Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
6701
[ "OBJECTIVE", ":", "We", "aimed", "to", "find", "the", "transcriptional", "mechanisms", "that", "regulate", "the", "IL-5", "gene", "to", "selectively", "control", "IL-5", "synthesis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 9, 0, 0 ]
6702
[ "METHODS", ":", "Allergen-specific", "T-cell", "clones", "and", "T-cell", "hybridomas", "were", "established", "from", "the", "peripheral", "blood", "lymphocytes", "of", "patients", "with", "asthma", ",", "and", "the", "transcriptional", "regulation", "of", "the", "IL-5", "gene", "was", "investigated", "with", "transient", "transfection", "and", "electrophoretic", "mobility", "shift", "analysis", "." ]
[ 0, 0, 0, 5, 6, 0, 7, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6703
[ "RESULTS", ":", "A", "human", "IL-5", "promoter/enhancer-luciferase", "gene", "construct", ",", "pIL-5", "(", "-511", ")", "Luc", ",", "was", "transcribed", "on", "activation", "of", "IL-5-producing", "T-cell", "clones", ",", "but", "not", "IL-5-nonproducing", "clones", "." ]
[ 0, 0, 0, 0, 1, 2, 2, 2, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0 ]
6704
[ "pIL-5", "(", "-511", ")", "Luc", "was", "transcribed", "by", "T-cell", "hybridomas", "derived", "from", "fusion", "between", "IL-5-producing", "T-cell", "clones", "and", "an", "IL-5", "gene-nonexpressing", "T-cell", "line", ",", "but", "not", "by", "hybridomas", "derived", "from", "IL-5-nonproducing", "T-cell", "clones", "." ]
[ 1, 2, 2, 2, 2, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]
6705
[ "IL-5", "synthesis", "was", "not", "only", "induced", "by", "T-cell", "receptor", "stimulation", "but", "also", "by", "IL-2", "receptor", "stimulation", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 0, 0 ]
6706
[ "Binding", "of", "NF-AT", ",", "NF-kappaB", ",", "and", "AP-1", "was", "induced", "by", "T-cell", "receptor", "(", "TcR", ")", "stimulation", ",", "although", "there", "was", "no", "significant", "upregulation", "of", "binding", "by", "IL-2", "stimulation", "." ]
[ 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
6707
[ "CONCLUSION", ":", "IL-5", "synthesis", "by", "human", "helper", "T", "cells", "is", "regulated", "at", "the", "transcriptional", "level", "." ]
[ 0, 0, 9, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0 ]
6708
[ "A", "unique", "transcriptional", "mechanism", "distinct", "from", "those", "regulating", "the", "IL-2", "or", "IL-4", "genes", "seems", "to", "control", "the", "IL-5", "gene", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 2, 0, 0, 0, 0, 1, 2, 0 ]
6709
[ "Selective", "regulation", "of", "IL-5", "gene", "transcription", "may", "be", "useful", "for", "treating", "eosinophlic", "inflammation", "." ]
[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6710
[ "Defining", "therapeutic", "targets", "by", "using", "adenovirus", ":", "blocking", "NF-kappaB", "inhibits", "both", "inflammatory", "and", "destructive", "mechanisms", "in", "rheumatoid", "synovium", "but", "spares", "anti-inflammatory", "mediators", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6711
[ "The", "role", "of", "the", "transcription", "factor", "NF-kappaB", "in", "the", "pathogenesis", "of", "rheumatoid", "arthritis", "has", "long", "been", "a", "subject", "of", "controversy", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6712
[ "We", "used", "an", "adenoviral", "technique", "of", "blocking", "NF-kappaB", "through", "overexpression", "of", "the", "inhibitory", "subunit", "IkappaBalpha", ",", "which", "has", "the", "advantage", "that", "it", "can", "be", "used", "in", "the", "diseased", "tissue", "itself", ",", "with", ">", "90", "%", "of", "the", "synovial", "macrophages", ",", "fibroblasts", ",", "and", "T", "cells", "infected", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 7, 0, 0, 7, 8, 0, 0 ]
6713
