Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
11601
[ "Inefficient", "DNA", "replication", "is", "also", "found", "in", "another", "monocyte", "cell", "line", ",", "THP-1" ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 5 ]
11602
[ "Activation", "of", "Ras", "and", "mitogen-activated", "protein", "kinase", "pathway", "by", "terminal", "complement", "complexes", "is", "G", "protein", "dependent", "." ]
[ 0, 0, 9, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11603
[ "Assembly", "of", "terminal", "complement", "complexes", "(", "TCC", ")", "C5b-7", ",", "C5b-8", ",", "and", "C5b-9", "on", "target", "cells", "during", "acute", "and", "chronic", "inflammation", "induces", "hydrolysis", "of", "plasma", "membrane", "phospholipids", "and", "heterotrimeric", "G", "protein", "activation", "." ]
[ 0, 0, 9, 10, 10, 0, 9, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11604
[ "TCC", "also", "stimulate", "a", "variety", "of", "cellular", "activities", ",", "which", "include", "cytokine", "synthesis", ",", "proto-oncogene", "activation", ",", "and", "mitotic", "signaling", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11605
[ "Now", "we", "report", "that", "sublytic", "TCC", "induced", "Ras", ",", "Raf-1", ",", "and", "extracellular", "signal-regulated", "kinase", "(", "ERK", ")", "1", "activation", "in", "JY25", "B", "cell", "line", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0 ]
11606
[ "When", "cells", "were", "exposed", "to", "C5b-9", ",", "GTP-bound", "Ras", "in", "anti-C5b-9", "immunoprecipitates", "was", "increased", "3.2-fold", "at", "2", "min", ",", "while", "GTP-bound", "Ras", "in", "anti-Ras", "immunoprecipitates", "was", "increased", "2-fold", "at", "10", "min", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
11607
[ "Both", "C5b-9", "and", "C5b-7", ",", "but", "not", "C5b6", ",", "increased", "Raf-1", "kinase", "activity", "maximum", "3.3-fold", "at", "2", "min", "and", "2.8-fold", "at", "5", "min", ",", "respectively", "." ]
[ 0, 9, 0, 9, 0, 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11608
[ "ERK1", "activity", "was", "2-fold", "increased", "by", "C5b-9", "at", "2", "min", "and", "by", "C5b-7", "at", "10", "min", ",", "over", "the", "C5b6", "level", "." ]
[ 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
11609
[ "The", "role", "of", "mitogen-activated", "protein", "kinase", "(", "MAPK", ")", "pathway", "on", "TCC", "-inducible", "mitotic", "signaling", "was", "evaluated", "by", "assessing", "DNA", "synthesis", "and", "activator", "protein", "1", "(", "AP-1", ")", "DNA-binding", "activity", "." ]
[ 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0 ]
11610
[ "The", "MAPK/ERK-specific", "inhibitor", "PD", "098", ",", "059", "abolished", "the", "C5b-9", "-induced", "DNA", "synthesis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0 ]
11611
[ "Involvement", "of", "G", "protein", "in", "the", "activation", "of", "MAPK", "pathway", "by", "TCC", "was", "indicated", "by", "inhibition", "of", "Raf-1", "and", "ERK1", "kinase", "activity", ",", "as", "well", "as", "the", "DNA", "synthesis", "by", "pretreatment", "of", "cells", "with", "pertussis", "toxin", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11612
[ "Overexpression", "of", "beta-adrenergic", "receptor", "kinase", "1", "carboxyl-terminal", "peptide", "in", "JY25", "cells", "also", "inhibited", "Raf-1", "and", "ERK1", "activity", ",", "indicating", "a", "direct", "involvement", "of", "G", "betagamma", "subunits", "in", "the", "signal", "transduction", "generated", "through", "activation", "of", "MAPK", "pathway", "by", "TCC", "assembly", "in", "the", "plasma", "membrane", "." ]
[ 0, 0, 9, 10, 10, 10, 0, 0, 0, 5, 6, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
11613
[ "Spontaneous", "occurrence", "of", "early", "region", "1A", "reiteration", "mutants", "of", "type", "5", "adenovirus", "in", "persistently", "infected", "human", "T-lymphocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
11614
