Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
12301
[ "Subsequent", "cross-linking", "of", "CD15", "increased", "CAT", "activity", "." ]
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12302
[ "CD15", "engagement", "by", "monoclonal", "antibody", "also", "attenuated", "IL-1", "beta", "transcript", "degradation", ",", "demonstrating", "that", "signaling", "via", "CD15", "also", "had", "posttranscriptional", "effects", "." ]
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12303
[ "Nuclear", "extracts", "of", "anti-", "CD15", "cross-linked", "cells", "demonstrated", "enhanced", "levels", "of", "the", "transcriptional", "factor", "activator", "protein-1", ",", "minimally", "changed", "nuclear", "factor-kappa", "B", ",", "and", "did", "not", "affect", "SV40", "promoter", "specific", "protein-1", "." ]
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12304
[ "We", "conclude", "that", "engagement", "of", "CD15", "on", "monocytes", "results", "in", "monocyte", "activation", "." ]
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12305
[ "In", "addition", "to", "its", "well-recognized", "adhesive", "role", ",", "CD15", "may", "function", "as", "an", "important", "signaling", "molecule", "capable", "of", "initiating", "proinflammatory", "events", "in", "monocytes", "that", "come", "into", "contact", "with", "activated", "endothelium", "." ]
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12306
[ "CD2", "signalling", "induces", "phosphorylation", "of", "CREB", "in", "primary", "lymphocytes", "." ]
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12307
[ "Promoter", "sequences", "responsive", "to", "cyclic", "AMP", "(", "cAMP", ")", "are", "found", "in", "a", "number", "of", "cellular", "genes", ",", "and", "bind", "transcription", "factors", "of", "the", "cAMP", "response", "element", "binding", "protein", "(", "CREB", ")", "/activating", "transcription", "factor-1", "(", "ATF-1", ")", "family", "." ]
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12308
[ "We", "have", "used", "a", "human", "T-lymphotropic", "virus", "type", "1", "(", "HTLV-1", ")", "model", "of", "cAMP", "response", "element", "(", "CRE", ")", "transcription", "to", "investigate", "the", "influence", "of", "lymphocyte", "activation", "on", "transcription", "from", "homologous", "regions", "in", "the", "viral", "promoter", "." ]
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12309
[ "We", "previously", "demonstrated", "increased", "HTLV-1", "transcription", "following", "CD2", "but", "not", "CD3", "receptor", "cross-linking", "." ]
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12310
[ "We", "hypothesized", "that", "this", "increased", "viral", "transcription", "was", "mediated", ",", "in", "part", ",", "through", "the", "phosphorylation", "of", "CREB", "." ]
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12311
[ "Therefore", ",", "we", "investigated", "CD2", "and", "CD3", "receptor", "-mediated", "signalling", "in", "primary", "human", "peripheral", "blood", "mononuclear", "cells", "(", "PBMC", ")", "." ]
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12312
[ "CD2", ",", "but", "not", "CD3", ",", "cross-linking", "increased", "cAMP", "detected", "by", "competitive", "enzyme-linked", "immunosorbent", "assay", "(", "ELISA", ")", "approximately", "fourfold", "." ]
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12313
[ "CD2", "cross-linking", "concurrently", "increased", "phosphorylation", "of", "CREB", "detected", "by", "immunoblot", "assay", "eightfold", "." ]
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12314
[ "Consistent", "with", "post-translational", "regulation", ",", "no", "change", "in", "total", "level", "of", "CREB", "protein", "was", "observed", "." ]
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12315
[ "Phosphorylation", "of", "CREB", "occurred", "through", "a", "herbimycin", "A", "and", "Rp-cAMP-", "sensitive", "pathway", ",", "suggesting", "phosphorylation", "required", "antecedent", "activation", "of", "both", "protein", "tyrosine", "kinases", "(", "PTK", ")", "and", "protein", "kinase", "A", "(", "PKA", ")", "." ]
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12316
[ "Both", "CD2", "and", "CD3", "cross-linking", "increased", "binding", "of", "nuclear", "proteins", "to", "a", "radiolabelled", "CRE", "oligonucleotide", "probe", "in", "electrophoretic", "mobility", "shift", "assays", "suggesting", "that", "lymphocyte", "activation", "enhances", "binding", "independently", "of", "phosphorylation", "of", "CREB", "at", "serine", "133", "." ]
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12317
[ "These", "data", "indicate", "specific", "modulation", "of", "the", "CREB/ATF-1", "family", "of", "transcription", "factors", "by", "the", "CD2", "signalling", "pathway", "and", "suggest", "CD2", "receptor", "modulation", "of", "CRE", "-mediated", "transcription", "following", "ligand", "engagement", "(", "e.g.", "cell-to-cell", "contact", ")", "." ]
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12318
[ "X-rays-induced", "secretion", "of", "cellular", "factor", "(", "s", ")", "that", "enhance", "(", "s", ")", "HIV-1", "promoter", "transcription", "in", "various", "non-irradiated", "transfected", "cell", "lines", "." ]
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12319
[ "Various", "cellular", "stress", "agents", "like", "ionizing", "radiation", "exposure", "could", "activate", "human", "immunodeficiency", "virus", "type", "1", "(", "HIV-", "1", ")", "replication", "or", "reporter", "gene", "expression", "." ]
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12320
[ "In", "addition", ",", "extracellular", "factor", "(", "s", ")", "released", "by", "X-ray-treated", "human", "colonic", "carcinoma", "cell", "line", "(", "HT29", ")", "might", "activate", "the", "long", "terminal", "repeat", "(", "LTR", ")", "of", "HIV-1", "in", "non-irradiated", "HT29", "cells", "." ]
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12321
[ "In", "the", "present", "report", "we", "show", "that", "in", "various", "transiently", "or", "stably", "transfected", "cell", "lines", ",", "X-ray", "irradiation", "up-regulates", "HIV-1", "LTR", "transcription", "through", "the", "kappaB", "regulatory", "elements", "." ]
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12322
