Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
5901
[ "Neutrophil", "maturation", "and", "the", "role", "of", "retinoic", "acid", "." ]
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5902
[ "Neutrophil", "maturation", "occurs", "in", "well", "defined", "morphological", "stages", "that", "correlate", "with", "the", "acquisition", "of", "molecular", "markers", "associated", "with", "neutrophil", "function", "." ]
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5903
[ "A", "variety", "of", "factors", "are", "known", "to", "play", "a", "role", "in", "terminal", "neutrophil", "maturation", ",", "including", "the", "vitamin", "A", "derivative", ",", "retinoic", "acid", "." ]
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5904
[ "Retinoic", "acid", "can", "directly", "modulate", "gene", "expression", "via", "binding", "to", "its", "nuclear", "receptors", ",", "which", "can", ",", "in", "turn", ",", "activate", "transcription", "of", "target", "genes", "." ]
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5905
[ "A", "role", "for", "retinoic", "acid", "during", "neutrophil", "maturation", "has", "been", "suggested", "from", "a", "variety", "of", "sources.", "Here", "we", "present", "a", "review", "of", "the", "mechanism", "of", "retinoic", "acid", "receptor", "action", "and", "the", "major", "evidence", "showing", "that", "normal", "retinoid", "signaling", "is", "required", "for", "neutrophil", "maturation", "." ]
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5906
[ "Human", "T-cell", "lymphotrophic", "virus", "type-I", "tax", "gene", "induces", "secretion", "of", "human", "macrophage", "inflammatory", "protein-1alpha", "." ]
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5907
[ "Human", "T-cell", "lymphotropic", "virus", "I", "(", "HTLV-I", ")", "encodes", "for", "a", "40-kDa", "protein", ",", "Tax", ",", "which", "is", "important", "for", "the", "immortalization", "of", "T", "cells", "." ]
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5908
[ "Tax", "has", "been", "shown", "to", "transactivate", "several", "cellular", "genes", "." ]
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5909
[ "In", "this", "study", ",", "we", "show", "that", "MIP-1alpha", "is", "selectively", "expressed", "and", "secreted", "in", "the", "tax", "transfected", "Jurkat", "cell", "line", "upon", "mitogen", "stimulation", "." ]
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5910
[ "Expression", "of", "MIP-1alpha-R", "mRNA", "in", "these", "cells", "suggests", "an", "autocrine", "role", "for", "this", "chemokine", "in", "HTLV-I", "infected", "T-cells", "." ]
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5911
[ "Induced", "MIP-1alpha", "expression", "and", "secretion", "in", "PMA/PHA", "stimulated", "tax", "transfected", "cells", "correlate", "with", "the", "noninduction", "of", "MNP-1", "transcription", "factor", ",", "which", "is", "intimately", "involved", "in", "downmodulating", "the", "MIP-1alpha", "gene", "." ]
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5912
[ "Copyright", "1999", "Academic", "Press", "." ]
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5913
[ "Dendritic", "cells", "and", "the", "pathogenesis", "of", "rheumatoid", "arthritis", "." ]
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5914
[ "Rheumatoid", "arthritis", "(", "RA", ")", "is", "a", "chronic", "autoimmune", "inflammatory", "disease", "in", "which", "unknown", "arthrogenic", "autoantigen", "is", "presented", "to", "CD4+", "T", "cells", "." ]
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5915
[ "The", "strong", "association", "of", "the", "disease", "with", "an", "epitope", "within", "the", "HLA-DR", "chain", "shared", "between", "various", "alleles", "of", "HLA-DR4", "and", "DR1", "emphasizes", "the", "importance", "of", "antigen", "presentation", "." ]
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5916
[ "This", "immune", "response", "predominantly", "occurs", "in", "the", "synovial", "tissue", "and", "fluid", "of", "the", "joints", "and", "autoreactive", "T", "cells", "are", "readily", "demonstrable", "in", "both", "the", "synovial", "compartment", "and", "blood", "." ]
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5917
[ "Circulating", "dendritic", "cells", "(", "DC", ")", "are", "phenotypically", "and", "functionally", "identical", "with", "normal", "peripheral", "blood", "(", "PB", ")", "DC", "." ]
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5918
[ "In", "the", "synovial", "tissue", ",", "fully", "differentiated", "perivascular", "DC", "are", "found", "in", "close", "association", "with", "T", "cells", "and", "with", "B", "cell", "follicles", ",", "sometimes", "containing", "follicular", "DC", "." ]
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5919
[ "These", "perivascular", "DC", "migrate", "across", "the", "activated", "endothelium", "from", "blood", "and", "receive", "differentiative", "signals", "within", "the", "joint", "from", "monocyte-derived", "cytokines", "and", "CD40-ligand+", "T", "cells", "." ]
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5920
[ "In", "the", "SF", ",", "DC", "manifest", "an", "intermediate", "phenotype", ",", "similar", "to", "that", "of", "monocyte-derived", "DC", "in", "vitro", "." ]
