Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
12601
[ "Porcine", "aortic", "endothelial", "cells", "(", "PAEC", ")", "were", "incubated", "for", "1", "hr", "30", "min", "or", "5", "hr", "with", "10", "%", "homologous", "porcine", "serum", "(", "control", ")", "or", "10", "%", "xenogeneic", "human", "serum", "and", "then", "perfused", "with", "total", "human", "leukocytes", "in", "a", "parallel", "plate", "flow", "chamber", "under", "laminar", "flow", "(", "1.5", "dynes/cm2", ")", "." ]
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12602
[ "Adherent", "cells", "were", "counted", "by", "digital", "image", "analysis", "." ]
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12603
[ "Xenogeneic", "human", "serum", "significantly", "(", "P", "<", "0.01", ")", "increased", "the", "number", "of", "adherent", "leukocytes", "as", "compared", "with", "porcine", "serum", "." ]
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12604
[ "A", "similar", "adhesive", "response", "was", "elicited", "by", "TNF", "alpha", "(", "100", "U/ml", ")", ",", "one", "of", "the", "most", "potent", "inducers", "of", "endothelial", "cell", "adhesive", "properties", ",", "here", "used", "as", "positive", "control", "." ]
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12605
[ "In", "order", "to", "elucidate", "possible", "mechanisms", "underlying", "endothelial", "cell", "activation", "by", "xenogeneic", "serum", ",", "we", "focussed", "on", "transcription", "factor", "NF-kappa", "B", ",", "a", "central", "regulator", "for", "the", "induction", "of", "different", "genes", ",", "including", "adhesive", "molecules", "and", "chemoattractants", "." ]
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12606
[ "By", "confocal", "fluorescence", "microscopy", ",", "we", "observed", "a", "positive", "staining", "for", "NF-kappa", "B", "(", "p65", "subunit", ")", "in", "the", "nuclei", "of", "PAEC", "exposed", "for", "1", "hr", "30", "min", "to", "human", "serum", ",", "which", "indicated", "NF-kappa", "B", "activation", "in", "this", "setting", "." ]
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12607
[ "At", "variance", ",", "in", "PAEC", "incubated", "with", "the", "homologous", "serum", ",", "NF-kappa", "B", "was", "strictly", "localized", "in", "the", "cell", "cytoplasm", "." ]
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12608
[ "Treatment", "of", "PAEC", "exposed", "to", "xenogeneic", "serum", "with", "the", "NF-kappa", "B", "inhibitors", "pyrrolidinedithiocarbamate", "(", "PDTC", ",", "25", "microM", ")", "and", "tosyl-phechloromethylketone", "(", "TPCK", ",", "25", "microM", ")", "significantly", "(", "P", "<", "0.01", ")", "reduced", "leukocyte", "adhesion", "in", "respect", "to", "PAEC", "treated", "with", "human", "serum", "alone", "." ]
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12609
[ "Findings", "that", "xenogeneic", "serum", "promotes", "leukocyte-endothelium", "interaction", "possibly", "through", "NF-kappa", "B", "activation", "might", "be", "relevant", "for", "designing", "future", "therapeutic", "strategies", "aimed", "at", "prolonging", "xenograft", "survival", "." ]
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12610
[ "Anaphylatoxins", "C5a", "and", "C3a", "induce", "nuclear", "factor", "kappaB", "activation", "in", "human", "peripheral", "blood", "monocytes", "." ]
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12611
[ "The", "anaphylatoxins", "C5a", "and", "C3a", "are", "involved", "in", "the", "regulation", "of", "cytokine", "production", "." ]
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12612
[ "In", "this", "study", "the", "capability", "of", "C5a", "and", "C3a", "to", "induce", "transcription", "factor", "activation", "was", "examined", "." ]
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12613
[ "C5a", "and", "C3a", "stimulation", "of", "human", "peripheral", "blood", "monocytes", "resulted", "in", "nuclear", "expression", "of", "a", "DNA", "binding", "activity", "with", "specificity", "to", "the", "kappaB", "sequence", "." ]
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12614
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12615
[ "C5a", "induced", "kappaB", "binding", "activity", "was", "detected", "15", "min", "after", "agonist", "stimulation", ",", "peaked", "at", "30-40", "min", ",", "and", "remained", "detectable", "at", "2", "h", "." ]
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12616
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12617
[ "Pertussis", "toxin", "treatment", "markedly", "decreased", "kappaB", "binding", "activities", "induced", "by", "both", "C5a", "and", "C3a", ",", "whereas", "cholera", "toxin", "displayed", "no", "inhibitory", "effect", "." ]
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12618
[ "Neither", "of", "the", "two", "toxins", "affected", "kappaB", "binding", "activity", "induced", "by", "TNFalpha", "in", "the", "same", "cells", "." ]
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12619
[ "These", "results", "imply", "a", "potential", "role", "of", "the", "anaphylatoxins", "C5a", "and", "C3a", "in", "regulating", "leukocytes", "gene", "expression", "through", "G", "protein-coupled", "transcription", "factor", "activation", "." ]
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12620
[ "Thrombopoietin", "and", "its", "receptor", "." ]
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12621
