id
stringlengths 1
5
| tokens
sequence | ner_tags
sequence |
---|---|---|
11701 | [
"In",
"addition",
"to",
"the",
"existing",
"isoform",
"(",
"Pax-5",
",",
"which",
"we",
"have",
"named",
"Pax-5a",
")",
",",
"we",
"have",
"isolated",
"three",
"new",
"isoforms",
",",
"Pax-5b",
",",
"Pax-5d",
",",
"and",
"Pax-5e",
",",
"from",
"murine",
"spleen",
"and",
"B-lymphoid",
"cell",
"lines",
"using",
"library",
"screenings",
"and",
"polymerase",
"chain",
"reaction",
"amplification",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
9,
0,
0,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11702 | [
"Isoforms",
"Pax-5b",
"and",
"Pax-5e",
"have",
"spliced",
"out",
"their",
"second",
"exon",
",",
"resulting",
"in",
"proteins",
"with",
"only",
"a",
"partial",
"DNA-binding",
"domain",
"."
] | [
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11703 | [
"Isoforms",
"Pax-5d",
"and",
"Pax-5e",
"have",
"deleted",
"the",
"3'-region",
",",
"which",
"encodes",
"the",
"transactivating",
"domain",
",",
"and",
"replaced",
"it",
"with",
"a",
"novel",
"sequence",
"."
] | [
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11704 | [
"The",
"existence",
"of",
"alternative",
"Pax-5",
"transcripts",
"was",
"confirmed",
"using",
"RNase",
"protection",
"assays",
"."
] | [
0,
0,
0,
0,
3,
4,
0,
0,
0,
9,
0,
0,
0
] |
11705 | [
"Furthermore",
",",
"Pax-5a",
"and",
"Pax-5b",
"proteins",
"were",
"detected",
"using",
"Western",
"blot",
"analysis",
"."
] | [
0,
0,
9,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0
] |
11706 | [
"Pax-5a",
"was",
"detectable",
"in",
"pro-",
",",
"pre-",
",",
"and",
"mature",
"B-cell",
"lines",
",",
"but",
"not",
"in",
"two",
"plasmacytomas",
";",
"Pax-5b",
"was",
"shown",
"to",
"be",
"present",
"at",
"low",
"levels",
"in",
"mature",
"B-cell",
"lines",
"and",
",",
"unexpectedly",
",",
"in",
"one",
"plasma",
"cell",
"line",
",",
"but",
"not",
"in",
"pro-B-cell",
"or",
"T-cell",
"lines",
"."
] | [
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
5,
6,
0
] |
11707 | [
"Mobility",
"shift",
"assays",
"showed",
"that",
"in",
"vitro",
"translated",
"Pax-5a",
"and",
"Pax-5d",
",",
"but",
"not",
"Pax-5b",
"or",
"Pax-5e",
",",
"could",
"interact",
"with",
"a",
"B-cell-specific",
"activator",
"protein-binding",
"site",
"on",
"the",
"blk",
"promoter",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
1,
2,
0
] |
11708 | [
"Using",
"this",
"assay",
",",
"we",
"also",
"showed",
"that",
"Pax-5d",
"was",
"present",
"in",
"nuclear",
"extracts",
"of",
"some",
"(",
"but",
"not",
"all",
")",
"B-lymphoid",
"lines",
"and",
"interacts",
"with",
"the",
"B-cell-specific",
"activator",
"protein-binding",
"site",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
1,
2,
2,
2,
0
] |
11709 | [
"The",
"pattern",
"of",
"differential",
"expression",
"of",
"alternatively",
"spliced",
"Pax-5",
"isoforms",
"suggests",
"that",
"they",
"may",
"be",
"important",
"regulators",
"of",
"transcription",
"during",
"B-cell",
"maturation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0
] |
11710 | [
"Reconstitution",
"of",
"T",
"cell",
"antigen",
"receptor-induced",
"Erk2",
"kinase",
"activation",
"in",
"Lck-negative",
"JCaM1",
"cells",
"by",
"Syk",
"."
] | [
0,
0,
9,
10,
10,
0,
9,
10,
0,
0,
0,
5,
6,
0,
9,
0
] |
11711 | [
"The",
"two",
"related",
"protein-tyrosine",
"kinases",
"Syk",
"and",
"Zap",
"are",
"rapidly",
"phosphorylated",
"on",
"tyrosine",
"residues",
"and",
"enzymatically",
"activated",
"upon",
"crosslinking",
"of",
"the",
"T",
"cell",
"antigen",
"receptor",
"."