[ "Mutants", "of", "type", "5", "adenovirus", "(", "Ad5", ")", "with", "reiterated", "DNA", "sequences", "in", "the", "E1a", "region", "appeared", "in", "a", "human", "T-lymphocyte", "cell", "line", ",", "Molt-4", ",", "persistently", "infected", "with", "H5sub304", ",", "a", "deletion/substitution", "mutant", "that", "has", "a", "wild-type", "phenotype", "in", "viral", "replication", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 5, 6, 6, 6, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11615
[ "Endonuclease", "analyses", "and", "DNA", "sequencing", "revealed", "DNA", "reiteration", "in", "each", "mutant", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11616
[ "In", "the", "four", "representative", "mutants", "investigated", ",", "the", "DNA", "reiterations", "all", "started", "within", "a", "six-base-pair", "consensus", "sequence", ",", "G", "(", "or", "C", ")", "CTGTG", ",", "located", "in", "the", "second", "exon", "of", "the", "E1a", "region", "(", "at", "nt", "1333", ",", "1367", ",", "or", "1419", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11617
[ "There", "was", "not", "any", "DNA", "homology", "between", "the", "breakpoints", "in", "the", "second", "exon", "and", "the", "inserting", "sequences", "(", "starting", "at", "nt", "532", ",", "710", ",", "or", "792", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11618
[ "Northern", "analyses", "suggested", "that", "the", "reiterated", "splicing", "sites", "of", "the", "representative", "mutants", "were", "all", "used", "in", "RNA", "splicing", ",", "and", "the", "closest", "donor", "and", "recipient", "joints", "were", "used", "most", "frequently", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11619
[ "These", "observations", "imply", "that", "during", "persistent", "infection", "Ad5", "underwent", "spontaneous", "mutations", "by", "sequence-specific", "breakage", "and", "nonhomologous", "end-end", "joining", "recombination", "events", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11620
[ "These", "E1a", "reiteration", "mutants", "could", "be", "propagated", "in", "HeLa", ",", "A549", ",", "and", "KB", "cells", ";", "they", "were", "genetically", "stable", ";", "and", "they", "killed", "CREF", "cells", "at", "a", "strikingly", "high", "frequency", "." ]
[ 0, 1, 0, 0, 0, 0, 0, 0, 5, 0, 5, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0 ]
11621
[ "Preliminary", "observations", "tend", "to", "correlate", "this", "CREF", "cell", "killing", "with", "the", "accumulation", "of", "the", "early", "viral", "proteins", "and/or", "viral", "DNA", "in", "the", "infected", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11622
[ "This", "degree", "of", "cell", "damage", "was", "not", "observed", "in", "Ad5wt", "or", "H5sub304", "infection", "of", "CREF", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]
11623
[ "The", "observed", "E1a", "reiterations", "provide", "a", "model", "to", "gain", "insight", "into", "understanding", "the", "evolutionary", "events", "of", "some", ",", "if", "not", "all", ",", "adenovirus", "types", "during", "many", "years", "of", "symbiotic", ",", "persistent", "relationship", "in", "human", "tonsils", "and", "adenoids", "and", "possibly", "other", "lymphoid", "organs", "." ]
[ 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11624
[ "Preferential", "presentation", "of", "herpes", "simplex", "virus", "T-cell", "antigen", "by", "HLA", "DQA1*0501/DQB1*0201", "in", "comparison", "to", "HLA", "DQA1*0201/DQB1*0201", "." ]
[ 0, 0, 0, 9, 10, 10, 10, 10, 0, 9, 10, 0, 0, 0, 9, 10, 0 ]
11625
[ "The", "HLA", "DQA1", "locus", "is", "polymorphic", "." ]
[ 0, 1, 2, 2, 0, 0, 0 ]
11626
[ "Haplotypes", "containing", "HLA", "DQA1*0501", ",", "but", "not", "HLA", "DQA1*0201", ",", "together", "with", "HLA", "DQB1*0201", "are", "associated", "with", "Grave", "'s", "disease", "and", "celiac", "sprue", "." ]
[ 0, 0, 1, 2, 0, 0, 0, 1, 2, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11627
[ "In", "this", "report", ",", "we", "demonstrate", "a", "functional", "correlate", "of", "DQA1", "polymorphism", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
11628
