Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
12901
[ "To", "study", "the", "molecular", "mechanisms", "of", "transcriptional", "control", "of", "CD95L", "expression", "in", "T", "cells", ",", "we", "investigated", "the", "human", "CD95L", "promoter", "in", "Jurkat", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0, 0, 0, 0, 1, 2, 2, 0, 5, 6, 6, 0 ]
12902
[ "Deletion", "studies", "revealed", "that", "the", "CD95L", "proximal", "promoter", "sequence", "from", "-220", "to", "the", "transcription", "start", "site", "is", "essential", "for", "T", "cell", "stimulation-induced", "expression", "of", "CD95L", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 9, 0 ]
12903
[ "In", "this", "study", ",", "we", "discovered", "a", "novel", "regulatory", "element", "located", "at", "-120", "of", "the", "CD95L", "promoter", "which", "contains", "DNA", "binding", "sites", "for", "SP-1", "and", "a", "yet", "unknown", "inducible", "factor", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
12904
[ "Mutation", "analysis", "demonstrated", "that", "binding", "of", "the", "inducible", "factor", "to", "the", "-120", "region", "is", "crucial", "for", "the", "biological", "function", "of", "the", "CD95L", "promoter", "upon", "T", "cell", "stimulation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 7, 8, 0, 0 ]
12905
[ "The", "DNA", "sequence", "at", "-120", "also", "contains", "two", "DNA", "motifs", "homologous", "to", "the", "binding", "site", "for", "NF-AT", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
12906
[ "NF-AT", "does", "not", "directly", "bind", "to", "this", "element", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
12907
[ "However", ",", "cotransfection", "studies", "with", "an", "NF-AT", "expression", "vector", "showed", "that", "NF-AT", "may", "confer", "a", "strong", "inducible", "activity", "to", "the", "CD95L", "promoter", "at", "this", "regulatory", "region", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0 ]
12908
[ "Our", "data", "also", "show", "that", "the", "immunosuppressive", "agent", "cyclosporin", "A", "down-regulates", "CD95L", "transcription", "by", "inhibiting", "the", "function", "of", "this", "positive", "regulatory", "element" ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12909
[ "A", "nongenomic", "mechanism", "for", "progesterone-mediated", "immunosuppression", ":", "inhibition", "of", "K+", "channels", ",", "Ca2+", "signaling", ",", "and", "gene", "expression", "in", "T", "lymphocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
12910
[ "The", "mechanism", "by", "which", "progesterone", "causes", "localized", "suppression", "of", "the", "immune", "response", "during", "pregnancy", "has", "remained", "elusive", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12911
[ "Using", "human", "T", "lymphocytes", "and", "T", "cell", "lines", ",", "we", "show", "that", "progesterone", ",", "at", "concentrations", "found", "in", "the", "placenta", ",", "rapidly", "and", "reversibly", "blocks", "voltage-gated", "and", "calcium-activated", "K+", "channels", "(", "KV", "and", "KCa", ",", "respectively", ")", ",", "resulting", "in", "depolarization", "of", "the", "membrane", "potential", "." ]
[ 0, 7, 8, 8, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12912
[ "As", "a", "result", ",", "Ca2+", "signaling", "and", "nuclear", "factor", "of", "activated", "T", "cells", "(", "NF-AT", ")", "-driven", "gene", "expression", "are", "inhibited", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0 ]
12913
[ "Progesterone", "acts", "distally", "to", "the", "initial", "steps", "of", "T", "cell", "receptor", "(", "TCR", ")", "-mediated", "signal", "transduction", ",", "since", "it", "blocks", "sustained", "Ca2+", "signals", "after", "thapsigargin", "stimulation", ",", "as", "well", "as", "oscillatory", "Ca2+", "signals", ",", "but", "not", "the", "Ca2+", "transient", "after", "TCR", "stimulation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
12914