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5921
[ "Like", "a", "delayed-type", "hypersensitivity", "response", ",", "the", "rheumatoid", "synovium", "represents", "an", "effector", "site", "." ]
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5922
[ "DC", "at", "many", "effector", "sites", "have", "a", "characteristic", "pattern", "of", "infiltration", "and", "differentiation", "." ]
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5923
[ "It", "is", "important", "to", "note", "that", "the", "effector", "response", "is", "not", "self-limiting", "in", "RA", "autoimmune", "inflammation", "." ]
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5924
[ "In", "this", "article", ",", "we", "argue", "that", "the", "presentation", "of", "self-antigen", "by", "DC", "and", "by", "autoantibody-producing", "B", "cells", "is", "critical", "for", "the", "perpetuation", "of", "the", "autoimmune", "response", "." ]
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5925
[ "Permanently", "arresting", "this", "ongoing", "immune", "response", "with", "either", "pharmaceutical", "agents", "or", "immunotherapy", "is", "a", "major", "challenge", "for", "immunology", "." ]
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5926
[ "Thymocyte-thymic", "epithelial", "cell", "interaction", "leads", "to", "high-level", "replication", "of", "human", "immunodeficiency", "virus", "exclusively", "in", "mature", "CD4", "(", "+", ")", "CD8", "(", "-", ")", "CD3", "(", "+", ")", "thymocytes", ":", "a", "critical", "role", "for", "tumor", "necrosis", "factor", "and", "interleukin-7", "." ]
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5927
[ "This", "work", "aims", "at", "identifying", "the", "thymocyte", "subpopulation", "able", "to", "support", "human", "immunodeficiency", "virus", "(", "HIV", ")", "replication", "under", "the", "biological", "stimuli", "of", "the", "thymic", "microenvironment", "." ]
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5928
[ "In", "this", "report", "we", "demonstrate", "that", "interaction", "with", "thymic", "epithelial", "cells", "(", "TEC", ")", "induces", "a", "high-level", "replication", "of", "the", "T-tropic", "primary", "isolate", "HIV-1", "(", "B-LAIp", ")", "exclusively", "in", "the", "mature", "CD4", "(", "+", ")", "CD8", "(", "-", ")", "CD3", "(", "+", ")", "thymocytes", "." ]
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5929
[ "Tumor", "necrosis", "factor", "(", "TNF", ")", "and", "interleukin-7", "(", "IL-7", ")", ",", "secreted", "during", "this", "interaction", ",", "are", "critical", "cytokines", "for", "HIV", "long", "terminal", "repeat", "transactivation", "through", "NF-kappaB", "-dependent", "activation", "." ]
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5930
[ "TNF", "is", "the", "major", "inducer", "of", "NF-kappaB", "and", "particularly", "of", "the", "p50-p65", "complex", ",", "whereas", "IL-7", "acts", "as", "a", "cofactor", "by", "sustaining", "the", "expression", "of", "the", "p75", "TNF", "receptor", "." ]
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5931
[ "The", "requirement", "for", "TNF", "is", "further", "confirmed", "by", "the", "observation", "that", "the", "inability", "of", "the", "intermediate", "CD4", "(", "+", ")", "CD8", "(", "-", ")", "CD3", "(", "-", ")", "thymocytes", "to", "replicate", "the", "virus", "is", "associated", "with", "a", "defect", "in", "TNF", "production", "during", "their", "interaction", "with", "TEC", "and", "correlates", "with", "the", "absence", "of", "nuclear", "NF-kappaB", "activity", "in", "these", "freshly", "isolated", "thymocytes", "." ]
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5932
[ "Addition", "of", "exogenous", "TNF", "to", "the", "intermediate", "thymocyte", "cultures", "induces", "NF-kappaB", "activity", "and", "is", "sufficient", "to", "promote", "HIV", "replication", "in", "the", "cocultures", "with", "TEC", "." ]
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5933
[ "The", "other", "major", "subpopulation", "expressing", "the", "CD4", "receptor", ",", "namely", ",", "the", "double-positive", "(", "DP", ")", "CD4", "(", "+", ")", "CD8", "(", "+", ")", "CD3", "(", "+/-", ")", "thymocytes", ",", "despite", "the", "entry", "of", "the", "virus", ",", "do", "not", "produce", "a", "significant", "level", "of", "virus", ",", "presumably", "because", "they", "are", "unresponsive", "to", "TNF", "and", "IL-7", "." ]
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5934
[ "Together", ",", "these", "data", "suggest", "that", "in", "vivo", ",", "despite", "an", "efficient", "entry", "of", "the", "virus", "in", "all", "the", "CD4", "(", "+", ")", "subpopulations", ",", "a", "high", "viral", "load", "may", "be", "generated", "exclusively", "within", "the", "mature", "CD4", "(", "+", ")", "CD8", "(", "-", ")", "CD3", "(", "+", ")", "subset", "of", "thymocytes", "." ]
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5935
[ "However", ",", "under", "conditions", "of", "inflammatory", "response", "after", "infection", ",", "TNF", "might", "also", "be", "present", "in", "the", "intermediate", "thymocyte", "compartment", ",", "leading", "to", "efficient", "HIV", "replication", "in", "these", "cells", "." ]