[ "T", "cells", "infiltrating", "a", "herpes", "simplex", "virus", "(", "HSV", ")", "lesion", "from", "a", "HLA", "DQ", "2", ",", "7", "individual", "yielded", "a", "virus-specific", "CD4+", "clone", "restricted", "by", "DQ2", "." ]
[ 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
11629
[ "Presentation", "of", "viral", "peptide", "and", "protein", "segregated", "with", "DQA1", "allele", ",", "because", "cell", "lines", "bearing", "DQA1*0501/DQB1*0201", "heterodimers", "presented", "antigen", "in", "proliferation", "and", "cytotoxicity", "assays", "much", "more", "efficiently", "than", "cell", "lines", "bearing", "DQA1*0201/DQB1*0201", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
11630
[ "Binding", "of", "viral", "peptide", "to", "cell", "lines", "bearing", "DQA1*0201", ",", "in", "comparison", "to", "DQA1*0501", ",", "was", "only", "moderately", "reduced", "and", "may", "not", "explain", "this", "effect", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11631
[ "Truncation", "and", "substitution", "analyses", "of", "peptide", "binding", "and", "T-cell", "activation", "were", "performed", "to", "determine", "which", "viral", "peptide", "residues", "contacting", "TCR", "might", "therefore", "be", "presented", "in", "an", "altered", "conformation", "by", "DQA1*0201/DQB1*0201", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
11632
[ "Residues", "432", ",", "435", ",", "437", ",", "438", ",", "and", "440", "(", "position", "P1", ",", "P4", ",", "P6", ",", "P7", ",", "and", "P9", ")", "contributed", "to", "DQ2", "binding", ",", "whereas", "residues", "431", ",", "433", ",", "434", ",", "and", "436", "(", "positions", "P", "1", ",", "P2", ",", "P3", ",", "and", "P5", ")", "contributed", "to", "TCR", "contact", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
11633
[ "Differential", "presentation", "of", "peptide", "by", "HLA", "DQ2", "heterodimers", "varying", "at", "the", "DQA1", "locus", "may", "have", "relevance", "to", "host", "defense", "and", "the", "pathogenesis", "of", "HLA", "DQ2", "-associated", "autoimmune", "diseases", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0 ]
11634
[ "Inhibitor", "(", "IK", ")", "of", "IFN-gamma", "induced", "HLA", "class", "II", "antigens", "expression", "also", "inhibits", "HLA", "class", "II", "constitutive", "expression", "in", "the", "human", "Raji", "B", "cell", "line", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 10, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0 ]
11635
[ "The", "expression", "of", "major", "histocompatibility", "complex", "(", "MHC", ")", "class", "II", "antigens", "is", "constitutive", "in", "professional", "antigen", "presenting", "cells", "(", "APCs", ")", "but", "can", "also", "be", "induced", "by", "interferon-gamma", "(", "IFN-gamma", ")", "on", "the", "majority", "of", "the", "non", "professional", "APCs", "(", "e.g", ".", "fibroblasts", ")", "." ]
[ 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0 ]
11636
[ "We", "have", "recently", "characterised", "a", "new", "factor", "called", "IK", "which", "is", "an", "efficient", "inhibitor", "of", "IFN-gamma", "induction", "of", "MHC", "class", "II", "antigens", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 10, 10, 0, 0 ]
11637
[ "Here", ",", "we", "demonstrate", "a", "novel", "role", "for", "IK", "in", "MHC", "class", "II", "expression", "since", "over-expression", "of", "this", "protein", "by", "stable", "transfection", "into", "human", "B", "cells", "led", "to", "a", "total", "disappearance", "of", "constitutive", "MHC", "class", "II", "mRNA", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 0 ]
11638
[ "The", "class", "II", "transactivator", "(", "CIITA", ")", "is", "necessary", "for", "both", "constitutive", "and", "IFN-gamma", "induced", "MHC", "class", "II", "expressions", "." ]
[ 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0, 0 ]
11639
[ "Examination", "of", "CIITA", "mRNA", "in", "IK", "stably", "transfected", "clones", "revealed", "a", "marked", "reduction", "of", "CIITA", "mRNA", "transcription", "." ]
[ 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0 ]
11640