] | [
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0
] |
11712 | [
"We",
"have",
"previously",
"reported",
"that",
"the",
"activation",
"of",
"Syk",
"is",
"less",
"dependent",
"on",
"the",
"Src",
"family",
"kinase",
"Lck",
"than",
"the",
"activation",
"of",
"Zap",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
9,
0
] |
11713 | [
"Here",
"we",
"report",
"that",
"overexpression",
"of",
"Syk",
"in",
"the",
"Lck-negative",
"JCaM1",
"cells",
"enabled",
"the",
"T",
"cell",
"antigen",
"receptor/CD3",
"complex",
"to",
"induce",
"a",
"normal",
"activation",
"of",
"the",
"mitogen-activated",
"protein",
"kinase",
"(",
"MAPK",
")",
"pathway",
"and",
"expression",
"of",
"a",
"nuclear",
"factor",
"of",
"activated",
"T",
"cells",
"reporter",
"construct",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
5,
6,
0,
0,
9,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
0,
0,
0
] |
11714 | [
"In",
"contrast",
",",
"Zap",
"and",
"other",
"protein-tyrosine",
"kinases",
"were",
"unable",
"to",
"reconstitute",
"these",
"signaling",
"pathways",
"when",
"expressed",
"at",
"the",
"same",
"levels",
"."
] | [
0,
0,
0,
9,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11715 | [
"In",
"parallel",
",",
"Syk",
"was",
"phosphorylated",
"on",
"tyrosine",
",",
"while",
"Zap",
"was",
"not",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0
] |
11716 | [
"The",
"Syk",
"-mediated",
"T",
"cell",
"antigen",
"receptor",
"-induced",
"MAPK",
"activation",
"was",
"detectable",
"within",
"1",
"min",
"of",
"receptor",
"stimulation",
"and",
"peaked",
"at",
"3-5",
"min",
"."
] | [
0,
9,
0,
9,
10,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11717 | [
"The",
"capacity",
"of",
"Syk",
"to",
"reconstitute",
"the",
"MAPK",
"response",
"required",
"the",
"catalytic",
"activity",
"of",
"Syk",
",",
"an",
"intact",
"autophosphorylation",
"site",
"(",
"Y518",
"and",
"Y519",
")",
",",
"both",
"Src",
"homology",
"2",
"domains",
"and",
"it",
"was",
"blocked",
"by",
"the",
"inhibitory",
"N17-mutated",
"dominant-negative",
"Ras",
"construct",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0
] |
11718 | [
"A",
"Y341",
"--",
">",
"F",
"mutant",
"of",
"Syk",
",",
"which",
"is",
"deficient",
"in",
"its",
"interaction",
"with",
"phospholipase",
"Cy1",
"and",
"Vav",
",",
"was",
"less",
"efficient",
"than",
"wild-type",
"Syk",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
0,
0,
9,
0
] |
11719 | [
"Our",
"results",
"suggest",
"that",
"Syk",
",",
"in",
"contrast",
"to",
"Zap",
",",
"can",
"transduce",
"signals",
"from",
"the",
"T",
"cell",
"antigen",
"receptor",
"independently",
"of",
"Lck",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
9,
0
] |
11720 | [
"Activation",
"of",
"the",
"transcription",
"factor",
"MEF2C",
"by",
"the",
"MAP",
"kinase",
"p38",
"in",
"inflammation",
"."
] | [
0,
0,
0,
9,
10,
10,
0,
0,
9,
10,
10,
0,
0,
0
] |
11721 | [
"For",
"cells",
"of",
"the",
"innate",
"immune",
"system",
"to",
"mount",
"a",
"host",
"defence",
"response",
"to",
"infection",
",",
"they",
"must",
"recognize",
"products",
"of",
"microbial",
"pathogens",
"such",
"as",
"lipopolysaccharide",
"(",
"LPS",
")",
",",
"the",
"endotoxin",
"secreted",
"by",
"Gram-negative",
"bacteria",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11722 | [
"These",
"cellular",
"responses",
"require",
"intracellular",
"signalling",
"pathways",
",",
"such",
"as",
"the",
"four",
"MAP",
"kinase",
"(",
"MAPK",
")",
"pathways",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
0
] |
11723 | [
"In",
"mammalian",
"cells",
"the",
"MAPK",
"p38",
"is",
"thought",
"to",
"play",
"an",
"important",
"role",
"in",
"the",
"regulation",
"of",
"cellular",
"responses",
"during",
"infection",
"through",
"its",
"effects",
"on",
"the",
"expression",
"of",
"proinflammatory",
"molecules",
"."
] | [
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11724 | [
"One",
"means",
"of",
"understanding",
"the",
"role",
"of",
"p38",
"in",
"these",
"responses",
"is",
"to",
"identify",
"proteins",
"with",
"functions",
"regulated",
"by",
"p38",
"-catalysed",
"phosphorylation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0
] |
11725 | [
"Here",
"we",
"demonstrate",
"a",
"link",
"between",
"the",
"p38",
"pathway",
"and",
"a",
"member",
"of",
"the",
"myocyte-enhancer",
"factor",
"2",
"(",
"MEF2",
")",
"group",
"of",
"transcription",
"factors",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0
] |
11726 | [
"We",
"found",
"that",
"in",
"monocytic",
"cells",
",",
"LPS",
"increases",
"the",
"transactivation",
"activity",
"of",
"MEF2C",
"through",
"p38",
"-catalysed",
"phosphorylation",
"."
