Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
6901
[ "Moreover", ",", "in", "a", "physiological", "coculture", "cellular", "assay", "system", ",", "we", "show", "that", "membrane-bound", "TNF-alpha", "and", "LT-alpha1beta2", "act", "virtually", "identically", "to", "their", "soluble", "forms", "in", "the", "regulation", "of", "HIV-1", "replication", "." ]
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6902
[ "Thus", ",", "cosignaling", "via", "the", "LT-beta", "and", "TNF-alpha", "receptors", "is", "probably", "involved", "in", "the", "modulation", "of", "HIV-1", "replication", "and", "the", "subsequent", "determination", "of", "HIV-1", "viral", "burden", "in", "monocytes", "." ]
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6903
[ "Intriguingly", ",", "surface", "expression", "of", "LT-alpha1beta2", "is", "up-regulated", "on", "a", "T", "cell", "line", "acutely", "infected", "with", "HIV-1", ",", "suggesting", "a", "positive", "feedback", "loop", "between", "HIV-1", "infection", ",", "LT-alpha1beta2", "expression", ",", "and", "HIV-1", "replication", "." ]
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6904
[ "Given", "the", "critical", "role", "that", "LT-alpha1beta2", "plays", "in", "lymphoid", "architecture", ",", "we", "speculate", "that", "LT-alpha1beta2", "may", "be", "involved", "in", "HIV-associated", "abnormalities", "of", "the", "lymphoid", "organs", "." ]
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6905
[ "Monoclonal", "anti-endothelial", "cell", "antibodies", "from", "a", "patient", "with", "Takayasu", "arteritis", "activate", "endothelial", "cells", "from", "large", "vessels", "." ]
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6906
[ "OBJECTIVE", ":", "To", "create", "monoclonal", "anti-endothelial", "cell", "antibodies", "(", "mAECA", ")", "from", "a", "patient", "with", "Takayasu", "arteritis", "to", "evaluate", "their", "ability", "to", "activate", "human", "umbilical", "vein", "endothelial", "cells", "(", "HUVEC", ")", ",", "and", "to", "characterize", "the", "mechanism", "of", "EC", "activation", "." ]
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6907
[ "METHODS", ":", "A", "panel", "of", "mAECA", "was", "generated", "from", "peripheral", "blood", "lymphocytes", "of", "a", "patient", "with", "Takayasu", "arteritis", ",", "using", "Epstein-Barr", "virus", "transformation", "." ]
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6908
[ "Activity", "against", "macrovascular", "EC", "(", "HUVEC", ")", "and", "microvascular", "EC", "(", "human", "bone", "marrow", "EC", "immortalized", "by", "SV40", ")", "antigens", "was", "detected", "by", "enzyme-linked", "immunosorbent", "assay", "." ]
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6909
[ "Inhibition", "studies", "were", "used", "to", "select", "the", "monoclonal", "antibodies", "(", "mAECA", ")", "which", "share", "the", "same", "EC", "epitope", "binding", "specificity", "as", "the", "total", "IgG-AECA", "from", "the", "Takayasu", "arteritis", "patient", "." ]
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6910
[ "The", "binding", "of", "the", "mAECA", "to", "human", "aortic", "EC", "was", "studied", "by", "immunohistochemistry", "." ]
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6911
[ "The", "secretion", "levels", "of", "interleukin-6", "(", "IL-6", ")", "and", "von", "Willebrand", "factor", "(", "vWF", ")", "were", "determined", ",", "to", "serve", "as", "markers", "for", "EC", "activation", "." ]
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6912
[ "The", "activated", "EC", "were", "examined", "for", "the", "adherence", "of", "a", "monocytic", "cell", "line", "(", "U937", ")", ",", "as", "well", "as", "for", "expression", "of", "vascular", "cell", "adhesion", "molecule", "1", ",", "intercellular", "adhesion", "molecule", "1", ",", "and", "E-selectin", "." ]
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6913
[ "In", "addition", ",", "nuclear", "extracts", "of", "the", "mAECA-treated", "EC", "were", "analyzed", "for", "the", "induction", "of", "translocation", "of", "nuclear", "factor", "kappaB", "(", "NF-kappaB", ")", ",", "using", "a", "specific", "NF-kappaB", "oligoprobe", "in", "an", "electrophoretic", "mobility", "shift", "assay", "." ]