[ "Taken", "together", "these", "results", "demonstrate", "that", "the", "IK", "protein", "plays", "a", "key", "role", "in", "the", "constitutive", "expression", "of", "MHC", "class", "II", "antigens", "and", "that", "inhibition", "induced", "by", "IK", "is", "upstream", "of", "CIITA", "in", "this", "regulatory", "pathway", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0 ]
11641
[ "Selective", "expression", "of", "an", "interleukin-12", "receptor", "component", "by", "human", "T", "helper", "1", "cells", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 0, 7, 8, 8, 8, 8, 0 ]
11642
[ "Interleukin-12", "(", "IL-12", ")", ",", "a", "heterodimeric", "cytokine", "produced", "by", "activated", "monocytes", "and", "dendritic", "cells", ",", "plays", "a", "crucial", "role", "in", "regulating", "interferon", "(", "IFN", ")", "-gamma", "production", "and", "in", "the", "generation", "of", "IFN-gamma-producing", "T", "helper", "1", "(", "Th1", ")", "cells", "." ]
[ 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 8, 8, 0 ]
11643
[ "Here", "we", "show", "that", "the", "IL-12", "receptor", "(", "IL-12R", ")", "beta", "2", "subunit", ",", "a", "recently", "cloned", "binding", "and", "signal", "transducing", "component", "of", "the", "IL-12R", ",", "is", "expressed", "on", "human", "Th1", "but", "not", "Th2", "clones", "and", "is", "induced", "during", "differentiation", "of", "human", "naive", "cells", "along", "the", "Th1", "but", "not", "the", "Th2", "pathway", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 7, 8, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 7, 0, 0 ]
11644
[ "IL-12", "and", "type", "I", "but", "not", "type", "II", "interferons", "induce", "expression", "of", "the", "IL-12R", "beta", "2", "chain", "during", "in", "vitro", "T", "cell", "differentiation", "after", "antigen", "receptor", "triggering", "." ]
[ 9, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0 ]
11645
[ "The", "selective", "expression", "and", "regulation", "of", "the", "IL-12R", "beta", "2", "subunit", "may", "help", "to", "understand", "the", "basis", "of", "Th1/Th2", "differentiation", "and", "may", "provide", "therapeutic", "options", "for", "altering", "the", "Th1/Th2", "balance", "in", "several", "immuno-pathological", "conditions", "such", "as", "autoimmune", "diseases", "and", "allergies", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11646
[ "The", "T", "cell", "activation", "factor", "NF-ATc", "positively", "regulates", "HIV-1", "replication", "and", "gene", "expression", "in", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
11647
[ "Clinical", "deterioration", "in", "human", "immunodeficiency", "virus", "type", "1", "(", "HIV-1", ")", "infection", "is", "associated", "with", "increased", "levels", "of", "viral", "replication", "and", "burden", "in", "the", "peripheral", "blood", "and", "lymphoid", "organs", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11648
[ "T", "cell", "activation", "and", "ensuing", "cellular", "gene", "activation", "can", "be", "critical", "for", "HIV-1", "replication", "." ]
[ 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11649
[ "The", "hypothesis", "that", "the", "nuclear", "factor", "of", "activated", "T", "cells", "(", "NF-AT", ")", "may", "influence", "HIV-1", "replication", "is", "therefore", "compelling", "given", "the", "tight", "correlation", "of", "HIV-1", "transcriptional", "induction", "to", "T", "cell", "activation", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0 ]
11650
[ "We", "report", "that", "certain", "NF-AT", "(", "Rel", ")", "family", "members", "productively", "bind", "the", "kappaB", "regulatory", "elements", ",", "synergize", "with", "NF-kappaB", "and", "Tat", "in", "transcriptional", "activation", "of", "HIV-1", ",", "and", "enhance", "HIV-1", "replication", "in", "T", "cells", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 1, 2, 2, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
11651
[ "These", "results", "link", "regulatory", "factors", "critical", "to", "T", "cell", "commitment", "directly", "to", "HIV-1", "replication", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0 ]