] | [
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0
] |
11727 | [
"One",
"consequence",
"of",
"MEF2C",
"activation",
"is",
"increased",
"c-jun",
"gene",
"transcription",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
1,
2,
0,
0
] |
11728 | [
"Our",
"results",
"show",
"that",
"p38",
"may",
"influence",
"host",
"defence",
"and",
"inflammation",
"by",
"maintaining",
"the",
"balance",
"of",
"c-Jun",
"protein",
"consumed",
"during",
"infection",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0
] |
11729 | [
"Cellular",
"redox",
"status",
"influences",
"both",
"cytotoxic",
"and",
"NF-kappa",
"B",
"activation",
"in",
"natural",
"killer",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
7,
8,
8,
0
] |
11730 | [
"The",
"role",
"of",
"cellular",
"redox",
"status",
"in",
"both",
"cytotoxic",
"activity",
"and",
"NF-kappa",
"B",
"activation",
"in",
"natural",
"killer",
"(",
"NK",
")",
"cells",
"was",
"investigated",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
7,
8,
8,
8,
8,
8,
0,
0,
0
] |
11731 | [
"The",
"results",
"indicate",
"that",
"stimulation",
"of",
"NK",
"cells",
",",
"either",
"freshly",
"isolated",
"from",
"peripheral",
"blood",
"lymphocytes",
"(",
"PBL",
")",
"or",
"long-term",
"cultured",
"NK",
"clones",
",",
"with",
"specific",
"cell",
"targets",
"results",
"in",
"an",
"increased",
"binding",
"activity",
"of",
"NF-kappa",
"B",
"and",
"AP-1",
"transcription",
"factors",
"measured",
"by",
"gel",
"retardation",
"."
] | [
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
7,
8,
8,
0,
7,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
10,
10,
0,
0,
0,
0,
0
] |
11732 | [
"Pretreatment",
"of",
"NK",
"cells",
"with",
"the",
"antioxidant",
"pyrrolidine",
"dithiocarbarmate",
"(",
"PDTC",
")",
"leads",
"to",
"the",
"inhibition",
"of",
"NF-kappa",
"B",
"activation",
"but",
"the",
"AP-1",
"binding",
"to",
"DNA",
"was",
"superinduced",
"."
] | [
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0
] |
11733 | [
"The",
"inhibition",
"of",
"NF-kappa",
"B",
"by",
"PDTC",
"paralleled",
"with",
"an",
"inhibition",
"of",
"spontaneous",
"cytotoxicity",
"mediated",
"by",
"NK",
"cells",
"."
] | [
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
11734 | [
"Moreover",
",",
"the",
"inhibitors",
"of",
"serine",
"proteases",
",",
"N-alpha-tosyl-L-lysine",
"chloromethyl",
"ketone",
"and",
"N-alpha-tosyl-L-phenylalanine",
"chloromethyl",
"ketone",
",",
"also",
"blocked",
"the",
"cytolytic",
"activity",
"of",
"NK",
"cells",
"against",
"the",
"sensitive",
"target",
"K562",
"."
] | [
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
5,
0
] |
11735 | [
"In",
"contrast",
",",
"NK",
"activity",
"was",
"not",
"affected",
"by",
"pretreatment",
"of",
"the",
"effector",
"cells",
"with",
"the",
"proteasome",
"inhibitor",
"N-acetyl-leu-leu-norleucinal",
"which",
"selectively",
"inhibits",
"NF-kappa",
"B",
"activation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0
] |
11736 | [
"Altogether",
",",
"these",
"results",
"support",
"the",
"hypothesis",
"that",
"the",
"activation",
"of",
"NK",
"cells",
"involved",
"transcriptional",
"and",
"post-transcriptional",
"events",
",",
"and",
"that",
"reactive",
"intermediates",
"may",
"play",
"an",
"important",
"role",
"in",
"the",
"molecular",
"processes",
"related",
"with",
"the",
"generation",
"of",
"a",
"cytotoxic",
"response",
"by",
"NK",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
11737 | [
"The",
"predominant",
"E2F",
"complex",
"in",
"human",
"primary",
"haemopoietic",
"cells",
"and",
"in",
"AML",
"blasts",
"contains",
"E2F-4",
",",
"DP-1",
"and",
"p130",
"."
] | [
0,
0,
9,
10,
0,
7,
8,
8,
8,
0,
0,
7,
8,
0,
9,
0,
9,
0,
9,
0
] |
11738 | [
"The",
"E2F",
"family",
"of",
"transcription",
"factors",
"are",
"thought",
"to",
"play",
"an",
"important",
"role",
"in",
"the",
"control",
"of",
"cell",
"cycle",
"progression",
"."