[ "We", "found", "that", "the", "spontaneous", "production", "of", "tumor", "necrosis", "factor", "alpha", "and", "other", "pro-inflammatory", "cytokines", "is", "NF-kappaB", "-dependent", "in", "rheumatoid", "synovial", "tissue", ",", "in", "contrast", "to", "the", "main", "anti-inflammatory", "mediators", ",", "like", "IL-10", "and", "-11", ",", "and", "the", "IL-1", "receptor", "antagonist", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 9, 10, 10, 0 ]
6714
[ "Of", "even", "more", "interest", ",", "IkappaBalpha", "overexpression", "inhibited", "the", "production", "of", "matrix", "metalloproteinases", "1", "and", "3", "while", "not", "affecting", "their", "tissue", "inhibitor", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
6715
[ "Blocking", "NF-kappaB", "in", "the", "rheumatoid", "joint", "thus", "has", "a", "very", "beneficial", "profile", ",", "reducing", "both", "the", "inflammatory", "response", "and", "the", "tissue", "destruction", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6716
[ "The", "adenoviral", "technique", "described", "here", "has", "widespread", "applicability", ",", "allowing", "rapid", "testing", "of", "the", "effects", "of", "blocking", "a", "potential", "therapeutic", "target", "in", "either", "cultures", "of", "normal", "cells", "or", "in", "the", "diseased", "tissue", "itself", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6717
[ "Resistance", "to", "tumor", "necrosis", "factor", "induced", "apoptosis", "in", "vitro", "correlates", "with", "high", "metastatic", "capacity", "of", "cells", "in", "vivo", "." ]
[ 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6718
[ "TNF", "is", "one", "of", "the", "cytokines", "secreted", "by", "the", "cells", "of", "the", "immune", "system", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6719
[ "Our", "data", "demonstrate", "that", "those", "cell", "lines", "lacking", "capability", "to", "form", "metastatic", "tumors", "in", "vivo", "are", "susceptible", "to", "TNF", "induced", "apoptosis", "in", "vitro", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
6720
[ "However", ",", "cell", "lines", "with", "high", "metastatic", "potential", "are", "resistant", "to", "TNF", "in", "vitro", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
6721
[ "Furthermore", ",", "the", "same", "cell", "lines", "were", "resistant", "to", "cytolytic", "action", "of", "other", "cytotoxic", "proteins", "secreted", "by", "LAK", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
6722
[ "Our", "data", "showed", "that", "TNF", "resistance", "in", "vitro", "correlates", "with", "the", "increased", "level", "of", "transcription", "factor", "NF-kappaB", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
6723
[ "This", "finding", "may", "provide", "a", "tool", "to", "improve", "current", "protocols", "of", "immunotherapy", "and", "insights", "to", "how", "tumor", "cells", "are", "or", "are", "not", "killed", "by", "LAK", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
6724
[ "Clonality", "analysis", "of", "granulocytes", "and", "T", "lymphocytes", "in", "healthy", "females", "by", "the", "PCR-based", "HUMARA", "method", "." ]
[ 0, 0, 0, 7, 0, 7, 8, 0, 0, 0, 0, 0, 0, 1, 0, 0 ]
6725
[ "Clonality", "analysis", "utilizing", "X-chromosome", "inactivation", "has", "been", "used", "in", "the", "study", "of", "various", "diseases", ",", "including", "hematological", "malignancies", "." ]
[ 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6726
[ "The", "human", "androgen", "receptor", "gene", "(", "HUMARA", ")", "assay", "is", "the", "newest", "of", "such", "methods", ",", "and", "the", "majority", "of", "the", "female", "population", "can", "be", "assessed", "by", "this", "relatively", "simple", "procedure", "." ]
[ 0, 1, 2, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6727
