id
stringlengths 1
5
| tokens
sequence | ner_tags
sequence |
---|---|---|
12101 | [
"During",
"fetal",
"development",
",",
"it",
"is",
"required",
"at",
"the",
"earliest",
"stage",
"of",
"T",
"cell",
"and",
"B",
"cell",
"specification",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
7,
8,
0,
0
] |
12102 | [
"In",
"the",
"adult",
",",
"however",
",",
"lymphoid",
"lineages",
"rely",
"on",
"Ikaros",
"at",
"distinct",
"phases",
"of",
"their",
"development",
"."
] | [
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0
] |
12103 | [
"Its",
"activity",
"is",
"essential",
"for",
"the",
"generation",
"of",
"B",
"cell",
"but",
"not",
"of",
"T",
"cell",
"precursors",
",",
"although",
"the",
"differentiation",
"of",
"the",
"latter",
"is",
"not",
"normal",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12104 | [
"A",
"significant",
"increase",
"in",
"CD4",
"thymocytes",
"and",
"their",
"immediate",
"precursors",
"is",
"detected",
",",
"and",
"because",
"these",
"cells",
"lack",
"markers",
"that",
"correlate",
"with",
"positive",
"selection",
",",
"a",
"deregulation",
"in",
"their",
"maturation",
"process",
"is",
"suggested",
"."
] | [
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12105 | [
"Furthermore",
",",
"Ikaros-null",
"thymocytes",
"hyperproliferate",
"in",
"response",
"to",
"T",
"cell",
"receptor",
"(",
"TCR",
")",
"signaling",
";",
"within",
"days",
"after",
"their",
"appearance",
"in",
"the",
"thymus",
",",
"clonally",
"expanding",
"populations",
"are",
"detected",
"."
] | [
0,
0,
0,
7,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12106 | [
"Deregulated",
"TCR",
"-mediated",
"responses",
"and",
"the",
"fast",
"kinetics",
"of",
"tumor",
"development",
"in",
"these",
"mutant",
"thymocytes",
"implicate",
"Ikaros",
"as",
"a",
"central",
"tumor",
"suppressor",
"gene",
"for",
"the",
"T",
"cell",
"lineage",
"."
] | [
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0
] |
12107 | [
"In",
"addition",
",",
"lack",
"of",
"natural",
"killer",
"cells",
"and",
"selective",
"defects",
"in",
"gamma",
"delta",
"T",
"cells",
"and",
"dendritic",
"antigen-presenting",
"cells",
"point",
"to",
"Ikaros",
"as",
"an",
"essential",
"factor",
"for",
"the",
"establishment",
"of",
"early",
"branchpoints",
"of",
"the",
"T",
"cell",
"pathway",
"."
] | [
0,
0,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0
] |
12108 | [
"The",
"dominant",
"interference",
"activity",
"of",
"Ikaros",
"isoforms",
"unable",
"to",
"bind",
"DNA",
"and",
"their",
"effects",
"in",
"lymphocyte",
"development",
"suggest",
"that",
"Ikaros",
"works",
"in",
"concert",
"with",
"other",
"factors",
"."
] | [
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0
] |
12109 | [
"The",
"role",
"of",
"Aiolos",
",",
"a",
"lymphoid-restricted",
"and",
"structurally",
"related",
"gene",
",",
"in",
"lymphoid",
"differentiation",
"is",
"discussed",
"."
] | [
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12110 | [
"A",
"model",
"is",
"proposed",
"that",
"defines",
"Ikaros",
"as",
"the",
"backbone",
"of",
"a",
"complex",
"regulatory",
"protein",
"network",
"that",
"controls",
"cell",
"fate",
"decisions",
"and",
"regulates",
"homeostasis",
"in",
"the",
"hemo-lymphoid",
"system",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12111 | [
"Changes",
"in",
"this",
"regulatory",
"network",
"may",
"reflect",
"differentiation",
"and",
"proliferation",
"adjustments",
"made",
"in",
"hemo-lymphoid",
"progenitors",
"and",
"precursors",
"as",
"they",
"give",
"rise",
"to",
"the",
"cells",
"of",
"our",
"immune",
"system",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12112 | [
"STAT1",
"pathway",
"is",
"involved",
"in",
"activation",
"of",
"caprine",
"arthritis-encephalitis",
"virus",
"long",
"terminal",
"repeat",
"in",
"monocytes",
"."
] | [
9,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
0,
7,
0
] |
12113 | [
"The",
"caprine",
"arthritis-encephalitis",
"virus",
"(",
"CAEV",
")",
"long",
"terminal",
"repeat",
"(",
"LTR",
")",
"is",
"activated",
"by",
"gamma",
"interferon",
"(",
"IFN-gamma",
")",
"in",
"promonocytic",
"cells",
"."
