Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
11901
[ "Both", "forms", "have", "DNA-binding", "domain", ",", "but", "AML1a", "lacks", "a", "putative", "transcriptional", "activation", "domain", "which", "AML1b", "has", "." ]
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11902
[ "Here", "we", "demonstrate", "that", "AML1a", ",", "which", "solely", "has", "no", "effects", "as", "a", "transcriptional", "regulator", ",", "dominantly", "suppresses", "transcriptional", "activation", "by", "AML1b", ",", "and", "that", "AML1a", "exhibits", "the", "higher", "affinity", "for", "DNA-binding", "than", "AML1b", "." ]
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11903
[ "Furthermore", "a", "dominant", "negative", "form", "of", "AML1", ",", "AML1a", ",", "totally", "suppressed", "granulocytic", "differentiation", "otherwise", "induced", "by", "granulocyte", "colony-stimulating", "factor", "when", "AML1a", "was", "overexpressed", "in", "32Dc13", "murine", "myeloid", "cells", "." ]
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11904
[ "Such", "differentiation", "block", "by", "AML1a", "was", "canceled", "by", "the", "concomitant", "overexpression", "of", "AML1b", "." ]
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11905
[ "These", "data", "strongly", "suggest", "that", "a", "transcriptionally", "active", "form", "of", "AML1", "is", "essential", "for", "the", "myeloid", "cell", "differentiation", "." ]
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11906
[ "In", "addition", ",", "we", "observed", "an", "altered", "expression", "level", "of", "AML1", "along", "with", "the", "myeloid", "differentiation", "in", "several", "hemopoietic", "cell", "lines", "." ]
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11907
[ "In", "these", "cases", ",", "at", "least", ",", "the", "AML1", "expression", "level", "is", "a", "potential", "regulator", "for", "myeloid", "cell", "differentiation", "." ]
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11908
[ "Nuclear", "factor-kappa", "B", "potently", "up-regulates", "the", "promoter", "activity", "of", "RANTES", ",", "a", "chemokine", "that", "blocks", "HIV", "infection", "." ]
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11909
[ "The", "complex", "network", "of", "cytokines", "that", "are", "involved", "in", "inflammatory", "and", "immunoregulatory", "responses", "plays", "a", "critical", "role", "in", "the", "pathogenesis", "of", "HIV", "infection", "." ]
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11910
[ "RANTES", "(", "regulated", "upon", "activation", ",", "normal", "T", "cell", "expressed", "and", "secreted", ")", "is", "a", "cytokine", "that", "belongs", "to", "the", "beta-chemokine", "family", ";", "it", "is", "chemoattractant", "for", "CD4+/CD45RO", "T", "cells", ",", "it", "is", "produced", "by", "various", "cell", "types", "including", "CD8+", "and", "CD4+", "T", "cells", "as", "well", "as", "monocytes/macrophages", ",", "and", "has", "recently", "been", "shown", "to", "suppress", "replication", "of", "macrophage-tropic", "strains", "of", "HIV", "in", "CD4+", "T", "cells", "." ]
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11911
[ "To", "investigate", "the", "molecular", "mechanisms", "of", "RANTES", "expression", ",", "the", "RANTES", "promoter", "region", "was", "analyzed", "by", "transient", "expression", "and", "gel-mobility", "shift", "assays", "." ]
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11912
[ "We", "demonstrate", "that", ":", "1", ")", "RANTES", "promoter", "activity", "is", "up-regulated", "by", "PMA", "plus", "ionomycin", ",", "coexpression", "of", "the", "p65", "subunit", "of", "nuclear", "factor", "(", "NF", ")", "-kappa", "B", ",", "the", "proinflammatory", "cytokines", "TNF-alpha", "and", "IL-1", "beta", ",", "and", "the", "CD28", "costimulatory", "pathway", ";", "2", ")", "the", "RANTES", "promoter", "region", "contains", "four", "NF-kappa", "B", "binding", "sites", "at", "positions", "-30", ",", "-44", ",", "-213", ",", "and", "-579", "relative", "to", "the", "transcription", "start", "site", ";", "3", ")", "one", "site", "(", "-213", ")", "is", "an", "NF-AT", "(", "nuclear", "factor", "of", "activated", "T", "cells", ")", "binding", "site", "that", "also", "has", "weak", "affinity", "to", "NF-kappa", "B", ",", "and", "the", "most", "distal", "site", "(", "-579", ")", "also", "serves", "as", "a", "CD28-responsive", "element", ";", "and", "4", ")", "mutation", "on", "any", "of", "those", "NF-kappa", "B", "sites", "or", "coexpression", "of", "I", "kappa", "B", "alpha", "(", "cytoplasmic", "inhibitor", "of", "NF-kappa", "B", ")", "markedly", "reduced", "the", "promoter", "activity", "." ]
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11913
[ "Thus", ",", "NF-kappa", "B", ",", "a", "potent", "transcriptional", "activator", "of", "HIV", "expression", ",", "is", "also", "involved", "in", "the", "expression", "of", "RANTES", ",", "a", "chemokine", "that", "blocks", "infection", "by", "macrophage-tropic", "strains", "of", "HIV", "." ]
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11914
[ "Pivotal", "role", "for", "the", "NFIL3/E4BP4", "transcription", "factor", "in", "interleukin", "3", "-mediated", "survival", "of", "pro-B", "lymphocytes", "." ]
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11915
[ "The", "E2A-HLF", "(", "hepatic", "leukemia", "factor", ")", "oncoprotein", ",", "generated", "in", "pro-B", "lymphocytes", "by", "fusion", "of", "the", "trans-activation", "domain", "of", "E2A", "to", "the", "basic", "region/leucine", "zipper", "(", "bZIP", ")", "domain", "of", "HLF", ",", "functions", "as", "an", "anti-apoptotic", "transcription", "factor", "in", "leukemic", "cell", "transformation", "." ]
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11916
[ "When", "introduced", "into", "interleukin", "3", "(", "IL-3", ")", "-dependent", "mouse", "pro-B", "lymphocytes", ",", "E2A-HLF", "prevents", "apoptosis", "induced", "by", "growth", "factor", "deprivation", ",", "suggesting", "that", "IL-3", "mediates", "cell", "survival", "through", "activation", "of", "a", "transcription", "factor", "whose", "activity", "can", "be", "constitutively", "replaced", "by", "the", "chimeric", "oncoprotein", "." ]
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11917
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11918
[ "The", "expression", "and", "binding", "activity", "of", "the", "Nfil3", "protein", "(", "also", "called", "E4bp4", ")", ",", "but", "not", "of", "Hlf", ",", "Dbp", ",", "or", "Tef", ",", "was", "found", "to", "be", "regulated", "by", "IL-3", "in", "mouse", "pro-B", "cell", "lines", "(", "Baf-3", "and", "FL5.12", ")", "." ]
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11919