[ "One", "problem", "in", "using", "these", "clonality", "analysis", "methods", ",", "however", ",", "is", "that", "there", "may", "be", "significant", "variation", "in", "Lyonization", "in", "blood", "cells", "in", "normal", "individuals", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0 ]
6728
[ "To", "determine", "the", "diversity", "in", "X-chromosome", "methylation", "patterns", ",", "which", "reflect", "Lyonization", ",", "assessed", "by", "the", "HUMARA", "assay", "in", "the", "supposedly", "normal", "population", ",", "we", "analyzed", "granulocytes", "and", "T", "cells", "from", "97", "relatively", "young", "(", "18-", "to", "35-year-old", ")", "healthy", "female", "volunteers", "." ]
[ 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6729
[ "We", "found", "that", "the", "methylation", "patterns", "in", "the", "two", "HUMARA", "alleles", "were", "distributed", "even", "more", "widely", ",", "both", "in", "granuloctyes", "and", "in", "T", "cells", ",", "than", "previously", "reported", "with", "other", "methods", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0 ]
6730
[ "We", "also", "found", "that", "the", "deviation", "of", "methylation", "in", "granulocytes", "and", "T", "cells", "was", "well", "correlated", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 8, 0, 0, 0, 0 ]
6731
[ "Thus", ",", "we", "conclude", "that", "appropriate", "controls", "from", "the", "same", "individuals", ",", "such", "as", "T", "cells", "in", "the", "case", "of", "stem", "cell", "disorders", ",", "should", "always", "be", "employed", "to", "conclusively", "determine", "whether", "certain", "cells", "of", "hematopoietic", "origin", "are", "clonal", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6732
[ "Functional", "B-cell", "response", "in", "intrahepatic", "lymphoid", "follicles", "in", "chronic", "hepatitis", "C", "." ]
[ 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6733
[ "Intrahepatic", "lymphoid", "follicle", "(", "ILF", ")", "formation", "is", "one", "of", "the", "most", "characteristic", "and", "commonly", "observed", "histological", "features", "in", "patients", "with", "chronic", "hepatitis", "C", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6734
[ "However", ",", "little", "is", "known", "regarding", "whether", "follicles", "in", "the", "liver", "belong", "to", "functional", "lymphoid", "tissues", ",", "where", "B", "cells", "are", "activated", ",", "differentiated", ",", "and", "proliferated", ",", "or", "if", "the", "lymphocytes", "are", "merely", "infiltrated", "after", "recruitment", "from", "the", "secondary", "lymphoid", "organs", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6735
[ "To", "ascertain", "this", "possibility", ",", "we", "examined", "the", "expression", "of", "markers", "for", "B-cell", "activation", ",", "differentiation", ",", "and", "proliferation", "in", "ILFs", "in", "patients", "with", "chronic", "hepatitis", "C", "using", "surgically", "resected", "specimens", ",", "and", "compared", "them", "with", "specimens", "of", "perihepatic", "lymph", "nodes", "by", "an", "immunohistochemical", "technique", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6736
[ "Germinal", "center", "(", "GC", ")", "formation", "in", "the", "ILFs", "was", "frequently", "found", "in", "HCV-positive", "cases", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6737
[ "The", "distribution", "of", "immunoglobulin", "M", "(", "IgM", ")", "-", ",", "IgD-", ",", "and", "IgG-positive", "cells", "and", "the", "expression", "patterns", "of", "Ki-67", ",", "CD23", ",", "or", "bcl-2", "and", "bcl-6", "gene", "products", "in", "the", "follicles", "with", "GC", "formation", "in", "the", "liver", "of", "patients", "with", "chronic", "hepatitis", "C", "were", "similar", "to", "those", "of", "lymph", "nodes", ",", "indicating", "that", "B", "cells", "are", "activated", ",", "proliferated", ",", "and", "differentiated", "in", "the", "ILFs", "with", "GC", "formation", "in", "patients", "with", "chronic", "hepatitis", "C", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6738