] | [
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
7,
8,
0
] |
12114 | [
"We",
"have",
"previously",
"shown",
"that",
"a",
"70-bp",
"element",
"is",
"necessary",
"and",
"sufficient",
"for",
"the",
"response",
"of",
"the",
"CAEV",
"LTR",
"to",
"this",
"cytokine",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0
] |
12115 | [
"At",
"the",
"5",
"'",
"end",
",",
"this",
"70-bp",
"IFN-gamma",
"response",
"element",
"contains",
"sequence",
"similarity",
"to",
"the",
"gamma",
"activated",
"site",
"(",
"GAS",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
0,
0
] |
12116 | [
"Here",
"we",
"demonstrate",
"that",
"the",
"putative",
"GAS",
"element",
"in",
"the",
"CAEV",
"LTR",
"binds",
"specifically",
"to",
"a",
"cellular",
"factor",
"induced",
"by",
"IFN-gamma",
"in",
"promonocytic",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
7,
8,
0
] |
12117 | [
"Substitution",
"mutations",
"in",
"this",
"consensus",
"sequence",
"eliminate",
"binding",
"of",
"the",
"inducible",
"factor",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12118 | [
"The",
"GAS",
"element",
"from",
"the",
"70-bp",
"motif",
"is",
"sufficient",
"to",
"confer",
"responsiveness",
"to",
"IFN-gamma",
"using",
"a",
"heterologous",
"minimal",
"promoter",
"."
] | [
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0
] |
12119 | [
"Consistent",
"with",
"the",
"binding",
"data",
",",
"the",
"same",
"mutations",
"in",
"the",
"GAS",
"element",
"eliminate",
"responsiveness",
"to",
"IFN-gamma",
"in",
"the",
"context",
"of",
"both",
"a",
"functional",
"CAEV",
"LTR",
"and",
"a",
"heterologous",
"promoter",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0
] |
12120 | [
"The",
"cellular",
"factor",
"that",
"binds",
"to",
"the",
"GAS",
"element",
"is",
"present",
"from",
"5",
"min",
"to",
"14",
"h",
"after",
"stimulation",
"with",
"IFN-gamma",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
12121 | [
"Binding",
"of",
"the",
"nuclear",
"factor",
"to",
"the",
"GAS",
"element",
"in",
"the",
"CAEV",
"LTR",
"is",
"inhibited",
"by",
"antibody",
"directed",
"against",
"STAT1",
"(",
"p91/84",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0
] |
12122 | [
"Thus",
",",
"the",
"GAS",
"sequence",
"in",
"the",
"CAEV",
"LTR",
"is",
"essential",
"for",
"the",
"response",
"to",
"IFN-gamma",
"and",
"a",
"STAT1-like",
"factor",
"binds",
"to",
"this",
"site",
"."
] | [
0,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
9,
0,
0,
9,
10,
0,
0,
0,
0,
0
] |
12123 | [
"The",
"STAT-1",
"signaling",
"pathway",
"provides",
"at",
"least",
"one",
"mechanism",
"for",
"activation",
"of",
"the",
"CAEV",
"LTR",
"by",
"IFN-gamma",
"in",
"monocytes",
"."
] | [
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
9,
0,
7,
0
] |
12124 | [
"These",
"data",
"are",
"the",
"first",
"demonstration",
"of",
"a",
"role",
"for",
"a",
"STAT",
"family",
"member",
"in",
"the",
"regulation",
"of",
"a",
"viral",
"promoter",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0
] |
12125 | [
"1",
",",
"25-Dihydroxyvitamin",
"D3",
"receptors",
"in",
"peripheral",
"blood",
"mononuclear",
"cells",
"from",
"patients",
"with",
"renal",
"insufficiency",
"."
] | [
9,
10,
10,
10,
10,
0,
7,
8,
8,
8,
0,
0,
0,
0,
0,
0
] |
12126 | [
"A",
"reduced",
"expression",
"of",
"the",
"vitamin",
"D",
"receptor",
"(",
"VDR",
")",
"in",
"parathyroid",
"glands",
"of",
"uremic",
"animals",
"and",
"humans",
"has",
"been",
"observed",
"."
