Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
7301
[ "p70", "(", "s6k", ")", "integrates", "phosphatidylinositol", "3-kinase", "and", "rapamycin-regulated", "signals", "for", "E2F", "regulation", "in", "T", "lymphocytes", "." ]
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7302
[ "In", "T", "lymphocytes", ",", "the", "hematopoietic", "cytokine", "interleukin-2", "(", "IL-2", ")", "uses", "phosphatidylinositol", "3-kinase", "(", "PI", "3-kinase", ")", "-induced", "signaling", "pathways", "to", "regulate", "E2F", "transcriptional", "activity", ",", "a", "critical", "cell", "cycle", "checkpoint", "." ]
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7303
[ "PI", "3-kinase", "also", "regulates", "the", "activity", "of", "p70", "(", "s6k", ")", ",", "the", "40S", "ribosomal", "protein", "S6", "kinase", ",", "a", "response", "that", "is", "abrogated", "by", "the", "macrolide", "rapamycin", "." ]
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7304
[ "This", "immunosuppressive", "drug", "is", "known", "to", "prevent", "T-cell", "proliferation", ",", "but", "the", "precise", "point", "at", "which", "rapamycin", "regulates", "T-cell", "cycle", "progression", "has", "yet", "to", "be", "elucidated", "." ]
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7305
[ "Moreover", ",", "the", "effects", "of", "rapamycin", "on", ",", "and", "the", "role", "of", "p70", "(", "s6k", ")", "in", ",", "IL-2", "and", "PI", "3-kinase", "activation", "of", "E2Fs", "have", "not", "been", "characterized", "." ]
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7306
[ "Our", "present", "results", "show", "that", "IL-2", "-and", "PI", "3-kinase", "-induced", "pathways", "for", "the", "regulation", "of", "E2F", "transcriptional", "activity", "include", "both", "rapamycin-resistant", "and", "rapamycin-sensitive", "components", "." ]
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7307
[ "Expression", "of", "a", "rapamycin-resistant", "mutant", "of", "p70", "(", "s6k", ")", "in", "T", "cells", "could", "restore", "rapamycin-suppressed", "E2F", "responses", "." ]
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7308
[ "Thus", ",", "the", "rapamycin-controlled", "processes", "involved", "in", "E2F", "regulation", "appear", "to", "be", "mediated", "by", "p70", "(", "s6k", ")", "." ]
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7309
[ "However", ",", "the", "rapamycin-resistant", "p70", "(", "s6k", ")", "could", "not", "rescue", "rapamycin", "inhibition", "of", "T-cell", "cycle", "entry", ",", "consistent", "with", "the", "involvement", "of", "additional", ",", "rapamycin-sensitive", "pathways", "in", "the", "control", "of", "T-cell", "cycle", "progression", "." ]
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7310
[ "The", "present", "results", "thus", "show", "that", "p70", "(", "s6k", ")", "is", "able", "to", "regulate", "E2F", "transcriptional", "activity", "and", "provide", "direct", "evidence", "for", "the", "first", "time", "for", "a", "link", "between", "IL-2", "receptors", ",", "PI", "3-kinase", ",", "and", "p70", "(", "s6k", ")", "that", "regulates", "a", "crucial", "G1", "checkpoint", "in", "T", "lymphocytes", "." ]
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7311
[ "Oxidative", "stress", "triggers", "STAT3", "tyrosine", "phosphorylation", "and", "nuclear", "translocation", "in", "human", "lymphocytes", "." ]
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7312
[ "Oxidizing", "agents", "are", "powerful", "activators", "of", "factors", "responsible", "for", "the", "transcriptional", "activation", "of", "cytokine-encoding", "genes", "involved", "in", "tissue", "injury", "." ]
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7313
[ "In", "this", "study", "we", "show", "evidence", "that", "STAT3", "is", "a", "transcription", "factor", "whose", "activity", "is", "modulated", "by", "H2O2", "in", "human", "lymphocytes", ",", "in", "which", "endogenous", "catalase", "had", "previously", "been", "inhibited", "." ]
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7314
[ "H2O2-induced", "nuclear", "translocation", "of", "STAT3", "to", "form", "sequence-specific", "DNA-bound", "complexes", "was", "evidenced", "by", "immunoblotting", "of", "nuclear", "fractions", "and", "electrophoretic", "mobility", "shift", "assays", ",", "and", "vanadate", "was", "found", "to", "strongly", "synergize", "with", "H2O2", "." ]
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7315
[ "Moreover", ",", "anti-", "STAT3", "antibodies", "specifically", "precipitated", "a", "protein", "of", "92", "kDa", "that", "becomes", "phosphorylated", "on", "tyrosine", "upon", "lymphocyte", "treatment", "with", "H2O2", "." ]
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7316
[ "Phenylarsine", "oxide", ",", "a", "tyrosine", "phosphatase", "inhibitor", ",", "and", "genistein", ",", "a", "tyrosine", "kinase", "inhibitor", ",", "cooperated", "and", "cancelled", ",", "respectively", ",", "the", "H2O2-promoted", "STAT3", "nuclear", "translocation", "." ]
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7317
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7318
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7319
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7320
[ "Transcriptional", "regulation", "of", "T", "lymphocyte", "development", "and", "function", "." ]
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7321
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7322
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7323
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7324
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7325
[ "In", "addition", "to", "increasing", "our", "understanding", "of", "the", "molecular", "pathways", "that", "regulate", "T", "cell", "development", "and", "function", ",", "these", "results", "have", "suggested", "novel", "targets", "for", "genetic", "and", "pharmacological", "manipulation", "of", "T", "cell", "immunity", "." ]
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7326
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7327
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7328
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7329
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7330
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7331
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7332
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7333
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7334
[ "IL-10", "is", "a", "well-known", "immunosuppressive", "and/or", "anti-inflammatory", "cytokine", "." ]
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7335
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7336
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7337
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7338
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7339
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7340
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7341
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7342
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7343
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7344
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7345
[ "Cell", "growth-regulated", "expression", "of", "mammalian", "MCM5", "and", "MCM6", "genes", "mediated", "by", "the", "transcription", "factor", "E2F", "." ]
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7346
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7347
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7348
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7349
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7350
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7351
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7362
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7367
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7368
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7372
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7373
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7374
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7376
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7377
[ "BACKGROUND", ":", "Tumor", "necrosis", "factor", "alpha", "(", "TNF-alpha", ")", "is", "an", "important", "mediator", "of", "septic", "shock", "." ]
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7378
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7379
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7380
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7382
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7383
[ "NF-kappaB", "DNA", "binding", "was", "evaluated", "by", "electrophoretic", "mobility", "shift", "assay", "." ]
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7384
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7385
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7386
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7387
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7388
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7389
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7390
[ "Copyright", "1999", "Academic", "Press", "." ]
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7391
[ "Amelioration", "of", "rat", "cerulein", "pancreatitis", "by", "guamerin-derived", "peptide", ",", "a", "novel", "elastase", "inhibitor", "." ]
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7392
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7394
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7395
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7398
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7399
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7400
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