Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
12401
[ "Our", "and", "the", "previously", "published", "lines", "differ", "in", "the", "deletion", "that", "was", "engineered", "and", "by", "the", "fact", "that", "we", "removed", "the", "neomycin-resistance", "promoter", "and", "structural", "gene", "via", "the", "cre-loxP", "recombination", "system", "." ]
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12402
[ "Characterization", "of", "our", "line", "led", "to", "two", "new", "findings", "." ]
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12403
[ "First", ",", "a", "substantial", "number", "of", "cells", "can", "express", "class", "II", "molecules", "in", "the", "absence", "of", "CIITA", ",", "albeit", "at", "5-fold", "reduced", "levels", ",", "most", "notably", "dendritic", "cells", "in", "s.c.", "lymph", "nodes", ";", "therefore", ",", "the", "CIITA", "gene", "can", "not", "be", "an", "absolute", "'", "master", "gene", "'", "controlling", "the", "expression", "of", "class", "II", "molecules", ",", "as", "had", "been", "thought", "." ]
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12404
[ "Second", ",", "in", "contrast", "to", "recent", "results", "on", "human", "cell", "lines", ",", "CIITA", "is", "not", "critically", "involved", "in", "the", "IFN-gamma", "-induced", "up-regulation", "of", "MHC", "class", "I", "genes", "." ]
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12405
[ "Interleukin-10", "stabilizes", "inhibitory", "kappaB-alpha", "in", "human", "monocytes", "." ]
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12406
[ "Interleukin-10", "(", "IL-10", ")", "protects", "animals", "from", "lethal", "endotoxemia", "." ]
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12407
[ "This", "beneficial", "effect", "is", "mediated", ",", "in", "part", ",", "by", "inhibition", "of", "inflammatory", "cytokine", "production", ",", "including", "tumor", "necrosis", "factor-alpha", "(", "TNF-alpha", ")", "." ]
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12408
[ "Evidence", "suggests", "that", "IL-10", "may", "inhibit", "activation", "of", "the", "transcription", "factor", "nuclear", "factor-kappaB", "(", "NF-kappaB", ")", "through", "an", "unknown", "mechanism", "." ]
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12409
[ "NF-kappaB", "activation", "in", "response", "to", "inflammatory", "signals", "is", "dependent", "upon", "degradation", "of", "its", "associated", "inhibitory", "peptide", ",", "inhibitory", "kappaB-alpha", "(", "IkappaB-alpha", ")", "." ]
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12410
[ "We", "hypothesized", "that", "IL-10", "prevents", "human", "monocyte", "NF-kappaB", "activation", "and", "resultant", "TNF-alpha", "production", "by", "stabilization", "of", "IkappaB-alpha", "." ]
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12411
[ "The", "purpose", "of", "this", "study", "was", "to", "determine", "the", "effect", "of", "IL-10", "on", "lipopolysaccharide", "(", "LPS", ")", "-induced", "human", "monocyte", "TNF-alpha", "production", ",", "NF-kappaB", "activation", ",", "and", "IkappaB-alpha", "degradation", "." ]
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12412
[ "Monocytes", "were", "isolated", "from", "human", "donors", "." ]
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12413
[ "Cells", "were", "stimulated", "with", "endotoxin", "(", "LPS", ",", "100", "ng/mL", ")", "with", "and", "without", "human", "IL-10", "(", "10", "ng/mL", ")", "." ]
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12414
[ "Following", "stimulation", ",", "TNF-alpha", "was", "measured", "in", "cell", "supernatants", "by", "ELISA", ",", "NF-kappaB", "activity", "by", "electrophoretic", "mobility", "shift", "assay", ",", "and", "IkappaB-alpha", "levels", "by", "Western", "blot", "." ]
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12415
[ "We", "observed", "that", "after", "LPS", "stimulation", "of", "human", "monocytes", ",", "TNF-alpha", "increased", "to", "798+/-67", "pg/mL", "(", "p", "<", ".001", "versus", "control", ")", "." ]
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12416
[ "IL-10", "attenuated", "LPS-stimulated", "TNF-alpha", "production", "(", "297+/-54", ";", "p", "<", ".001", "versus", "LPS", "alone", ")", "." ]
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12417
[ "After", "LPS", "stimulation", "in", "human", "monocytes", ",", "IkappaB-alpha", "protein", "levels", "decreased", ",", "and", "NF-kappaB", "DNA", "binding", "increased", "." ]
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12418
[ "IL-10", "pretreatment", "prevented", "LPS-induced", "decreases", "in", "IkappaB-alpha", "protein", "levels", "and", "attenuated", "NF-kappaB", "DNA", "binding", "." ]
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12419
[ "IL-10", "appears", "to", "prevent", "activation", "of", "NF-kappaB", "by", "preserving", "IkappaB-alpha", "protein", "levels", ",", "leading", "to", "a", "reduction", "in", "TNF-alpha", "release", "." ]
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12420
[ "Down-regulation", "of", "human", "granzyme", "B", "expression", "by", "glucocorticoids", "." ]
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12421
[ "Dexamethasone", "inhibits", "binding", "to", "the", "Ikaros", "and", "AP-1", "regulatory", "elements", "of", "the", "granzyme", "B", "promoter", "." ]
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12422
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12423
[ "Granzyme", "B", "gene", "transcription", "is", "induced", "in", "activated", "lymphocytes", "upon", "antigenic", "stimulation", ",", "and", "several", "regulatory", "regions", "including", "CBF", ",", "AP-1", ",", "and", "Ikaros", "binding", "sites", "have", "been", "shown", "to", "be", "essential", "in", "the", "control", "of", "granzyme", "B", "promoter", "activation", "." ]
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12424
[ "Dexamethasone", ",", "a", "glucocorticoid", "that", "is", "widely", "used", "as", "an", "immunomodulatory", "and", "anti-inflammatory", "agent", ",", "inhibits", "granzyme", "B", "mRNA", "transcript", "in", "phytohemagglutinin-activated", "peripheral", "blood", "mononuclear", "cells", "." ]
