Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
11201
[ "Redox", "regulation", "of", "the", "mitogen-activated", "protein", "kinase", "pathway", "during", "lymphocyte", "activation", "." ]
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11202
[ "We", "have", "previously", "demonstrated", "an", "obligatory", "requirement", "for", "intracellular", "reactive", "oxygen", "species", "generation", "during", "T", "lymphocyte", "activation", ",", "and", "have", "proposed", "that", "intracellular", "reactive", "oxygen", "species", "may", "act", "as", "signalling", "agents", "in", "the", "regulation", "of", "certain", "cellular", "processes", ",", "for", "example", ",", "during", "cell", "cycle", "entry", "." ]
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11203
[ "To", "test", "this", "hypothesis", ",", "we", "have", "been", "interested", "to", "determine", "which", ",", "if", "any", ",", "cell", "cycle", "entry", "events", "are", "affected", "by", "oxidative", "signalling", "." ]
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11204
[ "In", "earlier", "studies", ",", "we", "have", "identified", "the", "transcription", "factors", "NF-kappa", "B", "and", "AP-1", "as", "molecular", "targets", "for", "oxidative", "signalling", "processes", "during", "cell", "cycle", "entry", ",", "and", "have", "shown", "that", "oxidative", "signalling", "is", "involved", "in", "the", "regulation", "of", "early", "changes", "in", "gene", "expression", "during", "the", "G0", "to", "G1", "phase", "transition", "." ]
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11205
[ "To", "extend", "these", "initial", "observations", ",", "we", "have", "examined", "the", "effect", "of", "antioxidant", "treatment", "on", "the", "activity", "of", "the", "mitogen-activated", "protein", "kinases", "erk1", "and", "erk2", ",", "as", "members", "of", "a", "signal", "transduction", "pathway", "known", "to", "directly", "regulate", "transcription", "factor", "function", "." ]
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11206
[ "Using", "as", "a", "probe", "cysteamine", ",", "an", "aminothiol", "compound", "with", "both", "antioxidant", "and", "antiproliferative", "activity", ",", "we", "have", "identified", "erk2", ",", "a", "key", "element", "of", "the", "MAP", "kinase", "pathway", ",", "as", "being", "responsive", "to", "oxidative", "signalling", "during", "lymphocyte", "activation", "." ]
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11207
[ "These", "observations", "provide", "further", "evidence", "to", "suggest", "a", "role", "for", "intracellular", "oxidant", "generation", "as", "a", "regulatory", "mechanism", "during", "cell", "cycle", "entry", ",", "and", "establish", "a", "link", "between", "oxidative", "signalling", "and", "other", "aspects", "of", "the", "intracellular", "signalling", "network", "that", "is", "activated", "in", "response", "to", "mitogenic", "stimulation", "." ]
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11208
[ "Physical", "and", "functional", "interaction", "between", "the", "human", "T-cell", "lymphotropic", "virus", "type", "1", "Tax1", "protein", "and", "the", "CCAAT", "binding", "protein", "NF-Y", "." ]
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11209
[ "Tax1", ",", "a", "potent", "activator", "of", "human", "T-cell", "lymphotropic", "virus", "type", "1", "(", "HTLV-1", ")", "transcription", ",", "has", "been", "shown", "to", "modulate", "expression", "of", "many", "cellular", "genes", "." ]
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11210
[ "Tax1", "does", "not", "bind", "DNA", "directly", "but", "regulates", "transcription", "through", "protein-protein", "interactions", "with", "sequence-specific", "transcription", "factors", "." ]
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11211
[ "Using", "the", "yeast", "two-hybrid", "system", "to", "screen", "for", "proteins", "which", "interact", "with", "Tax1", ",", "we", "isolated", "the", "B", "subunit", "of", "the", "CCAAT", "binding", "protein", "NF-Y", "from", "a", "HeLa", "cDNA", "library", "." ]
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11212
[ "The", "interaction", "of", "Tax1", "with", "NF-YB", "was", "specific", "in", "that", "NF-YB", "did", "not", "interact", "with", "a", "variety", "of", "other", "transcription", "factors", ",", "including", "human", "immunodeficiency", "virus", "Tat", ",", "human", "papillomavirus", "E6", ",", "and", "Bicoid", ",", "or", "with", "the", "M7", "(", "amino", "acids", "29CP-AS", ")", "Tax1", "mutant", "." ]
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11213
[ "However", ",", "NF-YB", "did", "interact", "with", "the", "C-terminal", "Tax1", "mutants", "M22", "(", "130TL-AS", ")", "and", "M47", "(", "319LL-RS", ")", "." ]
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11214
[ "We", "also", "show", "that", "in", "vitro-translated", "NF-YB", "specifically", "bound", "to", "a", "glutathione", "S-transferase-Tax1", "fusion", "protein", "." ]
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11215
[ "Further", ",", "Tax1", "coimmunoprecipitated", "with", "NF-Y", "from", "nuclear", "extracts", "of", "HTLV-1-transformed", "cells", ",", "providing", "evidence", "for", "in", "vivo", "interaction", "of", "Tax1", "and", "NF-YB", "." ]
