Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
13901
[ "Interestingly", ",", "TGF-alpha", "production", "by", "eosinophils", "was", "up-regulated", "by", "IL-3", "and", "IL-5", "but", "was", "down-regulated", "by", "IL-4", "." ]
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13902
[ "Consistent", "with", "the", "ability", "of", "IL-4", "to", "regulate", "eosinophil", "responses", ",", "IL-4", "signaling", "molecules", "are", "present", "in", "human", "eosinophils", "." ]
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13903
[ "The", "observation", "that", "IL-4", "can", "differentially", "regulate", "the", "expression", "of", "TGF-alpha", "and", "TGF-beta1", "suggests", "that", "IL-4", "may", "serve", "as", "a", "physiologic", "molecular", "switch", "of", "TGF", "expression", "by", "the", "infiltrating", "eosinophils", "in", "wound", "healing", "and", "carcinogenesis", "." ]
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13904
[ "MLL", "and", "CALM", "are", "fused", "to", "AF10", "in", "morphologically", "distinct", "subsets", "of", "acute", "leukemia", "with", "translocation", "t", "(", "10", ";", "11", ")", ":", "both", "rearrangements", "are", "associated", "with", "a", "poor", "prognosis", "." ]
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13905
[ "The", "translocation", "t", "(", "10", ";", "11", ")", "(", "p13", ";", "q14", ")", "has", "been", "observed", "in", "acute", "lymphoblastic", "leukemia", "(", "ALL", ")", "as", "well", "as", "acute", "myeloid", "leukemia", "(", "AML", ")", "." ]
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13906
[ "A", "recent", "study", "showed", "a", "MLL/AF10", "fusion", "in", "all", "cases", "of", "AML", "with", "t", "(", "10", ";", "11", ")", "and", "various", "breakpoints", "on", "chromosome", "11", "ranging", "from", "q13", "to", "q23", "." ]
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13907
[ "We", "recently", "cloned", "CALM", "(", "Clathrin", "Assembly", "Lymphoid", "Myeloid", "leukemia", "gene", ")", ",", "the", "fusion", "partner", "of", "AF10", "at", "11q14", "in", "the", "monocytic", "cell", "line", "U937", "." ]
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13908
[ "To", "further", "define", "the", "role", "of", "these", "genes", "in", "acute", "leukemias", ",", "10", "cases", "(", "9", "AML", "and", "1", "ALL", ")", "with", "cytogenetically", "proven", "t", "(", "10", ";", "11", ")", "(", "p12-14", ";", "q13-21", ")", "and", "well-characterized", "morphology", ",", "immunophenotype", ",", "and", "clinical", "course", "were", "analyzed", "." ]
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13909
[ "Interphase", "fluorescence", "in", "situ", "hybridization", "(", "FISH", ")", "was", "performed", "with", "2", "YACs", "flanking", "the", "CALM", "region", ",", "a", "YAC", "contig", "of", "the", "MLL", "region", ",", "and", "a", "YAC", "spanning", "the", "AF10", "breakpoint", "." ]
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13910
[ "Rearrangement", "of", "at", "least", "one", "of", "these", "genes", "was", "detected", "in", "all", "cases", "with", "balanced", "t", "(", "10", ";", "11", ")", "." ]
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13911
[ "In", "4", "cases", ",", "including", "3", "AML", "with", "immature", "morphology", "(", "1", "AML-M0", "and", "2", "AML-M1", ")", "and", "1", "ALL", ",", "the", "signals", "of", "the", "CALM", "YACS", "were", "separated", "in", "interphase", "cells", ",", "indicating", "a", "translocation", "breakpoint", "within", "the", "CALM", "region", "." ]
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13912
[ "MLL", "was", "rearranged", "in", "3", "AML", "with", "myelomonocytic", "differentiation", "(", "2", "AML-M2", "and", "1", "AML-M5", ")", ",", "including", "1", "secondary", "AML", "." ]
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13913
[ "In", "all", "3", "cases", ",", "a", "characteristic", "immunophenotype", "was", "identified", "(", "CD4+", ",", "CD13", "-", ",", "CD33+", ",", "CD65s+", ")", "." ]
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13914
[ "AF-10", "was", "involved", "in", "5", "of", "6", "evaluable", "cases", ",", "including", "1", "case", "without", "detectable", "CALM", "or", "MLL", "rearrangement", "." ]
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13915
[ "In", "2", "complex", "translocations", ",", "none", "of", "the", "three", "genes", "was", "rearranged", "." ]
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13916
[ "All", "cases", "had", "a", "remarkably", "poor", "prognosis", ",", "with", "a", "mean", "survival", "of", "9.6", "+/-", "6.6", "months", "." ]
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13917
[ "For", "the", "7", "AML", "cases", "that", "were", "uniformly", "treated", "according", "to", "the", "AMLCG86/92", "protocols", ",", "disease-free", "and", "overall", "survival", "was", "significantly", "worse", "than", "for", "the", "overall", "study", "group", "(", "P", "=", ".03", "and", "P", "=", ".01", ",", "respectively", ")", "." ]
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13918
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13919
[ "The", "role", "of", "E-proteins", "in", "B-", "and", "T-lymphocyte", "development", "." ]
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13920
[ "Department", "of", "lymphocytes", "from", "hematopoietic", "stem", "cells", "is", "controlled", ",", "in", "part", ",", "by", "the", "activity", "of", "transcriptional", "regulatory", "proteins", "." ]
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13921
[ "In", "particular", ",", "one", "class", "of", "helix-loop-helix", "proteins", ",", "termed", "E-proteins", ",", "have", "been", "implicated", "in", "the", "regulation", "of", "gene", "expression", "during", "B-cell", "development", "." ]