] | [
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12127 | [
"Similar",
"results",
"have",
"been",
"obtained",
"by",
"our",
"own",
"group",
"in",
"peripheral",
"blood",
"mononuclear",
"cells",
"(",
"PBMC",
")",
"from",
"patients",
"with",
"secondary",
"hyperparathyroidism",
"to",
"chronic",
"renal",
"failure",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12128 | [
"However",
",",
"the",
"reasons",
"for",
"these",
"changes",
"are",
"not",
"clear",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12129 | [
"In",
"the",
"present",
"study",
",",
"we",
"have",
"investigated",
"the",
"specific",
"uptake",
"of",
"[",
"3H",
"]",
"1",
",",
"25",
"(",
"OH",
")",
"2D3",
"by",
"PBMC",
"of",
"11",
"women",
"with",
"advanced",
"chronic",
"renal",
"failure",
"(",
"A-CRF",
")",
",",
"6",
"women",
"with",
"mild-moderate",
"renal",
"insufficiency",
"(",
"M-CRF",
")",
",",
"and",
"23",
"healthy",
"women",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12130 | [
"The",
"mean",
"dissociation",
"constant",
"(",
"KD",
")",
"was",
"similar",
"in",
"both",
"groups",
"of",
"patients",
"and",
"in",
"healthy",
"women",
"(",
"A-CRF",
":",
"0.7",
"+/-",
"0.5",
"x",
"10",
"(",
"-10",
")",
"M",
";",
"M-CRF",
":",
"1.1",
"+/-",
"0.9",
"x",
"10",
"(",
"-10",
")",
"M",
";",
"controls",
":",
"1.0",
"+/-",
"0.6",
"x",
"10",
"(",
"-10",
")",
"M",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12131 | [
"However",
",",
"VDR",
"concentration",
"was",
"significantly",
"decreased",
"in",
"A-CRF",
"(",
"0.8",
"+/-",
"0.5",
"fmol/10",
"(",
"7",
")",
"cells",
"vs.",
"2.3",
"+/-",
"0.9",
"fmol/10",
"(",
"7",
")",
"cells",
"in",
"controls",
",",
"p",
"<",
"0.001",
")",
",",
"whereas",
"no",
"changes",
"were",
"seen",
"in",
"M-CRF",
"(",
"1.7",
"+/-",
"0.7",
"fmol/10",
"(",
"7",
")",
"cells",
"vs.",
"2.3",
"+/-",
"0.9",
"fmol/10",
"(",
"7",
")",
"cells",
"in",
"controls",
")",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12132 | [
"No",
"correlation",
"was",
"seen",
"between",
"VDR",
"and",
"serum",
"calcitriol",
"or",
"PTH",
"levels",
",",
"when",
"considering",
"both",
"groups",
"of",
"patients",
"together",
"or",
"separately",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12133 | [
"Conversely",
",",
"a",
"significant",
"negative",
"correlation",
"was",
"found",
"between",
"VDR",
"and",
"serum",
"creatinine",
"values",
"when",
"A-CRF",
"and",
"M-CRF",
"were",
"considered",
"altogether",
"(",
"r",
"=",
"-0.63",
";",
"p",
"<",
"0.01",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12134 | [
"Treatment",
"with",
"two",
"different",
"schedules",
"of",
"oral",
"calcitriol",
"(",
"five",
"patients",
"with",
"0.5",
"microgram/day",
"for",
"1",
"month",
"and",
"four",
"patients",
"with",
"2",
"micrograms/day",
"for",
"7",
"days",
")",
"did",
"not",
"change",
"VDR",
"concentrations",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0
] |
12135 | [
"We",
"conclude",
"that",
"the",
"low",
"levels",
"of",
"serum",
"1",
",",
"25",
"(",
"OH",
")",
"2D3",
"of",
"uremia",
"are",
"not",
"responsible",
"for",
"the",
"decrease",
"in",
"VDR",
"concentration",
"found",
"in",
"these",
"patients",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0
] |
12136 | [
"Transcription",
"factor",
"binding",
"to",
"the",
"core",
"promoter",
"of",
"the",
"human",
"monoamine",
"oxidase",
"B",
"gene",
"in",
"the",
"cerebral",
"cortex",
"and",
"in",
"blood",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
12137 | [
"Many",
"studies",
"show",
"that",
"monoamine",
"oxidase",
"B",
"in",
"blood",
"cells",
"is",
"a",
"biological",
"marker",
"for",
"personality",
"characteristics",
"such",
"as",
"sensation",
"seeking",
"."
