Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
14701
[ "We", "studied", "the", "functional", "interaction", "between", "human", "embryonic", "zeta", "2", "globin", "promoter", "and", "the", "alpha", "globin", "regulatory", "element", "(", "HS-40", ")", "located", "40", "kb", "upstream", "of", "the", "zeta", "2", "globin", "gene", "." ]
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14702
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14703
[ "Although", "sequences", "located", "between", "-559", "and", "-88", "of", "the", "zeta", "2", "globin", "gene", "were", "dispensable", "for", "its", "expression", "on", "enhancerless", "plasmids", ",", "they", "were", "required", "for", "the", "HS-40", "enhancer", "-mediated", "activity", "of", "the", "zeta", "2", "globin", "promoter", "." ]
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14704
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14705
[ "The", "functional", "domains", "of", "HS-40", "were", "also", "mapped", "." ]
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14706
[ "Bal", "31", "deletion", "mapping", "data", "suggested", "that", "one", "GATA-1", "motif", ",", "one", "GT", "motif", ",", "and", "two", "NF-E2/AP1", "motifs", "together", "formed", "the", "functional", "core", "of", "HS-40", "in", "the", "erythroid-specific", "activation", "of", "the", "zeta", "2", "globin", "promoter", "." ]
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14707
[ "Site-directed", "mutagenesis", "further", "demonstrated", "that", "the", "enhancer", "function", "of", "one", "of", "the", "two", "NF-E2/AP1", "motifs", "of", "HS-40", "is", "mediated", "through", "its", "binding", "to", "NF-E2", "but", "not", "AP1", "transcription", "factor", "." ]
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14708
[ "Finally", ",", "we", "did", "genomic", "footprinting", "of", "the", "HS-40", "enhancer", "region", "in", "K562", "cells", ",", "adult", "nucleated", "erythroblasts", ",", "and", "different", "nonerythroid", "cells", "." ]
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14709
[ "All", "sequence", "motifs", "within", "the", "functional", "core", "of", "HS-40", ",", "as", "mapped", "by", "transient", "expression", "analysis", ",", "appeared", "to", "bind", "a", "nuclear", "factor", "(", "s", ")", "in", "living", "K562", "cells", "but", "not", "in", "nonerythroid", "cells", "." ]
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14710
[ "On", "the", "other", "hand", ",", "only", "one", "of", "the", "apparently", "nonfunctional", "sequence", "motifs", "was", "bound", "with", "factors", "in", "vivo", "." ]
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14711
[ "In", "comparison", "to", "K562", ",", "nucleated", "erythroblasts", "from", "adult", "human", "bone", "marrow", "exhibited", "a", "similar", "but", "nonidentical", "pattern", "of", "nuclear", "factor", "binding", "in", "vivo", "at", "the", "HS-40", "region", "." ]
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14712
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14713
[ "Transcriptional", "regulation", "of", "the", "pyruvate", "kinase", "erythroid-specific", "promoter", "." ]
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14714
[ "Mammal", "pyruvate", "kinases", "are", "encoded", "by", "two", "genes", "." ]
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14715
[ "The", "L", "gene", "produces", "the", "erythroid", "(", "R-PK", ")", "or", "the", "hepatic", "(", "L-PK", ")", "isozymes", "by", "the", "alternative", "use", "of", "two", "promoters", "." ]
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14716
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14717
[ "A", "R-PK", "DNA", "fragment", "extending", "from", "-870", "to", "+54", "relative", "to", "the", "cap", "site", "confers", "erythroid", "specificity", "to", "a", "reporter", "gene", "." ]
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14718
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14719
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14720
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14721
[ "Furthermore", ",", "the", "substitution", "of", "this", "GATA", "binding", "site", "by", "a", "canonical", "TFIID", "binding", "site", "suppresses", "the", "promoter", "activity", "." ]
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14722
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14723
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14724
[ "Protease", "treatment", "of", "nuclear", "extracts", "distinguishes", "between", "class", "II", "MHC", "X1", "box", "DNA-binding", "proteins", "in", "wild-type", "and", "class", "II-deficient", "B", "cells", "." ]
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14725
[ "The", "X", "box", "region", "is", "critical", "for", "directing", "the", "expression", "of", "class", "II", "major", "histocompatibility", "complex", "genes", "in", "B", "lymphocytes", "." ]
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14726
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14727
[ "To", "further", "evaluate", "the", "role", "of", "X", "box", "DNA-binding", "proteins", "in", "class", "II", "gene", "expression", ",", "the", "role", "of", "the", "X", "box", "region", "was", "examined", "in", "both", "class", "II-positive", "and", "-negative", "lymphoid", "cells", "." ]
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14728
[ "In", "addition", "to", "the", "wild-type", "B", "cell", "line", "Raji", ",", "two", "class", "II", "transcriptional", "mutant", "cell", "lines", ",", "SJO", "and", "RJ2.2.5", ",", "and", "Jurkat", ",", "a", "class", "II", "negative", "T", "cell", "line", ",", "were", "examined", "." ]
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14729
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14730
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14731
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14732
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14733
[ "One", "of", "these", "cleaved", "products", "(", "band", "1", "pk", ")", "correlates", "with", "RFX", "activity", "." ]
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14734
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14735
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14736
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14737
[ "Human", "immunodeficiency", "viruses", "containing", "heterologous", "enhancer/promoters", "are", "replication", "competent", "and", "exhibit", "different", "lymphocyte", "tropisms", "." ]
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14738
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14739
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14740
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14741
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14742
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14743
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14744
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14745
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14746
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14747
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14748
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14749
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14750
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14780
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14789
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