "PCD/DCoH", ")", "is", "a", "dual-function", "protein", "." ]
[ 9, 10, 10, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0 ]
7422
[ "In", "the", "cytoplasm", "it", "acts", "as", "a", "dehydratase", "in", "the", "regeneration", "of", "tetrahydrobiopterin", ",", "the", "cofactor", "for", "aromatic", "amino", "acid", "hydroxylases", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]
7423
[ "In", "the", "nucleus", ",", "it", "functions", "as", "a", "dimerization", "cofactor", "of", "HNF1", "and", "increases", "the", "transcriptional", "activity", "of", "HNF1", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 9, 0 ]
7424
[ "To", "deepen", "our", "understanding", "of", "this", "protein", ",", "we", "characterized", "its", "expression", "in", "human", "tissues", "and", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7425
[ "Human", "PCD/DCoH", "was", "present", "predominantly", "in", "liver", "and", "kidney", ",", "with", "significant", "amounts", "in", "testis", "and", "ovary", ",", "trace", "amounts", "in", "lung", ",", "and", "undetectable", "levels", "in", "whole", "brain", ",", "heart", ",", "and", "spleen", "." ]
[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7426
[ "It", "was", "expressed", "in", "all", "of", "the", "cells", "that", "were", "examined", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7427
[ "Importantly", ",", "it", "was", "also", "present", "in", "the", "nucleus", "of", "HeLa", "cells", ",", "which", "lack", "HNF1", ",", "and", "in", "the", "cytoplasm", "of", "fibroblasts", "that", "have", "little", "or", "no", "tetrahydrobiopterin", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0 ]
7428
[ "The", "expression", "of", "human", "PCD/DCoH", "in", "the", "liver", "and", "nonhepatic", "cells", "was", "compared", "at", "both", "the", "mRNA", "and", "protein", "levels", "." ]
[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7429
[ "Although", "the", "mRNA", "level", "in", "liver", "was", "only", "fourfold", "higher", "than", "that", "in", "keratinocytes", "and", "fibroblasts", ",", "the", "hepatic", "PCD/DCoH", "protein", "level", "was", "20-fold", "higher", "than", "that", "in", "normal", "human", "epidermal", "keratinocytes", "and", "dermal", "fibroblasts", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 7, 8, 0 ]
7430
[ "Cloning", "of", "the", "5", "'", "and", "3", "'", "untranslated", "region", "(", "UTR", ")", "of", "human", "keratinocyte", "PCD/DCoH", "revealed", "that", "it", "has", "53", "bp", "more", "of", "GC-rich", "5", "'", "untranslated", "sequence", "than", "the", "published", "liver", "PCD/DCoH", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
7431
[ "In", "vitro", "transcription", "and", "translation", "analysis", "showed", "that", "the", "longer", "5", "'", "UTR", "resulted", "in", "about", "a", "35", "%", "decrease", "in", "translation", "efficiency", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7432
[ "These", "data", "show", "that", "human", "PCD/DCoH", "is", "not", "only", "present", "in", "cells", "where", "tetrahydrobiopterin", "is", "synthesized", "or", "HNF1", "is", "present", "but", "is", "a", "widely", "distributed", "protein", "." ]
[ 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7433
[ "Its", "differential", "expression", "in", "different", "tissues", "and", "cells", "is", "regulated", "not", "only", "at", "the", "transcriptional", "level", "but", "also", "at", "the", "translational", "level", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7434
[ "NF-kappaB", "regulates", "Fas/APO-1/CD95-", "and", "TCR-", "mediated", "apoptosis", "of", "T", "lymphocytes", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
7435
[ "The", "maintenance", "of", "lymphocyte", "homeostasis", "by", "apoptosis", "is", "a", "critical", "regulatory", "mechanism", "in", "the", "normal", "immune", "system", "." ]
[ 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7436