] | [
0,
0,
0,
0,
9,
10,
10,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12138 | [
"The",
"mechanism",
"underlying",
"this",
"association",
"is",
"so",
"far",
"not",
"explored",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12139 | [
"In",
"the",
"present",
"study",
"we",
"have",
"performed",
"electrophoretic",
"mobility-shift",
"assays",
"to",
"investigate",
"the",
"pattern",
"of",
"protein",
"binding",
"to",
"a",
"150",
"bp",
"fragment",
"of",
"the",
"proximal",
"5'-flanking",
"region",
"of",
"the",
"human",
"monoamine",
"oxidase",
"B",
"gene",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
0
] |
12140 | [
"We",
"compared",
"the",
"pattern",
"using",
"nuclear",
"extracts",
"from",
"human",
"brain",
"and",
"lymphocytes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0
] |
12141 | [
"Interestingly",
",",
"a",
"correlation",
"was",
"observed",
"between",
"monoamine",
"oxidase",
"B",
"enzyme",
"activity",
"in",
"blood",
"cells",
"(",
"platelets",
")",
"and",
"the",
"binding",
"pattern",
"of",
"two",
"uncharacterized",
"transcription",
"factors",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
7,
8,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12142 | [
"These",
"data",
"are",
"well",
"in",
"line",
"with",
"the",
"long-standing",
"notion",
"that",
"interindividual",
"differences",
"in",
"platelet",
"monoamine",
"oxidase",
"may",
"represent",
"differences",
"in",
"expression",
"of",
"the",
"enzyme",
"rather",
"than",
"genotypic",
"variation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12143 | [
"Enhanced",
"differentiation",
"of",
"HL-60",
"leukemia",
"cells",
"to",
"macrophages",
"induced",
"by",
"ciprofibrate",
"."
] | [
0,
0,
0,
5,
6,
6,
0,
7,
0,
0,
0,
0
] |
12144 | [
"Ciprofibrate",
",",
"an",
"hypolipidaemic",
"peroxisome",
"proliferator",
",",
"induced",
"differentiation",
"of",
"HL-60",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0
] |
12145 | [
"The",
"effect",
"was",
"greatly",
"potentiated",
"by",
"phorbol",
"12-myristate",
"13-acetate",
"at",
"a",
"concentration",
"where",
"neither",
"phorbol",
"ester",
"nor",
"ciprofibrate",
"alone",
"had",
"any",
"effect",
"on",
"these",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12146 | [
"As",
"occurs",
"for",
"HL-60",
"cell",
"differentiation",
"induced",
"by",
"high",
"phorbol",
"ester",
"concentration",
",",
"the",
"ciprofibrate-induced",
"phorbol",
"ester-dependent",
"differentiation",
"of",
"HL-60",
"cells",
"proceeded",
"through",
"the",
"monocytic/macrophage",
"pathway",
"and",
"induced",
"the",
"phosphorylation",
"of",
"proteins",
"with",
"similar",
"molecular",
"weights",
"suggesting",
"that",
"increased",
"protein",
"kinase",
"C",
"activity",
"may",
"be",
"involved",
"in",
"the",
"effect",
"."
] | [
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0
] |
12147 | [
"The",
"peroxisome",
"proliferator-activated",
"receptor",
"(",
"PPARalpha",
")",
"transcription",
"factor",
"is",
"expressed",
"in",
"HL-60",
"cells",
",",
"but",
"no",
"changes",
"were",
"observed",
"in",
"its",
"expression",
"upon",
"HL-60",
"cell",
"differentiation",
"."
] | [
0,
9,
10,
10,
10,
10,
10,
10,
10,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0
] |
12148 | [
"The",
"involvement",
"of",
"multiple",
"tumor",
"necrosis",
"factor",
"receptor",
"(",
"TNFR",
")",
"-associated",
"factors",
"in",
"the",
"signaling",
"mechanisms",
"of",
"receptor",
"activator",
"of",
"NF-kappaB",
",",
"a",
"member",
"of",
"the",
"TNFR",
"superfamily",
"."
] | [
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
10,
0
] |
12149 | [
"Receptor",
"activator",
"of",
"NF-kappaB",
"(",
"RANK",
")",
"is",
"a",
"recently",
"identified",
"member",
"of",
"the",
"tumor",
"necrosis",
"factor",
"receptor",
"superfamily",
"and",
"is",
"expressed",
"on",
"activated",
"T",
"cells",
"and",
"dendritic",
"cells",
"."
] | [
9,
10,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
0,
0,
0,
0,
0,
7,
8,
0,
7,
8,
0
] |
12150 | [
"Its",
"cognate",
"ligand",
"(",
"RANKL",
")",
"plays",
"significant",
"roles",
"in",
"the",
"activation",
"of",
"dendritic",
"cell",
"function",
"and",
"osteoclast",
"differentiation",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0
] |
12151 | [
"We",
"demonstrate",
"here",
"the",
"interaction",
"of",
"RANK",
"with",
"tumor",
"necrosis",
"factor",
"receptor-associated",
"factors",
"(",
"TRAFs",
")",
"1",
",",
"2",
",",
"3",
",",
"5",
",",
"and",
"6",
"both",
"in",
"vitro",
"and",
"in",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
9,
10,
10,
10,
10,
10,
10,
10,
10,
0,
9,
0,
9,
0,
9,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0
] |
12152 | [
"Mapping",
"of",
"the",
"structural",
"requirements",
"for",
"TRAF",
"/RANK",
"interaction",
"revealed",
"multiple",
"TRAF",
"binding",
"sites",
"clustered",
"in",
"two",
"distinct",
"domains",
"in",
"the",
"RANK",
"cytoplasmic",
"tail",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0
] |
12153 | [
"These",
"TRAF",
"binding",
"domains",
"were",
"shown",
"to",
"be",
"functionally",
"important",
"for",
"the",
"RANK",
"-dependent",
"induction",
"of",
"NF-kappaB",
"and",
"c-Jun",
"NH2-terminal",
"kinase",
"activities",
"."