11652
[ "Transcription", "mediated", "by", "NFAT", "is", "highly", "inducible", "in", "effector", "CD4+", "T", "helper", "2", "(", "Th2", ")", "cells", "but", "not", "in", "Th1", "cells", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 8, 8, 0, 0, 0, 7, 8, 0 ]
11653
[ "Transcriptional", "factors", "of", "the", "NFAT", "family", "play", "an", "important", "role", "in", "regulating", "the", "expression", "of", "several", "cytokine", "genes", "during", "the", "immune", "response", ",", "such", "as", "the", "genes", "for", "interleukin", "2", "(", "IL-2", ")", "and", "IL-4", ",", "among", "others", "." ]
[ 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 9, 0, 0, 0, 0 ]
11654
[ "Upon", "antigen", "stimulation", ",", "precursor", "CD4+", "T", "helper", "(", "pTh", ")", "cells", "proliferate", "and", "differentiate", "into", "two", "populations", "of", "effector", "cells", "(", "eTh1", "and", "eTh2", ")", ",", "each", "one", "expressing", "a", "specific", "pattern", "of", "cytokines", "that", "distinguishes", "them", "from", "their", "precursors", "." ]
[ 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11655
[ "eTh2", "cells", "are", "the", "major", "source", "of", "IL-4", ",", "while", "gamma", "interferon", "is", "produced", "by", "eTh1", "cells", "." ]
[ 7, 8, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 7, 8, 0 ]
11656
[ "Here", "we", "have", "used", "reporter", "transgenic", "mice", "to", "show", "that", "DNA", "binding", "and", "transcriptional", "activities", "of", "NFAT", "are", "transiently", "induced", "during", "the", "differentiation", "of", "pTh", "cells", "into", "either", "eTh1", "or", "eTh2", "cells", "to", "mediate", "the", "expression", "of", "IL-2", "as", "a", "common", "growth", "factor", "in", "both", "pathways", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 7, 0, 7, 8, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11657
[ "However", ",", "although", "NFAT", "DNA", "binding", "is", "similarly", "induced", "in", "both", "eTh1", "and", "eTh2", "cells", "upon", "antigen", "stimulation", ",", "only", "the", "NFAT", "complexes", "present", "in", "eTh2", "cells", "are", "able", "to", "mediate", "high-level", "transcription", ",", "and", "relatively", "little", "NFAT", "transcriptional", "activity", "was", "induced", "in", "eTh1", "cells", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 8, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 7, 8, 0 ]
11658
[ "In", "contrast", "to", "activated", "pTh", "cells", ",", "neither", "eTh1", "nor", "eTh2", "cells", "produced", "significant", "IL-2", "upon", "stimulation", ",", "but", "the", "high", "levels", "of", "NFAT", "transcriptional", "activities", "directly", "correlate", "with", "the", "IL-4", "production", "induced", "in", "response", "to", "antigen", "stimulation", "in", "eTh2", "cells", "." ]
[ 0, 0, 0, 0, 7, 8, 0, 0, 7, 0, 7, 8, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
11659
[ "These", "data", "suggest", "that", "activated", "NFAT", "is", "involved", "in", "the", "effector", "function", "of", "eTh2", "cells", "and", "that", "the", "failure", "of", "eTh1", "cells", "to", "produce", "IL-4", "in", "response", "to", "an", "antigen", "is", "due", ",", "at", "least", "partially", ",", "to", "a", "failure", "to", "induce", "high-level", "transcription", "of", "the", "IL-4", "gene", "by", "NFAT", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 7, 8, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 9, 0 ]
11660
[ "Regulation", "of", "NFAT", "could", "be", "therefore", "a", "critical", "element", "in", "the", "polarization", "to", "eTh1", "or", "eTh2", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 0 ]
11661
[ "Activation", "of", "the", "transcription", "factor", "NF-kappaB", "in", "lipopolysaccharide-stimulated", "U937", "cells", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 5, 6, 0 ]
11662
[ "During", "the", "course", "of", "serious", "bacterial", "infections", ",", "lipopolysaccharide", "(", "LPS", ")", "interacts", "with", "monocyte/macrophage", "receptors", ",", "resulting", "in", "the", "generation", "of", "inflammatory", "cytokines", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11663
