Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
13701
[ "Nuclear", "receptors", "are", "important", "regulators", "of", "erythroid", "cell", "development", "." ]
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13702
[ "Here", "we", "investigated", "the", "impact", "of", "retinoid", "X", "receptor", "(", "RXR", ")", ",", "retinoic", "acid", "receptor", "(", "RAR", ")", ",", "and", "of", "the", "c-erbA/thyroid", "hormone", "(", "T3", ")", "receptor", "(", "c-erbA/TR", ")", "on", "growth", "and", "differentiation", "of", "erythroid", "cells", "using", "an", "in", "vitro", "culture", "system", "of", "stem", "cell", "factor-dependent", "erythroid", "progenitors", "." ]
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13703
[ "RXR", ",", "RAR", ",", "and", "c-erbA/TR", "-specific", "ligands", "were", "found", "to", "induce", "erythroid-specific", "gene", "expression", "and", "to", "accelerate", "erythroid", "differentiation", "in", "culture", ",", "with", "T3", "being", "most", "effective", "." ]
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13704
[ "Furthermore", ",", "while", "ligand-activated", "c-erbA/TR", "accelerated", "differentiation", ",", "unliganded", "c-erbA/TR", "effectively", "blocked", "differentiation", "and", "supported", "sustained", "progenitor", "growth", "in", "culture", "." ]
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13705
[ "Thus", ",", "c-erbA/TR", "appears", "to", "act", "as", "a", "binary", "switch", "affecting", "erythroid", "cell", "fate", ":", "unliganded", "c-erbA/TR", "supports", "growth", "while", "ligand-activated", "c-erbA/TR", "induces", "differentiation", "." ]
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13706
[ "Additionally", ",", "to", "determine", "the", "impact", "of", "RXR", "for", "erythroid", "cell", "development", ",", "dominant", "interfering", "mutant", "RXRs", ",", "lacking", "the", "transcriptional", "activator", "functions", "AF-1", "and", "AF-2", ",", "or", "AF-2", "only", ",", "or", "the", "entire", "DNA-binding", "domain", ",", "were", "introduced", "into", "erythroid", "progenitor", "cells", "via", "recombinant", "retrovirus", "vectors", "and", "analyzed", "for", "RXR", "-specific", "effects", "." ]
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13707
[ "It", "was", "found", "that", "expression", "of", "wild-type", "RXR", "and", "of", "the", "RXR", "mutants", "devoid", "of", "AF-1", "and/or", "AF-2", "supported", "a", "transient", "outgrowth", "of", "erythroid", "cells", "." ]
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13708
[ "In", "marked", "contrast", ",", "expression", "of", "the", "dominant", "interfering", "deltaDNA-binding", "domain", "RXR", ",", "containing", "a", "deletion", "of", "the", "entire", "DNA-binding", "domain", ",", "was", "incompatible", "with", "erythroid", "cell", "growth", "in", "vitro", ",", "suggesting", "a", "pivotal", "role", "of", "RXR", "for", "erythroid", "cell", "development", "." ]
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13709
[ "Peripheral", "T", "lymphocytes", "from", "women", "with", "breast", "cancer", "exhibit", "abnormal", "protein", "expression", "of", "several", "signaling", "molecules", "." ]
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13710
[ "We", "examined", "signaling", "molecules", "of", "peripheral", "blood", "T", "lymphocytes", "obtained", "from", "women", "with", "breast", "cancer", "." ]
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13711
[ "In", "6", "of", "14", "patients", ",", "T", "lymphocytes", "displayed", "an", "impaired", "ability", "to", "translocate", "NFeB", "p65", "(", "Rel-A", ")", "following", "activation", "by", "anti-CD3", "and", "IL-2", "." ]
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13712
[ "This", "observation", "was", "made", "despite", "normal", "cytoplasmic", "levels", "of", "the", "Rel-A", "protein", "." ]
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13713
[ "We", "also", "detected", "abnormally", "low", "levels", "of", "the", "signaling", "molecules", "T-cell", "receptor", "(", "TCR", ")", "-zeta", ",", "ZAP-70", "and", "p56lck", "in", "4", "of", "14", "breast", "cancer", "patients", ",", "i.e.", ",", "defects", "in", "T-cell", "signaling", "molecules", "." ]
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13714
[ "T", "lymphocytes", "from", "6", "of", "the", "14", "patients", "also", "exhibited", "an", "increased", "expression", "of", "the", "dual", "specificity", "phosphatase", ",", "map", "kinase", "phosphatase-1", "(", "MKP-1", ")", "." ]
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13715
[ "MKP-1", "inactivates", "MAP", "kinase", "and", "therefore", "may", "interfere", "with", "the", "activation", "of", "c-jun", "and", "c-fos", "." ]
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13716
[ "Abnormalities", "of", "I", "or", "more", "signaling", "molecules", "were", "found", "in", "9", "of", "14", "patients", ";", "however", ",", "only", "3", "patients", "had", "T", "cells", "that", "exhibited", "all", "5", "defects", "." ]
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13717
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13718
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13719
[ "Finally", ",", "despite", "impaired", "Rel-A", "translocation", ",", "T", "cells", "were", "capable", "of", "transcribing", "IL-2", "." ]
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13720
[ "Impairments", "in", "the", "translocation", "of", "Rel-B", "and", "c-Rel", "further", "suggest", "that", "the", "NFKB", "family", "members", "Rel-A", ",", "Rel-B", "and", "c-Rel", "are", "not", "required", "for", "the", "transcription", "of", "IL-2", "in", "the", "peripheral", "T", "lymphocytes", "of", "patients", "with", "breast", "cancer", "." ]
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13721
[ "Specific", "glucocorticoid", "binding", "at", "different", "levels", "of", "human", "motor", "activity", "." ]
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13722
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13723
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13724
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13725
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13726
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13727
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13728
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13729
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13730
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13731
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13732
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13733
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13734
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13735
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13736
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13737
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13738
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13739
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13740
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13741
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13742
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13743
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13744
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13745
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13746
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13747
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13748
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13749
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13750
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