Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
13601
[ "The", "results", "of", "these", "and", "other", "studies", "suggest", "that", "additional", "C/EBPalpha", "target", "genes", ",", "possibly", "other", "cytokine", "receptors", ",", "are", "also", "important", "for", "the", "block", "in", "granulocyte", "differentiation", "observed", "in", "vivo", "in", "C/EBPalpha", "-deficient", "mice", "." ]
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13602
[ "Phosphatidylinositides", "bind", "to", "plasma", "membrane", "CD14", "and", "can", "prevent", "monocyte", "activation", "by", "bacterial", "lipopolysaccharide", "." ]
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13603
[ "Although", "bacterial", "lipopolysaccharides", "(", "LPS", ")", "and", "several", "other", "microbial", "agonists", "can", "bind", "to", "mCD14", "(", "membrane", "CD14", ")", ",", "a", "cell-surface", "receptor", "found", "principally", "on", "monocytes", "and", "neutrophils", ",", "host-derived", "mCD14", "ligands", "are", "poorly", "defined", "." ]
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13604
[ "We", "report", "here", "that", "phosphatidylinositol", "(", "PtdIns", ")", ",", "phosphatidylinositol-4-phosphate", ",", "and", "other", "phosphatidylinositides", "can", "bind", "to", "mCD14", "." ]
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13605
[ "Phosphatidylserine", "(", "PS", ")", ",", "another", "anionic", "glycerophospholipid", ",", "binds", "to", "mCD14", "with", "lower", "apparent", "affinity", "than", "does", "PtdIns", "." ]
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13606
[ "LPS-binding", "protein", ",", "a", "lipid", "transfer", "protein", "found", "in", "serum", ",", "facilitates", "both", "PS", "-and", "PtdIns-", "mCD14", "binding", "." ]
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13607
[ "PtdIns", "binding", "to", "mCD14", "can", "be", "blocked", "by", "anti-CD14", "monoclonal", "antibodies", "that", "inhibit", "LPS", "-mCD14", "binding", ",", "and", "PtdIns", "can", "inhibit", "both", "LPS", "-mCD14", "binding", "and", "LPS-induced", "responses", "in", "monocytes", "." ]
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13608
[ "Serum-equilibrated", "PtdIns", "also", "binds", "to", "mCD14-expressing", "cells", ",", "raising", "the", "possibility", "that", "endogenous", "PtdIns", "may", "modulate", "cellular", "responses", "to", "LPS", "and", "other", "mCD14", "ligands", "in", "vivo", "." ]
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13609
[ "Protein", "kinase", "C", "regulates", "Fas", "(", "CD95/APO-1", ")", "expression", "." ]
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13610
[ "Fas", "(", "CD95/APO-1", ")", "is", "a", "transmembrane", "protein", "of", "the", "TNF/neuron", "growth", "factor", "receptor", "family", "." ]
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13611
[ "Ligation", "of", "Fas", "by", "specific", "Abs", "or", "Fas", "ligand", "(", "FasL/CD95", "ligand", ")", "induces", "rapid", "apoptotic", "cell", "death", "in", "a", "variety", "of", "cell", "types", "." ]
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13612
[ "Despite", "progress", "in", "understanding", "the", "death", "signals", "transduced", "from", "Fas", ",", "very", "little", "is", "known", "with", "regard", "to", "the", "mechanisms", "by", "which", "Fas", "expression", "is", "regulated", "." ]
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13613
[ "Using", "our", "previously", "established", "murine", "T", "cell", "hybridoma", "model", "A1.1", ",", "we", "show", "that", "specific", "protein", "kinase", "C", "(", "PKC", ")", "inhibitors", "could", "block", "activation-induced", "Fas", "expression", "and", "apoptosis", "." ]
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13614
[ "The", "activation", "of", "PKC", "with", "PMA", "or", "1-oleoyl-2-acetyl-sn-glycerol", "could", "mimic", "the", "TCR", "signal", "by", "inducing", "the", "expression", "of", "Fas", "but", "not", "FasL", "." ]