[ "Transcription", "factor", "NF-kappaB", "is", "crucial", "in", "activating", "the", "transcription", "of", "genes", "encoding", "proinflammatory", "cytokines", "." ]
[ 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11664
[ "In", "this", "paper", ",", "we", "demonstrate", "that", "the", "activation", "of", "NF-kappaB", "by", "LPS", "in", "a", "promonocytic", "cell", "line", "(", "U937", ")", "followed", "a", "rather", "slow", "kinetics", ",", "depending", "on", "the", "rate", "of", "IkappaB-alpha", "inhibitor", "hydrolysis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 5, 6, 6, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
11665
[ "No", "degradation", "of", "p105", "and", "p100", "inhibitors", "was", "observed", "under", "these", "conditions", "." ]
[ 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
11666
[ "The", "transduction", "pathway", "leading", "to", "NF-kappaB", "activation", "in", "U937", "cells", "involved", "the", "intracellular", "generation", "of", "reactive", "oxygen", "species", "(", "ROS", ")", ",", "as", "demonstrated", "by", "the", "concomitant", "inhibitory", "effects", "of", "antioxidants", "on", "NF-kappaB", "activation", "and", "the", "emission", "of", "a", "fluorescent", "probe", "reacting", "intracellularly", "with", "hydrogen", "peroxide", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11667
[ "This", "ROS", "pathway", "was", "also", "characterized", "by", "the", "use", "of", "other", "inhibitors", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11668
[ "This", "finding", "indicates", "that", "phospholipase", "A2", "and", "5-lipoxygenase", "are", "also", "involved", "." ]
[ 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0 ]
11669
[ "However", ",", "the", "NF-kappaB", "activation", "pathway", "involving", "the", "acidic", "sphingomyelinase", "of", "the", "endolysosomial", "membrane", "did", "not", "seem", "to", "participate", "in", "the", "LPS-induced", "NF-kappaB", "activation", "in", "U937", "cells", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 5, 6, 0 ]
11670
[ "c-Rel", "is", "a", "target", "of", "pentoxifylline-mediated", "inhibition", "of", "T", "lymphocyte", "activation", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0 ]
11671
[ "The", "possible", "clinical", "use", "of", "the", "methyl", "xanthine", "derivative", ",", "pentoxifylline", "(", "PF", ")", ",", "for", "the", "treatment", "of", "T", "cell-dependent", "diseases", "is", "being", "noted", "with", "increasing", "interest", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11672
[ "In", "this", "paper", ",", "we", "studied", "the", "molecular", "consequences", "of", "PF", "treatment", "during", "lymphocyte", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0 ]
11673
[ "We", "found", "that", "in", "T", "cells", ",", "anti-CD3-induced", "c-Rel", "expression", "was", "blocked", "by", "PF", ",", "whereas", "the", "induction", "of", "other", "NF-kappaB", "family", "members", "was", "not", "significantly", "affected", "." ]
[ 0, 0, 0, 0, 7, 8, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0 ]
11674
[ "However", ",", "induction", "of", "NF-AT", ",", "which", "has", "the", "same", "signaling", "requirements", "as", "c-Rel", "induction", ",", "was", "not", "inhibited", "by", "PF", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
11675
[ "Among", "genes", "that", "respond", "to", "these", "transcription", "factors", ",", "IL-2", "mRNA", "induction", "was", "suppressed", "by", "PF", ",", "whereas", "IL-2R", "(", "alpha", ")", "chain", "mRNA", "induction", "was", "not", "affected", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 4, 0, 0, 0, 0, 0 ]
11676
[ "These", "observations", "implicated", "c-Rel", "as", "an", "IL-2", "promoter", "factor", ",", "for", "which", "experimental", "support", "was", "obtained", "from", "transient", "transfection", "experiments", "." ]
[ 0, 0, 0, 9, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11677
