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12101
[ "During", "fetal", "development", ",", "it", "is", "required", "at", "the", "earliest", "stage", "of", "T", "cell", "and", "B", "cell", "specification", "." ]
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12102
[ "In", "the", "adult", ",", "however", ",", "lymphoid", "lineages", "rely", "on", "Ikaros", "at", "distinct", "phases", "of", "their", "development", "." ]
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12103
[ "Its", "activity", "is", "essential", "for", "the", "generation", "of", "B", "cell", "but", "not", "of", "T", "cell", "precursors", ",", "although", "the", "differentiation", "of", "the", "latter", "is", "not", "normal", "." ]
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12104
[ "A", "significant", "increase", "in", "CD4", "thymocytes", "and", "their", "immediate", "precursors", "is", "detected", ",", "and", "because", "these", "cells", "lack", "markers", "that", "correlate", "with", "positive", "selection", ",", "a", "deregulation", "in", "their", "maturation", "process", "is", "suggested", "." ]
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12105
[ "Furthermore", ",", "Ikaros-null", "thymocytes", "hyperproliferate", "in", "response", "to", "T", "cell", "receptor", "(", "TCR", ")", "signaling", ";", "within", "days", "after", "their", "appearance", "in", "the", "thymus", ",", "clonally", "expanding", "populations", "are", "detected", "." ]
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12106
[ "Deregulated", "TCR", "-mediated", "responses", "and", "the", "fast", "kinetics", "of", "tumor", "development", "in", "these", "mutant", "thymocytes", "implicate", "Ikaros", "as", "a", "central", "tumor", "suppressor", "gene", "for", "the", "T", "cell", "lineage", "." ]
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12107
[ "In", "addition", ",", "lack", "of", "natural", "killer", "cells", "and", "selective", "defects", "in", "gamma", "delta", "T", "cells", "and", "dendritic", "antigen-presenting", "cells", "point", "to", "Ikaros", "as", "an", "essential", "factor", "for", "the", "establishment", "of", "early", "branchpoints", "of", "the", "T", "cell", "pathway", "." ]
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12108
[ "The", "dominant", "interference", "activity", "of", "Ikaros", "isoforms", "unable", "to", "bind", "DNA", "and", "their", "effects", "in", "lymphocyte", "development", "suggest", "that", "Ikaros", "works", "in", "concert", "with", "other", "factors", "." ]
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12109
[ "The", "role", "of", "Aiolos", ",", "a", "lymphoid-restricted", "and", "structurally", "related", "gene", ",", "in", "lymphoid", "differentiation", "is", "discussed", "." ]
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12110
[ "A", "model", "is", "proposed", "that", "defines", "Ikaros", "as", "the", "backbone", "of", "a", "complex", "regulatory", "protein", "network", "that", "controls", "cell", "fate", "decisions", "and", "regulates", "homeostasis", "in", "the", "hemo-lymphoid", "system", "." ]
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12111
[ "Changes", "in", "this", "regulatory", "network", "may", "reflect", "differentiation", "and", "proliferation", "adjustments", "made", "in", "hemo-lymphoid", "progenitors", "and", "precursors", "as", "they", "give", "rise", "to", "the", "cells", "of", "our", "immune", "system", "." ]
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12112
[ "STAT1", "pathway", "is", "involved", "in", "activation", "of", "caprine", "arthritis-encephalitis", "virus", "long", "terminal", "repeat", "in", "monocytes", "." ]
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12113
[ "The", "caprine", "arthritis-encephalitis", "virus", "(", "CAEV", ")", "long", "terminal", "repeat", "(", "LTR", ")", "is", "activated", "by", "gamma", "interferon", "(", "IFN-gamma", ")", "in", "promonocytic", "cells", "." ]
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12114
[ "We", "have", "previously", "shown", "that", "a", "70-bp", "element", "is", "necessary", "and", "sufficient", "for", "the", "response", "of", "the", "CAEV", "LTR", "to", "this", "cytokine", "." ]
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12115
[ "At", "the", "5", "'", "end", ",", "this", "70-bp", "IFN-gamma", "response", "element", "contains", "sequence", "similarity", "to", "the", "gamma", "activated", "site", "(", "GAS", ")", "." ]
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12116
[ "Here", "we", "demonstrate", "that", "the", "putative", "GAS", "element", "in", "the", "CAEV", "LTR", "binds", "specifically", "to", "a", "cellular", "factor", "induced", "by", "IFN-gamma", "in", "promonocytic", "cells", "." ]