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13615
[ "PKC", "-dependent", "Fas", "expression", "was", "also", "observed", "in", "several", "murine", "and", "human", "tumor", "cell", "lines", "." ]
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13616
[ "Since", "the", "inhibition", "of", "Ca2+", "redistribution", "by", "an", "inhibitor", "of", "intracellular", "Ca2+", "mobilization", ",", "8-", "(", "diethylamino", ")", "-octyl-3", ",", "4", ",", "5-trimethoxybenzoate", "hydrochloride", ",", "inhibited", "TCR-induced", "FasL", "but", "not", "Fas", ",", "the", "expression", "of", "Fas", "appears", "to", "be", "independent", "of", "Ca2+", "mobilization", "." ]
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13617
[ "Significantly", ",", "expression", "of", "the", "newly", "identified", "Fas-regulatory", "gene", ",", "TDAG51", ",", "was", "found", "to", "be", "dependent", "upon", "the", "activity", "of", "PKC", "." ]
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13618
[ "PKC", "activation", "only", "induced", "Fas", "expression", "in", "cells", "expressing", "wild-type", "TDAG51", "." ]
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13619
[ "Thus", ",", "Fas", "expression", "is", "likely", "mediated", "by", "PKC", "through", "TDAG51", "." ]
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13620
[ "Retinoic", "acid", "inhibits", "CD40", "+", "interleukin-4", "-mediated", "IgE", "production", "in", "vitro", "." ]
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13621
[ "To", "elucidate", "the", "role", "of", "retinoic", "acid", "(", "RA", ")", "in", "anti-CD40", "+", "interleukin-4", "(", "IL-4", ")", "-mediated", "B-cell", "activation", ",", "the", "effect", "of", "10", "(", "-12", ")", "to", "10", "(", "-6", ")", "mol/L", "RA", "was", "studied", "in", "anti-CD40", "(", "1", "microgram/mL", ")", "+", "IL-4", "(", "5", "ng/mL", ")", "-mediated", "proliferation", "and", "Ig", "synthesis", "by", "human", "peripheral", "blood", "mononuclear", "cells", "(", "PBMC", ")", "and", "B", "cells", "in", "healthy", "donors", "." ]
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13622
[ "Anti-CD40", "+", "IL-4", "-mediated", "proliferation", "of", "PBMC", "and", "B", "cells", "was", "inhibited", "by", "RA", "in", "a", "dose-dependent", "manner", ",", "with", "maximal", "inhibition", "of", "62", "%", "+/-", "5", "%", "in", "PBMC", "and", "55", "%", "+/-", "4.4", "%", "in", "B", "cells", "by", "all-trans", "RA", ",", "and", "58", "%", "+/-", "6.7", "%", "and", "51", "%", "+/-", "4.7", "%", ",", "respectively", "by", "13-cis", "RA", "." ]
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13623
[ "IgE", "synthesis", "was", "even", "more", "markedly", "inhibited", "by", "RA", "starting", "at", "concentrations", "of", ">", "10", "(", "-14", ")", "mol/L", "for", "B", "cells", "and", ">", "10", "(", "-10", ")", "mol/L", "for", "PBMC", "." ]
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13624
[ "Maximal", "inhibition", "of", "IgE", "production", "for", "B", "cells", "was", "at", "10", "(", "-8", ")", "mol/L", "for", "all-trans", "RA", "(", "94", "%", "+/-", "1.8", "%", ")", "and", "96", "%", "+/-", "3.2", "%", "for", "13-cis", "RA", "." ]
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13625
[ "Low", "concentrations", "of", "RA", "inhibiting", "IgE", "synthesis", "(", "10", "(", "-10", ")", "mol/L", ")", "affected", "neither", "B-cell", "proliferation", "nor", "the", "production", "of", "IgA", ",", "IgG", ",", "and", "IgM", "." ]
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13626
[ "Elucidation", "of", "the", "mechanism", "involved", "in", "this", "inhibition", "of", "IgE", "production", "shows", "that", "epsilon", "germline", "transcription", "is", "decreased", "by", "RA", ",", "whereas", "production", "of", "interferon-gamma", "(", "IFN-gamma", ")", "was", "not", "enhanced", "in", "the", "presence", "of", "RA", "." ]