] | [
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
9,
0,
9,
10,
10,
0,
0
] |
12154 | [
"Site-directed",
"mutagenesis",
"demonstrated",
"that",
"these",
"TRAF",
"binding",
"sites",
"exhibited",
"selective",
"binding",
"for",
"different",
"TRAF",
"proteins",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
12155 | [
"In",
"particular",
",",
"TRAF6",
"interacted",
"with",
"membrane-proximal",
"determinants",
"distinct",
"from",
"those",
"binding",
"TRAFs",
"1",
",",
"2",
",",
"3",
",",
"and",
"5",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
9,
0,
0,
9,
0
] |
12156 | [
"When",
"this",
"membrane-proximal",
"TRAF6",
"interaction",
"domain",
"was",
"deleted",
",",
"RANK",
"-mediated",
"NF-kappaB",
"signaling",
"was",
"completely",
"inhibited",
"while",
"c-Jun",
"NH2-terminal",
"kinase",
"activation",
"was",
"partially",
"inhibited",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0
] |
12157 | [
"An",
"NH2-terminal",
"truncation",
"mutant",
"of",
"TRAF6",
"inhibited",
"RANKL",
"-mediated",
"NF-kappaB",
"activation",
",",
"but",
"failed",
"to",
"affect",
"constitutive",
"signaling",
"induced",
"by",
"receptor",
"overexpression",
",",
"revealing",
"a",
"selective",
"role",
"for",
"TRAF6",
"in",
"ligand-induced",
"activation",
"events",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0
] |
12158 | [
"Stat6",
"inhibits",
"human",
"interleukin-4",
"promoter",
"activity",
"in",
"T",
"cells",
"."
] | [
9,
0,
0,
1,
2,
0,
0,
7,
8,
0
] |
12159 | [
"The",
"differentiation",
"of",
"naive",
"T-helper",
"(",
"Th",
")",
"cells",
"into",
"cytokine-secreting",
"effector",
"Th",
"cells",
"requires",
"exposure",
"to",
"multiple",
"signals",
",",
"including",
"exogenous",
"cytokines",
"."
] | [
0,
0,
0,
0,
7,
8,
8,
8,
8,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12160 | [
"Interleukin-4",
"(",
"IL-4",
")",
"plays",
"a",
"major",
"role",
"in",
"this",
"process",
"by",
"promoting",
"the",
"differentiation",
"of",
"IL-4",
"-secreting",
"Th2",
"cells",
"."
] | [
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
7,
8,
0
] |
12161 | [
"In",
"Th2",
"cells",
",",
"IL-4",
"gene",
"expression",
"is",
"tightly",
"controlled",
"at",
"the",
"level",
"of",
"transcription",
"by",
"the",
"coordinated",
"binding",
"of",
"multiple",
"transcription",
"factors",
"to",
"regulatory",
"elements",
"in",
"the",
"proximal",
"promoter",
"region",
"."
] | [
0,
7,
8,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12162 | [
"Nuclear",
"factor",
"of",
"activated",
"T",
"cell",
"(",
"NFAT",
")",
"family",
"members",
"play",
"a",
"critical",
"role",
"in",
"regulating",
"IL-4",
"transcription",
"and",
"interact",
"with",
"up",
"to",
"five",
"sequences",
"(",
"termed",
"P0",
"through",
"P4",
")",
"in",
"the",
"IL-4",
"promoter",
"."