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13922
[ "Recent", "analysis", "of", "gene-targeted", "mice", "has", "allowed", "a", "direct", "assessment", "of", "the", "functional", "roles", "of", "several", "E-protein", "family", "members", "in", "hematopoiesis", "." ]
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13923
[ "In", "this", "review", "we", "describe", "the", "defects", "in", "B-", "and", "T-", "lymphocyte", "development", "in", "mice", "carrying", "targeted", "mutations", "in", "the", "E-protein", "genes", "and", "discuss", "our", "current", "understanding", "of", "the", "role", "of", "these", "proteins", "in", "lymphoid", "development" ]
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13924
[ "Epstein-Barr", "virus-transforming", "protein", "latent", "infection", "membrane", "protein", "1", "activates", "transcription", "factor", "NF-kappaB", "through", "a", "pathway", "that", "includes", "the", "NF-kappaB-inducing", "kinase", "and", "the", "IkappaB", "kinases", "IKKalpha", "and", "IKKbeta", "." ]
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13925
[ "The", "Epstein-Barr", "virus", "oncoprotein", "latent", "infection", "membrane", "protein", "1", "(", "LMP1", ")", "is", "a", "constitutively", "aggregated", "pseudo-tumor", "necrosis", "factor", "receptor", "(", "TNFR", ")", "that", "activates", "transcription", "factor", "NF-kappaB", "through", "two", "sites", "in", "its", "C-terminal", "cytoplasmic", "domain", "." ]
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13926
[ "One", "site", "is", "similar", "to", "activated", "TNFRII", "in", "associating", "with", "TNFR-associated", "factors", "TRAF1", "and", "TRAF2", ",", "and", "the", "second", "site", "is", "similar", "to", "TNFRI", "in", "associating", "with", "the", "TNFRI", "death", "domain", "interacting", "protein", "TRADD", "." ]
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13927
[ "TNFRI", "has", "been", "recently", "shown", "to", "activate", "NF-kappaB", "through", "association", "with", "TRADD", ",", "RIP", ",", "and", "TRAF2", ";", "activation", "of", "the", "NF-kappaB-inducing", "kinase", "(", "NIK", ")", ";", "activation", "of", "the", "IkappaB", "alpha", "kinases", "(", "IKKalpha", "and", "IKKbeta", ")", ";", "and", "phosphorylation", "of", "IkappaB", "alpha", "." ]
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13928
[ "IkappaB", "alpha", "phosphorylation", "on", "Ser-32", "and", "Ser-36", "is", "followed", "by", "its", "degradation", "and", "NF-kappaB", "activation", "." ]
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13929
[ "In", "this", "report", ",", "we", "show", "that", "NF-kappaB", "activation", "by", "LMP1", "or", "by", "each", "of", "its", "effector", "sites", "is", "mediated", "by", "a", "pathway", "that", "includes", "NIK", ",", "IKKalpha", ",", "and", "IKKbeta", "." ]
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13930
[ "Dominant", "negative", "mutants", "of", "NIK", ",", "IKKalpha", ",", "or", "IKKbeta", "substantially", "inhibited", "NF-kappaB", "activation", "by", "LMP1", "or", "by", "each", "of", "its", "effector", "sites", "." ]
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13931
[ "Targeted", "disruption", "of", "the", "MyD88", "gene", "results", "in", "loss", "of", "IL-1-", "and", "IL-18-mediated", "function", "." ]
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13932
[ "MyD88", ",", "originally", "isolated", "as", "a", "myeloid", "differentiation", "primary", "response", "gene", ",", "is", "shown", "to", "act", "as", "an", "adaptor", "in", "interleukin-1", "(", "IL-1", ")", "signaling", "by", "interacting", "with", "both", "the", "IL-1", "receptor", "complex", "and", "IL-1", "receptor-associated", "kinase", "(", "IRAK", ")", "." ]
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13933
[ "Mice", "generated", "by", "gene", "targeting", "to", "lack", "MyD88", "have", "defects", "in", "T", "cell", "proliferation", "as", "well", "as", "induction", "of", "acute", "phase", "proteins", "and", "cytokines", "in", "response", "to", "IL-1", "." ]
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13934
[ "Increases", "in", "interferon-gamma", "production", "and", "natural", "killer", "cell", "activity", "in", "response", "to", "IL-18", "are", "abrogated", "." ]
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13935
[ "In", "vivo", "Th1", "response", "is", "also", "impaired", "." ]
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13936
[ "Furthermore", ",", "IL-18", "-induced", "activation", "of", "NF-kappaB", "and", "c-Jun", "N-terminal", "kinase", "(", "JNK", ")", "is", "blocked", "in", "MyD88-/-", "Th1-developing", "cells", "." ]
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13937
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13938
[ "Ciprofloxacin", "induces", "an", "immunomodulatory", "stress", "response", "in", "human", "T", "lymphocytes", "." ]
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13939
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13940
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13941
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13942
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13943
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13944
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13945
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13946
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13947
[ "A", "novel", "retinoic", "acid", "receptor", "(", "RAR", ")", "-selective", "antagonist", "inhibits", "differentiation", "and", "apoptosis", "of", "HL-60", "cells", ":", "implications", "of", "RARalpha", "-mediated", "signals", "in", "myeloid", "leukemic", "cells", "." ]