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6914
[ "RESULTS", ":", "Six", "mAECA", "were", "selected", ",", "the", "mixture", "of", "which", "produced", "100", "%", "inhibition", "of", "binding", "of", "the", "original", "IgG", "(", "from", "the", "patient", "with", "Takayasu", "arteritis", ")", "to", "HUVEC", "." ]
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6915
[ "All", "mAECA", "possessed", "high", "activity", "against", "macrovascular", "EC", ",", "but", "none", "had", "significant", "antimicrovascular", "EC", "activity", "." ]
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6916
[ "The", "mAECA", ",", "but", "not", "normal", "human", "IgG", ",", "had", "anti-human", "aortic", "EC", "activity", "." ]
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6917
[ "Four", "of", "the", "6", "mAECA", "activated", "EC", ",", "manifested", "by", "increased", "IL-6", "and", "vWF", "secretion", "." ]
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6918
[ "The", "4", "mAECA", "induced", "EC", "expression", "of", "adhesion", "molecules", "and", "increased", "adhesion", "of", "U937", "monocytic", "cells", "to", "EC", "." ]
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6919
[ "In", "addition", ",", "these", "mAECA", "stimulated", "the", "nuclear", "translocation", "of", "the", "NF-kappaB", "transcription", "factor", "." ]
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6920
[ "CONCLUSION", ":", "Our", "findings", "suggest", "that", "AECA", "may", "directly", "stimulate", "EC", "in", "Takayasu", "arteritis", "through", "elevation", "of", "adhesion", "molecule", "expression", "associated", "with", "NF-kappaB", "activation", "and", "adhesion", "of", "monocytes", ",", "and", "may", "therefore", "play", "a", "pathogenic", "role", "in", "the", "development", "of", "the", "vasculopathy", "in", "Takayasu", "arteritis", "." ]
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6921
[ "Cutting", "edge", ":", "expression", "of", "the", "NF", "of", "activated", "T", "cells", "in", "eosinophils", ":", "regulation", "by", "IL-4", "and", "IL-5", "." ]
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6922
[ "We", "report", "that", "NF-AT1", "and", "NF-AT4", "are", "expressed", "cytoplasmically", "in", "resting", "eosinophils", ",", "whereas", "NF-AT2", "and", "NF-AT3", "have", "not", "been", "seen", "." ]
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6923
[ "Likewise", ",", "NF-AT1", "mRNA", "and", "NF-AT4", "mRNA", "have", "been", "detected", "in", "resting", "eosinophils", ",", "and", "their", "levels", "can", "be", "significantly", "up-regulated", "by", "the", "Th2-associated", "cytokines", "IL-4", "and", "IL-5", "." ]
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6924
[ "There", "is", "no", "detectable", "NF-AT", "protein", "expression", "in", "the", "nuclei", "of", "resting", "eosinophils", "." ]
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6925
[ "However", "NF-ATs", "appear", "in", "the", "nuclei", "of", "IL-4-", ",", "IL-5-", ",", "or", "ionomycin-stimulated", "eosinophils", "." ]
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6926
[ "Only", "NF-AT1", "and", "NF-AT4", ",", "but", "not", "NF-AT2", "and", "NF-AT3", ",", "have", "translocated", "into", "the", "nuclei", "in", "IL-4-", "or", "IL-5-stimulated", "eosinophils", "." ]
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6927
[ "These", "findings", "delineate", "a", "novel", "pathway", "in", "the", "cytokine", "network", "in", "which", "Th2", "lymphocytes", "``", "control", "''", "eosinophils", "via", "the", "release", "of", "IL-4", "and", "IL-5", ",", "and", "activation", "of", "NF-AT", "in", "eosinophils", "." ]
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6928
[ "The", "findings", "also", "suggest", "that", "a", "later", "feedback", "``", "talking", "''", "may", "exist", "between", "eosinophils", "and", "Th2", "lymphocytes", "." ]
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6929
