Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
7101
[ "This", "is", "the", "first", "demonstration", "of", "a", "viral", "inhibition", "of", "CIITA", "expression", "." ]
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7102
[ "3-deazaadenosine", ",", "a", "S-adenosylhomocysteine", "hydrolase", "inhibitor", ",", "has", "dual", "effects", "on", "NF-kappaB", "regulation", "." ]
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7103
[ "Inhibition", "of", "NF-kappaB", "transcriptional", "activity", "and", "promotion", "of", "IkappaBalpha", "degradation", "." ]
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7104
[ "Previously", "we", "reported", "that", "3-deazaadenosine", "(", "DZA", ")", ",", "a", "potent", "inhibitor", "and", "substrate", "for", "S-adenosylhomocysteine", "hydrolase", "inhibits", "bacterial", "lipopolysaccharide-induced", "transcription", "of", "tumor", "necrosis", "factor-alpha", "and", "interleukin-1beta", "in", "mouse", "macrophage", "RAW", "264.7", "cells", "." ]
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7105
[ "In", "this", "study", ",", "we", "demonstrate", "the", "effects", "of", "DZA", "on", "nuclear", "factor-kappaB", "(", "NF-kappaB", ")", "regulation", "." ]
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7106
[ "DZA", "inhibits", "the", "transcriptional", "activity", "of", "NF-kappaB", "through", "the", "hindrance", "of", "p65", "(", "Rel-A", ")", "phosphorylation", "without", "reduction", "of", "its", "nuclear", "translocation", "and", "DNA", "binding", "activity", "." ]
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7107
[ "The", "inhibitory", "effect", "of", "DZA", "on", "NF-kappaB", "transcriptional", "activity", "is", "potentiated", "by", "the", "addition", "of", "homocysteine", "." ]
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7108
[ "Taken", "together", ",", "DZA", "promotes", "the", "proteolytic", "degradation", "of", "IkappaBalpha", ",", "but", "not", "IkappaBbeta", ",", "resulting", "in", "an", "increase", "of", "DNA", "binding", "activity", "of", "NF-kappaB", "in", "the", "nucleus", "in", "the", "absence", "of", "its", "transcriptional", "activity", "in", "RAW", "264.7", "cells", "." ]
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7109
[ "The", "reduction", "of", "IkappaBalpha", "by", "DZA", "is", "neither", "involved", "in", "IkappaB", "kinase", "complex", "activation", "nor", "modulated", "by", "the", "addition", "of", "homocysteine", "." ]
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7110
[ "This", "study", "strongly", "suggests", "that", "DZA", "may", "be", "a", "potent", "drug", "for", "the", "treatment", "of", "diseases", "in", "which", "NF-kappaB", "plays", "a", "central", "pathogenic", "role", ",", "as", "well", "as", "a", "useful", "tool", "for", "studying", "the", "regulation", "and", "physiological", "functions", "of", "NF-kappaB", "." ]
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7111
[ "The", "role", "of", "gamma/delta", "T", "cell", "receptor", "positive", "cells", "in", "pregnancy", "." ]
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7112
[ "PROBLEM", ":", "Due", "to", "the", "lack", "of", "classical", "HLA", "antigens", "on", "the", "trophoblast", ",", "fetal", "antigens", "are", "possibly", "presented", "in", "a", "non", "major", "histocompatibility", "complex", "(", "MHC", ")", "restricted", "way", "." ]
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7113
[ "Decidual", "gammadelta", "T", "cells", ",", "which", "significantly", "increase", "in", "number", "during", "pregnancy", ",", "might", "play", "a", "role", "in", "recognition", "of", "fetal", "antigens", "and", "also", "in", "determining", "the", "quality", "of", "the", "response", "to", "these", "antigens", "." ]
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7114
[ "Our", "study", "was", "aimed", "at", "investigating", "the", "role", "of", "this", "cell", "population", "in", "progesterone-dependent", "immunomodulation", "." ]
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7115
[ "METHOD", "OF", "STUDY", ":", "Peripheral", "lymphocytes", "from", "healthy", "pregnant", "women", "and", "from", "habitual", "aborters", "were", "tested", "by", "immunocytochemistry", "for", "the", "presence", "of", "gamma/delta", "T", "cell", "receptor", "(", "TCR", ")", "and", "progesterone", "receptor", "." ]
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7116
