Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
14501
[ "At", "nucleotide", "2", ",", "317", "we", "identified", "a", "homozygous", "A", "for", "G", "point", "mutation", "that", "predicts", "an", "isoleucine", "(", "ATT", ")", "for", "valine", "(", "GTT", ")", "substitution", "at", "amino", "acid", "729", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14502
[ "When", "the", "wild-type", "hGR", "and", "hGR-Ile", "729", "were", "expressed", "in", "COS-1", "cells", "and", "assayed", "for", "[", "3H", "]", "-Dexamethasone", "binding", ",", "the", "dissociation", "constants", "were", "0.799", "+/-", "0.068", "and", "1.54", "+/-", "0.06", "nM", "(", "mean", "+/-", "SEM", ")", "(", "P", "<", "0.01", ")", ",", "respectively", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14503
[ "When", "the", "wild-type", "hGR", "and", "hGR-Ile", "729", "were", "expressed", "in", "CV-1", "cells", "that", "were", "cotransfected", "with", "the", "mouse", "mammary", "tumor", "virus", "long", "terminal", "repeat", "fused", "to", "the", "chloramphenicol", "acetyl", "transferase", "(", "CAT", ")", "gene", ",", "the", "hGR-Ile", "729", "conferred", "a", "fourfold", "decrease", "in", "apparent", "potency", "on", "dexamethasone", "stimulation", "of", "CAT", "activity", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
14504
[ "The", "isoleucine", "for", "valine", "substitution", "at", "amino", "acid", "729", "impairs", "the", "function", "of", "the", "hGR", "and", "is", "the", "likely", "cause", "of", "primary", "cortisol", "resistance", "in", "this", "subject", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14505
[ "The", "transcriptionally", "active", "factors", "mediating", "the", "effect", "of", "the", "HTLV-I", "Tax", "transactivator", "on", "the", "IL-2R", "alpha", "kappa", "B", "enhancer", "include", "the", "product", "of", "the", "c-rel", "proto-oncogene", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 1, 2, 0 ]
14506
[ "The", "transactivator", "HTLV-I", "Tax", "activates", "the", "promoter", "of", "the", "gene", "coding", "for", "the", "interleukin", "2", "alpha-chain", "receptor", "(", "IL-2R", "alpha", ")", "via", "a", "kappa", "B", "site", "that", "can", "bind", "several", "protein", "species", "of", "the", "rel", "family", "." ]
[ 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 10, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
14507
[ "Tax1", "strongly", "activates", "the", "enhancer", "activity", "of", "this", "motif", ",", "in", "both", "epithelial", "HeLa", "and", "lymphoid", "Jurkat", "cells", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 5, 6, 6, 0 ]
14508
[ "This", "activation", "was", "not", "observed", "in", "undifferentiated", "embryocarcinoma", "F9", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]
14509
[ "Overexpression", "of", "the", "p50", ",", "p65", "and", "Rel", "proteins", "in", "these", "cells", "showed", "that", "significant", "activation", "of", "the", "IL-2R", "alpha", "kappa", "B", "site", "was", "observed", "only", "with", "Rel", "and", "Rel", "plus", "p65", "." ]
[ 0, 0, 0, 9, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0 ]
14510
[ "Moreover", ",", "whereas", "both", "Tax", "and", "phorbol", "12-myristate", "13-acetate", "(", "PMA", ")", "are", "able", "to", "efficiently", "induce", "the", "binding", "of", "NF-kappa", "B", "to", "the", "IL-2R", "alpha", "kappa", "B", "site", ",", "PMA", "is", "functionally", "inactive", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0 ]
14511
[ "Using", "the", "DNA", "affinity", "precipitation", "assay", ",", "we", "observed", "that", "Tax1", "is", "able", "to", "efficiently", "induce", "the", "binding", "of", "Rel", ",", "whereas", "PMA", "is", "not", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
14512
[ "This", "established", "a", "clear", "difference", "between", "both", "stimuli", ",", "indicating", "that", "Rel", "is", "the", "functionally", "active", "factor", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
14513