[ "PPARalpha", "activators", "inhibit", "cytokine-induced", "vascular", "cell", "adhesion", "molecule-1", "expression", "in", "human", "endothelial", "cells", "." ]
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6930
[ "BACKGROUND", ":", "Adhesion", "molecule", "expression", "on", "the", "endothelial", "cell", "(", "EC", ")", "surface", "is", "critical", "for", "leukocyte", "recruitment", "to", "atherosclerotic", "lesions", "." ]
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6931
[ "Better", "understanding", "of", "transcriptional", "regulation", "of", "adhesion", "molecules", "in", "ECs", "may", "provide", "important", "insight", "into", "plaque", "formation", "." ]
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6932
[ "Peroxisome", "proliferator-activated", "receptor-alpha", "(", "PPARalpha", ")", ",", "a", "member", "of", "the", "nuclear", "receptor", "family", ",", "regulates", "gene", "expression", "in", "response", "to", "certain", "fatty", "acids", "and", "fibric", "acid", "derivatives", "." ]
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6933
[ "The", "present", "study", "investigated", "PPARalpha", "expression", "in", "human", "ECs", "and", "their", "regulation", "of", "vascular", "cell", "adhesion", "molecule-1", "(", "VCAM-1", ")", "." ]
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6934
[ "METHODS", "AND", "RESULTS", ":", "Immunohistochemistry", "revealed", "that", "human", "carotid", "artery", "ECs", "express", "PPARalpha", "." ]
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6935
[ "Pretreatment", "of", "cultured", "human", "ECs", "with", "the", "PPARalpha", "activators", "fenofibrate", "or", "WY14643", "inhibited", "TNF-alpha-induced", "VCAM-1", "in", "a", "time-", "and", "concentration-dependent", "manner", ",", "an", "effect", "not", "seen", "with", "PPARgamma", "activators", "." ]
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6936
[ "Both", "PPARalpha", "activators", "decreased", "cytokine-induced", "VCAM-1", "mRNA", "expression", "without", "altering", "its", "mRNA", "half-life", "." ]
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6937
[ "Transient", "transfection", "of", "deletional", "VCAM-1", "promoter", "constructs", "and", "electrophoretic", "mobility", "shift", "assays", "suggest", "that", "fenofibrate", "inhibits", "VCAM-1", "transcription", "in", "part", "by", "inhibiting", "NF-kappaB", "." ]
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6938
[ "Finally", ",", "PPARalpha", "activators", "significantly", "reduced", "adhesion", "of", "U937", "cells", "to", "cultured", "human", "ECs", "." ]
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6939
[ "CONCLUSIONS", ":", "Human", "ECs", "express", "PPARalpha", ",", "a", "potentially", "important", "regulator", "of", "atherogenesis", "through", "its", "transcriptional", "control", "of", "VCAM-1", "gene", "expression", "." ]
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6940
[ "Such", "findings", "also", "have", "implications", "regarding", "the", "clinical", "use", "of", "lipid-lowering", "agents", ",", "like", "fibric", "acids", ",", "which", "can", "activate", "PPARalpha", "." ]
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6941
[ "CBP/p300", "integrates", "Raf", "/", "Rac", "-signaling", "pathways", "in", "the", "transcriptional", "induction", "of", "NF-ATc", "during", "T", "cell", "activation", "." ]
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6942
[ "NF-ATc", ",", "an", "inducibly", "expressed", "transcription", "factor", ",", "controls", "gene", "expression", "in", "T", "lymphocytes", "and", "cardiomyocytes", "." ]
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6943
[ "We", "show", "here", "that", "the", "transcriptional", "co-activators", "CBP/p300", "bind", "to", "and", "control", "the", "activity", "of", "the", "inducible", "N-terminal", "transactivation", "domain", "of", "NF-ATc", ",", "TAD-A", "." ]
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6944
[ "Similar", "to", "the", "N", "terminal", "transactivation", "domain", "of", "c-Jun", ",", "TAD-A", "is", "inducibly", "phosphorylated", ",", "but", "this", "phosphorylation", "is", "dispensable", "for", "the", "interaction", "with", "CBP/p300", "." ]