[ "To", "investigate", "the", "effect", "of", "treatment", "with", "a", "pan", "anti", "gamma/delta", "antibody", ",", "lymphocytes", "were", "incubated", "for", "3", "hr", "with", "the", "antibody", ",", "and", "then", "interleukin", "(", "IL", ")", "-10", ",", "IL-12", "and", "progesterone-induced", "blocking", "factor", "(", "PIBF", ")", "expression", "(", "by", "immuno-cytochemistry", ")", "as", "well", "as", "natural", "killer", "(", "NK", ")", "cell", "activity", "were", "determined", "." ]
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7117
[ "RESULTS", ":", "In", "peripheral", "blood", "of", "healthy", "pregnant", "women", "the", "percentage", "of", "gamma/delta", "TCR+", "cells", "was", "significantly", "higher", "(", "P", "<", "0.001", ")", "than", "in", "that", "of", "recurrent", "aborters", "or", "of", "non-pregnant", "individuals", "." ]
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7118
[ "Ninety-seven", "percent", "of", "gamma/delta", "TCR+", "pregnancy", "lymphocytes", "expressed", "progesterone", "receptor", "." ]
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7119
[ "Binding", "of", "a", "specific", "antibody", "to", "the", "gamma/delta", "TCR", "inhibited", "PIBF", "-as", "well", "as", "IL-10", "production", ",", "whereas", "it", "increased", "NK", "activity", "and", "IL-12", "expression", "." ]
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7120
[ "CONCLUSIONS", ":", "These", "data", "suggest", "the", "role", "of", "gamma/delta", "TCR-bearing", "lymphocytes", "in", "progesterone-dependent", "immunomodulation", "." ]
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7121
[ "Monocyte", "adhesion", "and", "spreading", "on", "human", "endothelial", "cells", "is", "dependent", "on", "Rho", "-regulated", "receptor", "clustering", "." ]
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7122
[ "The", "GTPase", "Rho", "is", "known", "to", "mediate", "the", "assembly", "of", "integrin-containing", "focal", "adhesions", "and", "actin", "stress", "fibers", "." ]
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7123
[ "Here", ",", "we", "investigate", "the", "role", "of", "Rho", "in", "regulating", "the", "distribution", "of", "the", "monocyte-binding", "receptors", "E-selectin", ",", "ICAM-1", ",", "and", "VCAM-1", "in", "human", "endothelial", "cells", "." ]
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7124
[ "Inhibition", "of", "Rho", "activity", "with", "C3", "transferase", "or", "N19RhoA", ",", "a", "dominant", "negative", "RhoA", "mutant", ",", "reduced", "the", "adhesion", "of", "monocytes", "to", "activated", "endothelial", "cells", "and", "inhibited", "their", "spreading", "." ]
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7125
[ "Similar", "effects", "were", "observed", "after", "pretreatment", "of", "endothelial", "cells", "with", "cytochalasin", "D", "." ]
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7126
[ "In", "contrast", ",", "dominant", "negative", "Rac", "and", "Cdc42", "proteins", "did", "not", "affect", "monocyte", "adhesion", "or", "spreading", "." ]
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7127
[ "C3", "transferase", "and", "cytochalasin", "D", "did", "not", "alter", "the", "expression", "levels", "of", "monocyte-binding", "receptors", "on", "endothelial", "cells", ",", "but", "did", "inhibit", "clustering", "of", "E-selectin", ",", "ICAM-1", ",", "and", "VCAM-1", "on", "the", "cell", "surface", "induced", "by", "monocyte", "adhesion", "or", "cross-linking", "antibodies", "." ]
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7128
[ "Similarly", ",", "N19RhoA", "inhibited", "receptor", "clustering", "." ]
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7129
[ "Monocyte", "adhesion", "and", "receptor", "cross-linking", "induced", "stress", "fiber", "assembly", ",", "and", "inhibitors", "of", "myosin", "light", "chain", "kinase", "prevented", "this", "response", "but", "did", "not", "affect", "receptor", "clustering", "." ]
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7130
[ "Finally", ",", "receptor", "clusters", "colocalized", "with", "ezrin/moesin/radixin", "proteins", "." ]
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7131
[ "These", "results", "suggest", "that", "Rho", "is", "required", "in", "endothelial", "cells", "for", "the", "assembly", "of", "stable", "adhesions", "with", "monocytes", "via", "the", "clustering", "of", "monocyte-binding", "receptors", "and", "their", "association", "with", "the", "actin", "cytoskeleton", ",", "independent", "of", "stress", "fiber", "formation", "." ]