[ "A", "factor", "(", "s", ")", ",", "which", "is", "processed", "by", "and", "acts", "upon", "a", "variety", "of", "cell", "types", ",", "was", "detected", "by", "addition", "to", "non-irradiated", "cells", "of", "either", "X-ray-treated", "cells", "or", "a", "conditioned", "medium", "taken", "from", "irradiated", "cultures", "." ]
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12323
[ "The", "magnitude", "of", "responsiveness", "is", "cell", "type", "dependent", "." ]
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12324
[ "In", "addition", ",", "X-ray", "activation", "of", "HIV-1", "LTR", "in", "transiently", "or", "stably", "transfected", "cell", "lines", "is", "inhibited", "by", "a", "potent", "antioxidant", "drug", ",", "pyrrolidine", "dithiocarbamate", "and", "by", "another", "drug", ",", "known", "for", "its", "role", "in", "the", "trapping", "of", "growth", "factors", ",", "suramin", "." ]
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12325
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12326
[ "Activation", "of", "the", "human", "delta-globin", "gene", "promoter", "in", "primary", "adult", "erythroid", "cells", "." ]
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12327
[ "Restoration", "of", "the", "CCAAT", "box", "or", "insertion", "of", "an", "erythroid", "Kruppel-like", "factor", "(", "EKLF", ")", "binding", "site", "in", "the", "delta", "promoter", "activates", "its", "expression", "in", "several", "erythroid", "cell", "lines", "." ]
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12328
[ "We", "extended", "these", "studies", "using", "a", "novel", "primary", "human", "adult", "erythroid", "cell", "(", "hAEC", ")", "system", "to", "investigate", "these", "effects", "at", "the", "late", "erythroblast", "stage", "." ]
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12329
[ "Restoration", "of", "the", "CCAAT", "box", "at", "-70", "bp", ",", "or", "insertion", "of", "an", "EKLF", "binding", "site", "at", "-85", "bp", "or", "-95", "bp", "in", "the", "promoter", "significantly", "increased", "delta", "globin", "gene", "expression", "in", "hAEC", "." ]
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12330
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12331
[ "Constitutive", "association", "of", "JAK1", "and", "STAT5", "in", "pro-B", "cells", "is", "dissolved", "by", "interleukin-4", "-induced", "tyrosine", "phosphorylation", "of", "both", "proteins", "." ]
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12332
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12333
[ "Mutual", "association", "of", "signal", "transducing", "proteins", "within", "the", "receptor", "complex", "was", "then", "studied", "in", "dependence", "of", "ligand", "stimulation", "." ]
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12334
[ "Besides", "ligand-induced", "receptor", "heterodimerization", "and", "contacts", "of", "the", "two", "IL-4", "receptor", "subunits", "alpha", "and", "gamma", "with", "Janus", "kinases", "JAK1", "and", "JAK3", "a", "prominent", "constitutive", "binding", "between", "JAK1", "and", "signal", "transducer", "and", "activator", "of", "transcription", "STAT5", "was", "detected", "." ]
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12335
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12336
[ "Association", "of", "JAK1", "and", "STAT5", "was", "found", "to", "occur", "exclusively", "between", "unphosphorylated", "proteins", "." ]
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12337
[ "Activation", "of", "human", "macrophages", "by", "mechanical", "ventilation", "in", "vitro", "." ]
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12338
[ "Positive-pressure", "mechanical", "ventilation", "supports", "gas", "exchange", "in", "patients", "with", "respiratory", "failure", "but", "is", "also", "responsible", "for", "significant", "lung", "injury", "." ]
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12339
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12340
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12341
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12342
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12343
[ "Nuclear", "factor-kappaB", "was", "found", "to", "be", "activated", "in", "ventilated", "macrophages", "." ]
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12344
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12345
[ "Dexamethasone", "prevented", "IL-8", "and", "tumor", "necrosis", "factor-alpha", "secretion", "in", "ventilated", "macrophages", "." ]
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12346
[ "Mechanical", "ventilation", "induced", "low", "levels", "of", "IL-8", "secretion", "by", "alveolar", "type", "II-like", "cells", "." ]
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12347
[ "Other", "lung", "cell", "types", "such", "as", "endothelial", "cells", ",", "bronchial", "cells", ",", "and", "fibroblasts", "failed", "to", "produce", "IL-8", "in", "response", "to", "a", "prolonged", "cyclic", "pressure-stretching", "load", "." ]
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12348
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12349
[ "Signaling", "pathways", "mediated", "by", "the", "TNF-", "and", "cytokine-receptor", "families", "target", "a", "common", "cis-element", "of", "the", "IFN", "regulatory", "factor", "1", "promoter", "." ]
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12350
[ "CD40", "activation", "of", "B", "cells", "is", "strongly", "influenced", "by", "the", "presence", "of", "cytokines", "." ]
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12351
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12352
[ "IFN", "regulatory", "factor", "1", "(", "IRF-1", ")", "is", "a", "transcription", "factor", "activated", "by", "either", "CD40", "or", "cytokines", "." ]
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12353
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12354
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12355
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12356
[ "In", "this", "system", ",", "simultaneous", "exposure", "to", "CD40L", "together", "with", "either", "IL-4", "or", "IFN-gamma", "does", "not", "lead", "to", "the", "activation", "of", "novel", "Rel/STAT", "complexes", "." ]
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12357
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12383
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