Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
5801
[ "This", "may", "have", "implications", "for", "pathophysiological", "conditions", "that", "involve", "the", "upregulation", "of", "these", "molecules", "(", "e.g.", "inflammation", "and", "atherosclerosis", ")", "." ]
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5802
[ "Protein", "kinase", "C-zeta", "mediates", "NF-kappa", "B", "activation", "in", "human", "immunodeficiency", "virus-infected", "monocytes", "." ]
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5803
[ "The", "molecular", "mechanisms", "regulating", "human", "immunodeficiency", "virus", "(", "HIV", ")", "persistence", "in", "a", "major", "cell", "reservoir", "such", "as", "the", "macrophage", "remain", "unknown", "." ]
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5804
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5805
[ "Although", "little", "information", "as", "to", "what", "signal", "transduction", "pathways", "mediate", "NF-kappa", "B", "activation", "in", "monocytes-macrophages", "is", "available", ",", "our", "previous", "work", "indicated", "that", "classical", "protein", "kinase", "C", "(", "PKC", ")", "isoenzymes", "were", "not", "involved", "in", "the", "HIV-mediated", "NF-kappa", "B", "activation", "." ]
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5806
[ "In", "this", "study", ",", "we", "have", "focused", "on", "atypical", "PKC", "isoenzymes", "." ]
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5807
[ "PKC-zeta", "belongs", "to", "this", "family", "and", "is", "known", "to", "be", "an", "important", "step", "in", "NF-kappa", "B", "activation", "in", "other", "cell", "systems", "." ]
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5808
[ "Immunoblotting", "experiments", "with", "U937", "cells", "demonstrate", "that", "PKC-zeta", "is", "present", "in", "these", "cells", ",", "and", "its", "expression", "can", "be", "downmodulated", "by", "antisense", "oligonucleotides", "(", "AO", ")", "." ]
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5809
[ "The", "HIV-mediated", "NF-kappa", "B", "activation", "is", "selectively", "reduced", "by", "AO", "to", "PKC-zeta", "." ]
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5810
[ "In", "addition", ",", "cotransfection", "of", "a", "negative", "dominant", "molecule", "of", "PKC-zeta", "(", "PKC-zeta", "mut", ")", "with", "NF-kappa", "B", "-dependent", "reporter", "genes", "selectively", "inhibits", "the", "HIV", "-but", "not", "phorbol", "myristate", "acetate-", "or", "lipopolysaccharide-mediated", "activation", "of", "NF-kappa", "B", "." ]
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5811
[ "That", "PKC-zeta", "is", "specific", "in", "regulating", "NF-kappa", "B", "is", "concluded", "from", "the", "inability", "of", "PKC-zeta", "(", "mut", ")", "to", "interfere", "with", "the", "basal", "or", "phorbol", "myristate", "acetate-inducible", "CREB", "-or", "AP1", "-dependent", "transcriptional", "activity", "." ]
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5812
[ "Lastly", ",", "we", "demonstrate", "a", "selective", "inhibition", "of", "p24", "production", "by", "HIV-infected", "human", "macrophages", "when", "treated", "with", "AO", "to", "PKC-zeta", "." ]
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5813
[ "Altogether", ",", "these", "results", "suggest", "that", "atypical", "PKC", "isoenzymes", ",", "including", "PKC-zeta", ",", "participate", "in", "the", "signal", "transduction", "pathways", "by", "which", "HIV", "infection", "results", "in", "the", "activation", "of", "NF-kappa", "B", "in", "human", "monocytic", "cells", "and", "macrophages", "." ]
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5814
[ "Induction", "of", "Bcl-x", "(", "L", ")", "expression", "by", "human", "T-cell", "leukemia", "virus", "type", "1", "Tax", "through", "NF-kappaB", "in", "apoptosis-resistant", "T-cell", "transfectants", "with", "Tax", "." ]
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5815
[ "Human", "T-cell", "leukemia", "virus", "type", "1", "(", "HTLV-1", ")", "Tax", "is", "thought", "to", "play", "a", "pivotal", "role", "in", "immortalization", "of", "T", "cells", "." ]
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5816
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5817
[ "In", "this", "study", ",", "we", "demonstrate", "that", "constitutive", "expression", "of", "bcl-xl", "but", "not", "bcl-2", ",", "bcl-xs", ",", "bak", ",", "bad", ",", "or", "bax", "was", "associated", "with", "apoptosis", "resistance", "after", "IL-2", "deprivation", "in", "CTLL-2", "cells", "that", "expressed", "Tax", "." ]
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5818
[ "Transient-transfection", "assays", "showed", "that", "bcl-x", "promoter", "was", "transactivated", "by", "wild-type", "Tax", "." ]
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5819
[ "Similar", "effects", "were", "observed", "in", "mutant", "Tax", "retaining", "transactivating", "ability", "through", "NF-kappaB", "." ]
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5820
[ "Deletion", "or", "substitution", "of", "a", "putative", "NF-kappaB", "binding", "site", "identified", "in", "the", "bcl-x", "promoter", "significantly", "decreased", "Tax", "-induced", "transactivation", "." ]
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5821
[ "This", "NF-kappaB-like", "element", "was", "able", "to", "form", "a", "complex", "with", "NF-kappaB", "family", "proteins", "in", "vitro", "." ]
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5822
[ "Furthermore", ",", "Tax", "-induced", "transactivation", "of", "the", "bcl-x", "promoter", "was", "also", "diminished", "by", "the", "mutant", "IkappaBalpha", ",", "which", "specifically", "inhibits", "NF-kappaB", "activity", "." ]