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13948
[ "Retinoic", "acid", "(", "RA", ")", "induces", "HL-60", "cells", "to", "differentiate", "terminally", "into", "mature", "granulocytes", ",", "which", "subsequently", "die", "by", "apoptosis", "." ]
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13949
[ "The", "biological", "effects", "of", "RA", "are", "mediated", "by", "two", "distinct", "families", "of", "transcription", "factors", ":", "retinoic", "acid", "receptors", "(", "RARs", ")", "and", "retinoid", "X", "receptors", "(", "RXRs", ")", "." ]
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13950
[ "RARs", "and", "RXRs", "form", "heterodimers", "and", "regulate", "retinoid-mediated", "gene", "expression", "." ]
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13951
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13952
[ "Using", "this", "RAR-selective", "antagonist", ",", "and", "RXR", "and", "RAR", "agonist", ",", "we", "demonstrate", "the", "RAR", "-mediated", "signaling", "pathway", "is", "important", "for", "differentiation", "and", "apoptosis", "of", "myeloid", "leukemic", "cells", "." ]
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13953
[ "Simple", "activation", "of", "RXRs", "is", "not", "sufficient", "to", "induce", "apoptosis", "of", "the", "cells", "." ]
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13954
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13955
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13956
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13957
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13958
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13959
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13960
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13961
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13962
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13963
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13964
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13965
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13966
[ "Isoelectric", "focusing", "demonstrated", "that", "TPO", "induced", "fetal", "and", "adult", "Hb", "synthesis", ",", "whereas", "EPO", "induced", "embryonic", ",", "fetal", ",", "and", "adult", "Hb", "synthesis", "." ]
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13967
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13968
[ "Role", "of", "GATA-1", "in", "proliferation", "and", "differentiation", "of", "definitive", "erythroid", "and", "megakaryocytic", "cells", "in", "vivo", "." ]
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13969
[ "To", "elucidate", "the", "contributions", "of", "GATA-1", "to", "definitive", "hematopoiesis", "in", "vivo", ",", "we", "have", "examined", "adult", "mice", "that", "were", "rendered", "genetically", "defective", "in", "GATA-1", "synthesis", "(", "Takahashi", "et", "al", ",", "J", "Biol", "Chem", "272", ":", "12611", ",", "1997", ")", "." ]
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13970
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13971
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13972
[ "These", "affected", "animals", "displayed", "marked", "splenomegaly", ",", "anemia", ",", "and", "thrombocytopenia", "." ]
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13973
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13974
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13975
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13976
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13977
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13978
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13979
[ "IL-13", ",", "a", "cytokine", "similar", "to", "IL-4", ",", "is", "a", "regulator", "of", "human", "B", "cell", "and", "monocyte", "functions", "." ]
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13980
[ "Biologic", "effects", "of", "IL-13", "on", "primary", "human", "NK", "and", "T", "cells", "have", "not", "been", "well", "defined", "." ]
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13981
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13982
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13983
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13984
[ "Additionally", ",", "IL-13", "suppresses", "IL-2-induced", "NK", "cytolytic", "and", "proliferative", "activities", "although", "less", "efficiently", "than", "IL-4", "." ]
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13985
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13986
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13987
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13988
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13989
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13990
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13991
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13992
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13993
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13994
[ "Inhibition", "of", "nuclear", "factor", "kappaB", "activation", "attenuates", "apoptosis", "resistance", "in", "lymphoid", "cells", "." ]
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13995
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13996
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13997
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13998
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13999
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14000
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