Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
5601
[ "This", "study", "has", "investigated", "DHEA", "modulation", "of", "LPS-induced", "monocyte", "cytotoxicity", "." ]
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5602
[ "Cytotoxicity", "markers", "assessed", "include", "tumor", "cell", "killing", ",", "IL-1", "secretion", ",", "reactive", "oxygen", "intermediate", "release", ",", "nitric", "oxide", "synthetase", "activity", "as", "measured", "by", "the", "release", "of", "reactive", "nitrogen", "intermediates", ",", "complement", "receptor-1", "cell", "surface", "protein", ",", "and", "TNF-alpha", "protein", "presence", "." ]
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5603
[ "Monocytes", "stimulated", "with", "LPS", "concentrations", "of", "1.0", "micrograms/ml", "displayed", "the", "above", "cytotoxic", "markers", ",", "whereas", "monocytes", "stimulated", "with", "DHEA", "alone", "or", "with", "LPS", "at", "a", "lower", "concentration", "of", "0.2", "ng/ml", "did", "not", "." ]
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5604
[ "However", ",", "when", "used", "simultaneously", ",", "DHEA", "and", "LPS", "0.2", "ng/ml", "displayed", "a", "synergistic", "effect", "on", "monocyte", "cytotoxicity", "against", "cancerous", "cell", "lines", ",", "IL-1", "secretion", ",", "reactive", "nitrogen", "intermediate", "release", ",", "complement", "receptor-1", "cell-surface", "protein", ",", "and", "TNF-alpha", "protein", "to", "levels", "comparable", "with", "levels", "obtained", "using", "LPS", "1.0", "microgram/ml", "." ]
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5605
[ "Finally", ",", "Scatchard", "plot", "analysis", "demonstrated", "the", "presence", "of", "a", "DHEA", "receptor", "in", "monocytes", ",", "suggesting", "that", "DHEA", "effects", "on", "LPS-stimulated", "monocytes", "are", "mediated", "through", "a", "receptor-dependent", "process", "." ]
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5606
[ "Interferons", "inhibit", "activation", "of", "STAT6", "by", "interleukin", "4", "in", "human", "monocytes", "by", "inducing", "SOCS-1", "gene", "expression", "." ]
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5607
[ "Interferons", "(", "IFNs", ")", "inhibit", "induction", "by", "IL-4", "of", "multiple", "genes", "in", "human", "monocytes", "." ]
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5608
[ "However", ",", "the", "mechanism", "by", "which", "IFNs", "mediate", "this", "inhibition", "has", "not", "been", "defined", "." ]
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5609
[ "IL-4", "activates", "gene", "expression", "by", "inducing", "tyrosine", "phosphorylation", ",", "homodimerization", ",", "and", "nuclear", "translocation", "of", "the", "latent", "transcription", "factor", ",", "STAT6", "(", "signal", "transducer", "and", "activator", "of", "transcription-6", ")", "." ]
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5610
[ "STAT6", "-responsive", "elements", "are", "characteristically", "present", "in", "the", "promoters", "of", "IL-4-inducible", "genes", "." ]
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5611
[ "Because", "STAT6", "activation", "is", "essential", "for", "IL-4", "-induced", "gene", "expression", ",", "we", "examined", "the", "ability", "of", "type", "I", "and", "type", "II", "IFNs", "to", "regulate", "activation", "of", "STAT6", "by", "IL-4", "in", "primary", "human", "monocytes", "." ]
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5612
[ "Pretreatment", "of", "monocytes", "with", "IFN-beta", "or", "IFN-gamma", ",", "but", "not", "IL-1", ",", "IL-2", ",", "macrophage", "colony-stimulating", "factor", ",", "granulocyte/macrophage", "colony-stimulating", "factor", ",", "IL-6", ",", "or", "transforming", "growth", "factor", "beta", "suppressed", "activation", "of", "STAT6", "by", "IL-4", "." ]
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5613
[ "This", "inhibition", "was", "associated", "with", "decreased", "tyrosine", "phosphorylation", "and", "nuclear", "translocation", "of", "STAT6", "and", "was", "not", "evident", "unless", "the", "cells", "were", "preincubated", "with", "IFN", "for", "at", "least", "1", "hr", "before", "IL-4", "stimulation", "." ]
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5614
[ "Furthermore", ",", "inhibition", "by", "IFN", "could", "be", "blocked", "by", "cotreatment", "with", "actinomycin", "D", "and", "correlated", "temporally", "with", "induction", "of", "the", "JAK/STAT", "inhibitory", "gene", ",", "SOCS-1", "." ]
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5615
[ "Forced", "expression", "of", "SOCS-1", "in", "a", "macrophage", "cell", "line", ",", "RAW264", ",", "markedly", "suppressed", "trans-activation", "of", "an", "IL-4-inducible", "reporter", "as", "well", "as", "IL-6-", "and", "IFN-gamma-induced", "reporter", "gene", "activity", "." ]
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5616
[ "These", "findings", "demonstrate", "that", "IFNs", "inhibit", "IL-4", "-induced", "activation", "of", "STAT6", "and", "STAT6", "-dependent", "gene", "expression", ",", "at", "least", "in", "part", ",", "by", "inducing", "expression", "of", "SOCS-1", "." ]
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5617
[ "An", "activation-responsive", "element", "in", "single", "C", "motif-1/lymphotactin", "promoter", "is", "a", "site", "of", "constitutive", "and", "inducible", "DNA-protein", "interactions", "involving", "nuclear", "factor", "of", "activated", "T", "cell", "." ]
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5618
[ "Single", "C", "motif-1", "(", "SCM-1", ")", "/lymphotactin", "is", "a", "C-type", "chemokine", "whose", "expression", "is", "activation", "dependent", ",", "cyclosporin", "A", "sensitive", "and", "restricted", "to", "CD8+", "T", "cells", ",", "double-negative", "thymocytes", ",", "gammadelta-type", "T", "cells", ",", "and", "NK", "cells", "." ]
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5619
[ "In", "humans", ",", "there", "are", "two", "highly", "homologous", "genes", "encoding", "SCM-1alpha", "and", "SCM-1beta", "." ]
