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5701
[ "Glucocorticoids", ",", "as", "a", "part", "of", "their", "physiological", "role", "in", "the", "control", "of", "inflammatory", "and", "immune", "processes", ",", "suppress", "the", "expression", "of", "interleukin-1", "(", "IL-1", ")", "and", "other", "cytokines", "." ]
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5702
[ "Human", "monocyte", "IL-1", "receptor", "antagonist", "(", "IL-1ra", ")", "messenger", "ribonucleic", "acid", "(", "mRNA", ")", "expression", "and", "protein", "secretion", "are", "inhibited", "by", "dexamethasone", "." ]
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5703
[ "We", "have", "now", "further", "studied", "the", "regulation", "of", "IL-1ra", "by", "the", "major", "physiological", "human", "glucocorticoid", ",", "cortisol", "." ]
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5704
[ "We", "found", "that", "cortisol", "incubation", "induced", "a", "decrease", "in", "IL-1ra", "mRNA", "expression", "and", "a", "significant", "inhibition", "of", "IL-1ra", "protein", "secretion", "in", "cell", "cultures", "of", "human", "peripheral", "monocytes", "stimulated", "with", "the", "bacterial", "endotoxin", "lipopolysaccharide", "(", "LPS", ")", "." ]
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5705
[ "Oral", "administration", "of", "276", "mumol", "cortisol", "to", "normal", "subjects", "also", "decreased", "LPS-induced", "IL-1ra", "synthesis", "in", "cultured", "monocytes", "." ]
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5706
[ "By", "coincubating", "the", "monocytes", "with", "either", "the", "mineralocorticoid", "antagonist", "spironolactone", "or", "the", "glucocorticoid", "receptor", "antagonist", "RU", "38486", ",", "the", "in", "vitro", "cortisol-induced", "inhibition", "of", "LPS-stimulated", "IL-1ra", "secretion", "was", "partially", "reversed", "." ]
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5707
[ "The", "mineralocorticoid", "aldosterone", "exerted", "a", "significant", "decrease", "in", "LPS-induced", "monocyte", "IL-1ra", "secretion", "in", "vitro", ",", "which", "was", "blocked", "by", "coincubation", "with", "spironolactone", "." ]
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5708
[ "In", "addition", ",", "the", "expression", "of", "mineralocorticoid", "receptor", "mRNA", "in", "human", "monocytes", "was", "observed", "by", "PCR", "of", "reversed", "transcribed", "RNA", "." ]
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5709
[ "Our", "results", "further", "indicate", "that", "corticosteroids", "physiologically", "control", "the", "IL-1/", "IL-1ra", "system", "during", "inflammatory", "or", "immune", "processes", "." ]
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5710
[ "Moreover", ",", "we", "provide", "evidence", "that", ",", "in", "addition", "to", "a", "glucocorticoid", "receptor", "-mediated", "effect", ",", "the", "mineralocorticoid", "receptor", "is", "involved", "in", "the", "inhibition", "of", "monocyte", "IL-1ra", "secretion", "by", "cortisol", "." ]
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5711
[ "Target", "structures", "of", "the", "CD8", "(", "+", ")", "-T-cell", "response", "to", "human", "cytomegalovirus", ":", "the", "72-kilodalton", "major", "immediate-early", "protein", "revisited", "." ]
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5712
[ "Cell-mediated", "immunity", "plays", "an", "essential", "role", "in", "the", "control", "of", "infection", "with", "the", "human", "cytomegalovirus", "(", "HCMV", ")", "." ]
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5713
[ "However", ",", "only", "a", "few", "CD8", "(", "+", ")", "-T-cell", "epitopes", "are", "known", ",", "with", "the", "majority", "being", "contained", "in", "the", "pp65", "phosphoprotein", ",", "which", "is", "believed", "to", "dominate", "the", "CD8", "(", "+", ")", "-T-cell", "response", "to", "HCMV", "." ]
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5714
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5715
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5716
[ "For", "this", "purpose", ",", "81", "pentadecamer", "peptides", "covering", "the", "complete", "491-amino-acid", "sequence", "of", "IE-1", "were", "tested", "on", "peripheral", "blood", "mononuclear", "cells", "of", "anti-HCMV", "immunoglobulin", "G-seropositive", "donors", "." ]
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5717
[ "At", "least", "10", "new", "epitopes", "were", "identified", ",", "and", "the", "fine", "specificity", "and", "presenting", "HLA", "molecule", "of", "the", "first", "of", "them", "was", "determined", "." ]
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5718
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5719
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5720
[ "In", "summary", ",", "our", "results", "suggest", "that", "IE-1", "is", "far", "more", "important", "as", "a", "CD8", "(", "+", ")", "-T-cell", "target", "than", "current", "opinion", "suggests", "." ]
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5721