] | [
9,
10,
10,
10,
10,
10,
10,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
12163 | [
"The",
"molecular",
"mechanisms",
"by",
"which",
"IL-4",
"induces",
"expression",
"of",
"the",
"IL-4",
"gene",
"are",
"not",
"known",
",",
"although",
"the",
"IL-4-activated",
"transcription",
"factor",
"signal",
"transducer",
"and",
"activator",
"of",
"transcription",
"6",
"(",
"Stat6",
")",
"is",
"required",
"for",
"this",
"effect",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
10,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0
] |
12164 | [
"We",
"report",
"here",
"that",
"Stat6",
"interacts",
"with",
"three",
"binding",
"sites",
"in",
"the",
"human",
"IL-4",
"promoter",
"by",
"electrophoretic",
"mobility",
"shift",
"assays",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0
] |
12165 | [
"These",
"sites",
"overlap",
"the",
"P1",
",",
"P2",
",",
"and",
"P4",
"NFAT",
"elements",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
12166 | [
"To",
"investigate",
"the",
"role",
"of",
"Stat6",
"in",
"regulating",
"IL-4",
"transcription",
",",
"we",
"used",
"Stat6",
"-deficient",
"Jurkat",
"T",
"cells",
"with",
"different",
"intact",
"IL-4",
"promoter",
"constructs",
"in",
"cotransfection",
"assays",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
9,
0,
0,
0,
0,
9,
0,
5,
6,
6,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0
] |
12167 | [
"We",
"show",
"that",
",",
"whereas",
"a",
"multimerized",
"response",
"element",
"from",
"the",
"germline",
"IgE",
"promoter",
"was",
"highly",
"induced",
"by",
"IL-4",
"in",
"Stat6-expressing",
"Jurkat",
"cells",
",",
"the",
"intact",
"human",
"IL-4",
"promoter",
"was",
"repressed",
"under",
"similar",
"conditions",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
9,
0,
0,
7,
8,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0
] |
12168 | [
"We",
"conclude",
"that",
"the",
"function",
"of",
"Stat6",
"is",
"highly",
"dependent",
"on",
"promoter",
"context",
"and",
"that",
"this",
"factor",
"promotes",
"IL-4",
"gene",
"expression",
"in",
"an",
"indirect",
"manner",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0
] |
12169 | [
"Epithelial",
"cell-initiated",
"inflammation",
"plays",
"a",
"crucial",
"role",
"in",
"early",
"tissue",
"damage",
"in",
"amebic",
"infection",
"of",
"human",
"intestine",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12170 | [
"BACKGROUND",
"&",
"AIMS",
":",
"Entamoeba",
"histolytica",
"infection",
"of",
"the",
"intestine",
"can",
"induce",
"severe",
"gut",
"inflammation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12171 | [
"The",
"aims",
"of",
"this",
"study",
"were",
"to",
"assess",
"the",
"role",
"of",
"the",
"host",
"inflammatory",
"response",
"in",
"the",
"tissue",
"damage",
"observed",
"with",
"amebiasis",
"and",
"the",
"role",
"of",
"the",
"intestinal",
"epithelial",
"cell",
"in",
"initiating",
"that",
"response",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0,
0
] |
12172 | [
"METHODS",
":",
"E.",
"histolytica",
"infection",
"was",
"established",
"in",
"human",
"intestinal",
"xenografts",
"in",
"severe",
"combined",
"immunodeficient",
"(",
"SCID-HU-INT",
")",
"mice",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12173 | [
"Human",
"intestinal",
"epithelial",
"cell",
"inflammatory",
"responses",
"to",
"amebic",
"infection",
"were",
"inhibited",
"by",
"the",
"intraluminal",
"administration",
"of",
"an",
"antisense",
"oligonucleotide",
"to",
"the",
"human",
"p65",
"subunit",
"of",
"nuclear",
"factor",
"kappaB",
",",
"and",
"the",
"role",
"of",
"neutrophils",
"in",
"tissue",
"damage",
"observed",
"with",
"amebiasis",
"was",
"studied",
"by",
"depleting",
"neutrophils",
"from",
"SCID-HU-INT",
"mice",
"."
] | [
7,
8,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
10,
10,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0
] |
12174 | [
"RESULTS",
":",
"Administration",
"of",
"the",
"antisense",
"oligonucleotide",
"blocked",
"the",
"production",
"of",
"human",
"interleukin",
"1beta",
"and",
"interleukin",
"8",
"by",
"intestinal",
"epithelial",
"cells",
"and",
"inhibited",
"neutrophil",
"influx",
"into",
"the",
"E.",
"histolytica-infected",
"intestinal",
"xenografts",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
10,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12175 | [
"Inhibition",
"of",
"the",
"gut",
"inflammatory",
"response",
"by",
"the",
"antisense",
"oligonucleotide",
"or",
"the",
"depletion",
"of",
"neutrophils",
"from",
"SCID-HU-",
"INT",
"mice",
"blocked",
"the",
"increase",
"in",
"intestinal",
"permeability",
"observed",
"with",
"amebic",
"infection",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12176 | [
"CONCLUSIONS",
":",
"Intestinal",
"epithelial",
"cells",
"initiate",
"an",
"inflammatory",
"response",
"with",
"resulting",
"neutrophil-mediated",
"tissue",
"damage",
"in",
"response",
"to",
"E.",
"histolytica",
"infection",
";",
"this",
"inflammatory",
"cascade",
"can",
"be",
"blocked",
"by",
"inhibiting",
"the",
"transcription",
"of",
"genes",
"regulated",
"by",
"nuclear",
"factor",
"kappaB",
"."
