Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
6601
[ "The", "nuclear", "localization", "of", "Delta19", "definitively", "demonstrates", "that", "the", "mechanisms", "by", "which", "beta-catenin", "localizes", "in", "the", "nucleus", "are", "completely", "independent", "of", "LEF/TCF", "factors", "." ]
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6602
[ "beta-Catenin", "and", "LEF-1", "complexes", "can", "activate", "reporter", "gene", "expression", "in", "a", "transformed", "T-lymphocyte", "cell", "line", "(", "Jurkat", ")", "but", "not", "in", "normal", "T", "lymphocytes", ",", "even", "though", "both", "factors", "are", "nuclear", "." ]
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6603
[ "Thus", ",", "localization", "of", "both", "factors", "to", "the", "nucleus", "is", "not", "sufficient", "for", "activation", "of", "gene", "expression", "." ]
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6604
[ "Excess", "beta-catenin", "can", "squelch", "reporter", "gene", "activation", "by", "LEF-1-beta-catenin", "complexes", "but", "not", "activation", "by", "the", "transcription", "factor", "VP16", "." ]
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6605
[ "Taken", "together", ",", "these", "data", "suggest", "that", "a", "third", "component", "is", "necessary", "for", "gene", "activation", "and", "that", "this", "third", "component", "may", "vary", "with", "cell", "type", "." ]
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6606
[ "Control", "of", "lymphocyte", "development", "by", "the", "Ikaros", "gene", "family", "." ]
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6607
[ "Lymphoid", "cell", "differentiation", "relies", "on", "precisely", "orchestrated", "gene", "activation", "and", "repression", "events", "." ]
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6608
[ "Gene", "targeting", "studies", "have", "demonstrated", "crucial", "roles", "for", "the", "transcription", "factors", "Ikaros", "and", "Aiolos", "in", "regulating", "multiple", "stages", "of", "B", "and", "T", "cell", "development", "." ]
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6609
[ "Recent", "experiments", "suggest", "that", "Ikaros", "and", "Aiolos", "set", "B", "cell", "antigen-receptor", "(", "BCR", ")", "-", "and", "TCR-mediated", "signaling", "thresholds", "and", "that", "the", "molecules", "exist", "within", "T", "cells", "in", "nuclear", "complexes", "that", "contain", "nucleosome", "remodeling", "and", "histone", "deacetylase", "activities", "." ]
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6610
[ "Transcriptional", "targeting", "of", "retroviral", "vectors", "to", "the", "erythroblastic", "progeny", "of", "transduced", "hematopoietic", "stem", "cells", "." ]
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6611
[ "Targeted", "expression", "to", "specific", "tissues", "or", "cell", "lineages", "is", "a", "necessary", "feature", "of", "a", "gene", "therapy", "vector", "for", "many", "clinical", "applications", ",", "such", "as", "correction", "of", "hemoglobinopathies", "or", "thalassemias", "by", "transplantation", "of", "genetically", "modified", "hematopoietic", "stem", "cells", "." ]
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6612
[ "We", "developed", "retroviral", "vectors", "in", "which", "the", "constitutive", "viral", "enhancer", "in", "the", "U3", "region", "of", "the", "3", "'", "LTR", "is", "replaced", "by", "an", "autoregulatory", "enhancer", "of", "the", "erythroid-specific", "GATA-1", "transcription", "factor", "gene", "." ]
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6613
[ "The", "replaced", "enhancer", "is", "propagated", "to", "the", "5", "'", "LTR", "upon", "integration", "into", "the", "target", "cell", "genome", "." ]
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6614
[ "The", "modified", "vectors", "were", "used", "to", "transduce", "human", "hematopoietic", "cell", "lines", ",", "cord", "blood-derived", "CD34", "(", "+", ")", "stem/progenitor", "cells", ",", "and", "murine", "bone", "marrow", "repopulating", "stem", "cells", "." ]
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6615
[ "The", "expression", "of", "appropriate", "reporter", "genes", "(", "triangle", "upLNGFR", ",", "EGFP", ")", "was", "analyzed", "in", "the", "differentiated", "progeny", "of", "transduced", "stem", "cells", "in", "vitro", ",", "in", "liquid", "culture", "as", "well", "as", "in", "clonogenic", "assay", ",", "and", "in", "vivo", ",", "after", "bone", "marrow", "transplantation", "in", "lethally", "irradiated", "mice", "." ]
