Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
13401
[ "Specific", "families", "of", "receptors", ",", "kinases", ",", "transcription", "factors", ",", "and", "cysteine", "proteases", ",", "termed", "caspases", ",", "are", "involved", "in", "the", "apoptotic", "cascade", "leading", "to", "proteolysis", "of", "specific", "substrates", "and", "to", "morphological", "changes", "associated", "with", "programmed", "cell", "death", "." ]
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13402
[ "Although", "common", "members", "of", "the", "apoptotic", "cascade", "are", "shared", "between", "different", "cell", "types", ",", "it", "appears", "that", "cell-specific", "factors", "can", "influence", "the", "response", "to", "a", "given", "apoptotic", "stimuli", "." ]
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13403
[ "Characterization", "and", "understanding", "of", "the", "basic", "mechanisms", "involved", "in", "the", "different", "pathways", "protecting", "or", "leading", "to", "cell", "death", "may", "provide", "novel", "ways", "to", "control", "inappropriate", "apoptosis", "involved", "in", "several", "diseases", "." ]
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13404
[ "Cross-priming", "of", "CTL", "responses", "in", "vivo", "does", "not", "require", "antigenic", "peptides", "in", "the", "endoplasmic", "reticulum", "of", "immunizing", "cells", "." ]
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13405
[ "It", "has", "been", "proposed", "that", "the", "cross-priming", "of", "CTL", "responses", "in", "vivo", "involves", "the", "transfer", "to", "host", "APCs", "of", "heat", "shock", "protein", "glycoprotein", "96", "-chaperoned", "antigenic", "peptides", "released", "from", "the", "endoplasmic", "reticulum", "(", "ER", ")", "of", "dying", "or", "infected", "cells", "." ]
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13406
[ "We", "have", "tested", "this", "possibility", "directly", "using", "TAP-deficient", "cell", "lines", "lacking", "antigenic", "ER", "peptides", "derived", "from", "two", "model", "Ags", ",", "the", "human", "adenovirus", "type", "5", "early", "regions", "E1A", "and", "E1B", "." ]
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13407
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13408
[ "Despite", "the", "absence", "of", "these", "ER", "peptides", ",", "the", "TAP1-/-", "cells", "were", "able", "to", "efficiently", "cross-prime", "E1A-", "and", "E1B-specific", "CTLs", "following", "immunization", "of", "syngeneic", "mice", "." ]
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13409
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13410
[ "A", "critical", "role", "of", "the", "p75", "tumor", "necrosis", "factor", "receptor", "(", "p75TNF-R", ")", "in", "organ", "inflammation", "independent", "of", "TNF", ",", "lymphotoxin", "alpha", ",", "or", "the", "p55TNF-R", "." ]
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13411
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13412
[ "We", "show", "here", "that", "at", "levels", "relevant", "to", "human", "disease", ",", "production", "of", "the", "human", "p75TNF-R", "in", "transgenic", "mice", "results", "in", "a", "severe", "inflammatory", "syndrome", "involving", "mainly", "the", "pancreas", ",", "liver", ",", "kidney", ",", "and", "lung", ",", "and", "characterized", "by", "constitutively", "increased", "NF-kappaB", "activity", "in", "the", "peripheral", "blood", "mononuclear", "cell", "compartment", "." ]
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13413
[ "This", "process", "is", "shown", "to", "evolve", "independently", "of", "the", "presence", "of", "TNF", ",", "lymphotoxin", "alpha", ",", "or", "the", "p55TNF-R", ",", "although", "coexpression", "of", "a", "human", "TNF", "transgene", "accelerated", "pathology", "." ]
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13414
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13415
[ "Expression", "status", "of", "BCL-6", "and", "syndecan-1", "identifies", "distinct", "histogenetic", "subtypes", "of", "Hodgkin", "'s", "disease", "." ]
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13416
[ "The", "tumor", "cells", "in", "most", "cases", "of", "Hodgkin", "'s", "disease", "(", "HD", ")", "have", "been", "recently", "recognized", "to", "originate", "from", "the", "B-cell", "lineage", ",", "but", "their", "precise", "differentiation", "stage", "is", "not", "fully", "clarified", "." ]
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13417
[ "Recently", ",", "we", "have", "reported", "that", "the", "histogenesis", "of", "B-cell", "lymphomas", "may", "be", "assessed", "by", "monitoring", "the", "expression", "pattern", "of", "BCL-6", ",", "a", "transcription", "factor", "expressed", "in", "germinal", "center", "(", "GC", ")", "B", "cells", ",", "and", "CD138/syndecan-1", "(", "syn-1", ")", ",", "a", "proteoglycan", "associated", "with", "post-GC", ",", "terminal", "B-cell", "differentiation", "." ]
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13418