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5620
[ "Here", "we", "examined", "the", "regulatory", "mechanism", "of", "the", "SCM-1", "genes", "." ]
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5621
[ "The", "luciferase", "reporter", "gene", "under", "the", "control", "of", "the", "5", "'", "flanking", "region", "of", "0.7", "kb", "was", "strongly", "induced", "upon", "activation", "with", "anti-CD3", "or", "PHA", "plus", "PMA", "only", "in", "SCM-1-producer", "T", "cell", "lines", "through", "a", "cyclosporin", "A-sensitive", "mechanism", "." ]
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5622
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5623
[ "In", "electrophoretic", "mobility", "shift", "assays", "using", "the", "E1", "oligonucleotide", "as", "probe", ",", "nuclear", "extracts", "from", "unstimulated", "T", "and", "B", "cell", "lines", "formed", "a", "constitutive", "complex", "termed", "complex", "I", ",", "while", "nuclear", "extracts", "from", "stimulated", "SCM-1-producer", "T", "cell", "lines", "formed", "a", "higher", "mobility", "complex", "termed", "complex", "II", "with", "a", "concomitant", "decrease", "in", "complex", "I", "." ]
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5624
[ "The", "shift", "from", "complex", "I", "to", "complex", "II", "seen", "only", "in", "SCM-1-producer", "T", "cell", "lines", "upon", "activation", "was", "completely", "suppressed", "by", "cyclosporin", "A", "." ]
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5625
[ "Both", "complexes", "were", "critically", "dependent", "on", "the", "NF-AT", "core", "sequence", "TTTCC", "in", "the", "E1", "element", "and", "were", "partially", "supershifted", "by", "anti-NF-ATp", "." ]
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5626
[ "One-hybrid", "assays", "in", "yeast", "isolated", "NF-ATp", "as", "an", "E1", "binding", "protein", ",", "and", "transfection", "of", "NF-ATp", "into", "T", "and", "B", "cell", "lines", "strongly", "enhanced", "the", "activation-dependent", "SCM-1", "promoter", "activity", "." ]
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5627
[ "Collectively", ",", "a", "unique", "mechanism", "involving", "NF-ATp", "appears", "to", "regulate", "the", "cell", "type-specific", "and", "activation-dependent", "expression", "of", "the", "SCM-1", "genes", "." ]
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5628
[ "Dopamine", "stimulates", "expression", "of", "the", "human", "immunodeficiency", "virus", "type", "1", "via", "NF-kappaB", "in", "cells", "of", "the", "immune", "system", "." ]
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5629
[ "Recent", "studies", "have", "reported", "that", "lymphocytes", "produce", ",", "transport", "and", "bind", "dopamine", "present", "in", "plasma", "." ]
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5630
[ "However", ",", "the", "action", "of", "dopamine", "on", "HIV-1", "gene", "expression", "in", "cells", "of", "the", "immune", "system", "has", "not", "yet", "been", "examined", "." ]
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5631
[ "Here", ",", "we", "have", "investigated", "the", "regulation", "of", "HIV-1", "expression", "by", "dopamine", "in", "Jurkat", "T", "cells", "and", "in", "primary", "blood", "mononuclear", "cells", "(", "PBMC", ")", "." ]
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5632
[ "HIV-1", "replication", "was", "increased", "by", "dopamine", ",", "which", "correlated", "with", "the", "increased", "levels", "of", "HIV-1", "transactivation", "." ]
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5633
[ "Our", "transient", "expression", "data", "revealed", "that", "dopamine", "stimulated", "transcription", "through", "the", "NF-kappaB", "element", "present", "in", "the", "long", "terminal", "repeat", "." ]
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5634
[ "The", "importance", "of", "NF-kappaB", "sites", "was", "confirmed", "by", "using", "vectors", "containing", "wild-type", "or", "mutant", "kappaB", "sites", "in", "a", "heterologous", "promoter", "." ]
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5635
[ "Consistent", "with", "the", "role", "of", "NF-kappaB", "in", "mediating", "dopamine", "responsiveness", ",", "the", "proteasome", "inhibitor", "MG132", "abolished", "dopamine-induced", "transcriptional", "activation", "." ]
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5636
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5637
[ "The", "combination", "of", "dopamine", "and", "TNF-alpha", "led", "to", "a", "stimulation", "of", "HIV-1", "transcription", "and", "replication", "." ]
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5638
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5639
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5640
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5641
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5642
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5643
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5644
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5645
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5646
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5647
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5648
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5649
[ "IL-10-activated", "STAT1", "could", "bind", "to", "the", "GAS-motif", "sequence", "in", "the", "promoter", "region", "of", "the", "Fcgamma", "receptor", ",", "but", "not", "to", "that", "in", "the", "promoter", "region", "of", "the", "COX-2", "gene", ",", "whereas", "IFN-gamma-activated", "STAT1", "and", "STAT5", "could", "bind", "to", "both", "sequences", "." ]
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5650
[ "IL-10", "inhibited", "IFN-gamma", "-induced", "STAT", "activation", "without", "newly", "synthesized", "protein", "." ]
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5651
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5652
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5653
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5654
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