Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
12201
[ "It", "has", "been", "shown", "that", "eosinophil", "stimulation", "by", "these", "cytokines", "is", "associated", "with", "increases", "in", "tyrosine", "phosphorylation", "of", "several", "cellular", "substrates", "." ]
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12202
[ "In", "the", "past", "few", "years", ",", "there", "has", "been", "some", "progress", "in", "defining", "the", "tyrosine", "kinases", "that", "are", "activated", "by", "the", "IL-3/IL-5/GM-CSF", "receptor", "beta-subunit", "in", "eosinophils", "." ]
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12203
[ "This", "review", "will", "concentrate", "on", "this", "topic", "and", "on", "its", "role", "for", "the", "regulation", "of", "eosinophil", "apoptosis", "." ]
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12204
[ "Requirement", "of", "GATA-1", "and", "p45", "NF-E2", "expression", "in", "butyric", "acid-induced", "erythroid", "differentiation", "." ]
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12205
[ "Butyric", "acid", "(", "BA", ")", "is", "known", "to", "induce", "overexpression", "of", "fetal", "hemoglobin", "and", "then", "erythroid", "differentiation", "." ]
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12206
[ "Therefore", ",", "BA", "is", "currently", "under", "clinical", "investigation", "as", "a", "potential", "therapy", "for", "the", "treatment", "of", "sickle", "cell", "disease", "and", "cancer", "." ]
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12207
[ "Nevertheless", ",", "the", "molecular", "mechanisms", "involved", "in", "BA-induced", "differentiation", "remain", "largely", "unknown", "." ]
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12208
[ "Previous", "reports", "have", "shown", "that", "BA-induced", "overexpression", "of", "erythroid", "genes", "occurred", "at", "the", "transcriptional", "level", ",", "suggesting", "the", "involvement", "of", "erythroid", "transcription", "factors", "." ]
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12209
[ "Here", ",", "we", "intend", "to", "demonstrate", "the", "requirement", "of", "GATA-1", "and", "NF-E2", "transcription", "factors", "in", "the", "BA-induced", "erythroid", "differentiation", "of", "human", "leukemic", "K562", "cells", "." ]
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12210
[ "Time-course", "experiments", "showed", "that", "nuclear", "levels", "of", "GATA-1", "and", "p45", "NF-E2", "proteins", "increased", "during", "BA", "treatment", "." ]
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12211
[ "Moreover", ",", "antisense", "oligodeoxynucleotides", "targeting", "either", "GATA-1", "or", "p45", "NF-E2", "proteins", "inhibited", "both", "protein", "expression", "and", "BA-induced", "differentiation", "." ]
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12212
[ "In", "contrast", ",", "BA-induced", "cell", "growth", "inhibition", "was", "not", "affected", "." ]
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12213
[ "These", "results", "provide", "the", "first", "direct", "evidence", "for", "the", "requirement", "of", "GATA-1", "and", "NF-E2", "in", "BA-induced", "differentiation", "process", "." ]
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12214
[ "Characterisation", "of", "regulatory", "sequences", "at", "the", "Epstein-Barr", "virus", "BamHI", "W", "promoter", "." ]
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12215
[ "Epstein-Barr", "virus", ",", "a", "human", "gammaherpesvirus", ",", "possesses", "a", "unique", "set", "of", "latent", "genes", "whose", "constitutive", "expression", "in", "B", "cells", "leads", "to", "cell", "growth", "transformation", "." ]
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12216
[ "The", "initiation", "of", "this", "growth", "transforming", "infection", "depends", "on", "a", "viral", "promoter", "in", "BamHI", "W", "(", "Wp", ")", "whose", "regulation", "is", "poorly", "understood", "." ]
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12217
[ "Using", "Wp", "reporter", "constructs", "in", "in", "vitro", "transfection", "assays", ",", "we", "found", "that", "Wp", "was", "11-", "to", "190-fold", "more", "active", "in", "B", "cell", "than", "in", "non-B", "cell", "lines", "and", "that", "three", "regions", "of", "the", "promoter", "(", "termed", "UAS1", ",", "UAS2", ",", "and", "UAS3", ")", "contributed", "to", "transcriptional", "activation", "." ]
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12218
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12219
[ "By", "contrast", ",", "UAS1", "(", "-140", "to", "-87", ")", "was", "B", "cell", "specific", "and", "was", "the", "key", "determinant", "of", "the", "promoter", "'s", "increased", "activity", "in", "B", "cell", "lines", "." ]
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12220
[ "Mutational", "analysis", "of", "UAS1", "sequences", "combined", "with", "in", "vitro", "bandshift", "assays", "revealed", "the", "presence", "of", "three", "binding", "sites", "for", "cellular", "factors", "in", "this", "region", "." ]
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12221
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12222
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12223
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12224
[ "In", "situ", "RT-PCR", "detection", "of", "Epstein-Barr", "virus", "immediate-early", "transcripts", "in", "CD4+", "and", "CD8+", "T", "lymphocytes", "." ]
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12225
[ "AIDS-related", "Epstein-Barr", "virus", "(", "EBV", ")", "-associated", "T", "cell", "lymphomas", "are", "emerging", "as", "a", "new", ",", "distinct", "histopathological", "entity", "." ]
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12226
[ "The", "pathway", "whereby", "EBV", "infects", "T", "cells", "as", "well", "as", "the", "initial", "EBV", "transcriptional", "program", "in", "T", "cells", "has", "not", "been", "established", "." ]
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12227
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12228
[ "Following", "EBV", "infection", ",", "Epstein-Barr", "nuclear", "antigen", "(", "EBNA", ")", "expression", "could", "be", "detected", "in", "T", "rosetting", "CD4+", "and", "CD8+", "T", "lymphocytes", "." ]
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12229
[ "Only", "a", "few", "cells", "showed", "viral", "capsid", "antigen", "(", "VCA", ")", "." ]
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12230
[ "EBV", "immediate-early", "gene", "transcripts", "(", "BZLF1", ",", "BRLF1", ",", "and", "BMLF1", ")", "encoded", "in", "the", "BamHI", "Z", ",", "R", ",", "and", "M", "fragments", "could", "be", "detected", "by", "in", "situ", "RT-PCR", "in", "the", "EBV", "producer", "cell", "line", "B95.8", "." ]
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12231
[ "Both", "BZLF1", "and", "BRLF1", "immediate-early", "transcripts", ",", "but", "not", "BMLF1", "transcript", ",", "could", "be", "detected", "in", "individual", "CD4+", "and", "CD8+", "T", "cells", "infected", "with", "EBV", "." ]
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12232
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12233
[ "The", "linkage", "between", "T-cell", "and", "dendritic", "cell", "development", "in", "the", "mouse", "thymus", "." ]
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12234
[ "Thymic", "dendritic", "cells", "(", "DC", ")", "mediate", "negative", "selection", "at", "a", "relatively", "late", "stage", "of", "the", "T-cell", "developmental", "pathway", "." ]
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12235
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12236
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12237
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12238
[ "In", "contrast", "to", "myeloid-related", "DC", ",", "granulocyte-macrophage", "colony-stimulating", "factor", "is", "not", "required", "for", "the", "development", "of", "these", "lymphoid-related", "DC", "in", "vivo", "or", "in", "vitro", "." ]
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12239
[ "DC", "can", "develop", "in", "mutant", "mice", "lacking", "mature", "T", "cells", ",", "provided", "the", "common", "precursors", "are", "present", "." ]
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12240
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12241
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12242
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12243
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12244
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12245
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12246
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12247
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12248
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12249
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12250
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12251
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12252
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12253
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12254
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12255
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