[ "The", "transcription", "factor", "NF-kappaB", "has", "been", "shown", "to", "play", "a", "role", "in", "protecting", "cells", "against", "death", "mediated", "by", "TNF", "We", "show", "here", "that", "NF-kappaB", "also", "has", "a", "role", "in", "regulating", "Fas", "/", "APO-1", "/", "CD95", "-mediated", "death", ",", "a", "major", "pathway", "of", "peripheral", "T", "cell", "death", "." ]
[ 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0 ]
7437
[ "Transfection", "of", "Jurkat", "cells", "with", "the", "NF-kappaB", "subunits", "p50", "and", "p65", "confers", "resistance", "against", "Fas-mediated", "apoptosis", "." ]
[ 0, 0, 5, 6, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0 ]
7438
[ "Reciprocally", ",", "inhibition", "of", "NF-kappaB", "activation", "by", "a", "soluble", "peptide", "inhibitor", "or", "a", "dominant", "form", "of", "the", "NF-kappaB", "inhibitor", ",", "IkappaB", ",", "makes", "the", "cells", "more", "susceptible", "to", "Fas-mediated", "apoptosis", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7439
[ "Furthermore", ",", "inhibition", "of", "NF-kappaB", "activation", "by", "a", "soluble", "peptide", "inhibitor", "rendered", "a", "T", "cell", "hybridoma", "more", "susceptible", "to", "TCR-mediated", "apoptosis", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0 ]
7440
[ "Correspondingly", ",", "transfection", "of", "p50", "and", "p65", "provided", "considerable", "protection", "from", "TCR-mediated", "apoptosis", "." ]
[ 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
7441
[ "These", "observations", "were", "corroborated", "by", "studies", "on", "Fas", "-mediated", "death", "in", "primary", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 7, 8, 0 ]
7442
[ "Concanavalin", "A-activated", "cycling", "T", "cell", "blasts", "from", "mice", "that", "are", "transgenic", "for", "the", "dominant", "IkappaB", "molecule", "have", "increased", "sensitivity", "to", "Fas-mediated", "apoptosis", ",", "associated", "with", "a", "down-regulation", "of", "NF-kappaB", "complexes", "in", "the", "nucleus", "." ]
[ 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0 ]
7443
[ "In", "addition", ",", "blocking", "TNF", ",", "itself", "a", "positive", "regulator", "of", "NF-kappaB", ",", "with", "neutralizing", "antibodies", "renders", "the", "cells", "more", "susceptible", "to", "anti-Fas-mediated", "apoptosis", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7444
[ "In", "summary", ",", "our", "results", "provide", "compelling", "evidence", "that", "NF-kappaB", "protects", "against", "Fas", "-mediated", "death", "and", "is", "likely", "to", "be", "an", "important", "regulator", "of", "T", "cell", "homeostasis", "and", "tolerance", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0 ]
7445
[ "T", "helper", "differentiation", "proceeds", "through", "Stat1-dependent", ",", "Stat4-dependent", "and", "Stat4-independent", "phases", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7446
[ "Much", "of", "our", "focus", "in", "understanding", "Th1/Th2", "development", "has", "been", "on", "the", "signals", "delivered", "by", "IL-12", "and", "IL-4", "as", "final", "determinants", "of", "terminal", "T", "cell", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 7, 8, 0, 0 ]
7447
[ "Because", "extinction", "of", "IL-12", "signaling", "in", "early", "Th2", "development", "could", "potentially", "be", "important", "in", "imprinting", "a", "more", "permanent", "Th2", "phenotype", "on", "a", "population", "of", "T", "cells", ",", "we", "have", "also", "examined", "various", "parameters", "regulating", "the", "IL-12", "signaling", "pathway", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
7448
[ "Whereas", "IL-4", "appears", "to", "repress", "functional", "IL-12", "signaling", "through", "inhibition", "of", "IL-12R", "beta", "2", "expression", ",", "IFN-gamma", "in", "the", "mouse", ",", "and", "IFN-alpha", "in", "the", "human", "appear", "to", "induce", "IL-12R", "beta", "2", "expression", "and", "promote", "IL-12", "responsiveness", "." ]
[ 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 9, 0, 0 ]
7449