[ "We", "conclude", "from", "these", "results", "that", "the", "functional", "activity", "of", "members", "of", "the", "rel", "family", "is", "regulated", "by", "their", "interaction", "with", "DNA", "and", "that", "Rel", "can", "be", "a", "potent", "transcriptional", "activator", "on", "specific", "kappa", "B", "sites", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
14514
[ "Transcriptional", "regulation", "of", "interleukin", "3", "(", "IL3", ")", "in", "primary", "human", "T", "lymphocytes", "." ]
[ 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 7, 8, 8, 0 ]
14515
[ "Role", "of", "AP-1-", "and", "octamer-binding", "proteins", "in", "control", "of", "IL3", "gene", "expression", "." ]
[ 0, 0, 9, 0, 9, 10, 0, 0, 0, 1, 2, 0, 0 ]
14516
[ "We", "have", "investigated", "the", "molecular", "and", "biochemical", "basis", "for", "activation", "of", "interleukin", "3", "(", "IL3", ")", "gene", "expression", "in", "primary", "human", "T", "lymphocytes", "following", "CD3", "and", "CD2", "receptor", "stimulation", "or", "activation", "by", "phytohemagglutinin", "plus", "phorbol", "12-myristate", "13-acetate", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0, 0, 0, 7, 8, 8, 0, 9, 0, 9, 10, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
14517
[ "Using", "transfection", "and", "reporter", "gene", "assays", "specifically", "designed", "for", "primary", "T", "lymphocytes", "in", "conjunction", "with", "gel", "retardation", "assays", ",", "Western", "blot", "analyses", "and", "UV", "cross-linking", "studies", ",", "we", "found", "that", "c-Jun", ",", "c-Fos", ",", "and", "octamer-binding", "proteins", "play", "a", "major", "role", "in", "transcriptional", "activation", "of", "the", "IL3", "gene", "via", "their", "interaction", "with", "two", "specific", "regions", "contained", "within", "the", "IL3", "5'-flanking", "sequence", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
14518
[ "Additionally", ",", "the", "region", "between", "bases", "-107", "and", "-59", "of", "the", "IL3", "promoter", "containing", "putative", "AP-2", "and", "Sp1", "binding", "motifs", "appears", "necessary", "for", "basal", "level", "expression", "of", "the", "IL3", "gene", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
14519
[ "The", "data", "also", "indicate", "that", "CD2", "receptor", "activation", "and", "phytohemagglutinin", "plus", "phorbol", "12-myristate", "13-acetate", "stimulation", "augment", "T", "cell", "IL3", "gene", "expression", "through", "the", "same", "cis-", "and", "trans-activating", "signals", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0, 7, 8, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14520
[ "These", "results", "should", "contribute", "to", "a", "better", "understanding", "of", "the", "regulation", "of", "IL3", "gene", "expression", "in", "human", "T", "lymphocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 7, 8, 8, 0 ]
14521
[ "Dimerization", "of", "NF-KB2", "with", "RelA", "(", "p65", ")", "regulates", "DNA", "binding", ",", "transcriptional", "activation", ",", "and", "inhibition", "by", "an", "I", "kappa", "B-alpha", "(", "MAD-3", ")", "." ]
[ 0, 0, 9, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0 ]
14522
[ "Inducible", "expression", "of", "human", "immunodeficiency", "virus", "(", "HIV", ")", "is", "regulated", "by", "a", "cellular", "transcription", "factor", ",", "nuclear", "factor", "kappa", "B", "(", "NF-kappa", "B", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 10, 0, 0 ]
14523
[ "NF-kappa", "B", "is", "composed", "of", "distinct", "subunits", ";", "five", "independent", "genes", ",", "NFKB1", "(", "p105", ")", ",", "NFKB2", "(", "p100", ")", ",", "RelA", "(", "p65", ")", ",", "c-rel", "and", "relB", ",", "that", "encode", "related", "proteins", "that", "bind", "to", "kappa", "B", "DNA", "elements", "have", "been", "isolated", "." ]
[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 1, 0, 1, 0, 0, 1, 0, 1, 0, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0 ]
14524