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7132
[ "Selection", "of", "the", "T", "cell", "repertoire", "." ]
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7133
[ "Advances", "in", "gene", "technology", "have", "allowed", "the", "manipulation", "of", "molecular", "interactions", "that", "shape", "the", "T", "cell", "repertoire", "." ]
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7134
[ "Although", "recognized", "as", "fundamental", "aspects", "of", "T", "lymphocyte", "development", ",", "only", "recently", "have", "the", "mechanisms", "governing", "positive", "and", "negative", "selection", "been", "examined", "at", "a", "molecular", "level", "." ]
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7135
[ "Positive", "selection", "refers", "to", "the", "active", "process", "of", "rescuing", "MHC-restricted", "thymocytes", "from", "programmed", "cell", "death", "." ]
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7136
[ "Negative", "selection", "refers", "to", "the", "deletion", "or", "inactivation", "of", "potentially", "autoreactive", "thymocytes", "." ]
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7137
[ "This", "review", "focuses", "on", "interactions", "during", "thymocyte", "maturation", "that", "define", "the", "T", "cell", "repertoire", ",", "with", "an", "emphasis", "placed", "on", "current", "literature", "within", "this", "field", "." ]
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7138
[ "CD28", "costimulation", "augments", "IL-2", "secretion", "of", "activated", "lamina", "propria", "T", "cells", "by", "increasing", "mRNA", "stability", "without", "enhancing", "IL-2", "gene", "transactivation", "." ]
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7139
[ "The", "pathways", "leading", "to", "activation", "in", "lamina", "propria", "(", "LP", ")", "T", "cells", "are", "different", "from", "peripheral", "T", "cells", "." ]
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7140
[ "LP", "T", "cells", "exhibit", "enhanced", "IL-2", "secretion", "when", "activated", "through", "the", "CD2", "pathway", "." ]
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7141
[ "Coligation", "of", "CD28", "leads", "to", "synergistic", "enhancement", "of", "IL-2", "secretion", "." ]
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7142
[ "Previous", "studies", "have", "characterized", "the", "CD28", "augmentation", "of", "TCR", "-mediated", "signaling", "in", "peripheral", "blood", "T", "cells", "through", "transcriptional", "activation", "of", "an", "IL-2", "promoter", "CD28", "response", "element", "(", "CD28RE", ")", ",", "along", "with", "enhanced", "mRNA", "stability", "." ]
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7143
[ "This", "study", "characterized", "molecular", "events", "involved", "in", "CD28", "costimulation", "of", "IL-2", "production", "in", "LP", "mononuclear", "cells", "(", "LPMC", ")", "." ]
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7144
[ "LPMC", "exhibited", "increased", "IL-2", "production", "in", "response", "to", "CD28", "costimulation", ",", "compared", "with", "cells", "activated", "through", "CD2", "alone", "." ]
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7145
[ "IL-2", "secretion", "was", "paralleled", "by", "increased", "expression", "of", "IL-2", "mRNA", ",", "resulting", "from", "enhanced", "IL-2", "mRNA", "stability", "." ]
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7146
[ "In", "contrast", "to", "transcriptional", "activation", "in", "PBMC", ",", "EMSA", "revealed", "that", "CD28", "coligation", "of", "CD2-activated", "LPMC", "does", "not", "result", "in", "increased", "binding", "of", "trans-factors", "to", "the", "CD28RE", ",", "nor", "did", "Western", "blots", "detect", "changes", "in", "I-kappaBalpha", "or", "I-kappaBbeta", "levels", "following", "CD28", "coligation", "." ]
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7147
[ "Furthermore", ",", "CD28", "coligation", "fails", "to", "enhance", "IL-2", "promoter-reporter", "or", "RE/AP", "construct", "expression", "in", "CD2-activated", "LPMC", "." ]
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7148
[ "The", "results", "reported", "herein", "indicate", "that", "the", "molecular", "mechanisms", "involved", "in", "CD28", "cosignaling", "and", "regulation", "of", "IL-2", "secretion", "in", "LP", "T", "cells", "are", "unique", "to", "that", "compartment", "and", "differ", "from", "those", "seen", "in", "peripheral", "blood", "T", "cells", "." ]