[ "K+", "channel", "blockade", "by", "progesterone", "is", "specific", ";", "other", "steroid", "hormones", "had", "little", "or", "no", "effect", ",", "although", "the", "progesterone", "antagonist", "RU", "486", "also", "blocked", "KV", "and", "KCa", "channels", "." ]
[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
12915
[ "Progesterone", "effectively", "blocked", "a", "broad", "spectrum", "of", "K+", "channels", ",", "reducing", "both", "Kv1.3", "and", "charybdotoxin-resistant", "components", "of", "KV", "current", "and", "KCa", "current", "in", "T", "cells", ",", "as", "well", "as", "blocking", "several", "cloned", "KV", "channels", "expressed", "in", "cell", "lines", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]
12916
[ "Progesterone", "had", "little", "or", "no", "effect", "on", "a", "cloned", "voltage-gated", "Na+", "channel", ",", "an", "inward", "rectifier", "K+", "channel", ",", "or", "on", "lymphocyte", "Ca2+", "and", "Cl-", "channels", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 9, 10, 0, 0, 0, 7, 0, 0, 9, 10, 0 ]
12917
[ "We", "propose", "that", "direct", "inhibition", "of", "K+", "channels", "in", "T", "cells", "by", "progesterone", "contributes", "to", "progesterone-induced", "immunosuppression", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0 ]
12918
[ "A", "mouse", "carrying", "genetic", "defect", "in", "the", "choice", "between", "T", "and", "B", "lymphocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0 ]
12919
[ "Transgenic", "mice", "with", "human", "CD3epsilon", "gene", "have", "been", "shown", "to", "exhibit", "early", "arrest", "of", "T", "cell", "development", "in", "the", "thymus", "." ]
[ 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0 ]
12920
[ "The", "present", "study", "shows", "that", ",", "instead", "of", "T", "cells", ",", "B", "cells", "are", "generated", "in", "the", "thymus", "of", "a", "line", ",", "tg", "epsilon26", ",", "of", "the", "human", "CD3epsilon", "transgenic", "mice", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0 ]
12921
[ "The", "accumulation", "of", "mature", "B", "cells", "in", "the", "thymus", "was", "found", "only", "in", "tg", "epsilon26", "mice", ",", "not", "in", "other", "human", "CD3epsilon", "transgenic", "mouse", "lines", "or", "other", "T", "cell-deficient", "mice", ",", "including", "CD3-epsilon", "knockout", "mice", "and", "TCR-beta/TCR-delta", "double", "knockout", "mice", "." ]
[ 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0 ]
12922
[ "Hanging", "drop-mediated", "transfer", "into", "2-deoxyguanosine-treated", "thymus", "lobes", "showed", "that", "lymphoid", "progenitor", "cells", "rather", "than", "thymus", "stromal", "cells", "were", "responsible", "for", "abnormal", "B", "cell", "development", "in", "tg", "epsilon26", "thymus", ",", "and", "that", "tg", "epsilon26", "fetal", "liver", "cells", "were", "destined", "to", "become", "B", "cells", "in", "normal", "thymus", "even", "in", "the", "presence", "of", "normal", "progenitor", "cells", "undergoing", "T", "cell", "development", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 7, 8, 8, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0 ]
12923
[ "These", "results", "indicate", "that", "lymphoid", "progenitor", "cells", "in", "tg", "epsilon26", "mice", "are", "genetically", "defective", "in", "thymic", "choice", "between", "T", "cells", "and", "B", "cells", ",", "generating", "B", "cells", "even", "in", "normal", "thymus", "environment", "." ]
[ 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 7, 8, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0 ]
12924
[ "Interestingly", ",", "tg", "epsilon26", "thymocytes", "expressed", "GATA-3", "and", "TCF-1", ",", "but", "not", "LEF-1", "and", "PEBP-2alpha", ",", "among", "T", "cell-specific", "transcription", "factors", "that", "are", "involved", "in", "early", "T", "cell", "development", ",", "indicating", "that", "GATA-3", "and", "TCF-1", "expressed", "during", "thymocyte", "development", "do", "not", "necessarily", "determine", "the", "cell", "fate", "into", "T", "cell", "lineage", "." ]