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6616
[ "The", "GATA-1", "autoregulatory", "enhancer", "effectively", "restricts", "the", "expression", "of", "the", "LTR-driven", "proviral", "transcription", "unit", "to", "the", "erythroblastic", "progeny", "of", "both", "human", "progenitors", "and", "mouse-repopulating", "stem", "cells", "." ]
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6617
[ "Packaging", "of", "viral", "particles", ",", "integration", "into", "the", "target", "genome", ",", "and", "stability", "of", "the", "integrated", "provirus", "are", "not", "affected", "by", "the", "LTR", "modification", "." ]
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6618
[ "Enhancer", "replacement", "is", "therefore", "an", "effective", "strategy", "to", "target", "expression", "of", "a", "retroviral", "transgene", "to", "a", "specific", "progeny", "of", "transduced", "hematopoietic", "stem", "cells", "." ]
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6619
[ "Regulation", "of", "Fas", "ligand", "expression", "and", "cell", "death", "by", "apoptosis-linked", "gene", "4", "." ]
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6620
[ "Programmed", "cell", "death", "is", "a", "process", "required", "for", "the", "normal", "development", "of", "an", "organism", "." ]
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6621
[ "One", "of", "the", "best", "understood", "apoptotic", "pathways", "occurs", "in", "T", "lymphocytes", "and", "is", "mediated", "by", "Fas", "/Fas", "ligand", "(", "FasL", ")", "interaction", "." ]
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6622
[ "During", "studies", "of", "apoptosis", "induced", "by", "T", "cell-receptor", "engagement", ",", "we", "identified", "ALG-4F", ",", "a", "truncated", "transcript", "that", "prevents", "T", "cell-receptor-induced", "FasL", "upregulation", "and", "cell", "death", "." ]
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6623
[ "Overexpression", "of", "full-length", "ALG-4", "induced", "transcription", "of", "FasL", "and", ",", "consequently", ",", "apoptosis", "." ]
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6624
[ "These", "results", "indicate", "that", "ALG-4", "is", "necessary", "and", "sufficient", "for", "FasL", "expression", "." ]
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6625
[ "Fas/", "FasL", "interaction", "initiates", "cell", "death", "in", "many", "other", "systems", ",", "and", "its", "dysregulation", "is", "a", "mechanism", "by", "which", "several", "pathologic", "conditions", "arise", "." ]
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6626
[ "Understanding", "the", "molecular", "mechanisms", "of", "FasL", "regulation", "could", "be", "very", "useful", "in", "elucidating", "how", "these", "diseases", "develop", "and", "in", "identifying", "potential", "therapeutic", "targets", "." ]
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6627
[ "The", "Epstein-Barr", "virus", "oncoprotein", "latent", "membrane", "protein", "1", "engages", "the", "tumor", "necrosis", "factor", "receptor-associated", "proteins", "TRADD", "and", "receptor-interacting", "protein", "(", "RIP", ")", "but", "does", "not", "induce", "apoptosis", "or", "require", "RIP", "for", "NF-kappaB", "activation", "." ]
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6628
[ "A", "site", "in", "the", "Epstein-Barr", "virus", "(", "EBV", ")", "transforming", "protein", "LMP1", "that", "constitutively", "associates", "with", "the", "tumor", "necrosis", "factor", "receptor", "1", "(", "TNFR1", ")", "-associated", "death", "domain", "protein", "TRADD", "to", "mediate", "NF-kappaB", "and", "c-Jun", "N-terminal", "kinase", "activation", "is", "critical", "for", "long-term", "lymphoblastoid", "cell", "proliferation", "." ]
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6629
[ "We", "now", "find", "that", "LMP1", "signaling", "through", "TRADD", "differs", "from", "TNFR1", "signaling", "through", "TRADD", "." ]
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6630
[ "LMP1", "needs", "only", "11", "amino", "acids", "to", "activate", "NF-kappaB", "or", "synergize", "with", "TRADD", "in", "NF-kappaB", "activation", ",", "while", "TNFR1", "requires", "approximately", "70", "residues", "." ]
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6631
[ "Further", ",", "LMP1", "does", "not", "require", "TRADD", "residues", "294", "to", "312", "for", "NF-kappaB", "activation", ",", "while", "TNFR1", "requires", "TRADD", "residues", "296", "to", "302", "." ]