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5823
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5824
[ "The", "beta-globin", "promoter", "is", "important", "for", "recruitment", "of", "erythroid", "Kruppel-like", "factor", "to", "the", "locus", "control", "region", "in", "erythroid", "cells", "." ]
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5825
[ "Erythroid", "Kruppel-like", "factor", "(", "EKLF", ")", ",", "which", "binds", "to", "the", "CACCC", "box", "in", "the", "beta-globin", "promoter", ",", "is", "required", "for", "the", "expression", "of", "the", "beta-globin", "gene", "in", "adult", "erythroid", "cells", "." ]
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5826
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5827
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5828
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5829
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5830
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5831
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5832
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5833
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5834
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5835
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5836
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5837
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5838
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5839
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5840
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5841
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5842
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5843
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5844
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5845
[ "In", "contrast", ",", "IL-2", "induces", "a", "rapid", "and", "transient", "tyrosine", "and", "serine", "phosphorylation", "of", "Stat3", "." ]
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5846
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5847
[ "CD3", "-mediated", "activation", "of", "Stat3", "is", "almost", "completely", "inhibited", "by", "a", "Src", "kinase", "inhibitor", "(", "PP1", ")", ",", "whereas", "IL-2", "-induced", "Stat3", "activation", "is", "unaffected", "." ]
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5848
[ "In", "conclusion", ",", "we", "show", "that", "CD3", "ligation", "by", "mAb", "and", "SE", "triggers", "a", "rapid", ",", "PP1", "-sensitive", "tyrosine", "and", "serine", "phosphorylation", "of", "Stat3", "in", "human", "CD4+", "T", "cells", "." ]
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5849
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5850
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5851
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5852
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5853
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5854
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5855
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5856
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5857
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5858
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5859
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5860
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5861
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5862
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5863
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5864
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5865
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5866
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5867
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5868
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5869
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5870
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5871
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5872
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5873
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5874
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5875
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5876
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5877
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5878
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5879
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5880
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5881
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5882
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5883
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5884
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5885
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5886
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5887
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5888
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5889
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5890
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5891
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5892
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5893
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5894
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5895
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5896
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5897
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5898
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5899
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5900
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