] | [
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11739 | [
"There",
"is",
"now",
"also",
"increasing",
"evidence",
"that",
"some",
"family",
"members",
"may",
"act",
"as",
"oncogenes",
"or",
"tumour",
"suppressor",
"genes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11740 | [
"The",
"characterization",
"of",
"these",
"proteins",
"in",
"human",
"primary",
"haemopoietic",
"cells",
"and",
"acute",
"myeloid",
"leukaemia",
"(",
"AML",
")",
"blasts",
"may",
"thus",
"give",
"an",
"insight",
"to",
"the",
"molecular",
"mechanisms",
"governing",
"proliferation",
"and",
"leukaemogenesis",
"in",
"these",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
0,
7,
8,
8,
8,
8,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11741 | [
"Therefore",
"we",
"analysed",
"the",
"expression",
"of",
"E2F",
"-DNA",
"binding",
"activity",
"and",
"the",
"constituent",
"proteins",
"found",
"in",
"the",
"complexes",
"in",
"human",
"primary",
"haemopoietic",
"cells",
"of",
"various",
"lineages",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
0,
0,
0,
0
] |
11742 | [
"We",
"also",
"studied",
"blasts",
"from",
"18",
"patients",
"with",
"acute",
"myeloid",
"leukaemia",
"(",
"AML",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11743 | [
"On",
"electromobility",
"shift",
"assays",
"(",
"EMSA",
")",
"a",
"single",
"E2F-DNA",
"binding",
"complex",
"was",
"detected",
"in",
"T",
"cells",
",",
"B",
"cells",
"and",
"monocytes",
"which",
"was",
"shown",
"to",
"contain",
"E2F-4",
",",
"DP-1",
"and",
"p130",
",",
"indicating",
"that",
"all",
"quiescent",
"haemopoietic",
"cells",
"have",
"the",
"same",
"complex",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
7,
8,
0,
7,
0,
0,
0,
0,
0,
9,
0,
9,
0,
9,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0
] |
11744 | [
"Examination",
"of",
"18",
"AML",
"samples",
"by",
"EMSA",
"revealed",
"the",
"presence",
"of",
"E2F",
"binding",
"and",
"no",
"gross",
"abnormalities",
"were",
"detected",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0
] |
11745 | [
"An",
"E2F-4/p130",
"complex",
"was",
"detected",
"in",
"representative",
"samples",
"of",
"all",
"FAB",
"types",
"analysed",
"."
] | [
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11746 | [
"Thus",
"abnormalities",
"of",
"E2F",
"function",
"are",
"unlikely",
"to",
"play",
"a",
"primary",
"pathogenic",
"role",
"in",
"AML",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11747 | [
"Characterization",
"of",
"a",
"mutant",
"cell",
"line",
"that",
"does",
"not",
"activate",
"NF-kappaB",
"in",
"response",
"to",
"multiple",
"stimuli",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0
] |
11748 | [
"Numerous",
"genes",
"required",
"during",
"the",
"immune",
"or",
"inflammation",
"response",
"as",
"well",
"as",
"the",
"adhesion",
"process",
"are",
"regulated",
"by",
"nuclear",
"factor",
"kappaB",
"(",
"NF-kappaB",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0
] |
11749 | [
"Associated",
"with",
"its",
"inhibitor",
",",
"I",
"kappaB",
",",
"NF-kappaB",
"resides",
"as",
"an",
"inactive",
"form",
"in",
"the",
"cytoplasm",
"."
] | [
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11750 | [
"Upon",
"stimulation",
"by",
"various",
"agents",
",",
"I",
"kappaB",
"is",
"proteolyzed",
"and",
"NF-kappaB",
"translocates",
"to",
"the",
"nucleus",
",",
"where",
"it",
"activates",
"its",
"target",
"genes",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11751 | [
"The",
"transduction",
"pathways",
"that",
"lead",
"to",
"I",
"kappaB",
"inactivation",
"remain",
"poorly",
"understood",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0
] |
11752 | [
"In",
"this",
"study",
",",
"we",
"have",
"characterized",
"a",
"cellular",
"mutant",
",",
"the",
"70/Z3-derived",
"1.3E2",
"murine",
"pre-B",
"cell",
"line",
",",
"that",
"does",
"not",
"activate",
"NF-kappaB",
"in",
"response",
"to",
"several",
"stimuli",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
6,
6,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0
] |
11753 | [
"We",
"demonstrate",
"that",
"upon",
"stimulation",
"by",
"lipopolysaccharide",
",",
"Taxol",
",",
"phorbol",
"myristate",
"acetate",
",",
"interleukin-1",
",",
"or",
"double-stranded",
"RNA",
",",
"I",
"kappaB",
"alpha",
"is",
"not",
"degraded",
",",
"as",
"a",
"result",
"of",
"an",
"absence",
"of",
"induced",
"phosphorylation",
"on",
"serines",
"32",
"and",
"36",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11754 | [
"Neither",
"a",
"mutation",
"in",
"I",
"kappaB",
"alpha",
"nor",
"a",
"mutation",
"in",
"p50",
"or",
"relA",
",",
"the",
"two",
"major",
"subunits",
"of",
"NF-kappaB",
"in",
"this",
"cell",
"line",
",",
"accounts",
"for",
"this",
"phosphorylation",
"defect",
"."