] | [
0,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0
] |
12177 | [
"Triptolide",
"induces",
"apoptotic",
"death",
"of",
"T",
"lymphocyte",
"."
] | [
0,
0,
0,
0,
0,
7,
8,
0
] |
12178 | [
"Extract",
"of",
"Tripterygium",
"wilfordii",
"Hook.",
"f",
"(",
"TWHf",
")",
"has",
"immunosuppressive",
"activity",
"and",
"has",
"been",
"used",
"as",
"anti-inflammatory",
"agent",
"in",
"traditional",
"Chinese",
"medicine",
"for",
"centuries",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12179 | [
"Recent",
"studies",
"have",
"demonstrated",
"that",
"triptolide",
"is",
"the",
"major",
"active",
"component",
"in",
"the",
"extract",
"that",
"inhibits",
"antigen",
"or",
"mitogen",
"-induced",
"T",
"cell",
"proliferation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0
] |
12180 | [
"In",
"attempting",
"to",
"investigate",
"its",
"effect",
"on",
"activation",
"of",
"T",
"lymphocytes",
",",
"we",
"found",
"triptolide",
"induces",
"apoptotic",
"death",
"of",
"T",
"cell",
"hybridomas",
"and",
"peripheral",
"T",
"cells",
"but",
"not",
"that",
"of",
"thymocytes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
7,
8,
8,
0,
0,
0,
0,
7,
0
] |
12181 | [
"The",
"triptolide-induced",
"apoptosis",
"is",
"accompanied",
"by",
"increase",
"of",
"DEVD-cleavable",
"caspases",
"activity",
"and",
"degradation",
"of",
"caspase",
"substrate",
"poly",
"(",
"ADP-ribose",
")",
"polymerase",
"(",
"PARP",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
9,
0,
9,
10,
10,
10,
10,
0,
9,
0,
0
] |
12182 | [
"A",
"specific",
"inhibitor",
"of",
"caspases",
",",
"zVAD-FMK",
",",
"prevents",
"triptolide-induced",
"PARP",
"degradation",
"and",
"DNA",
"fragmentation",
"but",
"not",
"growth",
"arrest",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12183 | [
"Furthermore",
",",
"enforced",
"expression",
"of",
"Bcl-2",
"inhibited",
"triptolide-induced",
"degradation",
"of",
"PARP",
"and",
"apoptosis",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
9,
0,
0,
0
] |
12184 | [
"These",
"results",
"indicate",
"that",
"triptolide",
"induces",
"T",
"cell",
"apoptosis",
"through",
"activating",
"caspases",
",",
"and",
"suggest",
"the",
"growth",
"arrest",
"and",
"apoptotic",
"effect",
"of",
"triptolide",
"may",
"contribute",
"to",
"the",
"immunosuppressive",
"activity",
"of",
"TWHf",
"extract"
] | [
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12185 | [
"A",
"novel",
"transcription",
"factor",
"regulates",
"expression",
"of",
"the",
"vacuolar",
"H+-ATPase",
"B2",
"subunit",
"through",
"AP-2",
"sites",
"during",
"monocytic",
"differentiation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
1,
2,
0,
0,
0,
0
] |
12186 | [
"During",
"monocyte-to-macrophage",
"differentiation",
",",
"the",
"cellular",
"content",
"of",
"vacuolar",
"H+-ATPase",
"(",
"V-ATPase",
")",
"increases",
"more",
"than",
"4-fold",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
0,
0
] |
12187 | [
"We",
"have",
"shown",
"previously",
"that",
"amplified",
"expression",
"of",
"the",
"B2",
"subunit",
"of",
"the",
"V-ATPase",
"occurs",
"solely",
"by",
"increased",
"transcription",
",",
"and",
"that",
"the",
"5'-untranslated",
"region",
"of",
"the",
"B2",
"gene",
",",
"containing",
"multiple",
"consensus",
"binding",
"sites",
"for",
"the",
"transcription",
"factors",
"AP-2",
"and",
"Sp1",
",",
"is",
"required",
"for",
"this",
"expression",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0
] |
12188 | [
"The",
"present",
"study",
"demonstrates",
"that",
"AP-2",
"binding",
"sequences",
"are",
"essential",
"for",
"increased",
"transcription",
"from",
"the",
"B2",
"promoter",
"during",
"monocyte-macrophage",
"differentiation",
"and",
"that",
"AP-2",
",",
"expressed",
"exogenously",
"in",
"THP-1",
"and",
"other",
"cells",
",",
"activates",
"transcription",
"from",
"the",
"B2",
"promoter",
"."