[ "We", "have", "previously", "found", "that", "NFKB2", "(", "p49/p52", ")", "acts", "in", "concert", "with", "RelA", "(", "p65", ")", "to", "stimulate", "the", "HIV", "enhancer", "in", "Jurkat", "T-leukemia", "cells", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 1, 2, 0, 5, 6, 6, 0 ]
14525
[ "Here", "we", "examine", "the", "biochemical", "basis", "for", "the", "transcriptional", "regulation", "of", "HIV", "by", "NFKB2", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
14526
[ "Using", "Scatchard", "analysis", ",", "we", "have", "determined", "the", "dissociation", "constants", "of", "homodimeric", "p49", "and", "heterodimeric", "p49/p65", "for", "binding", "to", "the", "HIV", "kappa", "B", "site", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]
14527
[ "p49", "has", "a", "approximately", "18-fold-lower", "affinity", "for", "the", "HIV", "kappa", "B", "site", "(", "KD", "=", "69.1", "pM", ")", "than", "does", "the", "approximately", "50-kDa", "protein", "NFKB1", "(", "p50", ")", "derived", "from", "p105", "(", "KD", "=", "3.9", "pM", ")", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
14528
[ "In", "contrast", ",", "the", "affinity", "of", "heterodimeric", "NFKB2", "(", "p49", ")", "/RelA", "(", "p65", ")", "for", "this", "site", "is", "approximately", "6-fold", "higher", "(", "KD", "=", "11.8", "pM", ")", "than", "that", "of", "p49", "alone", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
14529
[ "Consistent", "with", "these", "findings", ",", "in", "vitro", "transcription", "was", "stimulated", "18-fold", "by", "the", "addition", "of", "preformed", ",", "heterodimeric", "NFKB2", "(", "p49", ")", "/RelA", "(", "p65", ")", "protein", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0 ]
14530
[ "Transcriptional", "activation", "of", "the", "HIV", "enhancer", "was", "also", "subject", "to", "regulation", "by", "recently", "cloned", "I", "kappa", "B-alpha", "(", "MAD-3", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0 ]
14531
[ "Recombinant", "I", "kappa", "B-alpha", "(", "MAD-3", ")", "inhibited", "the", "DNA", "binding", "activity", "of", "p65", ",", "p49/p65", ",", "and", "p50/p65", "but", "stimulated", "the", "binding", "of", "NFKB2", "(", "p49", ")", "or", "NFKB1", "(", "p50", ")", "." ]
[ 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 9, 0, 0 ]
14532
[ "Functional", "activation", "of", "an", "HIV", "reporter", "plasmid", "by", "p49/p65", "in", "transiently", "transfected", "Jurkat", "T-leukemia", "cells", "was", "also", "inhibited", "by", "coexpression", "of", "MAD-3", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 9, 0 ]
14533
[ "(", "ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")" ]
[ 0, 0, 0, 0, 0, 0, 0 ]
14534
[ "The", "c-rel", "protooncogene", "product", "represses", "NF-kappa", "B", "p65", "-mediated", "transcriptional", "activation", "of", "the", "long", "terminal", "repeat", "of", "type", "1", "human", "immunodeficiency", "virus", "." ]
[ 0, 9, 10, 10, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14535
[ "The", "long", "terminal", "repeat", "(", "LTR", ")", "of", "the", "type", "1", "human", "immunodeficiency", "virus", "(", "HIV-1", ")", "and", "the", "5", "'", "regulatory", "region", "of", "the", "gene", "encoding", "the", "interleukin", "2", "receptor", "alpha", "subunit", "(", "IL-2R", "alpha", ")", "share", "functional", "kappa", "B", "enhancer", "elements", "involved", "in", "the", "regulation", "of", "these", "inducible", "transcription", "units", "during", "T-cell", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 9, 10, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0 ]
14536
[ "These", "kappa", "B", "enhancer", "elements", "are", "recognized", "by", "a", "structurally", "related", "family", "of", "interactive", "proteins", "that", "includes", "p50", ",", "p65", ",", "and", "the", "product", "of", "the", "c-rel", "protooncogene", "(", "c-Rel", ")", "." ]
[ 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 0, 0 ]
14537
[ "Recent", "biochemical", "studies", "have", "shown", "that", "p65", "and", "p50", "form", "the", "prototypical", "NF-kappa", "B", "complex", ",", "which", "is", "rapidly", "translocated", "from", "the", "cytoplasm", "to", "the", "nucleus", "during", "T-cell", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0 ]