] | [
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11755 | [
"As",
"well",
"as",
"culminating",
"in",
"the",
"inducible",
"phosphorylation",
"of",
"I",
"kappaB",
"alpha",
"on",
"serines",
"32",
"and",
"36",
",",
"all",
"the",
"stimuli",
"that",
"are",
"inactive",
"on",
"1.3E2",
"cells",
"exhibit",
"a",
"sensitivity",
"to",
"the",
"antioxidant",
"pyrrolidine",
"dithiocarbamate",
"(",
"PDTC",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11756 | [
"In",
"contrast",
",",
"stimuli",
"such",
"as",
"hyperosmotic",
"shock",
"or",
"phosphatase",
"inhibitors",
",",
"which",
"use",
"PDTC-insensitive",
"pathways",
",",
"induce",
"I",
"kappaB",
"alpha",
"degradation",
"in",
"1.3E2",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
5,
0
] |
11757 | [
"Analysis",
"of",
"the",
"redox",
"status",
"of",
"1.3E2",
"does",
"not",
"reveal",
"any",
"difference",
"from",
"wild-type",
"70Z/3",
"."
] | [
0,
0,
0,
0,
0,
0,
5,
0,
0,
0,
0,
0,
0,
0,
5,
0
] |
11758 | [
"We",
"also",
"report",
"that",
"the",
"human",
"T-cell",
"leukemia",
"virus",
"type",
"1",
"(",
"HTLV-1",
")",
"-derived",
"Tax",
"trans-activator",
"induces",
"NF-kappaB",
"activity",
"in",
"1.3E2",
",",
"suggesting",
"that",
"this",
"viral",
"protein",
"does",
"not",
"operate",
"via",
"the",
"defective",
"pathway",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11759 | [
"Finally",
",",
"we",
"show",
"that",
"two",
"other",
"I",
"kappaB",
"molecules",
",",
"I",
"kappaB",
"beta",
"and",
"the",
"recently",
"identified",
"I",
"kappaB",
"epsilon",
",",
"are",
"not",
"degraded",
"in",
"the",
"1.3E2",
"cell",
"line",
"following",
"stimulation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
10,
10,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
0,
0
] |
11760 | [
"Our",
"results",
"demonstrate",
"that",
"1.3E2",
"is",
"a",
"cellular",
"transduction",
"mutant",
"exhibiting",
"a",
"defect",
"in",
"a",
"step",
"that",
"is",
"required",
"by",
"several",
"different",
"stimuli",
"to",
"activate",
"NF-kappaB",
"."
] | [
0,
0,
0,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
11761 | [
"In",
"addition",
",",
"this",
"analysis",
"suggests",
"a",
"common",
"step",
"in",
"the",
"signaling",
"pathways",
"that",
"trigger",
"I",
"kappaB",
"alpha",
",",
"I",
"kappaB",
"beta",
",",
"and",
"I",
"kappaB",
"epsilon",
"degradation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
10,
10,
0,
0,
9,
10,
10,
0,
0
] |
11762 | [
"Involvement",
"of",
"Egr-1",
"/RelA",
"synergy",
"in",
"distinguishing",
"T",
"cell",
"activation",
"from",
"tumor",
"necrosis",
"factor-alpha",
"-induced",
"NF-kappa",
"B1",
"transcription",
"."
] | [
0,
0,
9,
10,
0,
0,
0,
7,
8,
0,
0,
9,
10,
10,
0,
9,
10,
0,
0
] |
11763 | [
"NF-kappa",
"B",
"is",
"an",
"important",
"transcription",
"factor",
"required",
"for",
"T",
"cell",
"proliferation",
"and",
"other",
"immunological",
"functions",
"."
] | [
9,
10,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0
] |
11764 | [
"The",
"NF-kappa",
"B1",
"gene",
"encodes",
"a",
"105-kD",
"protein",
"that",
"is",
"the",
"precursor",
"of",
"the",
"p50",
"component",
"of",
"NF-kappa",
"B",
"."
