Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
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sequence
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14401
[ "The", "present", "studies", "have", "examined", "the", "effects", "of", "vincristine-selected", ",", "multidrug", "resistance", "on", "12-O-tetradecanoylphorbol-13-acetate", "(", "TPA", ")", "-induced", "HL-60", "cell", "differentiation", "." ]
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14402
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14403
[ "By", "contrast", ",", "treatment", "of", "HL-60/vinc", "cells", "with", "okadaic", "acid", ",", "an", "inhibitor", "of", "serine/threonine", "protein", "phosphatases", ",", "induces", "c-jun", "transcription", ",", "growth", "arrest", ",", "and", "expression", "of", "the", "c-fms", "gene", "." ]
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14404
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14405
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14406
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14407
[ "Since", "TPA", "activates", "protein", "kinase", "C", "(", "PKC", ")", ",", "we", "examined", "translocation", "of", "PKC", "from", "the", "cytosol", "to", "the", "membrane", "fraction", "." ]
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14408
[ "Although", "HL-60", "and", "HL-60/vinc/R", "cells", "demonstrated", "translocation", "of", "PKC", "activity", ",", "this", "subcellular", "redistribution", "was", "undetectable", "in", "HL-60/vinc", "cells", "." ]
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14409
[ "Activity", "of", "the", "mitogen-activated", "protein", "kinase", "family", "with", "associated", "phosphorylation", "of", "c-Jun", "Y-peptide", "was", "markedly", "diminished", "in", "TPA-treated", "HL-60/vinc", "cells", ",", "but", "not", "in", "response", "to", "okadaic", "acid", "." ]
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14410
[ "Taken", "together", ",", "these", "findings", "suggest", "that", "vincristine", "resistance", "confers", "insensitivity", "to", "TPA-induced", "differentiation", "and", "can", "include", "defects", "in", "PKC", "-mediated", "signaling", "events", "and", "induction", "of", "jun/fos", "early", "response", "gene", "expression", "." ]
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14411
[ "Molecular", "basis", "of", "a", "multiple", "lymphokine", "deficiency", "in", "a", "patient", "with", "severe", "combined", "immunodeficiency", "." ]
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14412
[ "We", "have", "previously", "reported", "that", "the", "T", "lymphocytes", "of", "a", "child", "with", "severe", "combined", "immunodeficiency", "are", "defective", "in", "the", "transcription", "of", "several", "lymphokine", "genes", "that", "include", "IL2", ",", "IL3", ",", "IL4", ",", "and", "IL5", ",", "which", "encode", "interleukins", "2", ",", "3", ",", "4", ",", "and", "5", "(", "IL-2", ",", "-3", ",", "-4", ",", "and", "-5", ")", "." ]
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14413
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14414
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14415
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14416
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14417
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14418
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14419
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14420
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14421
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14422
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14423
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14424
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14425
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14426
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14428
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14429
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14430
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14431
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14432
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14433
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14434
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14435
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14436
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14437
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14438
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14439
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14440
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14441
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14442
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14444
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14445
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14449
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14450
[ "Lymphocytes", "from", "the", "site", "of", "disease", "suggest", "adenovirus", "is", "one", "cause", "of", "persistent", "or", "recurrent", "inflammatory", "arthritis", "." ]
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14451
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14452
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14453
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14454
[ "It", "is", "concluded", "that", "adenovirus", "may", "be", "one", "cause", "of", "persistent", "or", "recurrent", "inflammatory", "arthritis", "." ]
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14455
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14456
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14457
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14458
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14459
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14460
[ "In", "contrast", "to", "T", "cells", ",", "in", "fibroblasts", "PILOT", "gene", "expression", "requires", "only", "one", "signal", "(", "PMA", ")", "and", "is", "not", "affected", "by", "CyA", "." ]
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14461
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14462
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14463
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14464
[ "NF-kappa", "B", "is", "a", "pleiotropic", "regulator", "of", "a", "variety", "of", "genes", "implicated", "in", "the", "cellular", "response", "to", "injury", "." ]
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14465
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14466
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14467
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14468
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14469
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14470
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14471
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14472
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14473
[ "The", "p65", "subunit", "of", "NF-kappa", "B", "regulates", "I", "kappa", "B", "by", "two", "distinct", "mechanisms", "." ]
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14474
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14475
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14476
[ "Overexpression", "of", "p65", "increases", "endogenous", "I", "kappa", "B", "protein", "in", "both", "carcinoma", "and", "lymphoid", "cells", "by", "two", "mechanisms", ":", "protein", "stabilization", "and", "increased", "transcription", "of", "I", "kappa", "B", "mRNA", "." ]
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14477
[ "In", "contrast", ",", "p65", "delta", ",", "a", "naturally", "occurring", "splice", "variant", ",", "fails", "to", "markedly", "augment", "I", "kappa", "B", "protein", "levels", "." ]
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14478
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14479
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14480
[ "Lipopolysaccharide", "induces", "phosphorylation", "of", "MAD3", "and", "activation", "of", "c-Rel", "and", "related", "NF-kappa", "B", "proteins", "in", "human", "monocytic", "THP-1", "cells", "." ]
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14481
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14482
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14483
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14484
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14485
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14486
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14487
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14488
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14489
[ "A", "chimeric", "type", "II/type", "I", "interleukin-1", "receptor", "can", "mediate", "interleukin-1", "induction", "of", "gene", "expression", "in", "T", "cells", "." ]
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14490
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14491
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14492
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14493
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14494
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14495
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14496
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14497
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14498
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14499
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14500
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