14538
[ "This", "intracellular", "signaling", "complex", "potently", "stimulates", "kappa", "B-directed", "transcription", "from", "either", "the", "HIV-1", "LTR", "or", "the", "IL-2R", "alpha", "promoter", "via", "the", "strong", "transactivation", "domain", "present", "in", "p65", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
14539
[ "We", "now", "demonstrate", "that", "nuclear", "expression", "of", "human", "c-Rel", ",", "which", "is", "induced", "by", "either", "phorbol", "ester", "or", "tumor", "necrosis", "factor", "alpha", "with", "delayed", "kinetics", "relative", "to", "p65", ",", "markedly", "represses", "p65", "-mediated", "activation", "of", "these", "transcription", "units", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
14540
[ "These", "inhibitory", "effects", "of", "c-Rel", "correlate", "with", "its", "DNA-binding", "activity", "but", "not", "with", "its", "ability", "to", "heterodimerize", "with", "p50", ",", "suggesting", "that", "c-Rel", "inhibition", "involves", "competition", "with", "p50/p65", "for", "occupancy", "of", "the", "kappa", "B", "enhancer", "element", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]
14541
[ "Together", ",", "these", "findings", "suggest", "that", "one", "function", "of", "c-Rel", "is", "as", "a", "physiologic", "repressor", "of", "the", "HIV-1", "LTR", "and", "IL-2R", "alpha", "promoters", ",", "serving", "to", "efficiently", "counter", "the", "strong", "transcriptional", "activating", "effects", "of", "p65", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
14542
[ "Ras", "oncogene", "transformation", "of", "human", "B", "lymphoblasts", "is", "associated", "with", "lymphocyte", "activation", "and", "with", "a", "block", "of", "differentiation", "." ]
[ 1, 2, 0, 0, 7, 8, 8, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0 ]
14543
[ "The", "p21ras", "small", "GTP", "binding", "proteins", "participate", "in", "signal", "transduction", "from", "cell", "surface", "receptors", "and", "affect", "neoplastic", "transformation", "and", "development", "in", "many", "different", "cell", "types", "." ]
[ 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14544
[ "In", "the", "present", "study", ",", "we", "examined", "the", "relationship", "between", "ras", "transformation", "and", "differentiation", "of", "human", "B", "lymphocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 7, 8, 8, 0 ]
14545
[ "We", "show", "that", "the", "constitutive", "expression", "of", "the", "T24", "Ha-ras", "oncogene", "in", "EBV-immortalized", "B", "lymphoblasts", "was", "associated", "with", "the", "induction", "of", "the", "interleukin", "2", "receptor", "alpha", "subunit", ",", "with", "an", "impaired", "immunoglobulin", "gene", "expression", ",", "altered", "adhesion", "properties", "and", "increased", "survival", "in", "serum-free", "medium", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14546
[ "Since", "induction", "of", "the", "IL-2", "receptor", "alpha", "subunit", "is", "a", "hallmark", "of", "lymphocyte", "activation", ",", "we", "suggest", "that", "p21ras", "naturally", "triggers", "B", "cell", "activation", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0, 0 ]
14547
[ "The", "ras-transformed", "lymphocytes", "displayed", "a", "fully", "functional", "IL-2r", ",", "as", "assessed", "by", "c-fos", "induction", "following", "treatment", "with", "IL-2", ";", "nevertheless", ",", "they", "were", "not", "growth", "stimulated", "by", "this", "lymphokine", "." ]
[ 0, 0, 7, 0, 0, 0, 0, 9, 0, 0, 0, 0, 1, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14548
[ "The", "decreased", "expression", "of", "immunoglobulin", "genes", "indicates", "that", "the", "ras", "oncogene", "blocks", "terminal", "differentiation", "to", "plasma", "cells", ",", "possibly", "by", "inhibiting", "the", "activity", "of", "lymphocyte-specific", "transcription", "factors", "." ]