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7149
[ "These", "observations", "suggest", "a", "biological", "significance", "for", "different", "mechanisms", "of", "IL-2", "activation", "in", "initiation", "and", "maintenance", "of", "the", "cytokine", "repertoire", "found", "in", "the", "mucosa", "." ]
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7150
[ "Expression", "of", "Th1", "and", "Th2", "type", "cytokines", "responding", "to", "HBsAg", "and", "HBxAg", "in", "chronic", "hepatitis", "B", "patients", "." ]
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7151
[ "The", "cytokine", "pattern", "on", "viral", "antigen", "recognition", "is", "believed", "to", "exert", "a", "profound", "influence", "on", "the", "resolution", "of", "viral", "infections", "and", "viral", "clearance", "." ]
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7152
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7153
[ "Cytokine", "profiles", "of", "peripheral", "blood", "mononuclear", "cells", "associated", "with", "chronic", "hepatitis", "B", "were", "analysed", "by", "RT-PCR", "." ]
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7154
[ "Upon", "HBsAg", "stimulation", ",", "expression", "of", "IFN-gamma", ",", "IL-2", ",", "IL-4", ",", "and", "IL-10", "was", "detected", "in", "41", "%", ",", "8", "%", ",", "41", "%", ",", "and", "50", "%", "of", "the", "patients", ",", "respectively", "." ]
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7155
[ "Among", "these", "cytokines", ",", "the", "expression", "of", "IFN-gamma", "was", "associated", "with", "high", "levels", "of", "serum", "AST/ALT", "." ]
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7156
[ "However", ",", "we", "could", "not", "prove", "that", "Th2", "type", "cytokines", "had", "a", "protective", "effect", "on", "hepatocytes", "." ]
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7157
[ "Upon", "HBxAg", "stimulation", ",", "there", "was", "no", "recognizable", "association", "of", "cytokine", "patterns", "with", "AST/ALT", "levels", "." ]
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7158
[ "In", "conclusion", ",", "production", "of", "a", "Th1", "cytokine", ",", "IFN-gamma", ",", "by", "HBsAg", "-reactive", "cells", "was", "associated", "with", "hepatocyte", "damage", "in", "chronic", "hepatitis", "B", ",", "while", "no", "counteracting", "effect", "of", "Th2", "cytokines", "produced", "by", "those", "cells", "was", "observed", "." ]
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7159
[ "Apoptosis", "and", "growth", "inhibition", "in", "malignant", "lymphocytes", "after", "treatment", "with", "arsenic", "trioxide", "at", "clinically", "achievable", "concentrations", "[", "see", "comments", "]" ]
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7160
[ "BACKGROUND", ":", "Arsenic", "trioxide", "(", "As2O3", ")", "can", "induce", "clinical", "remission", "in", "patients", "with", "acute", "promyelocytic", "leukemia", "via", "induction", "of", "differentiation", "and", "programmed", "cell", "death", "(", "apoptosis", ")", "." ]
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7161
[ "We", "investigated", "the", "effects", "of", "As2O3", "on", "a", "panel", "of", "malignant", "lymphocytes", "to", "determine", "whether", "growth-inhibitory", "and", "apoptotic", "effects", "of", "As2O3", "can", "be", "observed", "in", "these", "cells", "at", "clinically", "achievable", "concentrations", "." ]
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7162
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7163
[ "Apoptosis", "was", "assessed", "by", "cell", "morphology", ",", "flow", "cytometry", ",", "annexin", "V", "protein", "level", ",", "and", "terminal", "deoxynucleotidyl", "transferase", "labeling", "of", "DNA", "fragments", "." ]
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7164
[ "Cellular", "proliferation", "was", "determined", "by", "5-bromo-2'-deoxyuridine", "incorporation", "into", "DNA", "and", "flow", "cytometry", "and", "by", "use", "of", "a", "mitotic", "arrest", "assay", "." ]
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7165
[ "Mitochondrial", "transmembrane", "potential", "(", "delta", "psi", "(", "m", ")", ")", "was", "measured", "by", "means", "of", "rhodamine", "123", "staining", "and", "flow", "cytometry", "." ]
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7166
