Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
14001
[ "These", "data", "suggest", "that", "inhibition", "of", "NFkappaB", "activation", "may", "provide", "a", "molecular", "approach", "to", "increase", "apoptosis", "sensitivity", "in", "anticancer", "treatment", "." ]
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14002
[ "Loss-", "and", "gain-of-function", "mutations", "reveal", "an", "important", "role", "of", "BSAP", "(", "Pax-5", ")", "at", "the", "start", "and", "end", "of", "B", "cell", "differentiation", "." ]
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14003
[ "Pax-5", "codes", "for", "the", "transcription", "factor", "BSAP", "which", "is", "expressed", "throughout", "B", "cell", "development", "except", "in", "terminally", "differentiated", "plasma", "cells", "." ]
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14004
[ "Gene", "targeting", "experiments", "in", "the", "mouse", "revealed", "a", "differential", "dependency", "of", "fetal", "and", "adult", "B-lymphopoiesis", "on", "this", "transcription", "factor", "." ]
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14005
[ "BSAP", "is", "required", "for", "B-lineage", "commitment", "in", "the", "fetal", "liver", "and", "for", "progression", "beyond", "an", "early", "pro-B", "cell", "stage", "in", "adult", "bone", "marrow", "." ]
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14006
[ "The", "characterization", "of", "Pax-5-deficient", "pro-B", "cells", "demonstrated", "an", "important", "role", "of", "BSAP", "in", "the", "regulation", "of", "the", "CD19", ",", "mb-1", "(", "Ig", "alpha", ")", "and", "N-myc", "genes", "as", "well", "as", "in", "the", "developmental", "pathway", "controlling", "VH-to-DHJH", "recombination", "at", "the", "immunoglobulin", "heavy-chain", "(", "IgH", ")", "locus", "." ]
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14007
[ "The", "human", "PAX-5", "gene", "was", "recently", "shown", "to", "participate", "together", "with", "the", "IgH", "locus", "in", "the", "chromosomal", "translocation", "t", "(", "9", ";", "14", ")", "(", "p13", ";", "q32", ")", "." ]
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14008
[ "This", "translocation", "is", "characteristic", "of", "a", "small", "subset", "of", "non-Hodgkin", "lymphomas", "exhibiting", "plasmacytoid", "differentiation", "." ]
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14009
[ "The", "translocated", "PAX-5", "gene", "is", "deregulated", "by", "the", "insertion", "of", "IgH", "regulatory", "elements", "into", "its", "5", "'", "region", ",", "which", "may", "contribute", "to", "tumorigenesis", "by", "interfering", "with", "the", "shut-down", "of", "PAX-5", "transcription", "and", "thus", "with", "the", "completion", "of", "plasma", "cell", "differentiation" ]
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14010
[ "Acetylation", "and", "modulation", "of", "erythroid", "Kruppel-like", "factor", "(", "EKLF", ")", "activity", "by", "interaction", "with", "histone", "acetyltransferases", "." ]
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14011
[ "Erythroid", "Kruppel-like", "factor", "(", "EKLF", ")", "is", "a", "red", "cell-specific", "transcriptional", "activator", "that", "is", "crucial", "for", "consolidating", "the", "switch", "to", "high", "levels", "of", "adult", "beta-globin", "expression", "during", "erythroid", "ontogeny", "." ]
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14012
[ "EKLF", "is", "required", "for", "integrity", "of", "the", "chromatin", "structure", "at", "the", "beta-like", "globin", "locus", ",", "and", "it", "interacts", "with", "a", "positive-acting", "factor", "in", "vivo", "." ]
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14013
[ "We", "find", "that", "EKLF", "is", "an", "acetylated", "transcription", "factor", ",", "and", "that", "it", "interacts", "in", "vivo", "with", "CBP", ",", "p300", ",", "and", "P/CAF", "." ]
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14014
[ "However", ",", "its", "interactions", "with", "these", "histone", "acetyltransferases", "are", "not", "equivalent", ",", "as", "CBP", "and", "p300", ",", "but", "not", "P/CAF", ",", "utilize", "EKLF", "as", "a", "substrate", "for", "in", "vitro", "acetylation", "within", "its", "trans-", "activation", "region", "." ]
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14015
[ "The", "functional", "effects", "of", "these", "interactions", "are", "that", "CBP", "and", "p300", ",", "but", "not", "P/CAF", ",", "enhance", "EKLF", "'s", "transcriptional", "activation", "of", "the", "beta-globin", "promoter", "in", "erythroid", "cells", "." ]
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14016
[ "These", "results", "establish", "EKLF", "as", "a", "tissue-specific", "transcription", "factor", "that", "undergoes", "post-translational", "acetylation", "and", "suggest", "a", "mechanism", "by", "which", "EKLF", "is", "able", "to", "alter", "chromatin", "structure", "and", "induce", "beta-globin", "expression", "within", "the", "beta-like", "globin", "cluster", "." ]