] | [
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
10,
0
] |
11765 | [
"Previously",
",",
"we",
"and",
"others",
"have",
"demonstrated",
"that",
"NF-kappa",
"B",
"regulates",
"the",
"NF-kappa",
"B1",
"gene",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
1,
2,
2,
0
] |
11766 | [
"In",
"this",
"manuscript",
"we",
"have",
"investigated",
"the",
"molecular",
"mechanisms",
"by",
"which",
"T",
"cell",
"lines",
"stimulated",
"with",
"phorbol",
"12-myristate",
"13-acetate",
"(",
"PMA",
")",
"and",
"phytohemagglutin",
"(",
"PHA",
")",
"display",
"significantly",
"higher",
"levels",
"of",
"NF-kappa",
"B1",
"encoding",
"transcripts",
"than",
"cells",
"stimulated",
"with",
"tumor",
"necrosis",
"factor-alpha",
",",
"despite",
"the",
"fact",
"that",
"both",
"stimuli",
"activate",
"NF-kappa",
"B",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
11767 | [
"Characterization",
"of",
"the",
"NF-kappa",
"B1",
"promoter",
"identified",
"an",
"Egr-1",
"site",
"which",
"was",
"found",
"to",
"be",
"essential",
"for",
"both",
"the",
"PMA/",
"PHA",
"-mediated",
"induction",
"as",
"well",
"as",
"the",
"synergistic",
"activation",
"observed",
"after",
"the",
"expression",
"of",
"the",
"RelA",
"subunit",
"of",
"NF-kappa",
"B",
"and",
"Egr-1",
"."
] | [
0,
0,
0,
1,
2,
2,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
10,
0,
9,
0
] |
11768 | [
"Furthermore",
",",
"Egr-1",
"induction",
"was",
"required",
"for",
"endogenous",
"NF-kappa",
"B1",
"gene",
"expression",
",",
"since",
"PMA/",
"PHA-stimulated",
"T",
"cell",
"lines",
"expressing",
"antisense",
"Egr-1",
"RNA",
"were",
"inhibited",
"in",
"their",
"ability",
"to",
"upregulate",
"NF-kappa",
"B1",
"transcription",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
5,
6,
6,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0
] |
11769 | [
"Our",
"studies",
"indicate",
"that",
"transcriptional",
"synergy",
"mediated",
"by",
"activation",
"of",
"both",
"Egr-1",
"and",
"NF-kappa",
"B",
"may",
"have",
"important",
"ramifications",
"in",
"T",
"cell",
"development",
"by",
"upregulating",
"NF-kappa",
"B1",
"gene",
"expression",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
10,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
1,
2,
2,
0,
0
] |
11770 | [
"The",
"synthesis",
"and",
"immunogenicity",
"of",
"varicella-zoster",
"virus",
"glycoprotein",
"E",
"and",
"immediate-early",
"protein",
"(",
"IE62",
")",
"expressed",
"in",
"recombinant",
"herpes",
"simplex",
"virus-1",
"."
] | [
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0
] |
11771 | [
"In",
"order",
"to",
"evaluate",
"the",
"conditions",
"for",
"optimal",
"expression",
"and",
"immunogenicity",
"of",
"varicella-zoster",
"virus",
"(",
"VZV",
")",
"proteins",
"in",
"a",
"herpes",
"simplex",
"virus-1",
"(",
"HSV-1",
")",
"vector",
",",
"we",
"selected",
"the",
"VZV",
"glycoprotein",
"E",
"(",
"gE",
")",
",",
"encoded",
"by",
"ORF",
"68",
"and",
"the",
"VZV",
"product",
"of",
"ORF",
"62",
",",
"an",
"immediate-early",
"major",
"tegument",
"protein",
"(",
"IE62",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0
] |
11772 | [
"Three",
"HSV/VZV",
"recombinants",
"were",
"generated",
":",
"(",
"1",
")",
"VZV",
"gE",
"protein",
"coding",
"sequences",
"along",
"with",
"the",
"promoter",
"region",
"were",
"inserted",
"into",
"the",
"thymidine",
"kinase",
"(",
"TK",
")",
"gene",
"of",
"HSV-1",
"strain",
"KOS",
";",
"(",
"2",
")",
"VZV",
"gE",
"expressed",
"from",
"the",
"HSV-1",
"ICP4",
"promoter",
"was",
"inserted",
"into",
"the",
"glycoprotein",
"C",
"(",
"gC",
")",
"gene",
"of",
"HSV-1",
"strain",
"F",
";",
"and",
"(",
"3",
")",
"VZV",
"IE62",
"protein",
"coding",
"sequences",
"under",
"the",
"control",
"of",
"the",
"HSV-1",
"ICP4",
"promoter",
"were",
"inserted",
"into",
"the",
"gC",
"gene",
"of",
"HSV-1",
"strain",
"F",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0
] |
11773 | [
"Immunoblot",
"analysis",
"and",
"immunoperoxidase",
"staining",
"of",
"infected",
"cell",
"monolayers",
"demonstrated",
"vector",
"expression",
"of",
"VZV",
"proteins",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11774 | [
"Following",
"intracranial",
"inoculation",
"in",
"mice",
",",
"both",
"VZV",
"gE-HSV",
"(",
"TK",
")",
"and",
"VZV",
"IE62-HSV",
"(",
"gC",
")",
"induced",
"an",
"IgG",
"response",
"against",
"VZV",
"gE",
"or",
"VZV",
"IE62",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
9,
10,
0,
9,
0,
0,
0,
9,
0,
0,
9,
10,
0,
9,
10,
0
] |
11775 | [
"When",
"tested",
"in",
"cytotoxicity",
"assays",
"using",
"T-lymphocytes",
"from",
"VZV",
"immune",
"human",
"donors",
",",
"the",
"range",
"of",
"precursor",
"frequencies",
"for",
"T-lymphocytes",
"that",
"recognized",
"VZV",
"gE",
"or",
"VZV",
"IE62",
"was",
"similar",
"whether",
"these",
"proteins",
"were",
"expressed",
"by",
"HSV-1",
"or",
"a",
"vaccinia",
"vector",
"."
