Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
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sequence
ner_tags
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6801
[ "To", "begin", "to", "elucidate", "the", "mechanisms", "that", "regulate", "the", "transcription", "of", "cytokine", "genes", ",", "we", "wanted", "to", "determine", "which", "transcription", "factors", "are", "activated", "by", "PGN", "in", "mouse", "RAW264.7", "and", "human", "THP-1", "macrophage", "cells", "." ]
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6802
[ "Our", "results", "demonstrated", "that", ":", "(", "i", ")", "PGN", "induced", "phosphorylation", "of", "the", "transcription", "factors", "ATF-1", "and", "CREB", ";", "(", "ii", ")", "ATF-1", "and", "CREB", "bound", "DNA", "as", "a", "dimer", "and", "induced", "transcriptional", "activation", "of", "a", "CRE", "reporter", "plasmid", ",", "which", "was", "inhibited", "by", "dominant", "negative", "CREB", "and", "ATF-1", ";", "(", "iii", ")", "PGN", "induced", "phosphorylation", "of", "c-Jun", ",", "protein", "synthesis", "of", "JunB", "and", "c-Fos", ",", "and", "transcriptional", "activation", "of", "the", "AP-1", "reporter", "plasmid", ",", "which", "was", "inhibited", "by", "dominant", "negative", "c-Fos", ";", "and", "(", "iv", ")", "PGN-induced", "activation", "of", "CREB/ATF", "and", "AP-1", "was", "mediated", "through", "CD14", "." ]
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6803
[ "This", "is", "the", "first", "study", "to", "demonstrate", "activation", "of", "CREB/ATF", "and", "AP-1", "transcription", "factors", "by", "PGN", "or", "by", "any", "other", "component", "of", "Gram-positive", "bacteria", "." ]
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6804
[ "Glucocorticoid", "receptors", "are", "down-regulated", "in", "inflamed", "colonic", "mucosa", "but", "not", "in", "peripheral", "blood", "mononuclear", "cells", "from", "patients", "with", "inflammatory", "bowel", "disease", "[", "see", "comments", "]" ]
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6805
[ "BACKGROUND", ":", "Growing", "evidence", "indicates", "that", "the", "immune", "system", "and", "the", "hypothalamic-pituitary-adrenal", "system", "are", "linked", "by", "several", "mechanisms", ",", "for", "example", "intracellular", "glucocorticoid", "receptors", "(", "hGR", ")", "." ]
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6806
[ "Glucocorticoids", "are", "the", "standard", "treatment", "of", "acute", "attacks", "of", "inflammatory", "bowel", "disease", "(", "IBD", ")", "." ]
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6807
[ "Binding", "of", "glucocorticoids", "to", "hGR", "down-regulates", "the", "transcription", "of", "inflammatory", "genes", "that", "can", "propagate", "IBD", "." ]
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6808
[ "PATIENTS", "AND", "METHODS", ":", "IBD", "patients", "were", "either", "treated", "with", "5-60", "mg", "of", "prednisolone", "for", "more", "than", "1", "week", "or", "were", "without", "glucocorticoid", "treatment", "for", "more", "than", "4", "weeks", "." ]
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6809
[ "hGR", "levels", "were", "determined", "from", "isolated", "cytosol", "of", "peripheral", "blood", "mononuclear", "cells", "(", "PBMCs", ")", "or", "mucosal", "biopsies", "using", "a", "radioassay", "with", "[", "3H", "]", "-dexamethasone", "." ]
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6810
[ "Interleukin", "(", "IL", ")", "6", "levels", "were", "determined", "by", "enzyme-linked", "immunosorbent", "assay", "(", "ELISA", ")", "." ]
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6811
[ "RESULTS", ":", "The", "systemic", "(", "PBMC", ")", "hGR", "levels", "of", "corticosteroid-treated", "IBD", "patients", "were", "significantly", "lower", "than", "those", "of", "control", "subjects", "(", "59.6", "+/-", "57.1", "dpm", "mg-1", "cytosol", "protein", "vs", "." ]
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6812
[ "227.0", "+/-", "90.8", "dpm", "mg-1", "cytosol", "protein", ",", "P", "=", "0.007", ")", "and", "IBD", "patients", "not", "receiving", "glucocorticoid", "treatment", "(", "179.7", "+/-", "171.3", "dpm", "mg-1", "cytosol", "protein", ",", "P", "=", "0.002", ")", "." ]
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6813
[ "Systemic", "hGR", "levels", "in", "untreated", "IBD", "patients", "did", "not", "differ", "significantly", "from", "those", "in", "control", "subjects", "." ]
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6814
[ "In", "patients", "with", "connective", "tissue", "diseases", ",", "systemic", "hGR", "levels", "were", "also", "found", "to", "be", "decreased", "in", "the", "absence", "of", "glucocorticoid", "treatment", "." ]
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6815