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13627
[ "To", "differentiate", "whether", "the", "RA", "effect", "was", "mediated", "by", "RA", "receptors", "alpha", ",", "beta", ",", "and", "gamma", ",", "the", "expression", "of", "the", "retinoic", "acid", "receptors", "(", "RAR", ")", "was", "examined", "by", "reverse", "transcriptase", "-polymerase", "chain", "reaction", "(", "RT-PCR", ")", "." ]
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13628
[ "The", "data", "show", "that", "unstimulated", "human", "peripheral", "B", "cells", "express", "mRNA", "of", "the", "RA", "receptor", "alpha", ",", "beta", ",", "and", "gamma", "." ]
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13629
[ "Using", "retinoids", "with", "different", "receptor", "binding", "specificity", "(", "CD336", ",", "CD437", ",", "CD2019", ",", "CD367", ")", ",", "dose-dependent", "inhibition", "of", "IgE", "synthesis", "was", "shown", "by", "all", "four", "derivates", ",", "but", "was", "most", "marked", "by", "an", "RA", "binding", "the", "alpha", "receptor", "with", "high", "specificity", "." ]
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13630
[ "Taken", "together", ",", "this", "study", "shows", "that", "RA", "inhibits", "IgE", "production", "of", "anti-CD40", "+", "IL-4-stimulated", "B", "cells", "in", "vitro", "." ]
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13631
[ "Copyright", "1998", "by", "The", "American", "Society", "of", "Hematology", "." ]
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13632
[ "Human", "T-cell", "leukemia", "virus", "type", "1", "Tax", "induction", "of", "NF-kappaB", "involves", "activation", "of", "the", "IkappaB", "kinase", "alpha", "(", "IKKalpha", ")", "and", "IKKbeta", "cellular", "kinases", "." ]
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13633
[ "Tax", "corresponds", "to", "a", "40-kDa", "transforming", "protein", "from", "the", "pathogenic", "retrovirus", "human", "T-cell", "leukemia", "virus", "type", "1", "(", "HTLV-1", ")", "that", "activates", "nuclear", "expression", "of", "the", "NF-kappaB/Rel", "family", "of", "transcription", "factors", "by", "an", "unknown", "mechanism", "." ]
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13634
[ "Tax", "expression", "promotes", "N-terminal", "phosphorylation", "and", "degradation", "of", "IkappaB", "alpha", ",", "a", "principal", "cytoplasmic", "inhibitor", "of", "NF-kappaB", "." ]
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13635
[ "Our", "studies", "now", "demonstrate", "that", "HTLV-1", "Tax", "activates", "the", "recently", "identified", "cellular", "kinases", "IkappaB", "kinase", "alpha", "(", "IKKalpha", ")", "and", "IKKbeta", ",", "which", "normally", "phosphorylate", "IkappaB", "alpha", "on", "both", "of", "its", "N-terminal", "regulatory", "serines", "in", "response", "to", "tumor", "necrosis", "factor", "alpha", "(", "TNF-alpha", ")", "and", "interleukin-1", "(", "IL-1", ")", "stimulation", "." ]
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13636
[ "In", "contrast", ",", "a", "mutant", "of", "Tax", "termed", "M22", ",", "which", "does", "not", "induce", "NF-kappaB", ",", "fails", "to", "activate", "either", "IKKalpha", "or", "IKKbeta", "." ]
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13637
[ "Furthermore", ",", "endogenous", "IKK", "enzymatic", "activity", "was", "significantly", "elevated", "in", "HTLV-1-infected", "and", "Tax-expressing", "T-cell", "lines", "." ]
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13638
[ "Transfection", "of", "kinase-deficient", "mutants", "of", "IKKalpha", "and", "IKKbeta", "into", "either", "human", "Jurkat", "T", "or", "293", "cells", "also", "inhibits", "NF-kappaB", "-dependent", "reporter", "gene", "expression", "induced", "by", "Tax", "." ]
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13639