[ "E1A", "oncogene", "induction", "of", "cellular", "susceptibility", "to", "killing", "by", "cytolytic", "lymphocytes", "through", "target", "cell", "sensitization", "to", "apoptotic", "injury", "." ]
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5722
[ "E1A", "oncogene", "expression", "increases", "mammalian", "cell", "susceptibility", "to", "lysis", "by", "cytolytic", "lymphocytes", "(", "CLs", ")", "at", "a", "stage", "in", "this", "intercellular", "interaction", "that", "is", "independent", "of", "cell", "surface", "recognition", "events", "." ]
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5723
[ "Since", "CLs", "can", "induce", "either", "apoptotic", "or", "necrotic", "cell", "death", ",", "we", "asked", "whether", "E1A", "sensitization", "to", "injury-induced", "apoptosis", "is", "sufficient", "to", "explain", "E1A", "-induced", "cytolytic", "susceptibility", "." ]
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5724
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5725
[ "In", "contrast", ",", "E1A-positive", "cells", "were", "no", "more", "susceptible", "to", "injury-induced", "necrosis", "than", "E1A-negative", "cells", "." ]
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5726
[ "Similar", "to", "induction", "of", "cytolytic", "susceptibility", "and", "in", "contrast", "to", "other", "E1A", "activities", ",", "cellular", "sensitization", "to", "chemically", "induced", "apoptosis", "depended", "on", "high-level", "E1A", "oncoprotein", "expression", "." ]
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5727
[ "Loss", "of", "both", "cytolytic", "susceptibility", "and", "sensitization", "to", "chemically", "induced", "apoptosis", "was", "coselected", "during", "in", "vivo", "selection", "of", "E1A-positive", "sarcoma", "cells", "for", "increased", "tumorigenicity", "." ]
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5728
[ "Furthermore", ",", "E1A", "mutant", "proteins", "that", "can", "not", "bind", "the", "cellular", "transcriptional", "coactivator", ",", "p300", ",", "and", "that", "fail", "to", "induce", "cytolytic", "susceptibility", "also", "failed", "to", "sensitize", "cells", "to", "injury-induced", "apoptosis", "." ]
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5729
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5730
[ "Copyright", "1999", "Academic", "Press", "." ]
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5731
[ "TCL1", "oncogene", "expression", "in", "AIDS-related", "lymphomas", "and", "lymphoid", "tissues", "." ]
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5732
[ "AIDS-related", "non-Hodgkin", "'s", "lymphoma", "(", "AIDS", "NHL", ")", "comprises", "a", "diverse", "and", "heterogeneous", "group", "of", "high-grade", "B", "cell", "tumors", "." ]
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5733
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5734
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5735
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5736
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5737
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5738
[ "We", "find", "that", "TCL1", "is", "expressed", "in", "the", "majority", "of", "AIDS", "IBLP", "tumors", "examined", "." ]
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5739
[ "TCL1", "protein", "expression", "is", "restricted", "to", "tumor", "cells", "in", "AIDS", "IBLP", "tissue", "samples", "analyzed", "with", "immunohistochemical", "staining", "." ]
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5740
[ "Hyperplastic", "lymph", "node", "and", "tonsil", "also", "exhibit", "strong", "TCL1", "protein", "expression", "in", "mantle", "zone", "B", "cells", "and", "in", "rare", "interfollicular", "zone", "cells", ",", "whereas", "follicle-center", "B", "cells", "(", "centroblasts", "and", "centrocytes", ")", "show", "weaker", "expression", "." ]
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5741
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5742
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5743
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5744
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5745
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5746
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5747
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5748
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5749
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5750
[ "Moreover", "T", "cell", "proliferation", "was", "unaffected", "by", "the", "addition", "of", "blocking", "Abs", "to", "both", "IL-2", "and", "the", "IL-2", "receptor", ",", "demonstrating", "that", "this", "form", "of", "costimulation", "by", "CD28", "was", "independent", "of", "IL-2", "." ]
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5751
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5752
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5758
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5759
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5760
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5761
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5762