[ "In", "contrast", "with", "the", "observation", "in", "T", "cells", ",", "c-Rel", "induction", "was", "not", "blocked", "by", "PF", "in", "B", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 7, 8, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
11678
[ "The", "greater", "selectivity", "of", "PF", ",", "compared", "with", "FK506", ",", "at", "both", "the", "molecular", "and", "cellular", "levels", "may", "prove", "advantageous", "in", "manipulating", "T", "cell", "responses", "in", "vivo", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0 ]
11679
[ "V3", "loop", "of", "human", "immunodeficiency", "virus", "type", "1", "suppresses", "interleukin", "2", "-induced", "T", "cell", "growth", "[", "published", "erratum", "appears", "in", "AIDS", "Res", "Hum", "Retroviruses", "1997", "May", "1", ";", "13", "(", "7", ")", ":", "633", "]" ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11680
[ "We", "tested", "the", "effect", "of", "three", "linear", "or", "two", "loop", "peptides", "derived", "from", "the", "V3", "region", "of", "the", "HTLV-III", "BH10", "clone", "or", "the", "SF2", "strain", "of", "human", "immunodeficiency", "virus", "type", "1", "on", "IL-2", "-driven", "T", "cell", "proliferation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 8, 0, 0 ]
11681
[ "V3-BH10", ",", "which", "consists", "of", "42", "amino", "acids", "and", "has", "a", "loop", "structure", ",", "suppressed", "IL-2", "-driven", "proliferation", "of", "all", "IL-2-dependent", "cells", "[", "Kit225", ",", "ED-40515", "(", "+", ")", ",", "KT-3", ",", "7-day", "PHA-blasts", ",", "and", "fresh", "peripheral", "blood", "mononuclear", "cells", "]", "tested", ",", "whereas", "it", "did", "not", "suppress", "the", "cell", "growth", "of", "IL-2-independent", "cell", "lines", "(", "Hut102", ",", "Molt-4", ",", "and", "Jurkat", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 5, 0, 5, 6, 6, 6, 0, 5, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 5, 0, 0, 5, 0, 0 ]
11682
[ "This", "suppressive", "effect", "was", "also", "seen", "in", "IL-2", "-driven", "cell", "growth", "of", "CD8-positive", "lymphocytes", "purified", "from", "7-day", "PHA-blasts", ",", "indicating", "that", "CD4", "molecules", "were", "not", "required", "for", "the", "suppression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]
11683
[ "The", "treatment", "with", "anti-V3", "loop", "monoclonal", "antibody", "(", "902", "antibody", ")", "completely", "abolished", "the", "suppressive", "effect", "of", "V3-BH10", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11684
[ "In", "addition", ",", "V3-BH10", "generated", "the", "arrest", "of", "Kit225", "cells", "and", "also", "purified", "CD8-positive", "lymphocytes", "in", "G1", "phase", "in", "the", "presence", "of", "IL-2", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
11685
[ "Neither", "chromatin", "condensation", "nor", "DNA", "fragmentation", "was", "detected", "in", "Kit225", "cells", "cultured", "with", "V3-BH10", "and", "IL-2", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 9, 0 ]
11686
[ "V3-BH10", "neither", "blocked", "radiolabeled", "IL-2", "binding", "to", "IL-2", "receptors", "nor", "affected", "tyrosyl", "phosphorylation", "of", "several", "cellular", "proteins", "(", "p120", ",", "p98", ",", "p96", ",", "p54", ",", "and", "p38", ")", ",", "which", "is", "immediately", "induced", "by", "IL-2", "stimulation", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
11687
[ "However", ",", "V3-BH10", "enhanced", "IL-2", "-induced", "mRNA", "expression", "of", "c-fos", "but", "not", "c-myc", "or", "junB", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 1, 0, 0, 1, 0, 1, 0 ]
11688
[ "Thus", ",", "the", "binding", "of", "V3", "loop", "of", "gp120", "to", "the", "cell", "surface", "molecule", "(", "s", ")", "appears", "to", "affect", "intracellular", "IL-2", "signaling", ",", "which", "leads", "to", "the", "suppression", "of", "IL-2", "-induced", "T", "cell", "growth" ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 8, 0 ]
11689