[ "We", "propose", "that", "Th1", "development", "can", "be", "considered", "in", "two", "stages", ",", "capacitance", "and", "development", "." ]
[ 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7450
[ "Capacitance", "would", "simply", "involve", "expression", "of", "IL-12R", "beta", "1", "and", "beta", "2", "subunits", ",", "regulated", "by", "TCR", ",", "IL-4", "and", "IFNs", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 10, 10, 0, 0, 0, 9, 0, 9, 0, 9, 0 ]
7451
[ "The", "second", "stage", ",", "development", ",", "we", "propose", "is", "the", "true", "IL-12", "induced", "developmental", "stage", ",", "involving", "expression", "of", "Stat4", "inducible", "proteins", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
7452
[ "In", "the", "human", ",", "this", "may", "also", "occur", "via", "IFN-alpha", ",", "which", "is", "able", "to", "activate", "Stat4", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0 ]
7453
[ "It", "is", "perhaps", "possible", "that", "all", "of", "Stat4", "actions", "on", "Th1", "development", "may", "be", "exert", "directly", "by", "Stat4", "at", "the", "IFN-gamma", "gene", ",", "however", "we", "suggest", "that", ",", "more", "likely", ",", "Stat4", "may", "act", "to", "induce", "Th1", "development", "through", "the", "induction", "of", "other", "non-cytokine", "genes", ",", "whose", "stable", "expression", "maintains", "the", "transcriptional", "state", "of", "a", "Th1", "cell", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 0, 0, 0, 0, 0, 0, 9, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
7454
[ "Lineage-specific", "activation", "of", "STAT3", "by", "interferon-gamma", "in", "human", "neutrophils", "." ]
[ 0, 0, 0, 9, 0, 9, 0, 7, 8, 0 ]
7455
[ "Binding", "of", "interferon-gamma", "(", "IFN-gamma", ")", "to", "its", "heterodimeric", "receptor", "induces", "activation", "of", "the", "tyrosine", "kinases", "JAK1", "and", "JAK2", "followed", "by", "tyrosine", "phosphorylation", "of", "STAT1alpha", "." ]
[ 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 9, 0 ]
7456
[ "Selective", "activation", "of", "STAT1alpha", "at", "the", "IFN-gamma", "receptor", "is", "achieved", "by", "specific", "interaction", "between", "a", "cytosolic", "tyrosine", "motif", "including", "Y440", "in", "the", "IFN-gamma", "receptor", "alpha-chain", "and", "the", "SH2", "domain", "of", "STAT1alpha", "." ]
[ 0, 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 9, 0 ]
7457
[ "We", "demonstrate", "that", ",", "in", "addition", "to", "STAT1alpha", ",", "STAT3", "is", "also", "activated", "by", "IFN-gamma", "in", "human", "neutrophils", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 9, 0, 7, 8, 0 ]
7458
[ "The", "activation", "of", "STAT3", "was", "not", "found", "in", "human", "eosinophils", ",", "monocytes", ",", "and", "HL-60", "cells", ",", "although", "the", "STAT3", "protein", "was", "expressed", "in", "these", "cells", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 7, 8, 0, 7, 0, 0, 5, 6, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0 ]
7459
[ "The", "cell", "type-specific", "activation", "of", "STAT3", "by", "IFN-gamma", "was", "also", "observed", "in", "neutrophils", "that", "are", "differentiated", "in", "vitro", "from", "human", "CD34+", "hematopoietic", "stem", "cells", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0 ]
7460
[ "These", "results", "indicate", "that", "a", "single", "cytokine", "receptor", "can", "activate", "different", "STAT", "family", "members", "in", "a", "cell-specific", "manner", ",", "which", "might", "result", "in", "cell-specific", "gene", "transcription", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7461
[ "Alternative", "polyadenylation", "events", "contribute", "to", "the", "induction", "of", "NF-ATc", "in", "effector", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0 ]
7462
[ "The", "transcription", "factor", "NF-ATc", "is", "synthesized", "in", "three", "prominent", "isoforms", "." ]
[ 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0 ]
7463