[ "Protein", "expression", "was", "assessed", "by", "western", "blot", "analysis", "or", "immunofluorescence", "." ]
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7167
[ "RESULTS", ":", "Therapeutic", "concentrations", "of", "As2O3", "(", "1-2", "microM", ")", "had", "dual", "effects", "on", "malignant", "lymphocytes", ":", "1", ")", "inhibition", "of", "growth", "through", "adenosine", "triphosphate", "(", "ATP", ")", "depletion", "and", "prolongation", "of", "cell", "cycle", "time", "and", "2", ")", "induction", "of", "apoptosis", "." ]
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7168
[ "As2O3-induced", "apoptosis", "was", "preceded", "by", "delta", "psi", "(", "m", ")", "collapse", "." ]
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7169
[ "DTT", "antagonized", "and", "BSO", "enhanced", "As2O3-induced", "ATP", "depletion", ",", "delta", "psi", "(", "m", ")", "collapse", ",", "and", "apoptosis", "." ]
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7170
[ "Caspase-3", "activation", ",", "usually", "resulting", "from", "delta", "psi", "(", "m", ")", "collapse", ",", "was", "not", "always", "associated", "with", "As2O3-induced", "apoptosis", "." ]
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7171
[ "As2O3", "induced", "PML", "(", "promyelocytic", "leukemia", ")", "protein", "degradation", "but", "did", "not", "modulate", "expression", "of", "cell", "cycle-related", "proteins", ",", "including", "c-myc", ",", "retinoblastoma", "protein", ",", "cyclin-dependent", "kinase", "4", ",", "cyclin", "D1", ",", "and", "p53", ",", "or", "expression", "of", "differentiation-related", "antigens", "." ]
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7172
[ "CONCLUSIONS", ":", "Substantial", "growth", "inhibition", "and", "apoptosis", "without", "evidence", "of", "differentiation", "were", "induced", "in", "most", "malignant", "lymphocytic", "cells", "treated", "with", "1-2", "microM", "As2O3", "." ]
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7173
[ "As2O3", "may", "prove", "useful", "in", "the", "treatment", "of", "malignant", "lymphoproliferative", "disorders", "." ]
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7174
[ "Control", "of", "cell", "cycle", "entry", "and", "apoptosis", "in", "B", "lymphocytes", "infected", "by", "Epstein-Barr", "virus", "." ]
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7175
[ "Infection", "of", "human", "B", "cells", "with", "Epstein-Barr", "virus", "(", "EBV", ")", "results", "in", "activation", "of", "the", "cell", "cycle", "and", "cell", "growth", "." ]
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7176
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7177
[ "In", "EBV", "infection", "most", "of", "the", "changes", ",", "including", "the", "early", "induction", "of", "cyclin", "D2", ",", "are", "dependent", "on", "expression", "of", "EBV", "genes", ",", "but", "an", "alteration", "in", "the", "E2F-4", "profile", "was", "partly", "independent", "of", "viral", "gene", "expression", ",", "presumably", "occurring", "in", "response", "to", "signal", "transduction", "activated", "when", "the", "virus", "binds", "to", "its", "receptor", ",", "CD21", "." ]
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7178
[ "By", "comparing", "the", "expression", "of", "genes", "controlling", "apoptosis", ",", "including", "those", "encoding", "several", "members", "of", "the", "BCL-2", "family", "of", "proteins", ",", "the", "known", "relative", "resistance", "of", "EBV-immortalized", "B-cell", "lines", "to", "apoptosis", "induced", "by", "low", "serum", "was", "found", "to", "correlate", "with", "expression", "of", "both", "BCL-2", "and", "A20", "." ]
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7179
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7180
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7181
[ "CTLA-4", "-Mediated", "inhibition", "of", "early", "events", "of", "T", "cell", "proliferation", "." ]
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7182
[ "CTLA-4", "engagement", "by", "mAbs", "inhibits", ",", "while", "CD28", "enhances", ",", "IL-2", "production", "and", "proliferation", "upon", "T", "cell", "activation", "." ]
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7183
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7184
[ "CTLA-4", "ligation", "inhibited", "CD3/", "CD28", "-induced", "IL-2", "mRNA", "accumulation", "by", "inhibiting", "IL-2", "transcription", ",", "which", "appears", "to", "be", "mediated", "in", "part", "through", "decreasing", "NF-AT", "accumulation", "in", "the", "nuclei", "." ]