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14017
[ "Recognition", "of", "herpes", "simplex", "virus", "type", "2", "tegument", "proteins", "by", "CD4", "T", "cells", "infiltrating", "human", "genital", "herpes", "lesions", "." ]
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14018
[ "The", "local", "cellular", "immune", "response", "to", "herpes", "simplex", "virus", "(", "HSV", ")", "is", "important", "in", "the", "control", "of", "recurrent", "HSV", "infection", "." ]
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14019
[ "The", "antiviral", "functions", "of", "infiltrating", "CD4-bearing", "T", "cells", "may", "include", "cytotoxicity", ",", "inhibition", "of", "viral", "growth", ",", "lymphokine", "secretion", ",", "and", "support", "of", "humoral", "and", "CD8", "responses", "." ]
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14020
[ "The", "antigens", "recognized", "by", "many", "HSV-specific", "CD4", "T", "cells", "localizing", "to", "genital", "HSV-2", "lesions", "are", "unknown", "." ]
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14021
[ "T", "cells", "recognizing", "antigens", "encoded", "within", "map", "units", "0.67", "to", "0.73", "of", "HSV", "DNA", "are", "frequently", "recovered", "from", "herpetic", "lesions", "." ]
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14022
[ "Expression", "cloning", "with", "this", "region", "of", "DNA", "now", "shows", "that", "tegument", "protein", "VP22", "and", "the", "viral", "dUTPase", ",", "encoded", "by", "genes", "UL49", "and", "UL50", ",", "respectively", ",", "are", "T-cell", "antigens", "." ]
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14023
[ "Separate", "epitopes", "in", "VP22", "were", "defined", "for", "T-cell", "clones", "from", "each", "of", "three", "patients", "." ]
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14024
[ "Reactivity", "with", "the", "tegument", "protein", "encoded", "by", "UL21", "was", "identified", "for", "an", "additional", "patient", "." ]
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14025
[ "Three", "new", "epitopes", "were", "identified", "in", "VP16", ",", "a", "tegument", "protein", "associated", "with", "VP22", "." ]
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14026
[ "Some", "tegument-specific", "CD4", "T-cell", "clones", "exhibited", "cytotoxic", "activity", "against", "HSV-infected", "cells", "." ]
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14027
[ "These", "results", "suggest", "that", "herpes", "simplex", "tegument", "proteins", "are", "processed", "for", "antigen", "presentation", "in", "vivo", "and", "are", "possible", "candidate", "compounds", "for", "herpes", "simplex", "vaccines", "." ]
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14028
[ "Fibrinogen", "activates", "NF-kappa", "B", "transcription", "factors", "in", "mononuclear", "phagocytes", "." ]
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14029
[ "Adhesion", "to", "extracellular", "matrices", "is", "known", "to", "modulate", "leukocyte", "activation", ",", "although", "the", "mechanisms", "are", "not", "fully", "understood", "." ]
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14030
[ "Mononuclear", "phagocytes", "are", "exposed", "to", "fibrinous", "provisional", "matrix", "throughout", "migration", "into", "inflammatory", "foci", ",", "so", "this", "study", "was", "undertaken", "to", "determine", "whether", "fibrinogen", "triggers", "activation", "of", "NF-kappa", "B", "transcription", "factors", "." ]
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14031
[ "U937", "cells", "differentiated", "with", "PMA", "in", "nonadherent", "culture", "were", "shown", "to", "express", "two", "fibrinogen-binding", "integrins", ",", "predominately", "CD11b/CD18", ",", "and", "to", "a", "lesser", "extent", ",", "CD11c/CD18", "." ]
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14032
[ "Cells", "stimulated", "with", "fibrinogen", "(", "10-100", "microg/ml", ")", "/Mn2+", "(", "50", "microM", ")", "for", "2", "h", "were", "examined", "by", "electrophoretic", "mobility", "shift", "assay", "." ]
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14033
[ "NF-kappa", "B", "activation", ",", "minimal", "in", "unstimulated", "cells", ",", "was", "substantially", "up-regulated", "by", "fibrinogen", "." ]
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14034
[ "Fibrinogen", "also", "caused", "activation", "of", "AP-1", ",", "but", "not", "SP1", "or", "cAMP", "response", "element-binding", "protein", "(", "CREB", ")", "factors", "." ]
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14035
[ "Blocking", "mAbs", "against", "CD18", "and", "CD11b", "abrogated", "fibrinogen", "-induced", "NF-kappa", "B", "activation", "." ]