[ "Oligoclonal", "expansion", "of", "B", "cells", "in", "the", "livers", "with", "ILFs", "was", "confirmed", "by", "an", "analysis", "of", "immunoglobulin", "heavy", "chain", "(", "IgH", ")", "gene", "rearrangement", "determined", "by", "polymerase", "chain", "reaction", "(", "PCR", ")", "." ]
[ 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6739
[ "These", "data", "strongly", "suggest", "that", "ILFs", "with", "GC", "formation", ",", "which", "are", "frequently", "found", "in", "patients", "with", "chronic", "hepatitis", "C", ",", "may", "functionally", "be", "the", "same", "as", "those", "found", "in", "lymph", "nodes", "with", "respect", "to", "B-cell", "expansion", "and", "maturation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0 ]
6740
[ "Downregulation", "of", "Wilms", "'", "tumor", "gene", "(", "WT1", ")", "is", "not", "a", "prerequisite", "for", "erythroid", "or", "megakaryocytic", "differentiation", "of", "the", "leukemic", "cell", "line", "K562", "." ]
[ 0, 0, 1, 2, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0 ]
6741
[ "The", "Wilms", "'", "tumor", "gene", "(", "WT1", ")", "encodes", "a", "transcription", "factor", "of", "the", "zinc", "finger", "type", "." ]
[ 0, 1, 2, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6742
[ "A", "high", "expression", "of", "WT1", "has", "been", "detected", "in", "a", "range", "of", "acute", "leukemias", ",", "and", "WT1", "is", "downregulated", "during", "induced", "differentiation", "of", "some", "leukemic", "cell", "lines", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]
6743
[ "Overexpression", "of", "WT1", "in", "some", "myeloid", "cell", "lines", "confers", "resistance", "to", "differentiation", "induction", "." ]
[ 0, 0, 9, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0 ]
6744
[ "These", "observations", "suggest", "that", "a", "high", "WT1", "expression", "in", "hematopoietic", "cells", "is", "incompatible", "with", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0, 0, 0, 0, 0 ]
6745
[ "In", "this", "study", ",", "each", "of", "the", "four", "different", "isoforms", "of", "WT1", "was", "constitutively", "overexpressed", "in", "the", "leukemic", "cell", "line", "K562", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0 ]
6746
[ "K562", "cells", "express", "endogenous", "WT1", ",", "which", "is", "downregulated", "as", "a", "response", "to", "induced", "differentiation", "along", "the", "erythroid", "and", "megakaryocytic", "pathways", "." ]
[ 5, 6, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0 ]
6747
[ "We", "now", "demonstrate", "that", "a", "forced", "exogenous", "expression", "of", "the", "four", "different", "isoforms", "of", "WT1", "in", "K562", "does", "not", "affect", "the", "differentiation", "response", ",", "as", "judged", "by", "accumulation", "of", "hemoglobin", "in", "response", "to", "hemin", "or", "the", "expression", "of", "megakaryocytic", "cell", "surface", "markers", "in", "response", "to", "12-O-tetradecanoylphorbol-13-acetate", "(", "TPA", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6748
[ "We", "conclude", "that", "downregulation", "of", "WT1", "during", "induced", "differentiation", "of", "K562", "cells", "is", "not", "a", "prerequisite", "for", "erythroid", "or", "megakaryocytic", "differentiation", "of", "these", "cells", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0 ]
6749
[ "Association", "of", "the", "interleukin-4", "receptor", "alpha", "chain", "with", "p47phox", ",", "an", "activator", "of", "the", "phagocyte", "NADPH", "oxidase", "in", "B", "cells", "." ]
[ 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 7, 9, 10, 0, 7, 8, 0 ]
6750