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12117
[ "Substitution", "mutations", "in", "this", "consensus", "sequence", "eliminate", "binding", "of", "the", "inducible", "factor", "." ]
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12118
[ "The", "GAS", "element", "from", "the", "70-bp", "motif", "is", "sufficient", "to", "confer", "responsiveness", "to", "IFN-gamma", "using", "a", "heterologous", "minimal", "promoter", "." ]
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12119
[ "Consistent", "with", "the", "binding", "data", ",", "the", "same", "mutations", "in", "the", "GAS", "element", "eliminate", "responsiveness", "to", "IFN-gamma", "in", "the", "context", "of", "both", "a", "functional", "CAEV", "LTR", "and", "a", "heterologous", "promoter", "." ]
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12120
[ "The", "cellular", "factor", "that", "binds", "to", "the", "GAS", "element", "is", "present", "from", "5", "min", "to", "14", "h", "after", "stimulation", "with", "IFN-gamma", "." ]
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12121
[ "Binding", "of", "the", "nuclear", "factor", "to", "the", "GAS", "element", "in", "the", "CAEV", "LTR", "is", "inhibited", "by", "antibody", "directed", "against", "STAT1", "(", "p91/84", ")", "." ]
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12122
[ "Thus", ",", "the", "GAS", "sequence", "in", "the", "CAEV", "LTR", "is", "essential", "for", "the", "response", "to", "IFN-gamma", "and", "a", "STAT1-like", "factor", "binds", "to", "this", "site", "." ]
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12123
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12124
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12125
[ "1", ",", "25-Dihydroxyvitamin", "D3", "receptors", "in", "peripheral", "blood", "mononuclear", "cells", "from", "patients", "with", "renal", "insufficiency", "." ]
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12126
[ "A", "reduced", "expression", "of", "the", "vitamin", "D", "receptor", "(", "VDR", ")", "in", "parathyroid", "glands", "of", "uremic", "animals", "and", "humans", "has", "been", "observed", "." ]
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12127
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12128
[ "However", ",", "the", "reasons", "for", "these", "changes", "are", "not", "clear", "." ]
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12129
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12130
[ "The", "mean", "dissociation", "constant", "(", "KD", ")", "was", "similar", "in", "both", "groups", "of", "patients", "and", "in", "healthy", "women", "(", "A-CRF", ":", "0.7", "+/-", "0.5", "x", "10", "(", "-10", ")", "M", ";", "M-CRF", ":", "1.1", "+/-", "0.9", "x", "10", "(", "-10", ")", "M", ";", "controls", ":", "1.0", "+/-", "0.6", "x", "10", "(", "-10", ")", "M", ")", "." ]
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12131
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12132
[ "No", "correlation", "was", "seen", "between", "VDR", "and", "serum", "calcitriol", "or", "PTH", "levels", ",", "when", "considering", "both", "groups", "of", "patients", "together", "or", "separately", "." ]
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12133
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12134
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12135
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12136
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12137
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12138
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12139
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12140
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12141
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12142
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12143
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12144
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12145
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12147
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12148
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12150
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12151
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12152
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12153
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[ "BACKGROUND", "&", "AIMS", ":", "Entamoeba", "histolytica", "infection", "of", "the", "intestine", "can", "induce", "severe", "gut", "inflammation", "." ]
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12172
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