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6632
[ "LMP1", "is", "partially", "blocked", "for", "NF-kappaB", "activation", "by", "a", "TRADD", "mutant", "consisting", "of", "residues", "122", "to", "293", "." ]
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6633
[ "Unlike", "TNFR1", ",", "LMP1", "can", "interact", "directly", "with", "receptor-interacting", "protein", "(", "RIP", ")", "and", "stably", "associates", "with", "RIP", "in", "EBV-transformed", "lymphoblastoid", "cell", "lines", "." ]
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6634
[ "Surprisingly", ",", "LMP1", "does", "not", "require", "RIP", "for", "NF-kappaB", "activation", "." ]
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6635
[ "Despite", "constitutive", "association", "with", "TRADD", "or", "RIP", ",", "LMP1", "does", "not", "induce", "apoptosis", "in", "EBV-negative", "Burkitt", "lymphoma", "or", "human", "embryonic", "kidney", "293", "cells", "." ]
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6636
[ "These", "results", "add", "a", "different", "perspective", "to", "the", "molecular", "interactions", "through", "which", "LMP1", ",", "TRADD", ",", "and", "RIP", "participate", "in", "B-lymphocyte", "activation", "and", "growth", "." ]
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6637
[ "Inhibition", "of", "NF-kappa", "B", "activity", "in", "human", "T", "lymphocytes", "induces", "caspase-dependent", "apoptosis", "without", "detectable", "activation", "of", "caspase-1", "and", "-3", "." ]
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6638
[ "NF-kappa", "B", "is", "involved", "in", "the", "transcriptional", "control", "of", "various", "genes", "that", "act", "as", "extrinsic", "and", "intrinsic", "survival", "factors", "for", "T", "cells", "." ]
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6639
[ "Our", "findings", "show", "that", "suppression", "of", "NF-kappa", "B", "activity", "with", "cell-permeable", "SN50", "peptide", ",", "which", "masks", "the", "nuclear", "localization", "sequence", "of", "NF-kappa", "B1", "dimers", "and", "prevents", "their", "nuclear", "localization", ",", "induces", "apoptosis", "in", "resting", "normal", "human", "PBL", "." ]
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6640
[ "Inhibition", "of", "NF-kappa", "B", "resulted", "in", "the", "externalization", "of", "phosphatidylserine", ",", "induction", "of", "DNA", "breaks", ",", "and", "morphological", "changes", "consistent", "with", "apoptosis", "." ]
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6641
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6642
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6643
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6644
[ "Preactivation", "of", "T", "cells", "resulting", "in", "NF-kappa", "B", "nuclear", "translocation", "protected", "cells", "from", "SN50-induced", "apoptosis", "." ]
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6645
[ "Our", "findings", "demonstrate", "an", "essential", "role", "of", "NF-kappa", "B", "in", "survival", "of", "naive", "PBL", "." ]
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6646
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6647
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6648
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6649
[ "N-formyl-methionyl-leucyl-phenylalanine", "(", "FMLP", ")", "and", "phorbol", "myristate", "acetate", "(", "PMA", ")", "induced", "tyrosine", "phosphorylation", "of", "42-", "and", "44-kDa", "proteins", ",", "which", "were", "identified", "as", "extracellular", "signal-regulated", "kinase", "(", "ERK", ")", ",", "in", "human", "monocytes", "." ]
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6650
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6651
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6652
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6653
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6677
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6678
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6679
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6682
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6683
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6684
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6688
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6696
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6698
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