Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
11401
[ "However", ",", "continuous", "treatments", "with", "subcytotoxic", "concentrations", "of", "etoposide", "(", "0.15", "microM", ")", "and", "ICRF-193", "(", "0.3", "microM", ")", "produced", "several", "similar", "effects", ",", "namely", "decreased", "cell", "proliferation", ",", "accumulation", "of", "cells", "at", "G2", ",", "increase", "in", "cell", "mass", ",", "and", "induction", "of", "differentiation", "." ]
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11402
[ "Under", "these", "conditions", ",", "etoposide", "produced", "a", "biphasic", "activation", "of", "protein", "kinase", "C", ",", "which", "consisted", "in", "an", "early", "transient", "activation", "(", "from", "hours", "1", "to", "6", ")", "of", "the", "membrane-bound", "enzyme", "followed", "by", "a", "later", "activation", "(", "hour", "48", ")", "of", "the", "total", ",", "membrane-bound", "and", "cytosolic", "enzyme", "." ]
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11403
[ "By", "contrast", ",", "ICRF-193", "only", "provoked", "a", "late", "activation", "(", "from", "hours", "72", "to", "96", ")", "of", "the", "total", "enzyme", "." ]
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11404
[ "When", "used", "at", "differentiation-inducing", "concentrations", ",", "both", "topoisomerase", "inhibitors", "caused", "a", "great", "stimulation", "of", "AP-1", "binding", "activity", ",", "with", "maximum", "value", "at", "hour", "12", "in", "etoposide-treated", "cells", "and", "at", "hour", "48", "in", "ICRF-193-treated", "cells", "." ]
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11405
[ "By", "contrast", ",", "the", "binding", "activity", "of", "the", "NF-kappa", "(", "B", ")", "and", "EGR-1", "transcription", "factors", "was", "little", "affected", "." ]
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11406
[ "It", "is", "concluded", "that", "topoisomerase", "II", "inhibitors", "may", "induce", "the", "differentiation", "of", "promonocytic", "cells", ",", "independently", "of", "their", "capacity", "to", "cause", "DNA", "strand", "breaks", "." ]
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11407
[ "However", ",", "there", "are", "other", "effects", ",", "such", "as", "the", "early", "activation", "of", "protein", "kinase", "C", ",", "which", "are", "probably", "derived", "from", "the", "production", "of", "primary", "DNA", "breakage", "by", "some", "anti-", "topoisomerase", "drugs", "." ]
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11408
[ "GATA-1", "DNA", "binding", "activity", "is", "down-regulated", "in", "late", "S", "phase", "in", "erythroid", "cells", "." ]
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11409
[ "We", "have", "set", "out", "to", "test", "a", "model", "for", "tissue-specific", "gene", "expression", "that", "relies", "on", "the", "early", "replication", "of", "expressed", "genes", "to", "sequester", "limiting", "activating", "transcription", "factors", "." ]
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11410
[ "Using", "an", "erythroid", "cell", "line", ",", "we", "have", "tested", "the", "changes", "in", "the", "DNA", "binding", "activity", "of", "the", "lineage-restricted", "transcription", "factor", "GATA-1", "through", "the", "cell", "cycle", "." ]
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11411
[ "We", "find", "that", "GATA-1", "activity", "is", "low", "in", "G1", ",", "peaks", "in", "mid-S", "phase", ",", "and", "then", "decreases", "in", "G2/M", "." ]
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11412
[ "In", "contrast", ",", "the", "binding", "activities", "of", "two", "ubiquitous", "transcription", "factors", ",", "Oct1", "and", "Sp1", ",", "remain", "high", "in", "G2/M", "." ]
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11413
[ "GATA-1", "protein", "and", "mRNA", "vary", "in", "a", "similar", "manner", "through", "the", "cell", "cycle", ",", "suggesting", "that", "the", "expression", "of", "the", "gene", "or", "the", "stability", "of", "its", "message", "is", "regulated", "." ]
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11414
[ "Although", "a", "number", "of", "transcription", "factors", "involved", "in", "the", "control", "of", "the", "cell", "cycle", "or", "DNA", "replication", "have", "been", "shown", "to", "peak", "in", "S", "phase", ",", "this", "is", "the", "first", "example", "of", "a", "lineage-restricted", "transcription", "factor", "displaying", "S", "phase-specific", "DNA", "binding", "activity", "." ]
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11415
[ "One", "interpretation", "of", "these", "data", "leads", "to", "a", "model", "in", "which", "the", "peak", "in", "GATA-1", "DNA", "binding", "amplifies", "the", "effect", "of", "early", "replication", "on", "the", "activation", "of", "erythroid-specific", "genes", "at", "the", "same", "time", "as", "preventing", "activation", "of", "non-erythroid", "genes", "containing", "GATA-responsive", "elements", "." ]