[ "Interleukin", "(", "IL", ")", "-4", "plays", "an", "important", "role", "in", "IgE", "synthesis", "in", "B", "cells", "and", "in", "Th2", "differentiation", "in", "T", "cells", "." ]
[ 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0, 0, 7, 0, 0, 7, 8, 0 ]
6751
[ "IL-4", "conducts", "its", "biological", "activities", "through", "binding", "to", "the", "IL-4", "receptor", "(", "IL-4R", ")", "on", "the", "surface", "of", "target", "cells", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
6752
[ "IL-4R", "are", "thought", "to", "be", "composed", "of", "the", "IL-4R", "alpha", "chain", "(", "IL-4R", "alpha", ")", "and", "either", "the", "IL-2R", "gamma", "chain", "or", "the", "IL-13R", "alpha", "chain", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 10, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 10, 10, 0 ]
6753
[ "We", "have", "previously", "shown", "that", "the", "membrane-proximal", "portion", "in", "the", "cytoplasmic", "domain", "of", "the", "human", "IL-4R", "alpha", "(", "hIL-4R", "alpha", ")", "is", "critical", "for", "proliferation", ",", "generation", "of", "germline", "epsilon", "transcript", ",", "and", "activation", "of", "STAT6", ",", "based", "on", "analyses", "of", "truncated", "hIL-4R", "alphas", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
6754
[ "In", "this", "study", ",", "we", "found", "that", "p47phox", ",", "an", "activator", "of", "the", "phagocyte", "NADPH", "oxidase", ",", "binds", "to", "this", "portion", "by", "the", "two-hybrid", "system", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 7, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6755
[ "Furthermore", ",", "we", "observed", "the", "association", "of", "p47phox", "with", "the", "hIL-4R", "alpha", "in", "B", "cells", "derived", "from", "a", "normal", "donor", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 0, 7, 8, 0, 0, 0, 0, 0, 0 ]
6756
[ "These", "results", "suggest", "that", "p47phox", "is", "involved", "in", "the", "signal", "transduction", "of", "IL-4", "in", "B", "cells", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 8, 0 ]
6757
[ "However", ",", "activation", "of", "STAT6", ",", "CD23", "expression", ",", "and", "IgE", "synthesis", "induced", "by", "IL-4", "were", "not", "affected", "in", "p47phox-deficient", "patients", ",", "which", "raises", "the", "possibility", "that", "p47phox", "may", "be", "important", "in", "other", "signaling", "activities", "as", "well", "in", "B", "cells", "." ]
[ 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
6758
[ "Effects", "of", "diesel", "organic", "extracts", "on", "chemokine", "production", "by", "peripheral", "blood", "mononuclear", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0 ]
6759
[ "BACKGROUND", ":", "Polyaromatic", "hydrocarbons", "(", "PAHs", ")", "associated", "with", "diesel", "exhaust", "particles", "(", "DEPs", ")", "are", "found", "in", "the", "atmospheric", "urban", "pollution", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6760
[ "Such", "compounds", "have", "been", "shown", "to", "favor", "IgE", "production", ",", "bronchial", "hyperresponsiveness", ",", "and", "airway", "inflammation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6761
[ "Chemokines", "are", "a", "group", "of", "chemotactic", "cytokines", "involved", "in", "the", "recruitment", "of", "inflammatory", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6762
[ "OBJECTIVE", ":", "We", "investigated", "the", "effect", "of", "DEP-PAHs", "on", "the", "release", "and", "mRNA", "expression", "of", "IL-8", ",", "MCP-1", ",", "and", "RANTES", "by", "PBMCs", "obtained", "from", "healthy", "subjects", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 7, 0, 0, 0, 0, 0 ]
6763
[ "METHODS", ":", "Protein", "production", "in", "supernatants", "was", "assessed", "by", "ELISA", ",", "and", "mRNA", "expression", "was", "evaluated", "by", "semiquantitative", "RT-PCR", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6764