[ "Thrombopoietin", "(", "TPO", ")", ",", "the", "primary", "physiological", "regulator", "of", "platelet", "production", ",", "was", "initially", "thought", "to", "be", "a", "lineage-specific", "factor", "acting", "predominantly", "on", "megakaryocytopoiesis", "." ]
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12622
[ "Detailed", "studies", "establish", "that", "this", "cytokine", "mediates", "biological", "effects", "on", "a", "broad", "spectrum", "of", "hematopoietic", "progenitor", "cells", ",", "including", "stem", "cells", "." ]
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12623
[ "TPO", "is", "a", "hormone", "constitutively", "produced", "mainly", "by", "the", "liver", "and", "kidney", "." ]
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12624
[ "Plasma", "TPO", "levels", "are", "regulated", "by", "the", "platelet", "and", "megakaryocyte", "mass", "through", "Mpl", "receptor", "binding", ",", "internalization", "and", "degradation", "." ]
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12625
[ "The", "Mpl", "receptor", "is", "a", "member", "of", "the", "hematopoietin", "receptor", "superfamily", "lacking", "intrinsic", "kinase", "activity", "." ]
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12626
[ "Upon", "ligand-induced", "Mpl", "homodimerization", ",", "the", "major", "signaling", "events", "for", "proliferation", "are", "mediated", "through", "the", "JAK2", "/STAT5", "pathway", ",", "while", "differentiation", "might", "occur", "through", "a", "prolonged", "activation", "of", "the", "MAPK", "pathway", "." ]
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12627
[ "Preclinical", "and", "clinical", "studies", "demonstrate", "the", "potential", "use", "of", "TPO", "in", "a", "variety", "of", "contexts", ",", "but", "it", "is", "too", "early", "to", "evaluate", "its", "benefit", "in", "reducing", "platelet", "transfusion", "." ]
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12628
[ "TAL1", "and", "LIM-only", "proteins", "synergistically", "induce", "retinaldehyde", "dehydrogenase", "2", "expression", "in", "T-cell", "acute", "lymphoblastic", "leukemia", "by", "acting", "as", "cofactors", "for", "GATA3", "." ]
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12629
[ "Previously", ",", "we", "have", "shown", "that", "TAL1", "and", "the", "LIM-only", "protein", "gene", "(", "LMO", ")", "are", "regularly", "coactivated", "in", "T-cell", "acute", "lymphoblastic", "leukemia", "(", "T-ALL", ")", "." ]
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12630
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12631
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12632
[ "One", "of", "the", "isolated", "genes", ",", "that", "for", "retinaldehyde", "dehydrogenase", "2", "(", "RALDH2", ")", ",", "was", "regularly", "expressed", "in", "most", "of", "the", "T-ALL", "cell", "lines", "that", "coexpressed", "TAL1", "and", "LMO", "." ]
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12633
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12634
[ "The", "RALDH2", "transcripts", "in", "T-ALL", "were", ",", "however", ",", "mostly", "initiated", "within", "the", "second", "intron", "." ]
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12635
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12636
[ "In", "addition", ",", "forced", "expression", "of", "GATA3", "potentiated", "the", "induction", "of", "RALDH2", "by", "TAL1", "and", "LMO", ",", "and", "these", "three", "factors", "formed", "a", "complex", "in", "vivo", "." ]
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12637
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12638
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12639
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12640
[ "Glucocorticoid", "receptors", "in", "human", "peripheral", "blood", "mononuclear", "cells", "in", "relation", "to", "age", "and", "to", "sport", "activity", "." ]
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12641
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12642
[ "Peripheral", "blood", "mononuclear", "cells", "(", "PBMCs", ")", "are", "a", "good", "model", "for", "studies", "of", "GR", "in", "humans", "." ]
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12643
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12644
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12645
[ "Variation", "of", "glucocorticoids", "in", "healthy", "aged", "subjects", "and", "athletes", "has", "been", "shown", "." ]
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12646
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12647
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12648
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12649
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12650
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12651
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12652
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12653
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12654
[ "Several", "neuroendocrine-immune", "interactions", "could", "be", "responsible", "for", "reduced", "GR", "levels", "with", "age", "and", "sport", "activity", "in", "man", "." ]
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12655
[ "Glycation-dependent", ",", "reactive", "oxygen", "species-mediated", "suppression", "of", "the", "insulin", "gene", "promoter", "activity", "in", "HIT", "cells", "." ]
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12656
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12657
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