] | [
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
9,
10,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11776 | [
"These",
"experiments",
"demonstrate",
"that",
"HSV-1",
"is",
"a",
"competent",
"vector",
"for",
"expression",
"of",
"these",
"VZV",
"proteins",
"and",
"support",
"the",
"feasibility",
"of",
"engineering",
"a",
"combined",
"vaccine",
"for",
"these",
"closely",
"related",
"alpha-herpesviruses",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11777 | [
"Constitutive",
"dephosphorylation",
"and",
"activation",
"of",
"a",
"member",
"of",
"the",
"nuclear",
"factor",
"of",
"activated",
"T",
"cells",
",",
"NF-AT1",
",",
"in",
"Tax-expressing",
"and",
"type",
"I",
"human",
"T-cell",
"leukemia",
"virus-infected",
"human",
"T",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0
] |
11778 | [
"The",
"tax",
"gene",
"product",
"of",
"the",
"type",
"I",
"human",
"T-cell",
"leukemia",
"virus",
"(",
"HTLV-I",
")",
"transactivates",
"interleukin-2",
"(",
"IL-2",
")",
"gene",
"through",
"activation",
"of",
"an",
"enhancer",
"termed",
"CD28",
"responsive",
"element",
"(",
"CD28RE",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
0,
0
] |
11779 | [
"Tax",
"activation",
"of",
"the",
"CD28RE",
"is",
"partially",
"mediated",
"by",
"a",
"member",
"of",
"the",
"nuclear",
"factor",
"of",
"activated",
"T",
"cells",
",",
"NF-AT1",
"."
] | [
9,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
0,
9,
0
] |
11780 | [
"We",
"have",
"previously",
"shown",
"that",
"NF-AT1",
"is",
"constitutively",
"active",
"in",
"Jurkat",
"T",
"cells",
"stably",
"transfected",
"with",
"the",
"Tax",
"cDNA",
",",
"although",
"the",
"underlying",
"molecular",
"mechanism",
"and",
"physiological",
"relevance",
"of",
"this",
"finding",
"remain",
"unclear",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11781 | [
"In",
"this",
"report",
",",
"we",
"demonstrate",
"that",
"the",
"active",
"form",
"of",
"NF-AT1",
"is",
"also",
"present",
"in",
"the",
"nuclei",
"of",
"HTLV-I-transformed",
"T",
"cells",
"that",
"express",
"the",
"Tax",
"protein",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
9,
10,
0
] |
11782 | [
"Interestingly",
",",
"the",
"constitutive",
"activation",
"of",
"NF-AT1",
"in",
"these",
"T",
"cells",
"is",
"associated",
"with",
"its",
"dephosphorylation",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0
] |
11783 | [
"Furthermore",
",",
"the",
"dephosphorylated",
"NF-AT1",
"can",
"be",
"rapidly",
"rephosphorylated",
"when",
"the",
"cells",
"are",
"incubated",
"with",
"cyclosporin",
"A",
",",
"an",
"immunosuppressant",
"inhibiting",
"the",
"serine/threonine",
"phosphatase",
"calcineurin",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0
] |
11784 | [
"These",
"results",
"suggest",
"that",
"activation",
"of",
"NF-AT1",
"in",
"Tax-expressing",
"and",
"HTLV-I-transformed",
"T",
"cells",
"results",
"from",
"its",
"dephosphorylation",
",",
"which",
"in",
"turn",
"may",
"be",
"due",
"to",
"deregulation",
"of",
"calcineurin"
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9
] |
11785 | [
"Expression",
"of",
"NFAT-family",
"proteins",
"in",
"normal",
"human",
"T",
"cells",
"."
] | [
0,
0,
9,
10,
0,
0,
7,
8,
8,
0
] |
11786 | [
"NFAT",
"proteins",
"constitute",
"a",
"family",
"of",
"transcription",
"factors",
"involved",
"in",
"mediating",
"signal",
"transduction",
"."