[ 0, 0, 0, 0, 7, 0, 9, 0, 9, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 9, 0, 9, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
12925
[ "Thus", ",", "tg", "epsilon26", "mice", "provide", "a", "novel", "mouse", "model", "in", "that", "lineage", "choice", "between", "T", "and", "B", "lymphocytes", "is", "genetically", "defective", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0 ]
12926
[ "Downstream", "activation", "of", "a", "TATA-less", "promoter", "by", "Oct-2", ",", "Bob1", ",", "and", "NF-kappaB", "directs", "expression", "of", "the", "homing", "receptor", "BLR1", "to", "mature", "B", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0 ]
12927
[ "The", "chemokine", "receptor", ",", "BLR1", ",", "is", "a", "major", "regulator", "of", "the", "microenvironmental", "homing", "of", "B", "cells", "in", "lymphoid", "organs", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0 ]
12928
[ "In", "vitro", "studies", "identify", "three", "essential", "elements", "of", "the", "TATA-less", "blr1", "core", "promoter", "that", "confer", "cell", "type-", "and", "differentiation-specific", "expression", "in", "the", "B", "cells", "of", "both", "humans", "and", "mice", ",", "a", "functional", "promoter", "region", "(", "-36", "with", "respect", "to", "the", "transcription", "start", "site", ")", ",", "a", "NF-kappaB", "motif", "(", "+44", ")", ",", "and", "a", "noncanonical", "octamer", "motif", "(", "+157", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12929
[ "The", "importance", "of", "these", "sites", "was", "confirmed", "by", "in", "vivo", "studies", "in", "gene-targeted", "mice", "deficient", "of", "either", "Oct-2", ",", "Bob1", ",", "or", "both", "NF-kappaB", "subunits", "p50", "and", "p52", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 9, 10, 10, 0, 9, 0 ]
12930
[ "In", "all", "of", "these", "animals", ",", "the", "expression", "of", "BLR1", "was", "reduced", "or", "absent", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
12931
[ "In", "mice", "deficient", "only", "of", "p52/NF-kappaB", ",", "BLR1", "expression", "was", "unaffected", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0 ]
12932
[ "Thus", "our", "data", "demonstrate", "that", "BLR1", "is", "a", "target", "gene", "for", "Oct-2", ",", "Bob1", ",", "and", "members", "of", "the", "NF-kappaB/Rel", "family", "and", "provides", "a", "link", "to", "the", "impaired", "B", "cell", "functions", "in", "mice", "deficient", "for", "these", "factors", "." ]
[ 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0 ]
12933
[ "CD4", "promoter", "transactivation", "by", "human", "herpesvirus", "6", "." ]
[ 1, 2, 0, 0, 0, 0, 0, 0 ]
12934
[ "The", "observation", "that", "human", "herpesvirus", "6", "(", "HHV-6", ")", "can", "induce", "CD4", "gene", "transcription", "and", "expression", "in", "CD4", "(", "-", ")", "cells", "was", "reported", "several", "years", "ago", "(", "P.Lusso", ",", "A.De", "Maria", ",", "M.Malnati", ",", "F.Lori", ",", "S.E.DeRocco", ",", "M.", "Baseler", ",", "and", "R.C.Gallo", ",", "Nature", "349", ":", "533-535", ",", "1991", ")", "and", "subsequently", "confirmed", "(", "P.Lusso", ",", "M.S.Malnati", ",", "A.Garzino-Demo", ",", "R.W.Crowley", ",", "E.", "O.Long", ",", "and", "R.C.Gallo", ",", "Nature", "362", ":", "458-462", ",", "1993", ";", "G.Furlini", ",", "M.", "Vignoli", ",", "E.Ramazzotti", ",", "M.C.Re", ",", "G.Visani", ",", "and", "M.LaPlaca", ",", "Blood", "87", ":", "4737-4745", ",", "1996", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12935
[ "Our", "objective", "was", "to", "identify", "the", "mechanisms", "underlying", "such", "phenomena", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12936
[ "Using", "reporter", "gene", "constructs", "driven", "by", "the", "CD4", "promoter", ",", "we", "report", "that", "HHV-6", "can", "efficiently", "transactivate", "such", "genetic", "elements", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12937