[ "These", "differ", "in", "the", "length", "of", "their", "C", "terminal", "peptides", "and", "mode", "of", "synthesis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7464
[ "Due", "to", "a", "switch", "from", "the", "use", "of", "a", "3", "'", "polyA", "site", "to", "a", "more", "proximal", "polyA", "site", ",", "NF-ATc", "expression", "switches", "from", "the", "synthesis", "of", "the", "two", "longer", "isoforms", "in", "naive", "T", "cells", "to", "that", "of", "short", "isoform", "A", "in", "T", "effector", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
7465
[ "The", "relative", "low", "binding", "affinity", "of", "cleavage", "stimulation", "factor", "CstF-64", "to", "the", "proximal", "polyA", "site", "seems", "to", "contribute", "to", "its", "neglect", "in", "naive", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
7466
[ "These", "alternative", "polyadenylation", "events", "ensure", "the", "rapid", "accumulation", "of", "high", "concentrations", "of", "NF-ATc", "necessary", "to", "exceed", "critical", "threshold", "levels", "of", "NF-ATc", "for", "gene", "induction", "in", "effector", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 7, 8, 0 ]
7467
[ "Estrogen", "and", "progesterone", "induction", "of", "survival", "of", "monoblastoid", "cells", "undergoing", "TNF-alpha", "-induced", "apoptosis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 9, 0, 0, 0 ]
7468
[ "Induction", "of", "apoptosis", "of", "mononucleated", "cells", "is", "a", "physiological", "process", "for", "regulating", "the", "intensity", "of", "the", "immune", "response", "." ]
[ 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7469
[ "The", "female", "steroid", "hormones", "estrogen", "(", "E2", ")", "and", "progesterone", "(", "Prog", ")", "are", "known", "to", "modulate", "the", "reactivity", "of", "the", "immune", "system", ";", "recently", "it", "has", "been", "demonstrated", "that", "they", "can", "regulate", "induction", "of", "apoptosis", "of", "endothelial", "cells", "and", "osteoblasts", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 7, 0 ]
7470
[ "TNF-alpha", "-mediated", "induction", "of", "apoptosis", "has", "been", "well", "characterized", "in", "myeloid", "cells", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
7471
[ "We", "investigated", "whether", "E2", "and", "Prog", "could", "interfere", "with", "TNF-alpha", "-induced", "apoptosis", "of", "the", "monoblastoid", "U937", "cell", "line", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 5, 6, 6, 6, 0 ]
7472
[ "Treatment", "with", "E2", "or", "Prog", "increased", "survival", "and", "prevented", "apoptosis", "induced", "by", "TNF-alpha", "in", "both", "undifferentiated", "and", "macrophage-like", "PMA-differentiated", "U937", "cells", ",", "as", "assessed", "by", "trypan", "blue", "exclusion", "cell", "counting", ",", "thymidine", "incorporation", ",", "AnnexinV", "labeling", ",", "followed", "by", "flow", "cytometry", "and", "DNA", "fragmentation", "studies", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7473
[ "This", "effect", "can", "be", "associated", "with", "the", "activation", "of", "specific", "hormone", "receptors", ",", "since", "we", "observed", "the", "expression", "of", "the", "estrogen", "receptor", "alpha", "(", "ER-alpha", ")", ",", "ER-beta", ",", "and", "progesterone", "receptor", "(", "PR", ")", "mRNAs", ";", "the", "ER-alpha", "protein", "expression", "was", "confirmed", "by", "immunocytochemical", "analysis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 3, 0, 0, 3, 0, 0, 3, 4, 4, 4, 4, 4, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]
7474
[ "In", "addition", ",", "hormone-mediated", "survival", "against", "apoptosis", "was", "concentration", "dependent", ",", "reaching", "the", "half-maximal", "effect", "at", "10", "nM", "and", "blocked", "by", "the", "ER", "antagonist", "ICI", "182", ",", "780", "in", "undifferentiated", "cells", ",", "further", "supporting", "a", "receptor-mediated", "mechanism", "of", "cell", "survival", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7475