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7185
[ "However", ",", "CTLA-4", "ligation", "did", "not", "appear", "to", "affect", "the", "CD28", "-mediated", "stabilization", "of", "IL-2", "mRNA", "." ]
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7186
[ "Further", ",", "CTLA-4", "engagement", "inhibited", "progression", "through", "the", "cell", "cycle", "by", "inhibiting", "the", "production", "of", "cyclin", "D3", ",", "cyclin-dependent", "kinase", "(", "cdk", ")", "4", ",", "and", "cdk6", "when", "the", "T", "cells", "were", "stimulated", "with", "anti-CD3/CD28", "and", "with", "anti-CD3", "alone", "." ]
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7187
[ "These", "results", "indicate", "that", "CTLA-4", "signaling", "inhibits", "events", "early", "in", "T", "cell", "activation", "both", "at", "IL-2", "transcription", "and", "at", "the", "level", "of", "IL-2", "-independent", "events", "of", "the", "cell", "cycle", ",", "and", "does", "not", "simply", "oppose", "CD28", "-mediated", "costimulation", "." ]
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7188
[ "The", "glucocorticoid", "receptor", "cooperates", "with", "the", "erythropoietin", "receptor", "and", "c-Kit", "to", "enhance", "and", "sustain", "proliferation", "of", "erythroid", "progenitors", "in", "vitro", "." ]
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7189
[ "Although", "erythropoietin", "(", "Epo", ")", "is", "essential", "for", "the", "production", "of", "mature", "red", "blood", "cells", ",", "the", "cooperation", "with", "other", "factors", "is", "required", "for", "a", "proper", "balance", "between", "progenitor", "proliferation", "and", "differentiation", "." ]
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7190
[ "In", "avian", "erythroid", "progenitors", ",", "steroid", "hormones", "cooperate", "with", "tyrosine", "kinase", "receptors", "to", "induce", "renewal", "of", "erythroid", "progenitors", "." ]
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7191
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7192
[ "Dexamethasone", "(", "Dex", ")", ",", "a", "synthetic", "glucocorticoid", "hormone", ",", "cooperated", "with", "Epo", "and", "stem", "cell", "factor", "to", "induce", "erythroid", "progenitors", "to", "undergo", "15", "to", "22", "cell", "divisions", ",", "corresponding", "to", "a", "10", "(", "5", ")", "-", "to", "10", "(", "6", ")", "-fold", "amplification", "of", "erythroid", "cells", "." ]
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7193
[ "Dex", "acted", "directly", "on", "erythroid", "progenitors", "and", "maintained", "the", "colony-forming", "capacity", "of", "the", "progenitor", "cells", "expanded", "in", "liquid", "cultures", "." ]
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7194
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7195
[ "Sustained", "proliferation", "of", "erythroid", "progenitors", "could", "be", "induced", "equally", "well", "from", "purified", "erythroid", "burst-forming", "units", "(", "BFU-E", ")", ",", "from", "CD34", "(", "+", ")", "blast", "cells", ",", "and", "from", "bone", "marrow", "depleted", "from", "CD34", "(", "+", ")", "cells", "." ]
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7196
[ "NF-kappaB", "functions", "as", "both", "a", "proapoptotic", "and", "antiapoptotic", "regulatory", "factor", "within", "a", "single", "cell", "type", "." ]
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7197
[ "Recently", "NF-kappaB", "has", "been", "shown", "to", "have", "both", "proapoptotic", "and", "antiapoptotic", "functions", "." ]
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7198
[ "In", "T", "cell", "hybridomas", ",", "both", "T", "cell", "activators", "and", "glucocorticoids", "induce", "apoptosis", "." ]
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7199
[ "Here", "we", "show", "that", "blockade", "of", "NF-kappaB", "activity", ",", "using", "a", "dominant", "negative", "IkappaBalpha", ",", "has", "opposite", "effects", "on", "these", "two", "apoptotic", "signals", "." ]
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7200
[ "Treatment", "with", "PMA", "plus", "ionomycin", "(", "P/I", ")", "results", "in", "the", "upregulation", "of", "Fas", "Ligand", "(", "FasL", ")", "and", "induction", "of", "apoptosis", "." ]
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