[ "Activation", "of", "the", "CD4", "promoter", "occurs", "in", "the", "presence", "of", "the", "viral", "DNA", "polymerase", "inhibitor", "phosphonoformic", "acid", ",", "which", "limits", "expression", "to", "the", "immediate-early", "and", "early", "classes", "of", "viral", "genes", "." ]
[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12938
[ "Using", "deletion", "mutants", "and", "specific", "CD4", "promoter", "mutants", ",", "we", "identified", "an", "ATF/CRE", "binding", "site", "located", "at", "nucleotides", "-67", "to", "-60", "upstream", "of", "the", "CD4", "gene", "transcription", "start", "site", "that", "is", "important", "for", "HHV-6", "transactivation", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12939
[ "The", "ATF/CRE", "site", "is", "also", "essential", "for", "CD4", "promoter", "activation", "by", "forskolin", ",", "an", "activator", "of", "adenylate", "cyclase", "." ]
[ 0, 1, 2, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12940
[ "Using", "electrophoretic", "mobility", "shift", "assays", "and", "specific", "antibodies", ",", "we", "showed", "that", "CREB-1", "binds", "specifically", "to", "the", "-79", "to", "-52", "region", "of", "the", "CD4", "promoter", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
12941
[ "Last", ",", "we", "have", "identified", "two", "open", "reading", "frames", "(", "ORFs", ")", "of", "HHV-6", ",", "U86", "and", "U89", "from", "the", "immediate-early", "locus", "A", ",", "that", "can", "transactivate", "the", "CD4", "promoter", "in", "HeLa", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 5, 6, 0 ]
12942
[ "However", ",", "transactivation", "of", "the", "CD4", "promoter", "by", "ORFs", "U86", "and", "U89", "is", "independent", "of", "the", "CRE", "element", ",", "suggesting", "that", "additional", "HHV-6", "ORFs", "are", "likely", "to", "contribute", "to", "CD4", "gene", "activation", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 0, 1, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0 ]
12943
[ "Taken", "together", ",", "our", "results", "will", "help", "to", "understand", "the", "complex", "interactions", "occurring", "between", "HHV-6", "and", "the", "CD4", "promoter", "and", "provide", "additional", "information", "regarding", "the", "class", "of", "transcription", "factors", "involved", "in", "the", "control", "of", "CD4", "gene", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0 ]
12944
[ "The", "PEBP2betaMYH11", "fusion", "created", "by", "Inv", "(", "16", ")", "(", "p13", ";", "q22", ")", "in", "myeloid", "leukemia", "impairs", "neutrophil", "maturation", "and", "contributes", "to", "granulocytic", "dysplasia", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0 ]
12945
[ "Chromosomal", "translocations", "involving", "the", "genes", "encoding", "the", "alpha", "and", "beta", "subunits", "of", "the", "Pebp2/Cbf", "transcription", "factor", "have", "been", "associated", "with", "human", "acute", "myeloid", "leukemia", "and", "the", "preleukemic", "condition", ",", "myelodysplasia", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12946
[ "Inv", "(", "16", ")", "(", "p13", ";", "q22", ")", "fuses", "the", "gene", "encoding", "the", "beta", "subunit", "of", "Pebp2", "to", "the", "MYH11", "gene", "encoding", "a", "smooth", "muscle", "myosin", "heavy", "chain", "(", "Smmhc", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 1, 2, 0, 0, 9, 10, 10, 10, 10, 0, 9, 0, 0 ]
12947
[ "To", "examine", "the", "effect", "of", "the", "inv", "(", "16", ")", "(", "p13", ";", "q22", ")", "on", "myelopoiesis", ",", "we", "used", "the", "hMRP8", "promoter", "element", "to", "generate", "transgenic", "mice", "expressing", "the", "Pebp2beta", "Smmhc", "chimeric", "fusion", "protein", "in", "myeloid", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 7, 8, 0 ]
12948
[ "Neutrophil", "maturation", "was", "impaired", "in", "PEBP2betaMYH11", "transgenic", "mice", "." ]
[ 7, 0, 0, 0, 0, 9, 0, 0, 0 ]
12949
[ "Although", "the", "transgenic", "mice", "had", "normal", "numbers", "of", "circulating", "neutrophils", ",", "their", "bone", "marrow", "contained", "increased", "numbers", "of", "immature", "neutrophilic", "cells", ",", "which", "exhibited", "abnormal", "characteristics", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0 ]