[ "Systemic", "hGR", "levels", "in", "patients", "with", "Crohn", "'s", "disease", "(", "CD", ")", "treated", "with", "steroids", "(", "66.6", "+/-", "61.0", "dpm", "mg-1", "cytosol", "protein", ")", "were", "not", "different", "from", "those", "in", "patients", "with", "ulcerative", "colitis", "(", "UC", ")", "(", "56.1", "+/-", "51.6", "dpm", "mg-1", "cytosol", "protein", ")", "." ]
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6816
[ "In", "contrast", "to", "these", "findings", ",", "mucosal", "hGR", "levels", "were", "significantly", "decreased", "in", "both", "steroid-treated", "(", "18.0", "+/-", "15.5", ")", "and", "not", "steroid-treated", "(", "37.8", "+/-", "30.5", ")", "patients", "compared", "with", "control", "subjects", "(", "125.6", "+/-", "97.1", ";", "P", "=", "0.00009", "and", "P", "=", "0.0008", "respectively", ")", "." ]
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6817
[ "IL-6", "levels", "in", "all", "IBD", "groups", "with", "and", "without", "steroids", "were", "significantly", "different", "from", "those", "in", "control", "subjects", "." ]
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6818
[ "CONCLUSION", ":", "In", "IBD", "there", "is", "no", "difference", "in", "systemic", "hGR", "levels", "between", "not", "steroid-treated", "patients", "and", "control", "subjects", ",", "in", "spite", "of", "inflammatory", "activity", "(", "IL-6", ")", "." ]
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6819
[ "Mucosal", "hGR", "levels", "were", "decreased", "independently", "of", "treatment", ",", "probably", "leading", "to", "a", "decreased", "protection", "against", "NF-kappaB", "action", "in", "the", "intestinal", "mucosa", "." ]
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6820
[ "ICSAT", "overexpression", "is", "not", "sufficient", "to", "cause", "adult", "T-cell", "leukemia", "or", "multiple", "myeloma", "." ]
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6821
[ "ICSAT", "(", "Interferon", "Consensus", "Sequence", "binding", "protein", "for", "Activated", "T", "cells", ")", "is", "a", "lymphocyte-specific", "member", "of", "the", "interferon", "regulatory", "factor", "(", "IRF", ")", "family", "of", "transcription", "factors", ",", "originally", "identified", "through", "Southwestern", "screening", "of", "the", "ATL", "(", "Adult", "T-cell", "leukemia", ")", "-16T", "expression", "library", "." ]
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6822
[ "In", "this", "study", ",", "we", "created", "transgenic", "mice", "overexpressing", "ICSAT", "in", "lymphocytes", "." ]
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6823
[ "Although", "spontaneous", "tumorigenesis", "was", "not", "observed", ",", "IL-2", "production", "with", "Concanavalin", "A", "stimulation", "was", "significantly", "increased", "in", "transgenic", "mice", "overexpressing", "ICSAT", "." ]
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6824
[ "ICSAT", "overexpression", "in", "lymphocytes", "seems", "insufficient", "for", "the", "leukemogenesis", "of", "ATL", "or", "multiple", "myeloma", "(", "MM", ")", ",", "however", ",", "it", "may", "regulate", "T", "cell", "activation", "and", "its", "overexpression", "may", "lead", "to", "leukemogenesis", "via", "controlling", "IL-2", "production", "." ]
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6825
[ "Copyright", "1999", "Academic", "Press", "." ]
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6826
[ "Altered", "memory", "T", "cell", "differentiation", "in", "patients", "with", "early", "rheumatoid", "arthritis", "." ]
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6827
[ "The", "chronic", "immune", "response", "in", "rheumatoid", "arthritis", "(", "RA", ")", "might", "be", "driven", "by", "activated", "Th1", "cells", "without", "sufficient", "Th2", "cell", "differentiation", "to", "down-modulate", "inflammation", "." ]
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6828
[ "To", "test", "whether", "disordered", "memory", "T", "cell", "differentiation", "contributes", "to", "the", "typical", "Th1-dominated", "chronic", "inflammation", "in", "RA", "we", "investigated", "differentiation", "of", "resting", "CD4+", "memory", "T", "cells", "in", "patients", "with", "early", "(", "6", "wk", "to", "12", "mo", ")", "untreated", "RA", "and", "in", "age-", "and", "sex-matched", "healthy", "controls", "in", "vitro", "." ]
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6829
[ "No", "difference", "in", "cytokine", "secretion", "profiles", "of", "freshly", "isolated", "memory", "T", "cells", "was", "detected", "between", "patients", "and", "controls", "." ]
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6830
[ "A", "cell", "culture", "system", "was", "then", "employed", "that", "permitted", "the", "differentiation", "of", "Th", "effectors", "from", "resting", "memory", "T", "cells", "by", "short", "term", "priming", "." ]