[ "RESULTS", ":", "Secretion", "of", "IL-8", "and", "RANTES", "increased", "in", "a", "dose-dependent", "manner", "with", "increasing", "concentrations", "of", "DEP-PAHs", "(", "range", ",", "0.5", "ng", "to", "50", "ng/mL", ")", "." ]
[ 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6765
[ "On", "the", "contrary", ",", "the", "release", "of", "MCP-1", "was", "significantly", "inhibited", ",", "also", "in", "a", "dose-dependent", "manner", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6766
[ "Messenger", "RNA", "production", "coding", "for", "IL-8", ",", "RANTES", ",", "and", "MCP-1", "showed", "parallel", "variations", "to", "the", "production", "of", "the", "correspondent", "proteins", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6767
[ "Effects", "of", "DEP-PAHs", "became", "significant", "at", "7", "hours", "and", "up", "to", "48", "hours", "time", "culture", "for", "MCP-1", ",", "and", "up", "to", "24", "hours", "time", "culture", "for", "IL-8", "and", "RANTES", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0 ]
6768
[ "Moreover", ",", "supernatants", "from", "DEP-PAH-activated", "cells", ",", "compared", "with", "those", "of", "controls", ",", "exhibited", "a", "significantly", "enhanced", "chemotactic", "activity", "for", "neutrophils", "and", "eosinophils", ",", "which", "was", "significantly", "inhibited", "by", "pretreatment", "with", "anti-IL-8", "and", "anti-RANTES", "neutralizing", "antibodies", ",", "respectively", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0 ]
6769
[ "CONCLUSION", ":", "These", "findings", "suggest", "that", "the", "chemokine", "pathways", "are", "modulated", "by", "DEP-PAHs", "at", "the", "transcriptional", "level", ",", "reinforcing", "the", "idea", "that", "the", "development", "of", "inflammatory", "reactions", "might", "be", "affected", "by", "diesel", "exhaust", "emission", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6770
[ "20-Epi", "analogues", "of", "1", ",", "25-dihydroxyvitamin", "D3", "are", "highly", "potent", "inducers", "of", "DRIP", "coactivator", "complex", "binding", "to", "the", "vitamin", "D3", "receptor", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 9, 10, 10, 0 ]
6771
[ "1", ",", "25-Dihydroxyvitamin", "D3", "(", "1", ",", "25", "(", "OH", ")", "2D3", ")", "plays", "a", "major", "role", "in", "the", "stimulation", "of", "bone", "growth", ",", "mineralization", ",", "and", "intestinal", "calcium", "and", "phosphate", "absorption", ";", "it", "also", "acts", "as", "a", "general", "inhibitor", "of", "cellular", "proliferation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6772
[ "Several", "new", ",", "clinically", "relevant", "compounds", "dissociate", "antiproliferative", "and", "calcemic", "activities", "of", "1", ",", "25", "(", "OH", ")", "2D3", ",", "but", "the", "molecular", "basis", "for", "this", "has", "not", "been", "clearly", "elucidated", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6773
[ "Here", ",", "we", "tested", "whether", "the", "potency", "of", "one", "class", "of", "compounds", ",", "20-epi", "analogues", ",", "to", "induce", "myeloid", "cell", "differentiation", ",", "is", "because", "of", "direct", "molecular", "effects", "on", "vitamin", "D", "receptor", "(", "VDR", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0 ]
6774
[ "We", "report", "that", "two", "20-epi", "analogues", ",", "MC1627", "and", "MC1288", ",", "induced", "differentiation", "and", "transcription", "of", "p21", "(", "Waf1", ",", "Cip1", ")", ",", "a", "key", "VDR", "target", "gene", "involved", "in", "growth", "inhibition", ",", "at", "a", "concentration", "100-fold", "lower", "than", "that", "of", "1", ",", "25", "(", "OH", ")", "2D3", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 1, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6775