[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 1, 2, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14549
[ "Somewhat", "unexpectedly", ",", "the", "constitutive", "p21ras", "activity", "did", "not", "cause", "an", "increased", "DNA", "binding", "of", "transcription", "factors", "PEA1", "(", "AP1", ")", ",", "PEA3", ",", "Oct-2", "or", "NF-kB" ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 9, 0, 9, 0, 9 ]
14550
[ "Comparative", "analysis", "of", "NFAT", "(", "nuclear", "factor", "of", "activated", "T", "cells", ")", "complex", "in", "human", "T", "and", "B", "lymphocytes", "." ]
[ 0, 0, 0, 9, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 7, 8, 8, 8, 8, 0 ]
14551
[ "Nuclear", "factor", "of", "activated", "T", "cells", "(", "NFAT", ")", "is", "a", "transcriptional", "activator", "that", "binds", "to", "sequences", "in", "the", "interleukin-2", "(", "IL-2", ")", "promoter", "and", "is", "thought", "to", "be", "largely", "responsible", "for", "the", "T", "cell-specific", "inducibility", "of", "IL-2", "expression", "." ]
[ 9, 10, 10, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
14552
[ "Electrophoretic", "mobility", "shift", "assays", "(", "EMSA", ")", "showed", "that", "specific", "NFAT", "binding", "activity", "could", "also", "be", "induced", "in", "human", "B", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
14553
[ "The", "B", "cell", "NFAT", "complex", ",", "however", ",", "was", "not", "functional", ",", "since", "it", "failed", "to", "activate", "transcription", "from", "an", "NFAT-driven", "chloramphenicol", "acetyltransferase", "(", "CAT", ")", "construct", "." ]
[ 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0 ]
14554
[ "Competition", "with", "an", "AP-1", "motif", "or", "with", "anti-Jun", "and", "anti-Fos", "antibodies", "abolished", "binding", "to", "the", "NFAT", "motif", "in", "both", "T", "and", "B", "cells", ",", "indicating", "that", "Jun", "and", "Fos", "are", "critical", "for", "NFAT", "complex", "formation", "in", "both", "cell", "types", "." ]
[ 0, 0, 0, 1, 2, 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 1, 2, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0 ]
14555
[ "Purified", "recombinant", "Jun", "and", "Fos", "proteins", "failed", "to", "bind", "directly", "to", "the", "NFAT", "motif", "." ]
[ 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
14556
[ "However", ",", "when", "combined", "with", "unstimulated", "B", "or", "T", "cell", "extracts", ",", "full-length", ",", "but", "not", "truncated", ",", "Jun/Fos", "heterodimers", "were", "able", "to", "form", "an", "NFAT", "complex", ",", "indicating", "the", "presence", "of", "a", "constitutively", "expressed", "nuclear", "factor", "(", "s", ")", "in", "B", "and", "T", "cells", "necessary", "for", "the", "formation", "of", "the", "NFAT", "complex", "in", "both", "cell", "types", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]
14557
[ "An", "NFAT", "oligonucleotide", "carrying", "mutations", "in", "the", "5", "'", "purine-rich", "part", "of", "the", "NFAT", "sequence", "failed", "to", "form", "a", "complex", "and", "to", "compete", "with", "the", "wild", "type", "motif", "for", "NFAT", "complex", "formation", "in", "both", "T", "and", "B", "cells", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 7, 8, 8, 8, 0 ]
14558
[ "We", "therefore", "propose", "a", "model", "whereby", "a", "core", "NFAT", "complex", "consisting", "of", "Jun", ",", "Fos", ",", "and", "a", "constitutive", "nuclear", "factor", "is", "formed", "in", "both", "T", "and", "B", "cells", ",", "but", "an", "additional", "factor", "and/or", "post-translational", "modification", "of", "a", "factor", ",", "missing", "in", "B", "cells", ",", "might", "be", "required", "for", "transactivation", "by", "NFAT", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
14559
[ "Differential", "autoregulation", "of", "glucocorticoid", "receptor", "expression", "in", "human", "T-", "and", "B-cell", "lines", "." ]
[ 0, 0, 0, 9, 10, 0, 0, 5, 6, 6, 6, 6, 0 ]
14560