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5763
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5764
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5765
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5766
[ "We", "provide", "evidence", "that", "Zta", "up-regulation", "of", "p53", "leads", "to", "p53", "-mediated", "interference", "with", "JAK", "/STAT", "activation", "of", "Qp", "." ]
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5767
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5768
[ "Reactive", "oxygen", "intermediate-release", "of", "fibre-exposed", "monocytes", "increases", "inflammatory", "cytokine-mRNA", "level", ",", "protein", "tyrosine", "kinase", "and", "NF-kappaB", "activity", "in", "co-cultured", "bronchial", "epithelial", "cells", "(", "BEAS-2B", ")", "." ]
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5769
[ "Some", "pulmonary", "diseases", "like", "bronchitis", "or", "asthma", "bronchiale", "are", "mediated", "by", "inflammatory", "mechanisms", "in", "bronchial", "epithelial", "cells", "." ]
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5770
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5771
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5772
[ "BM", "were", "exposed", "to", "Chrysotile", "B", "and", "soot", "particle", "FR", "101", "in", "a", "concentration", "of", "100", "microg/10", "(", "6", ")", "cells", "." ]
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5773
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5774
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5775
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5776
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5777
[ "These", "data", "suggest", "a", "ROI-dependent", "NF-kappaB", "mediated", "transcription", "of", "inflammatory", "cytokines", "in", "bronchial", "epithelial", "cells", "." ]
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5778
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5779
[ "CD8+", "T", "lymphocytes", "of", "HIV-1", "infected", "individuals", "produce", "a", "soluble", "factor", "that", "efficiently", "suppresses", "HIV-1", "replication", "at", "the", "transcriptional", "level", "." ]
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5780
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5781
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5782
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5783
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5784
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5785
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5786
[ "Inhibition", "of", "NF-kappa", "B", "activation", "in", "human", "T-cell", "lines", "by", "anetholdithiolthione", "." ]
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5787
[ "Nuclear", "factor", "(", "NF", ")", "-kappa", "B", "is", "a", "redox", "sensitive", "cytosolic", "transcription", "factor", "." ]
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5788
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5789
[ "Therefore", ",", "inhibition", "of", "NF-kappa", "B", "activation", "may", "be", "an", "effective", "strategy", "for", "acquired", "immunodeficiency", "syndrome", "therapy", "." ]
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5790
[ "Anetholdithiolthione", "(", "ADT", ",", "5-", "[", "p-methoxyphenyl", "]", "-3H-1", ",", "2-dithiol-3-thione", ")", "is", "an", "antioxidant", "which", "has", "been", "used", "to", "protect", "against", "acetaminophen-", "and", "CCl4-induced", "hepatotoxicity", ",", "lipid", "peroxidation", ",", "radiation", "injury", ",", "and", "also", "has", "been", "used", "clinically", "as", "an", "anti-choleretic", "agent", "." ]
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5791
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5792
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5793
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5794
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5795
[ "H2O2", "induced", "lipid", "peroxidation", "in", "Wurzburg", "cells", "was", "remarkably", "inhibited", "by", "ADT", "pretreatment", "." ]
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5796
[ "ADT", ",", "a", "pro-glutathione", "antioxidant", ",", "was", "observed", "to", "be", "capable", "of", "modulating", "NF-kappa", "B", "activation", "." ]
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5797
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5798
[ "Induction", "of", "endothelial", "adhesion", "molecules", "by", "the", "cytokine", "tumor", "necrosis", "factor-alpha", "(", "TNF", ")", "can", "occur", "independently", "of", "protein", "kinase", "C", "and", "activation", "of", "a", "protein", "tyrosine", "kinase", "(", "PTK", ")", "has", "recently", "been", "implicated", "in", "the", "upregulation", "of", "vascular", "cell", "adhesion", "molecule", "1", "(", "VCAM-1", ")", "by", "interleukin-4", "(", "IL-4", ")", "on", "endothelial", "cells", "." ]
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5799
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5800
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