Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
12801
[ "Copyright", "1998", "Academic", "Press", "." ]
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12802
[ "The", "human", "gene", "encoding", "the", "lectin-type", "oxidized", "LDL", "receptor", "(", "OLR1", ")", "is", "a", "novel", "member", "of", "the", "natural", "killer", "gene", "complex", "with", "a", "unique", "expression", "profile", "." ]
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12803
[ "LOX-1", "is", "an", "endothelial", "receptor", "for", "oxidized", "low-density", "lipoprotein", "that", "plays", "essential", "roles", "in", "atherogenesis", "." ]
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12804
[ "LOX-1", "has", "the", "highest", "homology", "with", "C-type", "lectin", "receptors", "expressed", "on", "natural", "killer", "cells", "." ]
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12805
[ "In", "the", "present", "study", ",", "we", "cloned", "and", "characterized", "the", "human", "LOX-1", "gene", "(", "HGMW-approved", "symbol", "OLR1", ")", "." ]
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12806
[ "The", "gene", "structure", "of", "LOX-1", "resembles", "that", "of", "the", "natural", "killer", "cell", "receptors", "." ]
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12807
[ "Fluorescence", "in", "situ", "hybridization", "and", "analyses", "of", "a", "yeast", "artificial", "chromosome", "contig", "revealed", "that", "the", "human", "LOX-1", "gene", "is", "located", "in", "the", "natural", "killer", "gene", "complex", "on", "chromosome", "12p12-p13", ",", "where", "the", "genes", "of", "the", "natural", "killer", "cell", "receptors", "cluster", "." ]
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12808
[ "In", "contrast", ",", "the", "expression", "pattern", "of", "LOX-1", "is", "different", "from", "that", "of", "the", "natural", "killer", "cell", "receptors", ";", "LOX-1", "is", "expressed", "in", "vascular-rich", "organs", ",", "but", "not", "in", "lymphocytes", "." ]
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12809
[ "A", "1753-bp", "fragment", "of", "the", "5", "'", "flanking", "region", "of", "the", "LOX-1", "gene", "had", "a", "functional", "promoter", "activity", "." ]
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12810
[ "This", "region", "contains", "binding", "sites", "for", "several", "transcription", "factors", ",", "including", "the", "STAT", "family", "and", "NF-IL6", ",", "and", "the", "expression", "of", "LOX-1", "was", "upregulated", "by", "several", "cytokines", "." ]
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12811
[ "These", "results", "demonstrate", "that", "the", "human", "LOX-1", "gene", "is", "a", "new", "member", "of", "the", "natural", "killer", "gene", "complex", "with", "a", "unique", "expression", "profile", "." ]
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12812
[ "Copyright", "1998", "Academic", "Press", "." ]
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12813
[ "Transcriptional", "regulation", "of", "the", "beta-casein", "gene", "by", "cytokines", ":", "cross-talk", "between", "STAT5", "and", "other", "signaling", "molecules", "." ]
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12814
[ "The", "beta-casein", "promoter", "has", "been", "widely", "used", "to", "monitor", "the", "activation", "of", "STAT", "(", "signal", "transducer", "and", "activator", "of", "transcription", ")", "5", "since", "STAT5", "was", "originally", "found", "as", "a", "mediator", "of", "PRL-inducible", "beta-casein", "expression", "." ]
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12815
[ "However", ",", "not", "only", "is", "expression", "of", "the", "beta-casein", "gene", "regulated", "by", "STAT5", "but", "it", "is", "also", "affected", "by", "other", "molecules", "such", "as", "glucocorticoid", "and", "Ras", "." ]
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12816
[ "In", "this", "report", ",", "we", "describe", "the", "transcriptional", "regulation", "of", "the", "beta-casein", "gene", "by", "cytokines", "in", "T", "cells", "." ]
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12817
[ "We", "have", "found", "that", "the", "beta-casein", "gene", "is", "expressed", "in", "a", "cytotoxic", "T", "cell", "line", ",", "CTLL-2", ",", "in", "response", "to", "interleukin-2", "(", "IL-2", ")", ",", "which", "activates", "STAT5", "." ]
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12818
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12819
[ "IL-2", "-induced", "beta-casein", "expression", "was", "enhanced", "by", "dexamethasone", ",", "and", "this", "synergistic", "effect", "of", "Dexamethasone", "requires", "the", "sequence", "between", "-155", "and", "-193", "in", "the", "beta-casein", "promoter", "." ]
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12820
[ "Coincidentally", ",", "a", "deletion", "of", "this", "region", "enhanced", "the", "IL-2", "-induced", "expression", "of", "beta-casein", "." ]
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12821
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12822
[ "In", "apparent", "contradiction", ",", "expression", "of", "a", "dominant", "negative", "form", "of", "Ras", ",", "RasN17", ",", "also", "inhibited", "IL-2", "-induced", "activation", "of", "the", "promoter", "containing", "the", "minimal", "beta-casein", "STAT5", "element", "as", "well", "as", "the", "promoters", "of", "CIS", "and", "OSM", "." ]
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12823
[ "In", "addition", ",", "Ras", "(", "G12V", ")", "complemented", "signaling", "by", "an", "erythropoietin", "receptor", "mutant", "defective", "in", "Ras", "activation", "and", "augmented", "the", "activation", "of", "the", "beta-casein", "promoter", "by", "the", "mutant", "erythropoietin", "receptor", "signaling", ",", "suggesting", "a", "possible", "role", "of", "Ras", "in", "Stat5", "-mediated", "gene", "expression", "." ]
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12824