[ "Regulation", "of", "glucocorticoid", "receptor", "(", "GR", ")", "expression", "by", "its", "cognate", "ligand", "was", "examined", "in", "the", "glucocorticoid-sensitive", "human", "leukemic", "T-cell", "line", "6TG1.1", "and", "in", "the", "human", "B-cell", "line", "IM-9", "." ]
[ 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 5, 6, 6, 6, 0 ]
14561
[ "In", "contrast", "to", "the", "decrease", "in", "GR", "mRNA", "seen", "in", "IM-9", "cells", "after", "treatment", "with", "1", "microM", "dexamethasone", "for", "16-18", "h", ",", "treatment", "of", "6TG1.1", "cells", "resulted", "in", "an", "8-fold", "increase", "in", "GR", "mRNA", ",", "as", "determined", "by", "Northern", "blot", "and", "RNase", "protection", "analysis", ",", "with", "a", "corresponding", "3-", "to", "4-fold", "increase", "in", "GR", "protein", "." ]
[ 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
14562
[ "Half-maximal", "induction", "of", "GR", "mRNA", "and", "protein", "in", "6TG1.1", "cells", "was", "observed", "between", "10-100", "nM", "dexamethasone", ",", "and", "inclusion", "of", "1", "microM", "RU", "38486", "completely", "blocked", "the", "effects", "of", "100", "nM", "dexamethasone", ",", "demonstrating", "that", "positive", "autoregulation", "of", "GR", "expression", "in", "6TG1.1", "cells", "is", "a", "receptor-mediated", "response", "." ]
[ 0, 0, 0, 3, 4, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 5, 6, 0, 0, 0, 0, 0 ]
14563
[ "Positive", "autoregulation", "of", "GR", "expression", "was", "also", "observed", "in", "glucocorticoid-resistant", "CEM-C1", "cells", ",", "which", "contain", "functional", "GR", ",", "but", "whose", "growth", "is", "unaffected", "by", "glucocorticoids", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14564
[ "Thus", ",", "positive", "autoregulation", "is", "neither", "a", "consequence", "nor", "the", "sole", "cause", "of", "growth", "arrest", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14565
[ "The", "degree", "of", "negative", "autoregulation", "in", "IM-9", "cells", "and", "positive", "autoregulation", "in", "6TG1.1", "cells", "was", "unaffected", "by", "inhibition", "of", "protein", "synthesis", "with", "cycloheximide", "." ]
[ 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14566
[ "Measurement", "of", "GR", "mRNA", "turnover", "in", "6TG1.1", "cells", "treated", "with", "actinomycin-D", "revealed", "a", "half-life", "of", "2.5", "h", ",", "which", "was", "unaffected", "by", "dexamethasone", "treatment", "." ]
[ 0, 0, 3, 4, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14567
[ "A", "similar", "half-life", "was", "determined", "in", "IM-9", "cells", "and", "was", "also", "unaffected", "by", "steroid", "treatment", "." ]
[ 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0 ]
14568
[ "These", "results", "are", "consistent", "with", "the", "interpretation", "that", "glucocorticoid-mediated", "autoregulation", "of", "GR", "expression", "is", "a", "tissue-specific", "primary", "transcriptional", "response", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
14569
[ "Induction", "of", "CD8", "antigen", "and", "suppressor", "activity", "by", "glucocorticoids", "in", "a", "CEM", "human", "leukemic", "cell", "clone", "." ]
[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0 ]
14570
[ "The", "relationship", "between", "glucocorticoid", "effect", "and", "regulation", "of", "cell", "surface", "antigens", "was", "investigated", "in", "two", "models", "of", "leukemic", "cell", "lines", ",", "CEM", "C7", "denoted", "(", "r+", ",", "ly+", ")", "and", "CEM", "C1", "(", "r+", ",", "ly-", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0 ]
14571
[ "The", "reactivity", "of", "murine", "monoclonal", "antibodies", ",", "anti-CD4-FITC", ",", "anti-CD8-FITC", ",", "anti-CD2-FITC", "and", "anti-calla-FITC", ",", "were", "analyzed", "using", "flow", "cytometry", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
14572
[ "The", "suppressor", "function", "was", "determined", "using", "[", "3H", "]", "thymidine", "incorporation", "into", "phytohemagglutinin-activated", "peripheral", "blood", "lymphocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