[ "We", "compared", "this", "sensitivity", "to", "analogue", "effects", "on", "VDR", "interacting", "proteins", ":", "RXR", ",", "GRIP-1", ",", "and", "DRIP205", ",", "a", "subunit", "of", "the", "DRIP", "coactivator", "complex", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
6776
[ "Compared", "with", "the", "interaction", "of", "VDR", "with", "RXR", "or", "GRIP-1", ",", "the", "differentiation", "dose-response", "most", "closely", "correlated", "to", "the", "ligand-dependent", "recruitment", "of", "the", "DRIP", "coactivator", "complex", "to", "VDR", "and", "to", "the", "ability", "of", "the", "receptor", "to", "activate", "transcription", "in", "a", "cell-free", "system", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6777
[ "These", "results", "provide", "compelling", "links", "between", "the", "efficiency", "of", "the", "20-epi", "analogue", "in", "inducing", "VDR", "/DRIP", "interactions", ",", "transactivation", "in", "vitro", ",", "and", "its", "enhanced", "ability", "to", "induce", "cellular", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6778
[ "SLP-76", "and", "Vav", "function", "in", "separate", ",", "but", "overlapping", "pathways", "to", "augment", "interleukin-2", "promoter", "activity", "." ]
[ 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0 ]
6779
[ "SLP-76", "and", "Vav", ",", "two", "hematopoietic", "cell", "specific", "molecules", ",", "are", "critical", "for", "T", "cell", "development", "and", "activation", "." ]
[ 9, 0, 9, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0 ]
6780
[ "Following", "T", "cell", "antigen", "receptor", "stimulation", ",", "SLP-76", "and", "Vav", "both", "undergo", "tyrosine", "phosphorylation", "and", "associate", "with", "each", "other", "via", "the", "SH2", "domain", "of", "Vav", "and", "phosphorylated", "tyrosines", "of", "SLP-76", "." ]
[ 0, 9, 10, 10, 10, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0 ]
6781
[ "Furthermore", ",", "SLP-76", "and", "Vav", "have", "a", "synergistic", "effect", "on", "interleukin", "(", "IL", ")", "-2", "promoter", "activity", "in", "T", "cells", "." ]
[ 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0, 0, 7, 8, 0 ]
6782
[ "In", "this", "report", ",", "we", "show", "that", "two", "tyrosines", ",", "Tyr-113", "and", "Tyr-128", ",", "of", "SLP-76", "are", "required", "for", "its", "binding", "to", "Vav", ",", "both", "in", "vitro", "and", "in", "intact", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6783
[ "Surprisingly", ",", "we", "find", "also", "that", "the", "interaction", "between", "SLP-76", "and", "Vav", "is", "not", "required", "for", "their", "cooperation", "in", "augmenting", "IL-2", "promoter", "activity", ",", "as", "the", "two", "molecules", "appear", "to", "function", "in", "different", "signaling", "pathways", "upstream", "of", "IL-2", "gene", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0 ]
6784
[ "Overexpression", "of", "SLP-76", "in", "the", "Jurkat", "T", "cell", "line", "potentiates", "the", "activities", "of", "both", "nuclear", "factor", "of", "activated", "T", "cells", "and", "AP-1", "transcription", "factors", "." ]
[ 0, 0, 9, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 9, 10, 10, 0 ]
6785
[ "In", "contrast", ",", "overexpression", "of", "Vav", "leads", "to", "enhanced", "nuclear", "factor", "of", "activated", "T", "cells", "activity", "without", "affecting", "AP-1", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 9, 0 ]
6786
[ "Additionally", ",", "overexpression", "of", "Vav", ",", "but", "not", "SLP-76", ",", "augments", "CD28-induced", "IL-2", "promoter", "activity", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 1, 2, 0, 0 ]
6787