[ "Similarly", ",", "a", "kinase-deficient", "mutant", "of", "NIK", "(", "NF-kappaB-inducing", "kinase", ")", ",", "which", "represents", "an", "upstream", "kinase", "in", "the", "TNF-alpha", "and", "IL-1", "signaling", "pathways", "leading", "to", "IKKalpha", "and", "IKKbeta", "activation", ",", "blocks", "Tax", "induction", "of", "NF-kappaB", "." ]
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13640
[ "However", ",", "plasma", "membrane-proximal", "elements", "in", "these", "proinflammatory", "cytokine", "pathways", "are", "apparently", "not", "involved", "since", "dominant", "negative", "mutants", "of", "the", "TRAF2", "and", "TRAF6", "adaptors", ",", "which", "effectively", "block", "signaling", "through", "the", "cytoplasmic", "tails", "of", "the", "TNF-alpha", "and", "IL-1", "receptors", ",", "respectively", ",", "do", "not", "inhibit", "Tax", "induction", "of", "NF-kappaB", "." ]
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13641
[ "Together", ",", "these", "studies", "demonstrate", "that", "HTLV-1", "Tax", "exploits", "a", "distal", "part", "of", "the", "proinflammatory", "cytokine", "signaling", "cascade", "leading", "to", "induction", "of", "NF-kappaB", "." ]
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13642
[ "The", "pathological", "alteration", "of", "this", "cytokine", "pathway", "leading", "to", "NF-kappaB", "activation", "by", "Tax", "may", "play", "a", "central", "role", "in", "HTLV-1-mediated", "transformation", "of", "human", "T", "cells", ",", "clinically", "manifested", "as", "the", "adult", "T-cell", "leukemia" ]
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13643
[ "Role", "of", "IKK1", "and", "IKK2", "in", "lipopolysaccharide", "signaling", "in", "human", "monocytic", "cells", "." ]
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13644
[ "Mononuclear", "phagocytes", "play", "a", "major", "role", "in", "immune", "and", "inflammatory", "responses", "." ]
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13645
[ "Bacterial", "lipopolysaccharide", "(", "LPS", ")", "induces", "monocytes", "to", "express", "a", "variety", "of", "genes", "by", "activating", "the", "NF-kappaB/Rel", "transcription", "factor", "family", "." ]
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13646
[ "Recently", ",", "we", "have", "reported", "that", "the", "tumor", "necrosis", "factor", "and", "interleukin", "1", "signaling", "pathways", "activate", "two", "kinases", ",", "IKK1", "and", "IKK2", "." ]
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13647
[ "Phosphorylation", "of", "the", "IkappaB", "cytoplasmic", "inhibitors", ",", "IkappaBalpha", ",", "IkappaBbeta", ",", "and", "IkappaBepsilon", ",", "by", "these", "kinases", "triggers", "proteolytic", "degradation", "and", "the", "release", "of", "NF-kappaB/Rel", "proteins", "into", "the", "nucleus", "." ]
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13648
[ "At", "present", ",", "the", "role", "of", "the", "IKKs", "in", "LPS", "signaling", "has", "not", "been", "investigated", "." ]
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13649
[ "Here", ",", "we", "report", "that", "LPS", "induces", "IKK", "activity", "in", "human", "monocytes", "and", "THP-1", "monocytic", "cells", "." ]
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13650
[ "The", "kinetics", "of", "activation", "of", "kinase", "activity", "in", "monocytic", "cells", "are", "relatively", "slow", "with", "maximal", "activity", "observed", "at", "60", "min", ",", "which", "coincides", "with", "the", "degradation", "of", "IkappaBs", "and", "the", "nuclear", "translocation", "of", "NF-kappaB", "." ]
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13651
[ "In", "transfection", "experiments", ",", "overexpression", "of", "wild", "type", "IKK1", ",", "a", "dominant", "negative", "mutant", "IKK1", "(", "K44M", ")", ",", "or", "wild", "type", "IKK2", "did", "not", "affect", "LPS-induced", "kappaB", "-dependent", "transcription", "in", "monocytic", "cells", "." ]
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