Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
13301
[ "Effector", "pathways", "for", "this", "guanine", "nucleotide", "binding", "protein", "in", "T", "cells", "are", "mediated", "by", "the", "serine/threonine", "kinase", "Raf-1", "and", "the", "Ras-related", "GTPase", "Rac-1", "." ]
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13302
[ "In", "fibroblasts", ",", "an", "important", "effector", "for", "the", "Ras", "oncogene", "is", "Phosphatidylinositol", "3-kinase", "(", "PtdIns", "3-kinase", ")", "." ]
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13303
[ "Activation", "of", "this", "lipid", "kinase", "is", "able", "to", "induce", "critical", "Rac-1", "signaling", "pathways", "and", "can", "couple", "p21ras", "to", "cell", "survival", "mechanisms", "via", "the", "serine/threonine", "kinase", "Akt/PKB", "." ]
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13304
[ "The", "role", "of", "PtdIns", "3-kinase", "in", "Ras", "signaling", "in", "T", "cells", "has", "not", "been", "explored", "." ]
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13305
[ "In", "the", "present", "study", ",", "we", "examined", "the", "ability", "of", "PtdIns", "3-kinase", "to", "initiate", "the", "Rac-1", "signaling", "pathways", "important", "for", "T", "cell", "activation", "." ]
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13306
[ "We", "also", "examined", "the", "possibility", "that", "Akt/PKB", "is", "regulated", "by", "Ras", "signaling", "pathways", "in", "T", "lymphocytes", "." ]
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13307
[ "The", "results", "show", "that", "Ras", "can", "initiate", "a", "Rac-1", "mediated", "pathway", "that", "regulates", "the", "transcriptional", "function", "of", "AP-1", "complexes", "." ]
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13308
[ "PtdIns", "3-kinase", "signals", "can", "not", "mimic", "p21ras", "and", "induce", "the", "Rac", "mediated", "responses", "of", "AP-1", "transcriptional", "activation", "." ]
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13309
[ "Moreover", ",", "neither", "TCR", "or", "Ras", "activation", "of", "AP-1", "is", "dependent", "on", "PtdIns", "3-kinase", "." ]
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13310
[ "PKB", "is", "activated", "in", "response", "to", "triggering", "of", "the", "T", "cell", "antigen", "receptor", ";", "PtdIns", "3-kinase", "activity", "is", "both", "required", "and", "sufficient", "for", "this", "TCR", "response", "." ]
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13311
[ "In", "contrast", ",", "p21ras", "signals", "are", "unable", "to", "induce", "Akt/PKB", "activity", "in", "T", "cell", "nor", "is", "Ras", "function", "required", "for", "Akt/PKB", "activation", "in", "response", "to", "the", "TCR", "." ]
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13312
[ "The", "present", "data", "thus", "highlight", "that", "PtdIns", "3-kinase", "and", "Akt/PKB", "are", "not", "universal", "Ras", "effector", "molecules", "." ]
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13313
[ "Ras", "can", "initiate", "Rac-1", "regulated", "signaling", "pathways", "in", "the", "context", "of", "T", "cell", "antigen", "receptor", "function", "independently", "of", "PtdIns", "3-kinase", "activity", "." ]
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13314
[ "Interleukin", "1beta", "mediates", "the", "modulatory", "effects", "of", "monocytes", "on", "LNCaP", "human", "prostate", "cancer", "cells", "." ]
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13315
[ "Proliferative", "and", "secretory", "responses", "in", "androgen-sensitive", "prostate", "cancer", "LNCaP", "cells", "are", "regulated", "by", "steroid", "and", "peptide", "hormones", "and", "by", "differentiation-promoting", "substances", "." ]
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13316
[ "In", "the", "present", "study", ",", "we", "evaluated", "whether", "peripheral", "blood", "monocytes", "that", "exhibit", "anti-tumour", "activity", "in", "haematopoietic", "and", "solid", "tumours", "influence", "growth", "and", "secretion", "in", "the", "LNCaP", "cell", "line", "." ]
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13317
[ "For", "this", "purpose", ",", "LNCaP", "cells", "were", "incubated", "with", "monocyte-conditioned", "medium", "(", "MCM", ")", ",", "and", "proliferation", "as", "well", "as", "expression", "of", "androgen", "receptor", "(", "AR", ")", "and", "secretion", "of", "prostate-specific", "antigen", "(", "PSA", ")", "were", "assessed", "." ]
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13318
[ "Conditioned", "medium", "from", "monocytes", "reduced", "proliferation", "in", "a", "dose-dependent", "manner", "." ]
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13319
[ "Incubation", "with", "40", "%", "MCM", "caused", "a", "50", "%", "reduction", "in", "cell", "proliferation", "." ]
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13320
[ "AR", "protein", "decreased", "by", "70", "%", "and", "PSA", "levels", "in", "supernatants", "from", "LNCaP", "cells", "were", "reduced", "by", "approximately", "80", "%", "following", "treatment", "with", "MCM", "." ]
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13321