[ "Other", "steroid", "receptor", "drugs", "such", "as", "Raloxifene", ",", "RU486", ",", "or", "the", "ICI", "182", ",", "780", "in", "PMA-differentiated", "cells", "displayed", "agonist", "activity", "by", "preventing", "TNF-alpha", "-induced", "apoptosis", "as", "efficiently", "as", "the", "hormones", "alone", ",", "providing", "further", "evidence", "to", "the", "notion", "that", "steroid", "receptor", "drugs", "may", "manifest", "agonist", "or", "antagonist", "activities", "depending", "on", "the", "cellular", "context", "in", "which", "they", "are", "studied", "." ]
[ 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7476
[ "Treatment", "with", "E2", "was", "also", "associated", "with", "a", "time-dependent", "decrease", "in", "the", "mRNA", "level", "of", "the", "proapoptotic", "Nip-2", "protein", ",", "supporting", "the", "hypothesis", "that", "hormone", "responsiveness", "of", "U937", "cells", "is", "mediated", "by", "target", "gene", "transcription", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0 ]
7477
[ "Together", ",", "these", "results", "demonstrate", "that", "ER", "and", "PR", "can", "be", "activated", "by", "endogenous", "or", "exogenous", "ligands", "to", "induce", "a", "genetic", "response", "that", "impairs", "TNF-alpha", "-induced", "apoptosis", "in", "U937", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 5, 6, 0 ]
7478
[ "The", "data", "presented", "here", "suggest", "that", "the", "female", "steroid", "receptors", "play", "a", "role", "in", "regulation", "of", "the", "immune", "response", "by", "preventing", "apoptosis", "of", "monoblastoid", "cells", ";", "this", "effect", "might", "have", "important", "consequences", "in", "the", "clinical", "use", "of", "steroid", "receptor", "drugs", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7479
[ "--", "Vegeto", ",", "E.", ",", "Pollio", ",", "G.", ",", "Pellicciari", ",", "C.", ",", "Maggi", ",", "A", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7480
[ "Estrogen", "and", "progesterone", "induction", "of", "survival", "of", "monoblastoid", "cells", "undergoing", "TNF-alpha", "-inuced", "apoptosis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 9, 0, 0, 0 ]
7481
[ "Dicarba-closo-dodecaboranes", "as", "a", "pharmacophore", "." ]
[ 0, 0, 0, 0, 0 ]
7482
[ "Retinoidal", "antagonists", "and", "potential", "agonists", "." ]
[ 0, 0, 0, 0, 0, 0 ]
7483
[ "Synthesis", "and", "biological", "evaluation", "of", "the", "first", "dicarba-closo-dodecaborane", "(", "carborane", ")", "derivatives", "of", "retinoids", "are", "described", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7484
[ "Their", "retinoidal", "activity", "were", "examined", "in", "terms", "of", "the", "differentiation-inducing", "ability", "toward", "human", "promyelocytic", "leukemia", "HL-60", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0 ]
7485
[ "High", "retinoidal", "activity", "(", "agonist", "or", "antagonist", "for", "retinoic", "acid", "receptor", "(", "RAR", ")", "requires", "a", "carboxylic", "acid", "moiety", "and", "an", "appropriate", "hydrophobic", "group", "located", "at", "a", "suitable", "position", "on", "the", "molecule", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7486
[ "The", "4-carboranyl-substituted", "compounds", "(", "7", ",", "11", ")", "showed", "antagonistic", "activity", "but", "no", "agonistic", "activity", "even", "in", "the", "presence", "of", "the", "potent", "synergist", "HX630", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7487
[ "On", "the", "other", "hand", ",", "the", "3-carboranyl-substituted", "compounds", "(", "8", ",", "12", ")", "showed", "potential", "agonistic", "activity", ",", "but", "no", "antagonistic", "activity", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7488
[ "The", "results", "indicates", "that", "carboranes", "are", "applicable", "as", "the", "hydrophobic", "moiety", "of", "biologically", "active", "molecules", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7489