12950
[ "In", "addition", ",", "PEBP2betaMYH11", "inhibited", "neutrophilic", "differentiation", "in", "colonies", "derived", "from", "hematopoietic", "progenitors", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
12951
[ "Coexpression", "of", "both", "PEBP2betaMYH11", "and", "activated", "NRAS", "induced", "a", "more", "severe", "phenotype", "characterized", "by", "abnormal", "nuclear", "morphology", "indicative", "of", "granulocytic", "dysplasia", "." ]
[ 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12952
[ "These", "results", "show", "that", "PEBP2betaMYH11", "can", "impair", "neutrophil", "development", "and", "provide", "evidence", "that", "alterations", "of", "Pebp2", "can", "contribute", "to", "the", "genesis", "of", "myelodysplasia", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
12953
[ "Human", "T", "cell", "leukemia", "virus-I", "(", "HTLV-I", ")", "Tax", "-mediated", "apoptosis", "in", "activated", "T", "cells", "requires", "an", "enhanced", "intracellular", "prooxidant", "state", "." ]
[ 9, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0 ]
12954
[ "We", "have", "shown", "that", "an", "estradiol-dependent", "activation", "of", "human", "T", "cell", "leukemia", "virus-I", "Tax", "leads", "to", "the", "inhibition", "of", "cell", "proliferation", "and", "to", "the", "induction", "of", "apoptosis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12955
[ "The", "present", "study", "demonstrates", "that", "a", "hormone-dependent", "activation", "of", "Tax", "promotes", "an", "enhanced", "prooxidant", "state", "in", "stably", "transfected", "Jurkat", "cells", "as", "measured", "by", "changes", "in", "the", "intracellular", "levels", "of", "glutathione", "and", "H2O2", ";", "these", "changes", "are", "followed", "by", "apoptotic", "cell", "death", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12956
[ "Additional", "stimulation", "of", "the", "CD3", "/TCR", "pathway", "enhances", "the", "oxidative", "and", "apoptotic", "effects", "." ]
[ 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]
12957
[ "Both", "Tax", "-mediated", "apoptosis", "and", "oxidative", "stress", "can", "be", "potently", "suppressed", "by", "antioxidants", ",", "as", "is", "seen", "with", "the", "administration", "of", "recombinant", "thioredoxin", "(", "adult", "T", "cell", "leukemia-derived", "factor", ")", "or", "pyrrolidine", "dithiocarbamate", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12958
[ "Hormone-induced", "Tax", "activation", "induces", "a", "long-lasting", "activation", "of", "NF-kappaB", ",", "which", "is", "a", "major", "target", "of", "reactive", "oxygen", "intermediates", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12959
[ "The", "long-term", "exposure", "of", "Jurkat", "cells", "to", "hormone", "eventually", "results", "in", "a", "selection", "of", "cell", "clones", "that", "have", "lost", "Tax", "activity", "." ]
[ 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
12960
[ "A", "subsequent", "transfection", "of", "these", "apparently", "``", "nonresponsive", "''", "clones", "allows", "the", "recovery", "of", "Tax", "responses", "in", "these", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
12961
[ "Our", "observations", "indicate", "that", "changes", "in", "the", "intracellular", "redox", "status", "may", "be", "a", "determining", "factor", "in", "Tax", "-mediated", "DNA", "damage", ",", "apoptosis", ",", "and", "selection", "against", "the", "long-term", "expression", "of", "Tax", "function", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
12962
[ "An", "allosteric", "drug", ",", "o", ",", "o'-bismyristoyl", "thiamine", "disulfide", ",", "suppresses", "HIV-1", "replication", "through", "prevention", "of", "nuclear", "translocation", "of", "both", "HIV-1", "Tat", "and", "NF-kappa", "B", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0 ]
12963