[ "We", "focused", "on", "the", "contribution", "of", "two", "major", "products", "of", "activated", "monocytes", ",", "prostaglandin", "E2", "and", "interleukin", "1beta", "(", "IL-1beta", ")", ",", "to", "the", "MCM", "modulatory", "action", "." ]
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13322
[ "LNCaP", "cells", "treated", "with", "prostaglandin", "E2", "showed", "neither", "a", "reduction", "in", "proliferation", "nor", "a", "down-regulation", "of", "AR", "and", "PSA", "levels", "." ]
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13323
[ "The", "effects", "of", "MCM", "on", "cellular", "proliferation", ",", "AR", "protein", "and", "PSA", "secretion", "were", "abolished", "by", "pretreatment", "of", "MCM", "with", "a", "neutralizing", "anti-IL-1beta", "antibody", "." ]
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13324
[ "In", "addition", ",", "recombinant", "IL-1beta", "was", "able", "to", "replace", "MCM", "for", "the", "inhibition", "of", "proliferation", "and", "down-regulation", "of", "AR", "and", "PSA", "proteins", "." ]
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13325
[ "LNCaP", "cells", "were", "shown", "to", "express", "the", "IL-1beta", "receptor", "type", "1", ",", "which", "transduces", "IL-1beta", "signal", "." ]
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13326
[ "Our", "findings", "reveal", "that", "monocyte-derived", "IL-1beta", "inhibits", "the", "proliferation", "of", "androgen-responsive", "prostate", "tumour", "cells", "and", "reduces", "AR", "and", "PSA", "levels", "." ]
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13327
[ "Differential", "responsiveness", "of", "the", "IL-5", "and", "IL-4", "genes", "to", "transcription", "factor", "GATA-3", "." ]
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13328
[ "The", "cytokines", "IL-4", "and", "IL-5", "are", "often", "coordinately", "produced", "by", "Th2", "cells", "as", "in", "asthma", "." ]
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13329
[ "However", ",", "it", "is", "unclear", "whether", "similar", "molecular", "mechanisms", "underlie", "transcription", "of", "the", "two", "genes", "." ]
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13330
[ "We", "have", "previously", "shown", "that", "the", "transcription", "factor", "GATA-3", "is", "expressed", "in", "Th2", "but", "not", "Th1", "cells", "and", "is", "crucial", "for", "activation", "of", "the", "IL-5", "promoter", "by", "different", "stimuli", "." ]
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13331
[ "In", "a", "different", "study", ",", "GATA-3", "was", "shown", "to", "be", "sufficient", "for", "the", "expression", "of", "IL-4", "and", "other", "Th2", "cytokine", "genes", "." ]
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13332
[ "Here", ",", "we", "show", "that", "ectopic", "expression", "of", "GATA-3", "is", "sufficient", "to", "drive", "IL-5", "but", "not", "IL-4", "gene", "expression", "." ]
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13333
[ "Also", ",", "in", "Th2", "cells", ",", "antisense", "GATA-3", "RNA", "inhibits", "IL-5", "but", "not", "IL-4", "promoter", "activation", "." ]
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13334
[ "The", "induction", "of", "IL-5", "gene", "expression", "by", "GATA-3", "involves", "high", "affinity", "binding", "of", "GATA-3", "to", "an", "inverted", "GATA", "repeat", "in", "the", "IL-5", "promoter", "." ]
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13335
[ "The", "interleukin", "2", "receptor", "alpha", "chain/CD25", "promoter", "is", "a", "target", "for", "nuclear", "factor", "of", "activated", "T", "cells", "." ]
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13336
[ "The", "expression", "of", "the", "murine", "interleukin", "(", "IL", ")", "-2", "receptor", "alpha", "chain/CD25", "is", "strongly", "induced", "at", "the", "transcriptional", "level", "after", "T", "cell", "activation", "." ]
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13337
[ "We", "show", "here", "that", "nuclear", "factor", "of", "activated", "T", "cell", "(", "NF-AT", ")", "factors", "are", "involved", "in", "the", "control", "of", "CD25", "promoter", "induction", "in", "T", "cells", "." ]
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13338
[ "NF-ATp", "and", "NF-ATc", "bind", "to", "two", "sites", "around", "positions", "-585", "and", "-650", "located", "upstream", "of", "the", "proximal", "CD25", "promoter", "." ]
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13339
[ "Immediately", "3", "'", "from", "these", "NF-AT", "motifs", ",", "nonconsensus", "sites", "are", "located", "for", "the", "binding", "of", "AP-1-like", "factors", "." ]
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13340
[ "Mutations", "of", "sites", "that", "suppress", "NF-AT", "binding", "impair", "the", "induction", "and", "strong", "NF-ATp", "-mediated", "transactivation", "of", "the", "CD25", "promoter", "in", "T", "cells", "." ]
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13341
[ "In", "T", "lymphocytes", "from", "NF-ATp", "-deficient", "mice", ",", "the", "expression", "of", "CD25", "is", "severely", "impaired", ",", "leading", "to", "a", "delayed", "IL-2", "receptor", "expression", "after", "T", "cell", "receptor", "(", "TCR", ")", "/", "CD3", "stimulation", "." ]