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5936
[ "NF-kappaB-mediated", "up-regulation", "of", "Bcl-x", "and", "Bfl-1/A1", "is", "required", "for", "CD40", "survival", "signaling", "in", "B", "lymphocytes", "." ]
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5937
[ "Activation", "of", "CD40", "is", "essential", "for", "thymus-dependent", "humoral", "immune", "responses", "and", "rescuing", "B", "cells", "from", "apoptosis", "." ]
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5938
[ "Many", "of", "the", "effects", "of", "CD40", "are", "believed", "to", "be", "achieved", "through", "altered", "gene", "expression", "." ]
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5939
[ "In", "addition", "to", "Bcl-x", ",", "a", "known", "CD40-regulated", "antiapoptotic", "molecule", ",", "we", "identified", "a", "related", "antiapoptotic", "molecule", ",", "A1/Bfl-1", ",", "as", "a", "CD40-inducible", "gene", "." ]
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5940
[ "Inhibition", "of", "the", "NF-kappaB", "pathway", "by", "overexpression", "of", "a", "dominant-active", "inhibitor", "of", "NF-kappaB", "abolished", "CD40", "-induced", "up-regulation", "of", "both", "the", "Bfl-1", "and", "Bcl-x", "genes", "and", "also", "eliminated", "the", "ability", "of", "CD40", "to", "rescue", "Fas", "-induced", "cell", "death", "." ]
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5941
[ "Within", "the", "upstream", "promoter", "region", "of", "Bcl-x", ",", "a", "potential", "NF-kappaB-binding", "sequence", "was", "found", "to", "support", "NF-kappaB", "-dependent", "transcriptional", "activation", "." ]
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5942
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5943
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5944
[ "Stimulation", "of", "neutrophil", "interleukin-8", "production", "by", "eosinophil", "granule", "major", "basic", "protein", "." ]
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5945
[ "We", "evaluated", "the", "ability", "of", "eosinophil", "granule", "major", "basic", "protein", "(", "MBP", ")", "to", "stimulate", "interleukin", "(", "IL", ")", "-8", "production", "by", "neutrophils", "." ]
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5946
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5947
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5948
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5949
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5950
[ "However", ",", "stimulation", "with", "MBP", "did", "not", "produce", "an", "increase", "in", "the", "binding", "activity", "of", "nuclear", "factor", "(", "NF", ")", "-kappaB", "or", "activator", "protein-1", "." ]
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5951
[ "No", "NF-IL-6", "binding", "activity", "was", "detected", "in", "the", "same", "nuclear", "extracts", "." ]
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5952
[ "In", "addition", ",", "stimulation", "with", "MBP", "prolonged", "the", "stability", "of", "IL-8", "mRNA", "." ]
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5953
[ "MBP", "also", "induced", "transient", "increases", "in", "mRNA", "for", "macrophage", "inflammatory", "protein", "(", "MIP", ")", "-1alpha", "and", "MIP-1beta", ",", "but", "did", "not", "stimulate", "the", "release", "of", "either", "chemokine", "." ]
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5954
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5955
[ "We", "postulate", "that", "MBP", "-induced", "release", "of", "IL-8", "by", "neutrophils", "may", "contribute", "to", "the", "pathophysiology", "of", "acute", "asthma", "and", "other", "inflammatory", "lung", "diseases", "." ]
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5956
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5957
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5965
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5966
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5973
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5974
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5975
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5976
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5977
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5978
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5979
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5980
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5982
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5983
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5985
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5986
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5987
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5988
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5990
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5991
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5992
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5994
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5995
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5996
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5999
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6000
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