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14036
[ "To", "determine", "the", "effects", "on", "transcriptional", "regulation", ",", "U937", "cells", "were", "transfected", "with", "a", "plasmid", "containing", "the", "HIV-1", "enhancer", "(", "bearing", "two", "NF-kappa", "B", "sites", ")", "coupled", "to", "a", "chloramphenicol", "acetyltransferase", "(", "CAT", ")", "reporter", "." ]
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14037
[ "Cells", "were", "subsequently", "stimulated", "with", "1", ")", "PMA", "for", "24", "h", ",", "inducing", "CAT", "activity", "by", "2.6-fold", ",", "2", ")", "fibrinogen", "/Mn2+", "for", "2", "h", ",", "inducing", "CAT", "activity", "by", "3.2-fold", ",", "or", "3", ")", "costimulation", "with", "fibrinogen", "and", "PMA", ",", "inducing", "5.7-fold", "the", "CAT", "activity", "induced", "by", "PMA", "alone", "." ]
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14038
[ "We", "conclude", "that", "contact", "with", "fibrinogen-derived", "proteins", "may", "contribute", "to", "mononuclear", "phagocyte", "activation", "by", "signaling", "through", "CD11b/CD18", ",", "resulting", "in", "selective", "activation", "of", "transcriptional", "regulatory", "factors", ",", "including", "NF-kappa", "B", "." ]
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14039
[ "Peripheral", "blood", "T", "cells", "and", "monocytes", "and", "B", "cell", "lines", "derived", "from", "patients", "with", "lupus", "express", "estrogen", "receptor", "transcripts", "similar", "to", "those", "of", "normal", "cells", "." ]
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14040
[ "OBJECTIVE", ":", "To", "identify", "and", "characterize", "estrogen", "receptor", "(", "ER", ")", "transcripts", "expressed", "in", "immune", "cells", "of", "patients", "with", "systemic", "lupus", "erythematosus", "(", "SLE", ")", "and", "healthy", "donors", "." ]
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14041
[ "METHODS", ":", "Peripheral", "blood", "monocytes", "and", "T", "cells", "were", "prepared", "from", "patients", "with", "SLE", "(", "n", "=", "6", ")", "and", "healthy", "donors", "(", "n", "=", "8", ")", "." ]
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14042
[ "T", "cells", "were", "separated", "into", "CD4", "and", "CD8", "." ]
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14043
[ "Some", "monocytes", "and", "T", "cells", "were", "stimulated", "with", "estradiol", ",", "PMA", ",", "and", "ionomycin", "." ]
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14044
[ "Epstein-Barr", "virus-transformed", "B", "cell", "lines", "(", "n", "=", "7", ")", "and", "B", "cell", "hybridomas", "(", "n", "=", "2", ")", "established", "from", "patients", "with", "SLE", "and", "a", "healthy", "individual", "were", "used", "as", "a", "B", "cell", "source", "." ]
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14045
[ "These", "cells", "were", "examined", "for", "ER", "mRNA", "by", "reverse", "transcription", "nested", "polymerase", "chain", "reaction", "." ]
[ 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0 ]
14046
[ "Amplified", "cDNA", "were", "sequenced", "by", "standard", "methods", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0 ]
14047
[ "RESULTS", ":", "In", "all", "cells", "tested", ",", "ER", "mRNA", "was", "expressed", "without", "prior", "in", "vitro", "stimulation", "." ]
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14048
[ "Partial", "sequences", "from", "exons", "1-8", "were", "nearly", "identical", "to", "the", "published", "sequence", "of", "the", "human", "ER", "mRNA", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0 ]
14049
[ "There", "were", "no", "notable", "differences", "in", "the", "ER", "transcripts", "between", "patients", "and", "healthy", "controls", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0 ]
14050
[ "Variant", "receptor", "transcripts", "lacking", "exon", "5", "or", "exon", "7", ",", "which", "encodes", "the", "hormone", "binding", "domain", ",", "were", "identified", "in", "the", "majority", "of", "the", "cells", "." ]
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14051
[ "Precise", "deletion", "of", "the", "exons", "suggests", "that", "they", "are", "alternatively", "spliced", "transcripts", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14052
[ "Whether", "the", "detected", "transcripts", "are", "translated", "into", "functional", "receptor", "proteins", "remains", "to", "be", "determined", "." ]
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14053
[ "In", "vitro", "stimulation", "did", "not", "affect", "ER", "mRNA", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 3, 4, 0, 0 ]
14054
[ "The", "presence", "of", "variants", "did", "not", "correlate", "with", "disease", "activity", "or", "medication", "." ]
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14055