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6831
[ "Marked", "differences", "were", "found", "in", "response", "to", "priming", "." ]
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6832
[ "Th2", "cells", "could", "be", "induced", "in", "all", "healthy", "controls", "by", "priming", "with", "anti-CD28", "in", "the", "absence", "of", "TCR", "ligation", "." ]
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6833
[ "By", "contrast", ",", "priming", "under", "those", "conditions", "resulted", "in", "Th2", "differentiation", "in", "only", "9", "of", "24", "RA", "patients", "." ]
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6834
[ "Exogenous", "IL-4", "could", "overcome", "the", "apparent", "Th2", "differentiation", "defect", "in", "seven", "patients", "but", "was", "without", "effect", "in", "the", "remaining", "eight", "patients", "." ]
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6835
[ "In", "all", "patients", "a", "marked", "decrease", "in", "IL-2-producing", "cells", "and", "a", "significant", "increase", "in", "well-differentiated", "Th1", "cells", "that", "produced", "IFN-gamma", "but", "not", "IL-2", "were", "evident", "after", "priming", "with", "anti-CD3", "and", "anti-CD28", "." ]
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6836
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6837
[ "The", "intracellular", "parasite", "Theileria", "parva", "protects", "infected", "T", "cells", "from", "apoptosis", "." ]
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6838
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6839
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6840
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6841
[ "The", "biological", "significance", "of", "NF-kappaB", "activation", "in", "T.", "parva-infected", "cells", ",", "however", ",", "has", "not", "yet", "been", "defined", "." ]
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6842
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6843
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6844
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6845
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6846
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6847
[ "Genetic", "variation", "in", "cytokine", "promoter", "regions", "is", "postulated", "to", "influence", "susceptibility", "to", "infection", ",", "but", "the", "molecular", "mechanisms", "by", "which", "such", "polymorphisms", "might", "affect", "gene", "regulation", "are", "unknown", "." ]
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6848
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6849
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6850
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6851
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6854
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6855
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6862
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6863
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6864
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6865
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6866
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6867
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6868
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6869
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6870
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6874
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6875
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6876
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6877
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6878
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6879
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6880
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6881
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6884
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6885
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6887
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6888
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6890
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6891
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6892
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6893
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6894
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6895
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6896
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6897
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6898
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6899
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6900
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