14573
[ "Dexamethasone", "treatment", "of", "a", "human", "leukemic", "cell", "clone", "CEM", "C7", "caused", "an", "increase", "in", "a", "subset", "of", "cells", "expressing", "the", "surface", "antigen", "CD8", ",", "which", "is", "present", "on", "suppressor", "and", "cytotoxic", "T-lymphocytes", "." ]
[ 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0 ]
14574
[ "By", "comparison", ",", "there", "was", "no", "modification", "of", "the", "expression", "of", "CD4", "antigen", ",", "which", "is", "expressed", "at", "high", "levels", "in", "these", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14575
[ "After", "two", "days", "of", "treatment", "with", "5", "x", "10", "(", "-8", ")", "M", "dexamethasone", ",", "CEM", "C7", "cells", "showed", "a", "two-fold", "increase", "in", "suppressor", "activity", "compared", "to", "untreated", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14576
[ "In", "contrast", ",", "there", "was", "no", "regulation", "by", "glucocorticoids", "of", "either", "the", "CD8", "or", "CD4", "antigens", "in", "the", "leukemic", "clone", "CEM", "C1", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 5, 6, 6, 6, 0 ]
14577
[ "Furthermore", ",", "no", "modification", "of", "the", "suppressor", "function", "in", "CEM", "C1", "cells", "by", "dexamethasone", "was", "observed", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0 ]
14578
[ "In", "the", "human", "leukemic", "cells", "studied", "here", ",", "the", "ability", "to", "induce", "CD8", "antigen", "expression", "in", "a", "CD4+", "cells", "correlates", "with", "the", "ability", "to", "induce", "cell", "lysis", "in", "a", "glucocorticoid", "receptor", "positive", "cell", "population", "." ]
[ 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14579
[ "Adenovirus", "E1A", "inhibits", "IFN", "-induced", "resistance", "to", "cytolysis", "by", "natural", "killer", "cells", "." ]
[ 9, 10, 0, 9, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
14580
[ "Infection", "of", "target", "cells", "with", "cytopathic", "viruses", "inhibits", "IFN", "induction", "of", "cytolytic", "resistance", "to", "NK", "cell-mediated", "cytolysis", "[", "IFN", "-mediated", "cytoprotection", "(", "IFN", "-MCP", ")", "]", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0 ]
14581
[ "It", "has", "been", "thought", "that", "the", "virally", "induced", "inhibition", "of", "IFN", "-MCP", "is", "secondary", "to", "the", "shutdown", "of", "cellular", "macromolecular", "synthesis", "that", "accompanies", "cytopathic", "virus", "infections", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14582
[ "Group", "C", ",", "adenovirus", "serotype", "5", "(", "Ad5", ")", "infection", "inhibits", "both", "IFN", "-MCP", "and", "cellular", "protein", "synthesis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
14583
[ "This", "study", "determined", "if", "the", "Ad5-induced", "inhibition", "of", "IFN", "-MCP", "was", "independent", "of", "adenovirus", "(", "Ad", ")", "infection", "and", "secondary", "only", "to", "the", "expression", "of", "the", "Ad", "early", "region", "1A", "gene", "(", "E1A", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 1, 0, 0 ]
14584
[ "To", "test", "this", "hypothesis", ",", "4-h", "NK", "cytolysis", "assays", "were", "performed", "on", "IFN-gamma-treated", "human", "cells", "infected", "with", "an", "Ad5", "E1A", "deletion", "mutant", ",", "dl343", ",", "or", "transfected", "with", "the", "Ad5", "E1A", "gene", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
14585
[ "IFN", "-MCP", "was", "not", "inhibited", "by", "infection", "with", "dl343", ",", "despite", "the", "production", "of", "large", "amounts", "of", "both", "early", "(", "E1B", ",", "p55", ")", "and", "late", "(", "hexon", ")", "Ad", "proteins", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0 ]
14586
[ "In", "contrast", "to", "E1A-negative", ",", "parental", "cell", "lines", ",", "IFN", "-MCP", "was", "blocked", "in", "Ad5", "E1A-transfected", "epithelial", "and", "fibroblastic", "cell", "lines", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]