[ "The", "efficacy", "of", "o", ",", "o'-bismyristoyl", "thiamine", "disulfide", "(", "BMT", ")", "was", "examined", "in", "detail", "against", "HIV-1", "laboratory", "isolates", "(", "HTLV-IIIB", ",", "JRFL", ",", "and", "MN", ")", ",", "primary", "isolates", "(", "KMT", "and", "KMO", ")", ",", "and", "simian", "immunodeficiency", "virus", "(", "SIVmac251", ")", "in", "vitro", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12964
[ "BMT", "inhibited", "the", "replication", "of", "HIV-1", "in", "both", "laboratory", "and", "primary", "isolates", "in", "vitro", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12965
[ "In", "addition", ",", "BMT", "exhibited", "antiviral", "activity", "against", "SIVmac251", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12966
[ "Minimizing", "energy", "studies", "of", "BMT", "structure", "reveal", "that", "a", "trans-disulfide", "of", "thiamine", "(", "holo", "drug", ")", "disulfide", "(", "TDS", ",", "protodrug", ")", "is", "allosterically", "transited", "to", "the", "reactive", "twisted", "disulfide", "of", "BMT", "(", "allo", "drug", ")", "by", "o", ",", "o'-bismyristoyl", "esterification", "of", "TDS", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12967
[ "BMT", "inhibits", "nuclear", "translocation", "of", "both", "HIV-1", "transactivator", "(", "TAT", ")", "and", "the", "cellular", "transcriptional", "nuclear", "factor-KB", "(", "NF-kappa", "B", ")", ",", "resulting", "in", "the", "suppression", "of", "HIV-1", "replication", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12968
[ "Glucocorticoid-induced", "apoptosis", "and", "regulation", "of", "NF-kappaB", "activity", "in", "human", "leukemic", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 8, 8, 0 ]
12969
[ "Glucocorticoid-induced", "apoptosis", "was", "investigated", "in", "glucocorticoid-sensitive", "6TG1.1", "and", "resistant", "ICR27TK.3", "human", "leukemic", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 5, 0, 0, 5, 6, 6, 6, 6, 0 ]
12970
[ "Following", "glucocorticoid", "treatment", "of", "6TG1.1", "cells", ",", "chromatin", "fragmentation", "was", "observed", "after", "a", "delay", "of", "24", "h", "." ]
[ 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12971
[ "Fragmentation", "was", "not", "observed", "in", "ICR27TK.3", "cells", "containing", "mutant", "glucocorticoid", "receptors", "(", "L753F", ")", "that", "are", "activation-deficient", "but", "retain", "the", "ability", "to", "repress", "AP-1", "activity", "." ]
[ 0, 0, 0, 0, 0, 5, 6, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
12972
[ "Nor", "was", "fragmentation", "observed", "after", "treatment", "with", "RU38486", ",", "indicating", "that", "repression", "of", "AP-1", "activity", "is", "not", "involved", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
12973
[ "As", "described", "in", "other", "systems", ",", "fragmentation", "required", "ongoing", "protein", "synthesis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12974
[ "However", ",", "inhibition", "of", "protein", "synthesis", "with", "cycloheximide", "anytime", "during", "the", "first", "18", "h", "of", "steroid", "treatment", "was", "as", "effective", "in", "blocking", "chromatin", "fragmentation", "as", "inhibition", "for", "the", "entire", "period", ",", "suggesting", "that", "synthesis", "of", "a", "component", "with", "a", "rapid", "turnover", "rate", "is", "required", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12975
[ "Dexamethasone", "treatment", "completely", "blocked", "12-O-tetradecanoylphorbol", "13-acetate", "induction", "of", "nuclear", "factor-kappaB", "(", "NF-kappaB", ")", "activity", "and", "elicited", "an", "increase", "in", "the", "amount", "of", "immunoreactive", "IkappaB", "alpha", "in", "sensitive", "6TG1.1", "cells", "but", "not", "in", "resistant", "ICR27TK.3", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 5, 6, 0, 0, 0, 0, 5, 6, 0 ]
12976