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13342
[ "Our", "data", "indicate", "an", "important", "role", "for", "NF-AT", "in", "the", "faithful", "expression", "of", "high", "affinity", "IL-2", "receptors", "and", "a", "close", "link", "between", "the", "TCR", "-mediated", "induction", "of", "IL-2", "and", "IL-2", "receptor", "alpha", "chain", "promoters", ",", "both", "of", "which", "are", "regulated", "by", "NF-AT", "factors", "." ]
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13343
[ "A", "novel", "mutation", "in", "the", "coding", "sequence", "of", "the", "FY*B", "allele", "of", "the", "Duffy", "chemokine", "receptor", "gene", "is", "associated", "with", "an", "altered", "erythrocyte", "phenotype", "." ]
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13344
[ "The", "Duffy", "blood", "group", "system", "is", "of", "clinical", "and", "biological", "significance", "." ]
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13345
[ "Antibodies", "to", "Duffy", "antigens", "are", "responsible", "for", "some", "cases", "of", "transfusion", "incompatibility", "and", "newborn", "hemolytic", "disease", "." ]
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13346
[ "The", "Duffy", "protein", "is", "a", "receptor", "for", "the", "Plasmodium", "vivax", "erythrocyte-binding", "protein", "and", "is", "also", "a", "receptor", "for", "various", "chemokines", "(", "thus", "renamed", "Duffy", "Antigen", "Receptor", "for", "Chemokines", "[", "DARC", "]", ")", "." ]
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13347
[ "The", "two", "Duffy", "polymorphic", "antigens", ",", "Fya", "and", "Fyb", "(", "coded", "by", "the", "FY*A", "and", "FY*B", "alleles", ")", ",", "are", "present", "on", "erythrocyte", "membranes", "." ]
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13348
[ "The", "Fy", "(", "a-b-", ")", "phenotype", "is", "the", "predominant", "one", "in", "populations", "of", "black", "people", "and", "also", "occurs", "in", "other", "populations", ",", "including", "some", "non-Ashkenazi", "Jewish", "groups", "." ]
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13349
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13350
[ "We", "describe", "here", "a", "novel", "mutation", ",", "present", "in", "the", "FY*B", "coding", "sequence", "(", "271C", "--", ">", "T", ")", ",", "that", "is", "associated", "with", "some", "Fy", "(", "b-", ")", "phenotypes", "among", "non-Ashkenazi", "Jews", "and", "among", "Brazilian", "blacks", "." ]
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13351
[ "The", "mutation", "is", "present", "in", "Fy", "(", "b-", ")", "individuals", ",", "who", "have", "wild-type", "FY*B", "GATA", "and", "carry", "the", "previously", "described", "304G", "--", ">", "A", "substitution", "." ]
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13352
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13353
[ "The", "271C", "--", ">", "T", "substitution", "represents", "a", "considerable", "change", "in", "chemical", "nature", "(", "Arg91", "--", ">", "Cys", ")", ",", "one", "which", "may", "affect", "the", "antigenic", "determinants", "of", "DARC", ",", "and", "thus", "be", "of", "clinical", "significance", "." ]
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13354
[ "The", "mutation", "may", "have", "implications", "for", "some", "physiological", "roles", "of", "DARC", "and", "be", "of", "interest", "in", "malaria", "research", "and", "in", "studies", "of", "population", "genetics", "." ]
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13355
[ "Establishment", "and", "characterization", "of", "EBV-positive", "and", "EBV-negative", "primary", "effusion", "lymphoma", "cell", "lines", "harbouring", "human", "herpesvirus", "type-8", "." ]
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13356
[ "In", "this", "study", "we", "report", "on", "the", "establishment", "and", "characterization", "of", "two", "novel", "lymphoma", "cell", "lines", "(", "CRO-AP/3", "and", "CRO-AP/5", ")", "which", "carry", "infection", "by", "human", "herpesvirus", "type-8", "(", "HHV-8", ")", "and", "have", "derived", "from", "AIDS-related", "primary", "effusion", "lymphoma", "(", "PEL", ")", "." ]
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13357
[ "These", "two", "cell", "lines", "are", "representative", "of", "different", "virologic", "subtypes", "of", "PEL", ",", "i.e", ".", "HHV-8+/EBV-", "PEL", "in", "the", "case", "of", "CRO-AP/3", "and", "HHV-8+/EBV+", "PEL", "in", "the", "case", "of", "CRO-AP/5", "." ]
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13358
[ "Consistent", "with", "the", "diagnosis", "of", "PEL", ",", "both", "CRO-AP/3", "and", "CRO-AP/5", "expressed", "indeterminate", "(", "i.e.", "non-B", ",", "non-T", ")", "phenotypes", "although", "immunogenotypic", "studies", "documented", "their", "B-cell", "origin", "." ]
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13359
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13378
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13379
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13380
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13382
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13389
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