[ "CONCLUSION", ":", "Monocytes", ",", "T", "cells", ",", "and", "B", "cells", "in", "patients", "express", "transcripts", "of", "the", "normal", "wild", "type", "ER", "and", "the", "hormone", "binding", "domain", "variants", "in", "vivo", "." ]
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14056
[ "DNA", "damaging", "agents", "induce", "expression", "of", "Fas", "ligand", "and", "subsequent", "apoptosis", "in", "T", "lymphocytes", "via", "the", "activation", "of", "NF-kappa", "B", "and", "AP-1", "." ]
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14057
[ "Apoptosis", "induced", "by", "DNA", "damage", "and", "other", "stresses", "can", "proceed", "via", "expression", "of", "Fas", "ligand", "(", "FasL", ")", "and", "ligation", "of", "its", "receptor", ",", "Fas", "(", "CD95", ")", "." ]
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14058
[ "We", "report", "that", "activation", "of", "the", "two", "transcription", "factors", "NF-kappa", "B", "and", "AP-1", "is", "crucially", "involved", "in", "FasL", "expression", "induced", "by", "etoposide", ",", "teniposide", ",", "and", "UV", "irradiation", "." ]
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14059
[ "A", "nondegradable", "mutant", "of", "I", "kappa", "B", "blocked", "both", "FasL", "expression", "and", "apoptosis", "induced", "by", "DNA", "damage", "but", "not", "Fas", "ligation", "." ]
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14060
[ "These", "stimuli", "also", "induced", "the", "stress-activated", "kinase", "pathway", "(", "SAPK", "/JNK", ")", ",", "which", "was", "required", "for", "the", "maximal", "induction", "of", "apoptosis", "." ]
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14061
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14062
[ "Mutations", "in", "the", "relevant", "NF-kappa", "B", "and", "AP-1", "binding", "sites", "eliminated", "these", "responses", "." ]
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14064
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14065
[ "A", "nonpeptidyl", "small", "molecule", "SB", "247464", ",", "capable", "of", "activating", "granulocyte-colony-stimulating", "factor", "(", "G-CSF", ")", "signal", "transduction", "pathways", ",", "was", "identified", "in", "a", "high-throughput", "assay", "in", "cultured", "cells", "." ]
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14066
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14067
[ "It", "also", "elevated", "peripheral", "blood", "neutrophil", "counts", "in", "mice", "." ]
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14068
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14069
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14070
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14071
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14072
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14073
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14074
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14075
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14076
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14077
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14078
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14079
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14080
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14081
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14082
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14083
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14084
[ "Mycobacterium", "tuberculosis", "mannose-capped", "lipoarabinomannan", "can", "induce", "NF-kappaB", "-dependent", "activation", "of", "human", "immunodeficiency", "virus", "type", "1", "long", "terminal", "repeat", "in", "T", "cells", "." ]
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14085
[ "Tuberculosis", "has", "emerged", "as", "an", "epidemic", ",", "extended", "by", "the", "large", "number", "of", "individuals", "infected", "with", "human", "immunodeficiency", "virus", "type", "1", "(", "HIV-1", ")", "." ]
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14086
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14087
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14088
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14089
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14090
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14091
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14092
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14093
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14094
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14095
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14096
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14097
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14098
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14099
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14100
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