[ "Inhibition", "of", "T", "cell", "signaling", "by", "mitogen-activated", "protein", "kinase-targeted", "hematopoietic", "tyrosine", "phosphatase", "(", "HePTP", ")", "." ]
[ 0, 0, 7, 8, 0, 0, 9, 10, 10, 10, 10, 10, 0, 9, 0, 0 ]
7490
[ "Activation", "of", "T", "lymphocytes", "to", "produce", "cytokines", "is", "regulated", "by", "the", "counterbalance", "of", "protein-tyrosine", "kinases", "and", "protein-tyrosine", "phosphatases", ",", "many", "of", "which", "have", "a", "high", "degree", "of", "substrate", "specificity", "because", "of", "physical", "association", "with", "their", "targets", "." ]
[ 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7491
[ "Overexpression", "of", "hematopoietic", "protein-tyrosine", "phosphatase", "(", "HePTP", ")", "results", "in", "suppression", "of", "T", "lymphocyte", "activation", "as", "measured", "by", "T", "cell", "antigen", "receptor", "-induced", "activation", "of", "transcription", "factors", "binding", "to", "the", "5", "'", "promoter", "of", "the", "interleukin-2", "gene", "." ]
[ 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
7492
[ "Efforts", "to", "pinpoint", "the", "exact", "site", "of", "action", "and", "specificity", "of", "HePTP", "in", "the", "signaling", "cascade", "revealed", "that", "HePTP", "acts", "directly", "on", "the", "mitogen-activated", "protein", "(", "MAP", ")", "kinases", "Erk1", "and", "2", "and", "consequently", "reduces", "the", "magnitude", "and", "duration", "of", "their", "catalytic", "activation", "in", "intact", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
7493
[ "In", "contrast", ",", "HePTP", "had", "no", "effects", "on", "N-terminal", "c-Jun", "kinase", "or", "on", "events", "upstream", "of", "the", "MAP", "kinases", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
7494
[ "The", "specificity", "of", "HePTP", "correlated", "with", "its", "physical", "association", "through", "its", "noncatalytic", "N", "terminus", "with", "Erk", "and", "another", "MAP", "kinase", ",", "p38", ",", "but", "not", "Jnk", "or", "other", "proteins", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0 ]
7495
[ "We", "propose", "that", "HePTP", "plays", "a", "negative", "role", "in", "antigen", "receptor", "signaling", "by", "specifically", "regulating", "MAP", "kinases", "in", "the", "cytosol", "and", "at", "early", "time", "points", "of", "T", "cell", "activation", "before", "the", "activation-induced", "expression", "of", "nuclear", "dual-specific", "MAP", "kinase", "phosphatases", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
7496
[ "p38", "mitogen-activated", "protein", "kinase", "mediates", "signal", "integration", "of", "TCR", "/CD28", "costimulation", "in", "primary", "murine", "T", "cells", "." ]
[ 9, 10, 10, 10, 0, 0, 0, 0, 9, 10, 0, 0, 0, 7, 8, 8, 0 ]
7497
[ "Optimal", "T", "cell", "activation", "requires", "two", "signals", ",", "one", "generated", "by", "TCR", "and", "another", "by", "the", "CD28", "costimulatory", "receptor", "." ]
[ 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 10, 0 ]
7498
[ "In", "this", "study", ",", "we", "investigated", "the", "regulation", "of", "costimulation-induced", "mitogen-activated", "protein", "kinase", "(", "MAPK", ")", "activation", "in", "primary", "mouse", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 7, 8, 8, 0 ]
7499
[ "In", "contrast", "to", "that", "reported", "for", "human", "Jurkat", "T", "cells", ",", "we", "found", "that", "p38", "MAPK", ",", "but", "not", "Jun", "NH2-terminal", "kinase", "(", "JNK", ")", ",", "is", "weakly", "activated", "upon", "stimulation", "with", "either", "anti-CD3", "or", "anti-CD28", "in", "murine", "thymocytes", "and", "splenic", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 7, 8, 0, 7, 8, 8, 0 ]
7500
[ "However", ",", "p38", "MAPK", "is", "activated", "strongly", "and", "synergistically", "by", "either", "CD3/CD28", "coligation", "or", "PMA/Ca2+", "ionophore", "stimulation", ",", "which", "mimics", "TCR", "-", "CD3/CD28", "-mediated", "signaling", "." ]
[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0 ]