[ "These", "findings", "suggest", "that", "the", "synergy", "between", "SLP-76", "and", "Vav", "in", "regulating", "IL-2", "gene", "expression", "reflects", "the", "cooperation", "between", "different", "signaling", "pathways", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6788
[ "Rel/NF-kappaB", "can", "trigger", "the", "Notch", "signaling", "pathway", "by", "inducing", "the", "expression", "of", "Jagged1", ",", "a", "ligand", "for", "Notch", "receptors", "." ]
[ 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 0 ]
6789
[ "Jagged1", "belongs", "to", "the", "DSL", "family", "of", "ligands", "for", "Notch", "receptors", "that", "control", "the", "proliferation", "and", "differentiation", "of", "various", "cell", "lineages", "." ]
[ 9, 0, 0, 0, 9, 10, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6790
[ "However", ",", "little", "is", "known", "about", "the", "transcription", "factors", "that", "regulate", "its", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6791
[ "Here", ",", "we", "show", "that", "Jagged1", "is", "a", "Rel/NF-kappaB-responsive", "gene", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 1, 2, 0 ]
6792
[ "Both", "c-Rel", "and", "RelA", "induced", "jagged1", "gene", "expression", ",", "whereas", "a", "mutant", "defective", "for", "transactivation", "did", "not", "." ]
[ 0, 9, 0, 9, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6793
[ "Importantly", ",", "jagged1", "transcripts", "were", "also", "upregulated", "by", "endogenous", "NF-kappaB", "activation", "and", "this", "effect", "was", "inhibited", "by", "a", "dominant", "mutant", "of", "IkappaBalpha", ",", "a", "physiological", "inhibitor", "of", "NF-kappaB", "." ]
[ 0, 0, 3, 4, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0 ]
6794
[ "Cell", "surface", "expression", "of", "Jagged1", "in", "c-Rel-expressing", "cell", "monolayers", "led", "to", "a", "functional", "interaction", "with", "lymphocytes", "expressing", "the", "Notch1/TAN-1", "receptor", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 9, 10, 0 ]
6795
[ "This", "correlated", "with", "the", "initiation", "of", "signaling", "downstream", "of", "Notch", ",", "as", "evidenced", "by", "increased", "levels", "of", "HES-1", "transcripts", "in", "co-cultivated", "T", "cells", "and", "of", "CD23", "transcripts", "in", "co-cultivated", "B", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 7, 8, 0, 0, 3, 4, 0, 0, 7, 8, 0 ]
6796
[ "Consistent", "with", "its", "Rel/NF-kappaB", "-dependent", "induction", ",", "Jagged1", "was", "found", "to", "be", "highly", "expressed", "in", "splenic", "B", "cells", "where", "c-Rel", "is", "expressed", "constitutively", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 9, 0, 0, 0, 0 ]
6797
[ "These", "results", "demonstrate", "that", "c-Rel", "can", "trigger", "the", "Notch", "signaling", "pathway", "in", "neighboring", "cells", "by", "inducing", "jagged1", "gene", "expression", ",", "and", "suggest", "a", "role", "for", "Jagged1", "in", "B-cell", "activation", ",", "differentiation", "or", "function", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 0, 0, 0, 0, 0, 0 ]
6798
[ "These", "findings", "also", "highlight", "the", "potential", "for", "an", "interplay", "between", "the", "Notch", "and", "NF-kappaB", "signaling", "pathways", "in", "the", "immune", "system", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
6799
[ "Bacterial", "peptidoglycan", "induces", "CD14", "-dependent", "activation", "of", "transcription", "factors", "CREB/ATF", "and", "AP-1", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 9, 10, 10, 0, 9, 0 ]
6800
[ "Peptidoglycan", "(", "PGN", ")", ",", "the", "major", "cell", "wall", "component", "of", "Gram-positive", "bacteria", ",", "induces", "secretion", "of", "cytokines", "in", "macrophages", "through", "CD14", ",", "the", "pattern", "recognition", "receptor", "that", "binds", "lipopolysaccharide", "and", "other", "microbial", "products", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]