[ "In", "addition", ",", "mild", "detergent", "treatment", "of", "cell", "extracts", "indicated", "that", "a", "substantial", "amount", "of", "cytoplasmic", "NF-kappaB", "is", "complexed", "with", "IkappaB", "alpha", "or", "some", "other", "inhibitory", "factor.", "These", "results", "suggest", "that", "induction", "of", "a", "labile", "inhibitory", "factor", "such", "as", "IkappaB", "alpha", "may", "contribute", "to", "glucocorticoid-induced", "apoptosis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0 ]
12977
[ "Inhibition", "of", "HIV-1", "replication", "by", "combination", "of", "a", "novel", "inhibitor", "of", "TNF-alpha", "with", "AZT", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
12978
[ "The", "small", "molecule", "S9a", "was", "derived", "from", "an", "established", "tumor", "necrosis", "factor-alpha", "(", "TNF-alpha", ")", "inhibitor", "(", "Canventol", ")", "by", "replacement", "of", "the", "isopropylidine", "group", "with", "a", "phenyl", "ring", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12979
[ "S9a", "at", "10", "to", "100", "nM", "inhibited", "HIV", "production", "as", "potently", "as", "3'-azido-3'-deoxythymidine", "(", "AZT", ")", ",", "an", "inhibitor", "of", "viral", "reverse", "transcriptase", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
12980
[ "Furthermore", ",", "S9a", "and", "AZT", "in", "combination", ",", "at", "noncytoxic", "concentrations", "strongly", "inhibited", "HIV-1", "replication", "that", "was", "more", "than", "additive", "and", "substantially", "prolonged", "the", "appearance", "of", "virus", "both", "in", "acutely", "infected", "CD4+", "lymphocytes", "(", "SupT", ")", "in", "culture", "and", "in", "peripheral", "blood", "mononuclear", "cells", "(", "PBMCs", ")", "infected", "with", "a", "primary", "HIV-1", "isolate", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0 ]
12981
[ "S9a", "inhibited", "TNF-alpha", "promoter-driven", "reporter", "gene", "activity", "." ]
[ 0, 0, 1, 2, 2, 2, 0, 0 ]
12982
[ "It", "was", "proposed", "that", "the", "mechanism", "of", "antiviral", "action", "of", "S9a", "was", "on", "the", "host", "cell", ",", "by", "blocking", "TNF-alpha", "transcription", "via", "a", "Tat", "-induced", "tar-independent", "loop", ",", "which", "decreases", "downstream", "NF-kappaB", "activation", "of", "HIV-1", "long", "terminal", "repeat", "(", "LTR", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0 ]
12983
[ "S9a", "was", "superior", "to", "the", "first", "generation", "compound", "Canventol", ",", "which", "was", "superior", "to", "the", "natural", "compound", "sarcophytol", "A", ",", "demonstrating", "that", "further", "structure-based", "enhancement", "of", "potency", "of", "these", "compounds", "is", "feasible", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12984
[ "This", "study", "suggests", "a", "therapeutic", "approach", "against", "AIDS", "by", "application", "of", "two", "drugs", ",", "one", "against", "a", "cellular", "and", "the", "other", "a", "viral", "target", ",", "which", "may", "provide", "an", "approach", "to", "the", "problem", "of", "frequent", "emergence", "of", "resistant", "variants", "to", "combinations", "of", "drugs", "that", "target", "only", "HIV", "genes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12985
[ "Highly", "polarized", "HLA", "class", "II", "antigen", "processing", "and", "presentation", "by", "human", "intestinal", "epithelial", "cells", "." ]
[ 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 7, 8, 8, 8, 0 ]
12986
[ "The", "high", "concentration", "of", "foreign", "antigen", "in", "the", "lumen", "of", "the", "gastrointestinal", "tract", "is", "separated", "from", "the", "underlying", "lymphocytes", "by", "a", "single", "cell", "layer", "of", "polarized", "epithelium", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12987
[ "Intestinal", "epithelial", "cells", "can", "express", "HLA", "class", "II", "antigens", "and", "may", "function", "as", "antigen-presenting", "cells", "to", "CD4", "(", "+", ")", "T", "cells", "within", "the", "intestinal", "mucosa", "." ]
[ 7, 8, 8, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0 ]
12988