[ "A", "negative", "role", "for", "phosphoinositide", "3-kinase", "in", "T-cell", "antigen", "receptor", "function", "." ]
[ 0, 0, 0, 0, 9, 10, 0, 9, 10, 10, 0, 0 ]
11690
[ "BACKGROUND", ":", "A", "delicate", "balance", "between", "positive", "and", "negative", "regulatory", "mechanisms", "during", "T-cell", "activation", "determines", "the", "specificity", "and", "magnitude", "of", "an", "immune", "response", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11691
[ "Phosphoinositide", "3-kinase", "(", "PI", "3-kinase", ")", "is", "activated", "by", "a", "diverse", "set", "of", "receptors", "that", "determine", "T-cell", "function", ",", "including", "the", "T-cell", "antigen", "receptor", "(", "TCR", ")", ",", "the", "costimulatory", "receptor", "CD28", ",", "and", "negative", "regulators", "of", "T-cell", "activation", "such", "as", "CTLA-4", "." ]
[ 9, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 7, 0, 0, 0, 9, 0 ]
11692
[ "PI", "3-kinase", "is", "also", "regulated", "by", "the", "haematopoietic", "cytokines", "that", "determine", "T-cell", "differentiation", "and", "lymphocyte", "proliferation", "." ]
[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 7, 0, 0 ]
11693
[ "PI", "3-kinase", "can", "thus", "dynamically", "influence", "the", "outcome", "of", "the", "immune", "reactions", "at", "various", "stages", "." ]
[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11694
[ "In", "this", "study", ",", "we", "investigated", "the", "importance", "of", "PI", "3-kinase", "in", "TCR", "-directed", "T-cell", "activation", "using", "activated", "or", "inhibitory", "versions", "of", "PI", "3-kinase", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 7, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
11695
[ "RESULTS", ":", "Certain", "aspects", "of", "TCR", "responses", "such", "as", "the", "induction", "of", "transcriptional", "activity", "of", "AP1", "and", "serum", "response", "factor", "were", "not", "affected", "by", "expression", "of", "the", "mutant", "forms", "of", "PI", "3-kinase", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
11696
[ "We", "found", ",", "however", ",", "that", "PI", "3-kinase", "profoundly", "influenced", "the", "transactivation", "capacity", "of", "'", "nuclear", "factor", "of", "activated", "T", "cells", "'", "(", "NF-AT", ")", "elicited", "by", "the", "TCR", ":", "expression", "of", "an", "activated", "form", "of", "PI", "3-kinase", "inhibited", "TCR", "-mediated", "NF-AT", "responses", ",", "whereas", "expression", "of", "a", "dominant", "negative", "mutant", "of", "PI", "3-kinase", "potently", "enhanced", "TCR", "-controlled", "NF-AT", "induction", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 0, 9, 0, 0 ]
11697
[ "These", "effects", "of", "PI", "3-kinase", "were", "not", "mediated", "by", "previously", "identified", "PI", "3-kinase", "effectors", ",", "such", "as", "protein", "kinase", "B", ",", "a", "positive", "regulator", "of", "PI", "3-kinase", ",", "or", "the", "GTPase", "Rac", ",", "and", "are", "therefore", "likely", "to", "involve", "a", "novel", ",", "as", "yet", "unknown", ",", "effector", "molecule", "." ]
[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11698
[ "CONCLUSIONS", ":", "Our", "results", "establish", "that", "PI", "3-kinase", "can", "both", "positively", "and", "negatively", "regulate", "T-cell", "function", ",", "and", "uncover", "a", "previously", "unrecognized", "function", "for", "PI", "3-kinase", "in", "T", "cells", "as", "a", "selective", "negative", "regulator", "of", "TCR", "-signalling", "events", "and", "therefore", "as", "a", "determinant", "of", "T-cell", "homeostasis", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0 ]
11699
[ "The", "Pax-5", "gene", "is", "alternatively", "spliced", "during", "B-cell", "development", "." ]
[ 0, 1, 2, 0, 0, 0, 0, 7, 0, 0 ]
11700
[ "The", "transcription", "factor", "Pax-5", "is", "expressed", "during", "the", "early", "stages", "of", "B-cell", "differentiation", "and", "influences", "the", "expression", "of", "several", "B-cell-specific", "genes", "." ]
[ 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]