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11416
[ "These", "results", "may", "also", "relate", "to", "recent", "data", "implicating", "GATA-1", "function", "in", "apoptosis", "and", "cell", "cycle", "progression" ]
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11417
[ "Activation", "of", "the", "NF-kappaB", "pathway", "by", "inflammatory", "stimuli", "in", "human", "neutrophils", "." ]
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11418
[ "Activated", "neutrophils", "have", "the", "ability", "to", "upregulate", "the", "expression", "of", "many", "genes", ",", "in", "particular", "those", "encoding", "cytokines", "and", "chemokines", ",", "and", "to", "subsequently", "release", "the", "corresponding", "proteins", "." ]
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11419
[ "Although", "little", "is", "known", "to", "date", "concerning", "the", "regulation", "of", "gene", "transcription", "in", "neutrophils", ",", "it", "is", "noteworthy", "that", "many", "of", "these", "genes", "depend", "on", "the", "activation", "of", "transcription", "factors", ",", "such", "as", "NF-kappaB", ",", "for", "inducible", "expression", "." ]
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11420
[ "We", "therefore", "investigated", "whether", "NF-kappaB/Rel", "proteins", "are", "expressed", "in", "human", "neutrophils", ",", "as", "well", "as", "their", "fate", "on", "cell", "activation", "." ]
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11421
[ "We", "now", "report", "that", "dimers", "consisting", "of", "p50", "NFkappaB1", ",", "p65", "RelA", ",", "and/or", "c-Rel", "are", "present", "in", "neutrophils", "and", "that", "the", "greater", "part", "of", "these", "protein", "complexes", "is", "physically", "associated", "with", "cytoplasmic", "IkappaB-alpha", "in", "resting", "cells", "." ]
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11422
[ "Following", "neutrophil", "stimulation", "with", "proinflammatory", "agonists", "(", "such", "as", "lipopolysaccharide", "[", "LPS", "]", ",", "tumor", "necrosis", "factor-alpha", "[", "TNF-alpha", "]", ",", "and", "fMet-Leu-Phe", ")", "that", "induce", "the", "production", "of", "cytokines", "and", "chemokines", "in", "these", "cells", ",", "NF-kappaB/Rel", "proteins", "translocated", "to", "nuclear", "fractions", ",", "resulting", "in", "a", "transient", "induction", "of", "NF-kappaB", "DNA", "binding", "activity", ",", "as", "determined", "in", "gel", "mobility", "shift", "assays", "." ]
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11423
[ "The", "onset", "of", "both", "processes", "was", "found", "to", "be", "closely", "paralleled", "by", ",", "and", "dependent", "on", ",", "IkappaB-alpha", "degradation", "." ]
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11424
[ "Proinflammatory", "neutrophil", "stimuli", "also", "promoted", "the", "accumulation", "of", "IkappaB-alpha", "mRNA", "transcripts", ",", "resulting", "in", "the", "reexpression", "of", "the", "IkappaB-alpha", "protein", "." ]
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11425
[ "To", "our", "knowledge", ",", "this", "constitutes", "the", "first", "indication", "that", "NF-kappaB", "activation", "may", "underlie", "the", "action", "of", "proinflammatory", "stimuli", "towards", "human", "neutrophil", "gene", "expression", "and", ",", "as", "such", ",", "adds", "a", "new", "facet", "to", "our", "understanding", "of", "neutrophil", "biology", "." ]
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11426
[ "Two", "distinct", "pathways", "of", "interleukin-5", "synthesis", "in", "allergen-specific", "human", "T-cell", "clones", "are", "suppressed", "by", "glucocorticoids", "." ]
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11427
[ "Glucocorticoids", "(", "GC", ")", "have", "long", "been", "used", "as", "the", "most", "effective", "agents", "for", "the", "treatment", "of", "allergic", "diseases", "accompanied", "by", "eosinophilia", "such", "as", "chronic", "asthma", "and", "atopic", "dermatitis", "." ]
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11428
[ "The", "development", "of", "chronic", "eosinophilic", "inflammation", "is", "dependent", "on", "interleukin-5", "(", "IL-5", ")", ",", "a", "selective", "eosinophil-activating", "factor", ",", "produced", "by", "helper", "T", "cells", "." ]
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11429
[ "To", "delineate", "the", "regulatory", "mechanisms", "of", "human", "IL-5", "synthesis", ",", "we", "established", "allergen-specific", "CD4+", "T-cell", "clones", "from", "asthmatic", "patients", "." ]
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11430
[ "GC", "efficiently", "suppressed", "IL-5", "synthesis", "of", "T-cell", "clones", "activated", "via", "either", "T-cell", "receptor", "(", "TCR", ")", "or", "IL-2", "receptor", "(", "IL-2R", ")", "." ]
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11431