[ "These", "results", "collectively", "reveal", "a", "complex", "interaction", "of", "STAT5", "with", "other", "signaling", "pathways", "and", "illustrate", "that", "regulation", "of", "gene", "expression", "requires", "integration", "of", "opposing", "signals" ]
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12825
[ "GATA-3", "represses", "gp91phox", "gene", "expression", "in", "eosinophil-committed", "HL-60-C15", "cells", "." ]
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12826
[ "To", "study", "the", "regulatory", "mechanism", "of", "gp91phox", "gene", "expression", "in", "eosinophils", ",", "we", "transiently", "transfected", "eosinophil-committed", "HL-60-C15", "cells", "with", "gp91phox", "promoter", "constructs", ",", "and", "identified", "a", "negative", "element", "from", "bp", "-267", "to", "-246", "of", "the", "gp91phox", "gene", ",", "the", "deletion", "of", "which", "caused", "an", "83", "%", "increase", "in", "promoter", "activity", "." ]
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12827
[ "Electrophoresis", "mobility", "shift", "assays", "demonstrated", "GATA-3", "binds", "to", "the", "GATA", "consensus", "site", "from", "bp", "-256", "to", "-250", "." ]
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12828
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12829
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12830
[ "Uncoupling", "activation-dependent", "HS1", "phosphorylation", "from", "nuclear", "factor", "of", "activated", "T", "cells", "transcriptional", "activation", "in", "Jurkat", "T", "cells", ":", "differential", "signaling", "through", "CD3", "and", "the", "costimulatory", "receptors", "CD2", "and", "CD28", "." ]
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12831
[ "CD3", ",", "CD2", ",", "and", "CD28", "are", "functionally", "distinct", "receptors", "on", "T", "lymphocytes", "." ]
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12832
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12833
[ "Ligation", "of", "CD3", "also", "induces", "the", "tyrosine", "phosphorylation", "of", "HS1", ",", "a", "75-kDa", "hematopoietic", "cell-specific", "intracellular", "signaling", "protein", "of", "unknown", "function", "." ]
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12834
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12835
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12836
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12837
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12838
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12839
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12840
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12841
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12842
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12843
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12844
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12845
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12846
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12847
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12848
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12849
[ "We", "conclude", "that", "cord", "lymphocyte", "activation", "exhibits", "an", "adult-type", "profile", "." ]
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12850
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12851
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12852
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12853
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12854
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12855
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12856
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12858
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12859
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12860
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12862
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12863
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12864
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12865
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12866
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12867
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12868
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12869
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12870
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12871
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12872
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12873
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12874
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12875
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12876
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12877
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12878
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12879
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12880
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12881
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12882
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12883
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12884
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12885
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12886
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12887
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12888
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12889
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12890
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12891
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12892
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12893
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12894
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12895
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12896
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12897
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12898
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12899
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12900
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