[ "Northern", "blot", "analysis", "showed", "that", "Nfil3/E4bp4", "is", "regulated", "as", "a", "``", "delayed-early", "''", "IL-3-responsive", "gene", ",", "requiring", "de", "novo", "protein", "synthesis", "." ]
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11920
[ "In", "the", "absence", "of", "IL-3", ",", "enforced", "expression", "of", "the", "human", "NFIL3/E4BP4", "cDNA", "promoted", "the", "survival", "but", "not", "the", "growth", "of", "IL-3-dependent", "pro-B", "cells", "." ]
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11921
[ "Our", "results", "implicate", "NFIL3/E4BP4", "(", "nuclear", "factor", "regulated", "by", "IL-3/adenovirus", "E4", "promoter", "binding", "protein", ")", "in", "a", "distinct", "growth", "factor-regulated", "signaling", "pathway", "that", "is", "responsible", "for", "the", "survival", "of", "early", "B-cell", "progenitors", ",", "and", "whose", "alteration", "by", "E2A-HLF", "leads", "to", "childhood", "B", "lineage", "leukemia", "." ]
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11922
[ "Detection", "of", "adenovirus", "DNA", "in", "peripheral", "blood", "mononuclear", "cells", "by", "polymerase", "chain", "reaction", "assay", "." ]
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11923
[ "Adenovirus", "can", "establish", "persistent", "infections", "which", "may", "reactivate", "and", "cause", "disease", "in", "immunocompromised", "hosts", "." ]
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11924
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11925
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11926
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11927
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11928
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11929
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11930
[ "In", "comparison", ",", "PBMC", "from", "two", "children", "with", "fatal", "adenoviral", "infection", "were", "both", "strongly", "positive", "for", "adenovirus", "DNA", "." ]
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11931
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11932
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11933
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11934
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11935
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11936
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11937
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11938
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11939
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11940
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11941
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11942
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11943
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11944
[ "Common", "and", "distinct", "intracellular", "signaling", "pathways", "in", "human", "neutrophils", "utilized", "by", "platelet", "activating", "factor", "and", "FMLP", "." ]
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11945
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11946
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11947
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11948
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11949
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11950
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11951
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11952
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11953
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11954
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11955
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11956
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11957
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11958
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11959
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11960
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11961
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11962
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11963
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11964
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11965
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11966
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11967
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11968
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11969
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11970
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11971
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11972
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11973
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11974
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11975
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11976
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11977
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11978
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11979
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11980
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11981
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11982
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11983
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11984
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11985
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11986
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11987
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11988
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11989
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11990
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11991
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11992
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11993
[ "Rather", ",", "the", "binding", "affinity", "is", "probably", "influenced", "by", "the", "expression", "of", "cytosolic", "factors", "that", "affect", "glucocorticoid", "receptor", "function", "." ]
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11994
[ "Shared", "gamma", "(", "c", ")", "subunit", "within", "the", "human", "interleukin-7", "receptor", "complex", "." ]
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11995
[ "A", "molecular", "basis", "for", "the", "pathogenesis", "of", "X-linked", "severe", "combined", "immunodeficiency", "." ]
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11996
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11997
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11998
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11999
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12000
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