Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
13201
[ "When", "levels", "were", "semiquantitated", "using", "densitometry", ",", "significant", "decreases", "of", "TCRzeta", "(", "P", "=", "0.029", ")", "and", "p56", "(", "lck", ")", "(", "P", "=", "0.029", ")", "but", "not", "CD3epsilon", "(", "P", "=", "0.131", ")", ",", "compared", "with", "control", "levels", ",", "were", "found", "." ]
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13202
[ "In", "patients", "treated", "with", "IL-2/", "IFN", "alpha", "-based", "therapy", ",", "relative", "levels", "of", "TCRzeta", "increased", "significantly", "(", "P", "=", "0.002", ")", "on", "day", "15", "of", "cycle", "one", "compared", "with", "the", "baseline", "." ]
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13203
[ "Correlations", "of", "TCRzeta", "or", "p56", "(", "lck", ")", "levels", "with", "response", "or", "disease", "variables", ",", "except", "for", "lower", "TCRzeta", "levels", "(", "P", "<", "0.001", ")", "in", "the", "presence", "of", "bone", "metastases", ",", "were", "not", "found", "." ]
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13204
[ "Abnormal", "NFkappaB", "activation", "after", "stimulation", "with", "phorbol", "myristate", "acetate/ionomycin", "and/or", "anti-CD3", "monoclonal", "antibody", "was", "found", "in", "59", "%", "of", "patients", "(", "17", "of", "28", ")", "and", "was", "not", "accounted", "for", "by", "the", "advanced", "age", "of", "the", "study", "cohort", "." ]
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13205
[ "Activation", "of", "NFkappaB", "in", "peripheral", "blood", "T", "cells", "was", "inducible", "during", "cytokine", "therapy", "in", "four", "of", "six", "individuals", "who", "displayed", "impaired", "NFkappaB", "activity", "prior", "to", "therapy", "." ]
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13206
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13207
[ "In", "the", "majority", "of", "patients", "with", "advanced", "RCC", ",", "peripheral", "blood", "T", "cells", "express", "TCRzeta", "and", "p56", "(", "lck", ")", ",", "and", "in", "a", "subset", ",", "reduced", "levels", "of", "these", "TCRzeta", "associated", "molecules", "are", "seen", "that", "may", "increase", "during", "cytokine", "-based", "therapy", "." ]
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13208
[ "Abnormal", "activation", "of", "NFkappaB", "is", "also", "present", "in", ">", "50", "%", "of", "patients", "and", "may", "also", "revert", "to", "normal", "during", "IL-2/", "IFN", "alpha", "-based", "treatment", "." ]
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13209
[ "This", "alteration", "in", "NFkappaB", "activation", "occurred", "in", "the", "presence", "of", "normal", "expression", "of", "TCRzeta-associated", "signaling", "elements", "." ]
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13210
[ "The", "clinical", "significance", "of", "these", "findings", "remains", "unclear", "." ]
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13211
[ "Identification", "of", "transcription", "factors", "expressed", "during", "ATRA-induced", "neutrophil", "differentiation", "of", "HL60", "cells", "." ]
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13212
[ "A", "recent", "clinical", "therapeutic", "initiative", "has", "been", "the", "use", "of", "chemical", "agents", "which", "induce", "the", "leukaemic", "cells", "to", "overcome", "their", "block", "in", "differentiation", "." ]
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13213
[ "In", "order", "to", "understand", "this", "block", "the", "cascade", "of", "molecular", "events", "needs", "to", "be", "characterized", "." ]
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13214
[ "Haemopoietic", "differentiation", "is", "ultimately", "controlled", "at", "the", "level", "of", "gene", "transcription", "which", "is", "mediated", "by", "an", "array", "of", "transcription", "factors", "." ]
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13215
[ "Many", "transcription", "factors", "contain", "similar", "structural", "protein", "sequences", ",", "and", "we", "have", "used", "an", "RT-PCR-based", "approach", "to", "isolate", "sequences", ",", "from", "transcription", "factor", "gene", "families", "which", "share", "similar", "domains", "." ]
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13216
[ "Degenerate", "primers", "corresponding", "to", "the", "TFIIIA", "zinc-finger", "consensus", "amino", "acid", "sequences", "and", "to", "the", "POU-homeodomain", "and", "POU-specific", "domain", "were", "used", "to", "amplify", "genes", "on", "the", "basis", "that", "they", "contained", "similarities", "in", "structural", "motifs", "shared", "within", "these", "families", "of", "transcription", "factors", "." ]
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13217
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13218
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13219
[ "RNA", "extracted", "from", "uninduced", ",", "ATRA-induced", "CD38+", "cells", ",", "and", "vitamin", "D3", "treated", "maturing", "cell", "cultures", "were", "amplified", "using", "the", "degenerate", "primers", "." ]
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13220
[ "PCR", "fragments", "were", "cloned", ",", "sequenced", ",", "clustered", "into", "homologous", "groups", ",", "and", "the", "group", "sequences", "searched", "on", "the", "GenBank", "database", "." ]
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13221
[ "The", "Oct", "1", "transcription", "factor", ",", "and", "a", "very", "close", "homologue", ",", "KIAA0144", ",", "was", "identified", "using", "the", "POU", "family", "primers", "." ]
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13222
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13223
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13224
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13225
[ "GATA-3", "-dependent", "enhancer", "activity", "in", "IL-4", "gene", "regulation", "." ]
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13226
[ "Previously", ",", "we", "analyzed", "the", "proximal", "IL-4", "promoter", "in", "directing", "Th2-specific", "activity", "." ]
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13227
[ "An", "800-base", "pair", "proximal", "promoter", "conferred", "some", "Th2-selective", "expression", "in", "transgenic", "mice", "." ]
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13228
[ "However", ",", "this", "region", "directed", "extremely", "low", "reporter", "mRNA", "levels", "relative", "to", "endogenous", "IL-4", "mRNA", ",", "suggesting", "that", "full", "gene", "activity", "requires", "additional", "enhancer", "elements", "." ]
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13229
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13230
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13231
[ "Some", "enhancing", "regions", "contained", "consensus", ",", "GATA", "sites", "that", "bound", "Th2-specific", "complexes", "." ]
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13232
[ "However", ",", "retroviral", "transduction", "of", "GATA-3", "into", "developing", "T", "cells", "induced", "IL-5", "to", "full", "Th2", "levels", ",", "but", "only", "partially", "restored", "IL-4", "production", "." ]
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13233
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13234
[ "Position", "effect", "of", "translocations", "involving", "the", "inactive", "X", "chromosome", ":", "physical", "linkage", "to", "XIC/XIST", "does", "not", "lead", "to", "long-range", "de", "novo", "inactivation", "in", "human", "differentiated", "cells", "." ]
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13235
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13236
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13237
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13238
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13239
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13240
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13241
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13242
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13243
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13244
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13245
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13246
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13247
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13248
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13249
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13250
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13251
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13252
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13253
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13254
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13278
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13279
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13280
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13284
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13285
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13286
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13287
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13288
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13289
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13290
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13291
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13294
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13299
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