[ "Using", "tetanus", "toxoid", "specific", "and", "HLA-DR-restricted", "T", "lymphocytes", ",", "we", "show", "that", "polarized", "intestinal", "epithelial", "cells", "directed", "to", "express", "HLA-DR", "molecules", "are", "able", "to", "initiate", "class", "II", "processing", "only", "after", "internalization", "of", "antigen", "from", "their", "apical", "surface", "." ]
[ 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12989
[ "Coexpression", "of", "the", "class", "II", "transactivator", "CIITA", "in", "these", "cells", ",", "which", "stimulates", "highly", "efficient", "class", "II", "processing", "without", "the", "characteristic", "decline", "in", "barrier", "function", "seen", "in", "polarized", "monolayers", "treated", "with", "the", "proinflammatory", "cytokine", "gamma-IFN", ",", "facilitates", "antigen", "processing", "from", "the", "basolateral", "surface", "." ]
[ 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12990
[ "In", "both", "cases", ",", "peptide", "presentation", "to", "T", "cells", "via", "class", "II", "molecules", "was", "restricted", "to", "the", "basolateral", "surface", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12991
[ "These", "data", "indicate", "a", "highly", "polarized", "functional", "architecture", "for", "antigen", "processing", "and", "presentation", "by", "intestinal", "epithelial", "cells", ",", "and", "suggest", "that", "the", "functional", "outcome", "of", "antigen", "processing", "by", "the", "intestinal", "epithelium", "is", "both", "dependent", "on", "the", "cellular", "surface", "at", "which", "the", "foreign", "antigen", "is", "internalized", "and", "by", "the", "underlying", "degree", "of", "mucosal", "inflammation" ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12992
[ "Tobacco", "smoke", "induces", "coordinate", "activation", "of", "HSF", "and", "inhibition", "of", "NFkappaB", "in", "human", "monocytes", ":", "effects", "on", "TNFalpha", "release", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 7, 8, 0, 0, 0, 9, 0, 0 ]
12993
[ "Tobacco", "smoke", "(", "TS", ")", "exposure", "is", "a", "major", "risk", "factor", "for", "human", "disease", ",", "and", "macrophages", "of", "healthy", "smokers", "have", "a", "depressed", "capacity", "to", "release", "cytokines", ",", "including", "tumor", "necrosis", "factor", "(", "TNF", ")", "alpha", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0 ]
12994
[ "TS", "induces", "the", "synthesis", "of", "heat", "shock", "(", "HS", ")", "/stress", "proteins", "(", "HSP", ")", ",", "and", ",", "in", "particular", ",", "of", "Hsp70", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
12995
[ "We", "determined", "whether", "Hsp70", "induction", "by", "TS", "was", "mediated", "by", "the", "activation", "of", "the", "HS", "transcription", "factor", ",", "HSF", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0 ]
12996
[ "HSF", "activation", "has", "been", "shown", "to", "inhibit", "NFkappaB", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 9, 0 ]
12997
[ "Thus", ",", "we", "also", "determined", "the", "effects", "of", "TS", "on", "NFkappaB", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
12998
[ "U937", "cells", "and", "human", "peripheral", "blood", "monocytes", "were", "exposed", "to", "TS", ",", "binding", "activities", "of", "the", "respective", "transcription", "factors", "were", "analyzed", ",", "and", "Hsp70", "expression", "and", "TNFalpha", "release", "were", "determined", "in", "parallel", "." ]
[ 5, 6, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
12999
[ "TS", "activated", "HSF", ",", "which", "was", "associated", "with", "Hsp70", "overexpression", "and", "inhibition", "of", "NFkappaB", "binding", "activity", "and", "TNFalpha", "release", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0 ]
13000
[ "The", "altered", "cytokine", "profile", "observed", "in", "smokers", "may", "relate", "to", "an", "HSF", "/", "Hsp70", "-mediated", "inhibition", "of", "NFkappaB", "activity", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 9, 0, 0 ]