[ "Induction", "of", "IL-5", "mRNA", "upon", "TCR", "and", "IL-2R", "stimulation", "was", "totally", "inhibited", "by", "dexamethasone", "." ]
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11432
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11433
[ "Electrophoretic", "mobility", "shift", "assay", "analysis", "suggested", "that", "AP-1", "and", "NF-kappaB", "are", "among", "the", "possible", "targets", "of", "GC", "actions", "on", "TCR-stimulated", "T", "cells", "." ]
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11434
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11435
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11436
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11437
[ "We", "investigated", "the", "functional", "role", "of", "Itk", ",", "a", "member", "of", "the", "cytoplasmic", "tyrosine", "kinase", "Tec", "family", ",", "in", "T", "cell", "activation", "." ]
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11438
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11439
[ "The", "tyrosine", "kinase", "activity", "in", "the", "anti-", "Itk", "immunoprecipitate", "was", "significantly", "activated", "upon", "these", "stimulations", "." ]
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11440
[ "Interleukin-2", "(", "IL-2", ")", "promoter", "activity", "stimulated", "by", "cross-linking", "of", "CD2", ",", "TCR", "/CD3", ",", "and", "CD28", "with", "antibodies", "was", "significantly", "reduced", "by", "transient", "expression", "of", "an", "Itk", "mutant", "lacking", "the", "kinase", "activity", "." ]
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11441
[ "The", "reduction", "paralleled", "a", "decrease", "in", "tyrosine", "phosphorylation", "of", "endogenous", "wild-type", "Itk", "." ]
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11442
[ "Stimulation", "of", "CD2", "or", "TCR/CD3", "induced", "activation", "of", "the", "nuclear", "factor", "of", "activated", "T", "cells", "(", "NFAT", ")", ",", "the", "binding", "site", "of", "which", "is", "included", "in", "the", "IL-2", "gene", "promoter", "." ]
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11443
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11444
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11445
[ "Expression", "of", "LAZ3/BCL6", "in", "follicular", "center", "(", "FC", ")", "B", "cells", "of", "reactive", "lymph", "nodes", "and", "FC-derived", "non-Hodgkin", "lymphomas", "." ]
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11446
[ "Chromosomal", "translocation", "resulting", "in", "abnormal", "expression", "of", "the", "LAZ3/BCL6", "gene", "in", "B", "cells", "has", "been", "implicated", "in", "the", "tumorigenesis", "of", "non-Hodgkin", "lymphoma", "(", "NHL", ")", "." ]
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11447
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11448
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11449
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11450
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11451
[ "All", "cases", "of", "follicular", ",", "mixed", "small", "and", "large", "cell", "lymphomas", "showed", "LAZ3/BCL6", "expression", "confined", "to", "the", "neoplastic", "follicles", "." ]
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11452
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11464
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11468
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11469
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11470
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11471
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11472
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11473
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11474
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11475
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11476
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11478
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11480
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11481
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11482
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11483
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11484
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11485
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11486
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11487
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11489
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11490
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11491
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11493
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11495
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11496
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11497
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11499
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