] | [
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11787 | [
"Using",
"a",
"panel",
"of",
"specific",
"antisera",
"in",
"immunoprecipitation",
"assays",
",",
"we",
"found",
"that",
"NFATp",
"(",
"135",
"kDa",
")",
"is",
"constitutively",
"expressed",
"in",
"normal",
"human",
"T",
"cells",
",",
"while",
"synthesis",
"of",
"NFATc",
"(",
"predominant",
"form",
"of",
"86",
"kDa",
")",
"is",
"induced",
"by",
"ionomycin",
"treatment",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11788 | [
"NFAT4/x",
"was",
"very",
"weakly",
"expressed",
"in",
"unstimulated",
"cells",
",",
"and",
"its",
"level",
"did",
"not",
"increase",
"upon",
"treatment",
"with",
"activating",
"agents",
"."
] | [
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11789 | [
"NFAT3",
"protein",
"was",
"not",
"observed",
"under",
"any",
"conditions",
"."
] | [
9,
10,
0,
0,
0,
0,
0,
0,
0
] |
11790 | [
"Higher-molecular-weight",
"species",
"of",
"NFATc",
"(",
"of",
"110",
"and",
"140",
"kDa",
")",
"were",
"also",
"detected",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11791 | [
"In",
"addition",
",",
"translation",
"of",
"NFATc",
"mRNA",
"apparently",
"initiates",
"at",
"two",
"different",
"AUG",
"codons",
",",
"giving",
"rise",
"to",
"proteins",
"that",
"differ",
"in",
"size",
"by",
"36",
"amino",
"acids",
"."
] | [
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11792 | [
"Additional",
"size",
"heterogeneity",
"of",
"both",
"NFATc",
"and",
"NFATp",
"results",
"from",
"phosphorylation",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0
] |
11793 | [
"In",
"contrast",
"to",
"ionomycin",
"treatment",
",",
"exposure",
"of",
"cells",
"to",
"phorbol",
"myristate",
"acetate",
"(",
"PMA",
")",
"plus",
"anti-CD28",
"did",
"not",
"induce",
"NFATc",
",",
"indicating",
"that",
"under",
"these",
"conditions",
",",
"interleukin-2",
"synthesis",
"by",
"these",
"cells",
"is",
"apparently",
"independent",
"of",
"NFATc",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
11794 | [
"In",
"DNA",
"binding",
"assays",
",",
"both",
"PMA",
"plus",
"anti-CD28",
"and",
"PMA",
"plus",
"ionomycin",
"resulted",
"in",
"nuclear",
"NFAT",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
11795 | [
"Surprisingly",
",",
"the",
"PMA-ionomycin-induced",
"synthesis",
"of",
"NFATc",
"that",
"was",
"detected",
"by",
"immunoprecipitation",
"was",
"not",
"mirrored",
"in",
"the",
"DNA",
"binding",
"assays",
":",
"nearly",
"all",
"of",
"the",
"activity",
"was",
"due",
"to",
"NFATp",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
11796 | [
"This",
"is",
"the",
"first",
"study",
"of",
"expression",
"of",
"all",
"family",
"members",
"at",
"the",
"protein",
"level",
"in",
"normal",
"human",
"T",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0
] |
11797 | [
"Of",
"the",
"GATA-binding",
"proteins",
",",
"only",
"GATA-4",
"selectively",
"regulates",
"the",
"human",
"IL-5",
"gene",
"promoter",
"in",
"IL-5",
"producing",
"cells",
"which",
"express",
"multiple",
"GATA-binding",
"proteins",
"."
] | [
0,
0,
9,
10,
0,
0,
9,
0,
0,
0,
1,
2,
2,
2,
0,
9,
0,
0,
0,
0,
0,
9,
10,
0
] |
11798 | [
"Interleukin-5",
"(",
"IL-5",
")",
"is",
"produced",
"by",
"T",
"lymphocytes",
"and",
"known",
"to",
"support",
"B",
"cell",
"growth",
"and",
"eosinophilic",
"differentiation",
"of",
"the",
"progenitor",
"cells",
"."
] | [
9,
0,
9,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11799 | [
"Using",
"ATL-16T",
"cells",
"which",
"express",
"IL-5",
"mRNA",
",",
"we",
"have",
"identified",
"a",
"region",
",",
"within",
"the",
"human",
"IL-5",
"gene",
"promoter",
",",
"that",
"regulates",
"IL-5",
"gene",
"transcription",
"."
] | [
0,
5,
6,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
1,
2,
0,
0
] |
11800 | [
"This",
"cis-acting",
"sequence",
"contains",
"the",
"core",
"binding",
"motif",
",",
"(",
"A/T",
")",
"GATA",
"(",
"A/G",
")",
",",
"for",
"GATA-binding",
"family",
"proteins",
"and",
"thus",
"suggests",
"the",
"involvement",
"of",
"these",
"family",
"members",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.