14587
[ "Genetic", "mapping", "studies", "within", "the", "E1A", "gene", "demonstrated", "that", "expression", "of", "only", "the", "first", "exon", "of", "E1A", "was", "sufficient", "to", "inhibit", "IFN", "-MCP", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 9, 0, 0 ]
14588
[ "DNA", "sequence", "homology", "of", "E1A", "genes", "between", "different", "Ad", "groups", "(", "group", "A", ",", "Ad12", ";", "group", "C", ",", "Ad5", ")", "is", "limited", "almost", "entirely", "to", "three", "conserved", "regions", "located", "within", "the", "first", "exon", "of", "E1A", "." ]
[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0 ]
14589
[ "Because", "IFN", "-MCP", "was", "also", "blocked", "in", "Ad12", "E1A-transfected", "cell", "lines", ",", "expression", "of", "one", "or", "more", "of", "the", "E1A-conserved", "regions", "may", "be", "necessary", "to", "inhibit", "IFN", "-MCP", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 0, 0 ]
14590
[ "In", "summary", ",", "the", "expression", "of", "E1A", "gene", "products", "inhibited", "IFN", "-MCP", "independently", "of", "virus", "infection", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0 ]
14591
[ "E1A", "'s", "inhibition", "of", "IFN", "-MCP", "has", "the", "net", "effect", "of", "promoting", "the", "selective", "NK", "cell-mediated", "clearance", "of", "Ad-infected", "or", "Ad-transformed", "human", "cells", "." ]
[ 1, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14592
[ "A", "protein", "of", "the", "AP-1", "family", "is", "a", "component", "of", "nuclear", "factor", "of", "activated", "T", "cells", "." ]
[ 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0 ]
14593
[ "Nuclear", "factor", "of", "activated", "T", "cells", "(", "NF-AT", ")", "is", "a", "transcriptional", "activator", "involved", "in", "the", "induction", "of", "IL-2", "gene", "expression", "." ]
[ 9, 10, 10, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0 ]
14594
[ "The", "response", "element", "for", "NF-AT", "is", "a", "sequence", "localized", "between", "-285/-254", "in", "the", "IL-2", "regulatory", "region", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
14595
[ "The", "composition", "of", "NF-AT", "protein", "is", "still", "not", "fully", "elucidated", "." ]
[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0 ]
14596
[ "We", "demonstrate", "that", ",", "in", "normal", "human", "T", "cells", ",", "an", "AP-1", "protein", "is", "a", "component", "of", "the", "NF-AT", "protein", "complex", "." ]
[ 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
14597
[ "This", "was", "evidenced", "by", "the", "ability", "of", "the", "AP-1", "site", "to", "compete", "with", "the", "NF-AT", "site", "for", "binding", "to", "NF-AT", "and", "by", "the", "capacity", "of", "immobilized", "anti-Jun", "and", "anti-Fos", "antibodies", "to", "deplete", "NF-AT", "-binding", "activity", "from", "nuclear", "extracts", "of", "activated", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
14598
[ "There", "was", "no", "detectable", "binding", "of", "in", "vitro", "translated", "Jun/Fos", "heterodimer", "(", "AP-1", ")", "to", "the", "NF-AT", "sequence", ",", "and", "the", "NF-AT", "sequence", "was", "unable", "to", "inhibit", "the", "binding", "of", "Jun/Fos", "to", "the", "AP-1", "sequence", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 1, 2, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 1, 2, 0 ]
14599
[ "The", "presence", "of", "an", "AP-1", "protein", "in", "the", "NF-AT", "protein", "complex", "may", "regulate", "NF-AT", "-binding", "activity", "through", "protein-protein", "interaction", "." ]
[ 0, 0, 0, 0, 9, 10, 0, 0, 9, 10, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
14600
[ "Interaction", "between", "NF-kappa", "B", "-and", "serum", "response", "factor", "-binding", "elements", "activates", "an", "interleukin-2", "receptor", "alpha-chain", "enhancer", "specifically", "in", "T", "lymphocytes", "." ]
[ 0, 0, 1, 2, 0, 1, 2, 2, 2, 2, 0, 0, 1, 2, 2, 2, 0, 0, 7, 8, 0 ]