] | [
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
7,
0,
0,
0,
9,
0,
0,
0,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
12189 | [
"In",
"mobility",
"shift",
"assays",
",",
"a",
"nuclear",
"factor",
"from",
"THP-1",
"and",
"U-937",
"cells",
"was",
"identified",
"that",
"binds",
"to",
"several",
"AP-2",
"response",
"elements",
"within",
"the",
"B2",
"promoter",
",",
"but",
"does",
"not",
"react",
"with",
"AP-2",
"antibodies",
",",
"and",
"has",
"a",
"DNA",
"sequence",
"binding",
"affinity",
"profile",
"that",
"differs",
"from",
"AP-2",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
5,
6,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
12190 | [
"These",
"findings",
"suggest",
"that",
"a",
"novel",
"AP-2-like",
"transcription",
"factor",
"is",
"responsible",
"for",
"V-ATPase",
"B",
"subunit",
"amplification",
"during",
"monocyte",
"differentiation",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
9,
10,
10,
0,
0,
7,
0,
0
] |
12191 | [
"c-Jun",
"and",
"GST-pi",
"expression",
"in",
"human",
"plasma",
"cells",
"."
] | [
9,
0,
9,
0,
0,
7,
8,
8,
0
] |
12192 | [
"Bone",
"marrow",
"samples",
"from",
"33",
"patients",
"affected",
"by",
"MM",
"and",
"MGUS",
",",
"and",
"8",
"patients",
"not",
"affected",
"by",
"lymphoproliferative",
"diseases",
"were",
"studied",
"for",
"expression",
"of",
"c-Jun",
"(",
"a",
"component",
"of",
"the",
"transcription",
"factor",
"AP-1",
")",
"and",
"glutathione-S-transferase",
"pi",
"(",
"GST-pi",
")",
"using",
"immunocytochemical",
"methods",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
0
] |
12193 | [
"A",
"high",
"and",
"frequent",
"expression",
"of",
"these",
"two",
"proteins",
"was",
"found",
"both",
"in",
"MM",
"and",
"MGUS",
"patients",
"(",
"31/33",
"patients",
"positive",
"for",
"c-Jun",
"and",
"29/33",
"patients",
"positive",
"for",
"GST-pi",
")",
"and",
"in",
"controls",
"not",
"affected",
"by",
"monoclonal",
"gammopathy",
"(",
"7/8",
"patients",
"positive",
"for",
"both",
"c-Jun",
"and",
"GST-pi",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0
] |
12194 | [
"No",
"statistically",
"significant",
"correlation",
"was",
"found",
"between",
"c-Jun-",
"and",
"GST-pi-positive",
"plasma",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
12195 | [
"The",
"expression",
"of",
"these",
"two",
"proteins",
"was",
"not",
"related",
"to",
"clinical",
"or",
"laboratory",
"data",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12196 | [
"Our",
"results",
"seem",
"to",
"confirm",
"a",
"possible",
"role",
"of",
"the",
"transcriptional",
"complex",
"AP-1",
"in",
"activating",
"GST-pi",
"promoter",
"in",
"human",
"plasma",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
1,
2,
0,
7,
8,
8,
0
] |
12197 | [
"Activation",
"of",
"signaling",
"pathways",
"and",
"prevention",
"of",
"apoptosis",
"by",
"cytokines",
"in",
"eosinophils",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0
] |
12198 | [
"Inhibition",
"of",
"apoptosis",
"in",
"eosinophils",
"by",
"cytokines",
"such",
"as",
"IL-5",
"and",
"GM-CSF",
"may",
"play",
"an",
"important",
"role",
"in",
"the",
"pathogenesis",
"of",
"allergic",
"and",
"parasitic",
"disorders",
"."
] | [
0,
0,
0,
0,
7,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12199 | [
"Recently",
",",
"there",
"has",
"been",
"some",
"progress",
"in",
"the",
"understanding",
"of",
"the",
"signal",
"transduction",
"pathways",
"activated",
"by",
"these",
"cytokines",
"in",
"eosinophils",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0
] |
12200 | [
"The",
"IL-3",
",",
"IL-5",
"and",
"GM-CSF",
"receptors",
"share",
"a",
"common",
"signal",
"transducer",
"that",
"possesses",
"no",
"intrinsic",
"kinase",
"domain",
"."
] | [
0,
9,
0,
9,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.