Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
7001
[ "RCC-S", "did", "not", "alter", "the", "cytoplasmic", "levels", "of", "RelA", "and", "NF-kappaB1", "but", "did", "suppress", "their", "nuclear", "localization", "and", "inhibited", "the", "activation", "of", "RelA/NF-kappaB1", "binding", "complexes", "." ]
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7002
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7003
[ "It", "also", "appears", "that", "NF-kappaB", "suppression", "by", "RCC-S", "may", "contribute", "to", "the", "immunosuppression", "of", "host", "immunity", "." ]
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7004
[ "STAT1", "activation", "during", "monocyte", "to", "macrophage", "maturation", ":", "role", "of", "adhesion", "molecules", "." ]
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7005
[ "Human", "monocytes", "isolated", "from", "peripheral", "blood", "of", "healthy", "donors", "show", "a", "time-dependent", "differentiation", "into", "macrophages", "upon", "in", "vitro", "cultivation", ",", "closely", "mimicking", "their", "in", "vivo", "migration", "and", "maturation", "into", "extravascular", "tissues", "." ]
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7006
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7007
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7008
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7009
[ "Moreover", ",", "the", "effect", "of", "cell", "adhesion", "to", "fibronectin", "or", "laminin", "was", "studied", "to", "investigate", "mechanisms", "involved", "in", "STAT1", "activation", "." ]
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7010
[ "Compared", "with", "monocytes", "adherent", "on", "plastic", "surfaces", ",", "freshly", "isolated", "cells", "allowed", "to", "adhere", "either", "to", "fibronectin-", "or", "laminin-coated", "flasks", "exhibited", "an", "increased", "STAT1", "binding", "activity", "both", "in", "control", "and", "in", "IFN-gamma-treated", "cells", "." ]
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7011
[ "The", "molecular", "events", "leading", "to", "enhanced", "STAT1", "activation", "and", "cytokine", "responsiveness", "concerned", "both", "Y701", "and", "S727", "STAT1", "phosphorylation", "." ]
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7012
[ "Exogenous", "addition", "of", "transforming", "growth", "factor-beta", ",", "which", "exerts", "an", "inhibitory", "effect", "on", "some", "monocytic", "differentiation", "markers", ",", "inhibited", "macrophage", "maturation", ",", "integrin", "expression", "and", "STAT1", "binding", "activity", "." ]
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7013
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7014
[ "Expression", "and", "role", "of", "PML", "gene", "in", "normal", "adult", "hematopoiesis", ":", "functional", "interaction", "between", "PML", "and", "Rb", "proteins", "in", "erythropoiesis", "." ]
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7015
[ "The", "expression", "of", "the", "PML", "gene", "was", "investigated", "in", "purified", "early", "hematopoietic", "progenitor", "cells", "(", "HPCs", ")", "induced", "to", "unilineage", "erythroid", "or", "granulocytic", "differentiation", "." ]
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7016
[ "PML", "mRNA", "and", "protein", ",", "while", "barely", "detectable", "in", "quiescent", "HPCs", ",", "are", "consistently", "induced", "by", "growth", "factor", "stimulation", "through", "the", "erythroid", "or", "granulocytic", "lineage", "." ]
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7017
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7018
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7019
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7020
[ "These", "findings", "suggest", "that", "PML", "is", "required", "for", "early", "hematopoiesis", "and", "erythroid", ",", "but", "not", "granulocytic", "maturation", "." ]
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7021
[ "The", "pattern", "of", "PML", "expression", "in", "normal", "hematopoiesis", "mimics", "that", "of", "retinoblastoma", "pRb", "105", "." ]
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7022
[ "Combined", "treatment", "of", "HPCs", "with", "alpha-PML", "and", "alpha-Rb", "oligomers", "inhibited", "both", "PML", "and", "Rb", "protein", "expression", "and", "completely", "blocked", "erythroid", "colony", "development", "." ]
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7023
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7024
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7025
[ "Binding", "characteristics", "of", "the", "glucocorticoid", "receptor", "in", "peripheral", "blood", "lymphocytes", "in", "multiple", "sclerosis", "." ]
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7026
[ "Although", "the", "exact", "etiology", "of", "multiple", "sclerosis", "(", "MS", ")", "remains", "unresolved", ",", "immune", "reactions", "are", "believed", "to", "be", "the", "central", "pathogenic", "mechanisms", "." ]
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7027
[ "Endogenous", "and", "therapeutic", "steroid", "hormones", "affect", "the", "immune", "system", ",", "and", "inflammatory", "diseases", "are", "associated", "with", "activation", "of", "the", "hypothalamic-pituitary-adrenal", "axis", ",", "providing", "evidence", "of", "an", "immune-endocrine", "interplay", "." ]
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7028
[ "Function", "tests", "in", "MS", "have", "revealed", "dysregulation", "of", "the", "hypothalamic-pituitary-adrenal", "system", "in", "a", "substantial", "proportion", "of", "patients", "." ]
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7029
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7030
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7031
[ "No", "effect", "of", "age", ",", "sex", ",", "course", ",", "duration", "or", "severity", "of", "disease", ",", "or", "prior", "steroid", "treatments", "was", "detected", "." ]
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7032
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7033
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7034
[ "These", "data", "suggest", "that", "the", "physiological", "relationship", "between", "binding", "and", "function", "of", "the", "glucocorticoid", "receptor", "is", "disturbed", "in", "MS", "." ]
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7035
[ "Phorbol", "ester-induced", "mononuclear", "cell", "differentiation", "is", "blocked", "by", "the", "mitogen-activated", "protein", "kinase", "kinase", "(", "MEK", ")", "inhibitor", "PD98059", "." ]
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7036
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7037
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7038
[ "The", "activity", "of", "JNK1", "was", "also", "significantly", "induced", ",", "with", "JNK1", "protein", "levels", "increasing", "moderately", "during", "exposure", "to", "TPA", "." ]
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7039
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7040
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7041
[ "We", "conclude", "that", "activation", "of", "the", "MEK", "/ERK", "signaling", "pathway", "is", "necessary", "for", "TPA-induced", "mononuclear", "cell", "differentiation", "." ]
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7042
[ "Glucocorticoid", "receptors", "in", "anorexia", "nervosa", "and", "Cushing", "'s", "disease", "." ]
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7043
[ "BACKGROUND", ":", "Patients", "with", "anorexia", "nervosa", "do", "not", "display", "cushingoid", "features", "in", "spite", "of", "elevated", "cortisol", "plasma", "levels", "." ]
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7044
[ "Whether", "a", "cortisol", "resistance", "or", "a", "reduced", "availability", "of", "the", "metabolic", "substrates", "necessary", "to", "develop", "the", "effect", "of", "glucocorticoids", "is", "responsible", "for", "this", "has", "not", "been", "established", "." ]
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7045
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7046
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7047
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7048
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7049
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7050
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