[ "In", "this", "study", ",", "we", "have", "applied", "these", "two", "markers", "to", "the", "study", "of", "HD", "histogenesis", "." ]
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13419
[ "We", "have", "found", "that", "in", "nodular", "lymphocyte", "predominance", "HD", "(", "NLPHD", ")", "tumor", "cells", "consistently", "display", "the", "BCL-6", "(", "+", ")", "/", "syn-1", "(", "-", ")", "phenotype", ",", "indicating", "their", "derivation", "from", "GC", "B", "cells", "." ]
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13420
[ "Conversely", ",", "classic", "HD", "(", "CHD", ")", "is", "heterogeneous", "because", "the", "tumor", "cells", "of", "a", "fraction", "of", "CHD", "display", "the", "BCL-6", "(", "-", ")", "/", "syn-1", "(", "+", ")", "phenotype", "of", "post-GC", "B-cells", ",", "whereas", "another", "fraction", "of", "CHD", "is", "constituted", "by", "a", "mixture", "of", "tumor", "cells", "reflecting", "the", "GC", "(", "BCL-6", "(", "+", ")", "/", "syn-1", "(", "-", ")", ")", "or", "post-GC", "(", "BCL-6", "(", "-", ")", "/", "syn-1", "(", "+", ")", ")", "phenotypes", "." ]
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13421
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13422
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13423
[ "Molecular", "and", "cellular", "analysis", "of", "human", "immunodeficiency", "virus-induced", "apoptosis", "in", "lymphoblastoid", "T-cell-line-expressing", "wild-type", "and", "mutated", "CD4", "receptors", "." ]
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13424
[ "We", "have", "previously", "shown", "that", "the", "presence", "of", "the", "CD4", "cytoplasmic", "tail", "is", "critical", "for", "human", "immunodeficiency", "virus", "(", "HIV", ")", "-induced", "apoptosis", "(", "J.Corbeil", ",", "M.Tremblay", ",", "and", "D.D.Richman", ",", "J.Exp.Med.183", ":", "39-48", ",", "1996", ")", "." ]
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13425
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13426
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13427
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13428
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13429
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13430
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13431
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13432
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13433
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13434
[ "We", "have", "determined", "how", "the", "phosphorylation", "of", "the", "retinoblastoma", "family", "(", "pRb", ",", "p107", ",", "and", "p130", ")", "is", "governed", "in", "individual", "cell", "cycle", "phases", "of", "Daudi", "B-cells", "during", "cell", "cycle", "exit", "triggered", "by", "alpha-interferon", "(", "alpha-IFN", ")", "." ]
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13435
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13436
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13437
[ "In", "contrast", ",", "p107", "is", "dephosphorylated", "and", "is", "then", "depleted", "from", "cells", "as", "they", "exit", "the", "cell", "cycle", "." ]
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13438
[ "p130", ",", "predominantly", "in", "Form", "1", ",", "and", "hypophosphorylated", "pRb", "bind", "an", "E2F", "DNA", "binding", "site", ";", "p130", "complexes", "E2F-4", ",", "whereas", "pRb", "binds", "both", "E2F-4", "and", "E2F-1", "." ]
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13439
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13440
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13441
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13442
[ "The", "entry", "of", "microorganisms", "into", "the", "body", "induces", "inflammatory", "processes", "." ]
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13443
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13444
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13445
[ "MRP14", "(", "Macrophage", "migration", "inhibitory", "related", "protein", ")", "and", "MRP8", ",", "two", "S-100", "proteins", "contained", "in", "high", "concentrations", "in", "these", "cells", "are", "obviously", "essential", "for", "adhesion", "and", "migration", "of", "monocytes", "and", "granulocytes", "." ]
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13446
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13479
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13482
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13492
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13493
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13495
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13496
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13497
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13498
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13499
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13500
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