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12425
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12426
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12427
[ "Electromobility", "shift", "assay", "revealed", "that", "dexamethasone", "abolished", "the", "binding", "of", "nuclear", "transcription", "factors", "to", "the", "Ikaros", "binding", "site", "and", "reduced", "AP-1", "binding", "activity", "." ]
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12428
[ "These", "results", "indicate", "that", "dexamethasone", "is", "able", "to", "abrogate", "the", "transcriptional", "activity", "of", "the", "human", "granzyme", "B", "gene", "promoter", "by", "inhibiting", "the", "binding", "of", "nuclear", "factors", "at", "the", "AP-1", "and", "Ikaros", "sites", "." ]
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12429
[ "Glucocorticoid", "receptors", "on", "mononuclear", "leukocytes", "in", "polycystic", "ovary", "syndrome", "." ]
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12430
[ "OBJECTIVE", ":", "Many", "studies", "have", "suggested", "that", "there", "is", "a", "possible", "hormonal", "dysregulation", "of", "hypothalamic-pituitary-adrenal", "(", "HPA", ")", "axis", "and", "an", "increased", "cortisol", "clearance", "in", "patients", "with", "polycystic", "ovary", "syndrome", "(", "PCOS", ")", "." ]
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12431
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12432
[ "METHOD", ":", "For", "this", "purpose", ",", "the", "number", "and", "affinity", "of", "GR", "in", "peripheral", "mononuclear", "leukocytes", "(", "MNL", ")", "of", "10", "patients", "with", "PCOS", "and", "10", "healthy", "women", "(", "controls", ")", "were", "determined", "." ]
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12433
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12434
[ "CONCLUSIONS", ":", "These", "results", "suggest", "that", "the", "alterations", "in", "the", "HPA", "axis", "and", "in", "the", "cortisol", "metabolism", "observed", "in", "PCOS", "are", "not", "related", "to", "GR", "deficiency", "." ]
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12435
[ "Heterogeneous", "expression", "of", "the", "lipocalin", "NGAL", "in", "primary", "breast", "cancers", "." ]
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12436
[ "We", "have", "previously", "shown", "that", "neu", "oncogene-initiated", "rat", "mammary", "carcinomas", "uniquely", "over-express", "neu-related", "lipocalin", "(", "NRL", ")", ",", "a", "member", "of", "the", "calycin", "protein", "superfamily", "." ]
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12437
[ "Here", ",", "we", "characterize", "the", "putative", "human", "homolog", "of", "NRL", ",", "neutrophil", "gelatinase-associated", "lipocalin", "(", "NGAL", ")", "." ]
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12438
[ "ngal", "gene", "expression", "was", "found", "at", "moderate", "levels", "in", "only", "2", "of", "17", "human", "tissues", "examined", ",", "breast", "and", "lung", "." ]
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12439
[ "When", "breast", "cancers", "were", "examined", "for", "NGAL", "mRNA", "and", "protein", "levels", ",", "they", "were", "found", "to", "exhibit", "heterogeneous", "expression", "." ]
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12440
[ "NGAL", "levels", "varied", "in", "these", "tumors", "from", "undetectable", "to", "exceeding", "those", "in", "normal", "breast", "parenchyma", "." ]
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12441
[ "Immuno-histochemical", "analysis", "confirmed", "the", "presence", "of", "NGAL", "within", "breast", "carcinoma", "cells", "but", "detected", "only", "low", "levels", "of", "this", "protein", "in", "normal", "ductal", "epithelium", "." ]
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12442
[ "In", "contrast", ",", "large", "amounts", "of", "the", "protein", "were", "localized", "to", "the", "lumen", "of", "normal", "breast", "ducts", "in", "the", "vicinity", "of", "NGAL", "-expressing", "tumors", "." ]
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12443
[ "Interestingly", ",", "unlike", "NRL", "in", "rat", "mammary", "carcinomas", ",", "no", "significant", "association", "between", "NGAL", "expression", "and", "HER-2/neu", "activation", "was", "found", "in", "human", "breast", "tumors", "." ]
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12444
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12445
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12446
[ "No", "significant", "association", "between", "NGAL", "expression", "and", "disease-free", "or", "overall", "survival", "was", "observed", "." ]
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12447
[ "BASH", ",", "a", "novel", "signaling", "molecule", "preferentially", "expressed", "in", "B", "cells", "of", "the", "bursa", "of", "Fabricius", "." ]
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12448
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12449
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12450
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12451
[ "BASH", "shows", "a", "substantial", "sequence", "similarity", "to", "SLP-76", ",", "an", "adaptor", "protein", "functioning", "in", "TCR", "-signal", "transduction", "." ]
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12452
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12453
[ "Overexpression", "of", "BASH", "results", "in", "suppression", "of", "the", "NF-AT", "activation", "induced", "by", "BCR", "-cross-linking", "." ]
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12454
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12455
[ "Granulocyte", "colony-stimulating", "factor", "activates", "a", "72-kDa", "isoform", "of", "STAT3", "in", "human", "neutrophils", "." ]
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12456
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12457
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12458
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12459
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