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6945
[ "Constitutive", "active", "versions", "of", "c-Raf", "and", "Rac", "synergistically", "enhance", "the", "CBP/p300", "-mediated", "increase", "of", "TAD-A", "activity", ",", "indicating", "the", "important", "role", "CBP/p300", "plays", "in", "the", "integration", "of", "T", "cell", "activation", "signals", "." ]
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6946
[ "Since", "a", "mutation", "of", "CBP", "abolishing", "HAT", "activity", "is", "almost", "as", "active", "as", "wild-type", "CBP", "in", "T", "cells", ",", "functions", "of", "CBP/p300", "other", "than", "histone", "acetylation", "appear", "to", "control", "the", "NF-AT", "-dependent", "transcription", "in", "T", "cells", "." ]
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6947
[ "Immune", "functions", ",", "clinical", "parameters", "and", "hormone", "receptor", "status", "in", "breast", "cancer", "patients", "." ]
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6948
[ "We", "have", "carried", "out", "a", "detailed", "analysis", "of", "the", "cellular", "immune", "functions", "of", "breast", "cancer", "patients", "in", "comparison", "with", "healthy", "controls", "." ]
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6949
[ "A", "possible", "correlation", "between", "immune", "and", "clinical", "parameters", "was", "analysed", "in", "50", "breast", "cancer", "patients", "." ]
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6950
[ "Immune", "parameters", ",", "natural", "killer", "cell", "and", "T", "lymphocyte", "functions", "and", "the", "numbers", "of", "circulating", "T", "lymphocytes", "were", "analysed", "against", "the", "clinical", "parameters", "comprising", "the", "tumour", "burden", ",", "the", "stage", "of", "the", "disease", "and", "the", "expression", "of", "hormone", "receptors", "on", "the", "tumour", "." ]
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6951
[ "In", "order", "to", "analyse", "the", "immune", "function", "data", "effectively", ",", "low", "responders", "were", "identified", "with", "stringent", "cut-off", "values", "." ]
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6952
[ "Considerably", "higher", "proportions", "of", "low", "responders", "were", "found", "among", "the", "patient", "population", "." ]
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6953
[ "Elevated", "numbers", "of", "circulating", "T", "lymphocytes", "and", "CD3", "-directed", "cytolysis", "correlated", "with", "the", "expression", "of", "oestrogen", "receptors", "independently", "of", "the", "clinical/histological", "parameters", "." ]
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6954
[ "Latent", "membrane", "protein", "1", "of", "Epstein-Barr", "virus", "interacts", "with", "JAK3", "and", "activates", "STAT", "proteins", "." ]
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6955
[ "Latent", "membrane", "protein", "1", "(", "LMP1", ")", "acts", "like", "a", "permanently", "activated", "receptor", "of", "the", "tumor", "necrosis", "factor", "(", "TNF", ")", "-receptor", "superfamily", "and", "is", "absolutely", "required", "for", "B", "cell", "immortalization", "by", "Epstein-Barr", "virus", "." ]
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6956
[ "Molecular", "and", "biochemical", "approaches", "demonstrated", "that", "LMP1", "usurps", "cellular", "signaling", "pathways", "resulting", "in", "the", "induction", "of", "NF-kappaB", "and", "AP-1", "via", "two", "C-terminal", "activating", "regions", "." ]
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6957
[ "We", "demonstrate", "here", "that", "a", "third", "region", "encompassing", "a", "proline", "rich", "sequence", "within", "the", "33", "bp", "repetitive", "stretch", "of", "LMP1", "'s", "C-terminus", "is", "required", "for", "the", "activation", "of", "Janus", "kinase", "3", "(", "JAK3", ")", "." ]
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6958
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