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11216
[ "We", "further", "demonstrate", "that", "Tax1", "specifically", "activated", "the", "NF-Y-responsive", "DQbeta", "promoter", ",", "as", "well", "as", "a", "minimal", "promoter", "which", "contains", "only", "the", "Y-box", "element", "." ]
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11217
[ "In", "addition", ",", "mutation", "of", "the", "Y-box", "element", "alone", "abrogated", "Tax1", "-mediated", "activation", "." ]
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11218
[ "Taken", "together", ",", "these", "data", "indicate", "that", "Tax1", "interacts", "with", "NF-Y", "through", "the", "B", "subunit", "and", "that", "this", "interaction", "results", "in", "activation", "of", "the", "major", "histocompatibility", "complex", "class", "II", "promoter", "." ]
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11219
[ "Through", "activation", "of", "this", "and", "other", "NF-Y", "driven", "promoters", ",", "the", "Tax1", "-NF-Y", "interaction", "may", "play", "a", "critical", "role", "in", "causing", "cellular", "transformation", "and", "HTLV-1", "pathogenesis", "." ]
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11220
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11221
[ "Transcription", "factor", "E2F", "binds", "to", "cellular", "promoters", "of", "certain", "growth-", "and", "cell", "cycle-controlling", "genes", "and", "forms", "distinct", "heteromeric", "complexes", "with", "other", "nuclear", "proteins", "." ]
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11222
[ "It", "has", "therefore", "been", "proposed", "that", "E2F", "is", "involved", "in", "cellular", "proliferation", "control", "." ]
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11223
[ "Human", "T-cell", "leukemia", "virus", "type", "I", "(", "HTLV-I", ")", "is", "an", "etiological", "agent", "of", "adult", "T-cell", "leukemia", "(", "ATL", ")", "." ]
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11224
[ "We", "show", "here", "by", "mobility-shift", "assay", "that", "E2F-containing", "DNA-binding", "complexes", "were", "detected", "in", "HTLV-I-infected", "T-cell", "lines", "and", "leukemic", "cells", "obtained", "from", "ATL", "patients", "but", "not", "in", "an", "uninfected", "T-cell", "line", ",", "Jurkat", ",", "and", "normal", "peripheral", "blood", "mononuclear", "cells", "." ]
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11225
[ "The", "Tax", "protein", ",", "encoded", "by", "HTLV-I", ",", "is", "a", "potent", "transcription", "activator", "of", "viral", "and", "several", "cellular", "genes", "." ]
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11226
[ "We", "demonstrate", "that", "expression", "of", "Tax", "can", "induce", "the", "E2F-containing", "DNA-binding", "complexes", "in", "Jurkat", "T", "cells", "." ]
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11227
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11228
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11229
[ "Dissociation", "of", "the", "Jak", "kinase", "pathway", "from", "G-CSF", "receptor", "signaling", "in", "neutrophils", "." ]
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11230
[ "Activation", "of", "the", "granulocyte", "colony-stimulating", "factor", "receptor", "(", "G-CSFR", ")", "induces", "rapid", "tyrosine", "phosphorylation", "of", "multiple", "intracellular", "substrates", "in", "proliferating", "cells", "and", "nonproliferating", ",", "terminally", "differentiated", "neutrophils", "." ]
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11231
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11232
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11233
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11234
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11235
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11236
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11237
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11238
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11239
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11240
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11241
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11242
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11243
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11244
[ "In", "addition", ",", "RNase", "protection", "assays", "revealed", "that", "anti-CD3/", "PMA-stimulated", "T", "cells", "from", "a", "substantial", "proportion", "of", "elderly", "subjects", "exhibited", "decreased", "levels", "of", "c-fos", "and/or", "c-jun", "mRNA", "compared", "to", "T", "cells", "from", "young", "subjects", "." ]
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11245
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11246
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11247
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11248
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11282
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11283
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11285
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11286
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